Microglia-specific localisation of a novel calcium binding protein, Iba1

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works

Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045 · see citing works

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

Maddon, P. J., Dalgleish, A. G., McDougal, J. S., Clapham, P. R., Weiss, R. A., & Axel, R. (1986) · Cell · doi:10.1016/0092-8674(86)90590-8 · Cited by 2,003 · see citing works

The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3

Dijkstra, C. D., Döpp, E. A., Joling, P., & Kraal, G. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2463-8_50 · Cited by 1,598 · see citing works

Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466 · see citing works

Activation of microglial cells by β-amyloid protein and interferon-γ

Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314 · see citing works

Functional plasticity of microglia: A review

Streit, W. J., Graeber, M. B., & Kreutzberg, G. W. (1988) · Glia · doi:10.1002/glia.440010502 · Cited by 937 · see citing works

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

Perry, V. H., Hume, D. A., & Gordon, S. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90215-5 · Cited by 902 · see citing works

A Novel Geneiba1in the Major Histocompatibility Complex Class III Region Encoding an EF Hand Protein Expressed in a Monocytic Lineage

Imai, Y., Ibata, I., Ito, D., Ohsawa, K., & Kohsaka, S. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1112 · Cited by 872 · see citing works

Macrophages and microglia in the nervous system

Perry, V. H., & Gordon, S. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90110-5 · Cited by 747 · see citing works

Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3.

Robinson, A. P., White, T. M., & Mason, D. W. (1986) · PubMed Central · Cited by 598 · see citing works

Lectin binding by resting and reactive microglia

Streit, W. J., & Kreutzberg, G. W. (1987) · Journal of Neurocytology · doi:10.1007/bf01795308 · Cited by 496 · see citing works

Brain macrophages: evaluation of microglia and their functions

Thomas, W. E. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90007-9 · Cited by 441 · see citing works

Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin

Streit, W. J., & Kreutzberg, G. W. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902680209 · Cited by 387 · see citing works

An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4).

Streit, W. J. (1990) · Journal of Histochemistry & Cytochemistry · doi:10.1177/38.11.2212623 · Cited by 372 · see citing works

Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells

Graeber, M. B., Streit, W. J., & Kreutzberg, G. W. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210104 · Cited by 367 · see citing works

The EF-hand family of calcium-modulated proteins

Persechini, A., Moncrief, N. D., & Kretsinger, R. H. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90097-0 · Cited by 362 · see citing works

Specific Tropism of HIV-1 for Microglial Cells in Primary Human Brain Cultures

Watkins, B. A., Dorn, H. H., Kelly, W. B., Armstrong, R. C., Potts, A. J., Michaels, F. H., Kufta, C. V., & Dubois-Dalcq, M. E. (1990) · Science · doi:10.1126/science.2200125 · Cited by 340 · see citing works

Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy

Graeber, M. B., Tetzlaff, W., Streit, W. J., & Kreutzberg, G. W. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90585-x · Cited by 333 · see citing works

Identity of ED2‐positive perivascular cells in rat brain

Graeber, M. B., Streit, W. J., & Kreutzberg, G. W. (1989) · Journal of Neuroscience Research · doi:10.1002/jnr.490220114 · Cited by 280 · see citing works

Modulation of CD4 antigen on macrophages and microglia in rat brain.

Perry, V. H., & Gordon, S. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.4.1138 · Cited by 229 · see citing works

Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis

Woodroofe, M. N., Bellamy, A. S., Feldmann, M., DAVISON, A. N., & Cuzner, M. L. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90100-0 · Cited by 186 · see citing works

Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

Haga, S., Akai, K., & Ishii, T. (1989) · Acta Neuropathologica · doi:10.1007/bf00687883 · Cited by 179 · see citing works

Progressive expression of immunomolecules on microglial cells in rat dorsal hippocampus following transient forebrain ischemia

Morioka, T., Kalehua, A. N., & Streit, W. J. (1992) · Acta Neuropathologica · doi:10.1007/bf00308474 · Cited by 140 · see citing works

A special type of senile plaque, possibly an initial stage

Probst, A., Brunnschweiler, H., Lautenschläger, C., & ULRICH, J. (1987) · Acta Neuropathologica · doi:10.1007/bf00692843 · Cited by 127 · see citing works

Plasminogen Binds Specifically to α‐Enolase on Rat Neuronal Plasma Membrane

Nakajima, K., Hamanoue, M., Takemoto, N., Hattori, T., Kato, K., & Kohsaka, S. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062048.x · Cited by 122 · see citing works

Neuronal Survival Factor from Bovine Brain Is Identical to Neuron‐Specific Enolase

Takei, N., Kondo, J., Nagaike, K., Ohsawa, K., Kato, K., & Kohsaka, S. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08277.x · Cited by 98 · see citing works

Characterisation of two new monoclonal antibodies directed against rat microglia

Gehrmann, J., & Kreutzberg, G. W. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903130302 · Cited by 72 · see citing works

The microglial reaction in the rat hippocampus following global ischemia: immuno-electron microscopy

Gehrmann, J., Bonnekoh, P., Miyazawa, T., Oschlies, U., Dux, E., Hossmann, K., & Kreutzberg, G. W. (1992) · Acta Neuropathologica · doi:10.1007/bf00227735 · Cited by 69 · see citing works

Induction of Urokinase‐Type Plasminogen Activator in Rat Facial Nucleus by Axotomy of the Facial Nerve

Nakajima, K., Reddington, M., Kohsaka, S., & Kreutzberg, G. W. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062500.x · Cited by 55 · see citing works

Spontaneous intracellular calcium oscillations in cortical astrocytes from a patient with intractable childhood epilepsy (Rasmussen's Encephalitis)

Manning, T. J., & Sontheimer, H. W. (1997) · Glia · doi:10.1002/(sici)1098-1136(199711)21:3 · Cited by 46 · see citing works

De novo production of α2-macroglobulin in cultured astroglia from rat brain

Saitoh, S., Iijima, N., Ikeda, M., Nakajima, K., Kimura, M., Katsuki, M., Mori, T., & Kohsaka, S. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90079-q · Cited by 25 · see citing works

Physiology of Microglia

Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547 · see citing works

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., Katsura, K., Katayama, Y., Asoh, S., & Ohta, S. (2007) · Nature Medicine · doi:10.1038/nm1577 · Cited by 2,572 · see citing works

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.020 · Cited by 1,973 · see citing works

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643 · see citing works

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616 · see citing works

Microglial interactions with synapses are modulated by visual experience

Tremblay, M.-È., Lowery, R. L., & Majewska, A. K. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000527 · Cited by 1,542 · see citing works

Control of microglial neurotoxicity by the fractalkine receptor

Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531 · see citing works

Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain

Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., et al. (2014) · Science · doi:10.1126/science.1252304 · Cited by 1,472 · see citing works

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Grossman, N., Bono, D. C., Dedic, N., Kodandaramaiah, S. B., Rudenko, A., Suk, H., Cassara, A. M., Neufeld, E., Kuster, N., Tsai, L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.024 · Cited by 996 · see citing works

Review: Activation patterns of microglia and their identification in the human brain

Boche, D., Perry, V., & Nicoll, J. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12011 · Cited by 903 · see citing works

Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice

Zhao, J., Bi, W., Xiao, S., Lan, X., Cheng, X., Zhang, J., Lu, D., Wei, W., Wang, Y., Li, H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-42286-8 · Cited by 905 · see citing works

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

Streit, W. J., Braak, H., Xue, Q.-S., & Bechmann, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0556-6 · Cited by 727 · see citing works

Microglia: biology and pathology

Graeber, M., & Streit, W. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0622-0 · Cited by 729 · see citing works

Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness

Calcia, M., Bonsall, D. R., Bloomfield, P. S., Selvaraj, S., Barichello, T., & Howes, O. D. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4218-9 · Cited by 710 · see citing works

Efficient derivation of microglia-like cells from human pluripotent stem cells

Muffat, J., Li, Y., Yuan, B., Mitalipova, M., Omer, A., Corcoran, S., Bakiasi, G., Tsai, L.-H., Aubourg, P., Ransohoff, R. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4189 · Cited by 651 · see citing works

TAM receptors regulate multiple features of microglial physiology

Fourgeaud, L., Través, P. G., Tufail, Y., Leal-Bailey, H., Lew, E. D., Burrola, P. G., Callaway, P., Zagórska, A., Rothlin, C. V., Nimmerjahn, A., et al. (2016) · Nature · doi:10.1038/nature17630 · Cited by 600 · see citing works

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

Kim, M.-S., Kim, Y., Choi, H., Kim, W., Park, S., Lee, D., Kim, D. K., Kim, H. J., Choi, H., Hyun, D.-W., et al. (2020) · Gut · doi:10.1136/gutjnl-2018-317431 · Cited by 614 · see citing works

Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6

Vallières, L., Campbell, I. L., Gage, F. H., & Sawchenko, P. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00486.2002 · Cited by 598 · see citing works

Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved

Pineau, I., & Lacroix, S. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21149 · Cited by 592 · see citing works

Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, After Transient Focal Cerebral Ischemia In Rat Brain

Ito, D., Tanaka, K., Suzuki, S., Dembo, T., & Fukuuchi, Y. (2001) · Stroke · doi:10.1161/01.str.32.5.1208 · Cited by 594 · see citing works

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

Hopperton, K. E., Mohammad, D., Trépanier, M. O., Giuliano, V, & Bazinet, R. P. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.246 · Cited by 567 · see citing works

Extracellular ATP or ADP Induce Chemotaxis of Cultured Microglia through G_i/o-Coupled P2Y Receptors

Honda, S., Sasaki, Y., Ohsawa, K., Imai, Y., Nakamura, Y., Inoue, K., & Kohsaka, S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01975.2001 · Cited by 561 · see citing works

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

Walker, D. G., & Lue, L.-F. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0139-9 · Cited by 562 · see citing works

Retinal microglia: Just bystander or target for therapy?

Karlstetter, M., Scholz, R., Rutar, M., Wong, W. T., Provis, J. M., & Langmann, T. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.11.004 · Cited by 550 · see citing works

Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

Nobili, A., Latagliata, E. C., Viscomi, M. T., Cavallucci, V., Cutuli, D., Giacovazzo, G., Krashia, P., Rizzo, F. R., Marino, R., Federici, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms14727 · Cited by 514 · see citing works

NG2 Is a Major Chondroitin Sulfate Proteoglycan Produced after Spinal Cord Injury and Is Expressed by Macrophages and Oligodendrocyte Progenitors

Jones, L. L., Yamaguchi, Y., Stallcup, W. B., & Tuszynski, M. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02792.2002 · Cited by 482 · see citing works

Chemokine Expression by Glial Cells Directs Leukocytes to Sites of Axonal Injury in the CNS

Babcock, A. A., Kuziel, W. A., Rivest, S., & Owens, T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07922.2003 · Cited by 472 · see citing works

The Ins2 Akita Mouse as a Model of Early Retinal Complications in Diabetes

Barber, A. J., Antonetti, D. A., Kern, T. S., Reiter, C. E. N., Soans, R. S., Krady, J. K., Levison, S. W., Gardner, T. W., & Bronson, S. K. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1340 · Cited by 472 · see citing works

Glia: Initiators and progressors of pathology in Parkinson's disease

Halliday, G. M., & Stevens, C. H. (2011) · Movement Disorders · doi:10.1002/mds.23455 · Cited by 423 · see citing works

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

Peng, W., Cotrina, M. L., Han, X., Yu, H., Bekar, L. K., Blum, L., Takano, T., Tian, G.-F., Goldman, S. A., & Nedergaard, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902531106 · Cited by 425 · see citing works

Microglia and Inflammation in Alzheimers Disease

Mandrekar-Colucci, S., & Landreth, G. E. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791012071 · Cited by 421 · see citing works

Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia

Ohsawa, K., Imai, Y., Kanazawa, H., Sasaki, Y., & Kohsaka, S. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.17.3073 · Cited by 420 · see citing works

Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration

Harada, T., Harada, C., Kohsaka, S., Wada, E., Yoshida, K., Ohno, S., Mamada, H., Tanaka, K., Parada, L. F., & Wada, K. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09228.2002 · Cited by 325 · see citing works

Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment

Shen, X., Dong, Y., Xu, Z., Wang, H., Miao, C., Soriano, S. G., Sun, D., Baxter, M. G., Zhang, Y., & Xie, Z. (2013) · Anesthesiology · doi:10.1097/aln.0b013e3182834d77 · Cited by 393 · see citing works

Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice

Biesmans, S., Meert, T. F., Bouwknecht, J. A., Acton, P. D., Davoodi, N., Haes, P. D., Kuijlaars, J., Langlois, X., Matthews, L. J. R., Donck, L. V., et al. (2013) · Mediators of Inflammation · doi:10.1155/2013/271359 · Cited by 382 · see citing works

Microglia/macrophage‐specific protein Iba1 binds to fimbrin and enhances its actin‐bundling activity

Ohsawa, K., Imai, Y., Sasaki, Y., & Kohsaka, S. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02213.x · Cited by 368 · see citing works

β-Caryophyllene: A Sesquiterpene with Countless Biological Properties

Francomano, F., Caruso, A., Barbarossa, A., Fazio, A., Torre, C. L., Ceramella, J., Mallamaci, R., Saturnino, C., Iacopetta, D., & Sinicropi, M. S. (2019) · Applied Sciences · doi:10.3390/app9245420 · Cited by 358 · see citing works

Microglia and ischemic stroke: a double-edged sword.

Patel, A. R., Ritzel, R. M., McCullough, L. D., & Liu, F. (2013) · Europe PMC (PubMed Central) · Cited by 355 · see citing works

Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia

Simard, A. R., & Rivest, S. (2004) · The FASEB Journal · doi:10.1096/fj.04-1517fje · Cited by 354 · see citing works

The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination

Chen, Y., Wu, H., Wang, S., Koito, H., Li, J., Ye, F., Hoang, J., Escobar, S. S., Gow, A., Arnett, H. A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2410 · Cited by 346 · see citing works

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

Jordão, J. F., Thévenot, E., Markham-Coultes, K., Scarcelli, T., Weng, Y.-Q., Xhima, K., O'Reilly, M., Huang, Y., McLaurin, J., Hynynen, K., et al. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.05.008 · Cited by 326 · see citing works

Iba1 Is an Actin-Cross-Linking Protein in Macrophages/Microglia

Sasaki, Y., Ohsawa, K., Kanazawa, H., Kohsaka, S., & Imai, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5388 · Cited by 373 · see citing works

Microglial cell population dynamics in the injured adult central nervous system

Ladeby, R., Wirenfeldt, M., Garcia-Ovejero, D., Fenger, C., Dissing-Olesen, L., Dalmau, I., & Finsen, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.009 · Cited by 334 · see citing works

Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma

Hirose, K., Discolo, C. M., Keasler, J. R., & Ransohoff, R. M. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20619 · Cited by 331 · see citing works

The Multifaceted Profile of Activated Microglia

Lynch, M. A. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8077-9 · Cited by 323 · see citing works

Reduced Retina Microglial Activation and Improved Optic Nerve Integrity with Minocycline Treatment in the DBA/2J Mouse Model of Glaucoma

Bosco, A., Inman, D. M., Steele, M. R., Wu, G., Soto, I., Marsh‐Armstrong, N., Hubbard, W. C., Calkins, D. J., Horner, P. J., & Vetter, M. L. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1337 · Cited by 322 · see citing works

Morphometric characterization of microglial phenotypes in human cerebral cortex

Torres-Platas, S. G., Comeau, S., Rachalski, A., Bo, G. D., Cruceanu, C., Turecki, G., Giros, B., & Mechawar, N. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-12 · Cited by 313 · see citing works

Microglial pathology

Streit, W. J., Xue, Q.-S., Tischer, J., & Bechmann, I. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0142-6 · Cited by 317 · see citing works

Microbiota from young mice counteracts selective age-associated behavioral deficits

Boehme, M., Guzzetta, K. E., Bastiaanssen, T. F. S., van de Wouw, M., Moloney, G. M., Gual-Grau, A., Spichak, S., Olavarría-Ramírez, L., Fitzgerald, P., Morillas, E., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00093-9 · Cited by 313 · see citing works

Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology

Hendrickx, D. A. E., van Eden, C. G., Schuurman, K. G., Hamann, J., & Huitinga, I. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.04.007 · Cited by 313 · see citing works

Intracellular signaling in M‐CSF‐induced microglia activation: Role of Iba1

Imai, Y., & Kohsaka, S. (2002) · Glia · doi:10.1002/glia.10149 · Cited by 359 · see citing works

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

Tremblay, M., Zettel, M. L., Ison, J. R., Allen, P. D., & Majewska, A. K. (2012) · Glia · doi:10.1002/glia.22287 · Cited by 309 · see citing works

Involvement of P2X 4 and P2Y 12 receptors in ATP‐induced microglial chemotaxis

Ohsawa, K., Irino, Y., Nakamura, Y., Akazawa, C., Inoue, K., & Kohsaka, S. (2007) · Glia · doi:10.1002/glia.20489 · Cited by 301 · see citing works

P2Y ₁₂ receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases: P2Y ₁₂ Expression on Human Microglia

Mildner, A., Huang, H., Radke, J., Stenzel, W., & Priller, J. (2017) · Glia · doi:10.1002/glia.23097 · Cited by 301 · see citing works

c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia

Waetzig, V., Czeloth, K., Hidding, U., Mielke, K., Kanzow, M., Brecht, S., Goetz, M. E., Lucius, R., Herdegen, T., & Hanisch, U. (2005) · Glia · doi:10.1002/glia.20173 · Cited by 291 · see citing works

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Flores, J., Noël, A., Foveau, B., Lynham, J., Lecrux, C., & LeBlanc, A. C. (2018) · Nature Communications · doi:10.1038/s41467-018-06449-x · Cited by 288 · see citing works

AAV <i>cis</i> -regulatory sequences are correlated with ocular toxicity

Xiong, W., Wu, D. M., Xue, Y., Wang, S. K., Chung, M. J., Ji, X., Rana, P., Zhao, S. R., Mai, S., & Cepko, C. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821000116 · Cited by 249 · see citing works

Age‐dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

Xu, H., Chen, M., Manivannan, A., Lois, N., & Forrester, J. V. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00351.x · Cited by 277 · see citing works

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

Simmons, D. A., Casale, M., Alcon, B., Pham, N., Narayan, N., & LYNCH, G. S. (2007) · Glia · doi:10.1002/glia.20526 · Cited by 277 · see citing works

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

Qin, L., Liu, Y., Hong, J., & Crews, F. T. (2013) · Glia · doi:10.1002/glia.22479 · Cited by 271 · see citing works

Beyond Activation: Characterizing Microglial Functional Phenotypes

Lier, J., Streit, W. J., & Bechmann, I. (2021) · Cells · doi:10.3390/cells10092236 · Cited by 274 · see citing works

Tumour‐associated microglia/macrophages predict poor prognosis in high‐grade gliomas and correlate with an aggressive tumour subtype

Sørensen, M. D., Dahlrot, R. H., Boldt, H. B., Hansen, S., & Kristensen, B. W. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12428 · Cited by 273 · see citing works

Mechanically-compliant intracortical implants reduce the neuroinflammatory response

Nguyen, J. K., Park, D. J., Skousen, J. L., Hess-Dunning, A. E., Tyler, D. J., Rowan, S. J., Weder, C., & Capadona, J. R. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/5/056014 · Cited by 274 · see citing works

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

Brettschneider, J., Toledo, J. B., Van Deerlin, V. M., Elman, L., McCluskey, L., Lee, V. M.-Y., & Trojanowski, J. Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039216 · Cited by 268 · see citing works

Early microglial colonization of the human forebrain and possible involvement in periventricular white‐matter injury of preterm infants

Verney, C., Monier, A., Fallet‐Bianco, C., & Gressèns, P. (2010) · Journal of Anatomy · doi:10.1111/j.1469-7580.2010.01245.x · Cited by 266 · see citing works

The human side of microglia

Smith, A. M., & Dragunow, M. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.12.001 · Cited by 256 · see citing works

D‐Serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

Sasabe, J., Chiba, T., Yamada, M., Okamoto, K., Nishimoto, I., Matsuoka, M., & Aiso, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601840 · Cited by 269 · see citing works

Human adult neurogenesis across the ages: An immunohistochemical study

Dennis, C. V., Suh, L. S., Rodriguez, M. L., Kril, J. J., & Sutherland, G. T. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12337 · Cited by 265 · see citing works

Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan

Larsen, P. H., Wells, J. E. A., Stallcup, W. B., Opdenakker, G., & Yong, V. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11127.2003 · Cited by 260 · see citing works

Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

Bachstetter, A. D., Van Eldik, L. J., Schmitt, F. A., Neltner, J. H., Ighodaro, E. T., Webster, S. J., Patel, E., Abner, E. L., Kryscio, R. J., & Nelson, P. T. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0209-z · Cited by 258 · see citing works

Cancer Stem Cell-Specific Scavenger Receptor CD36 Drives Glioblastoma Progression

Hale, J. S., Otvos, B., Sinyuk, M., Alvarado, A. G., Hitomi, M., Stoltz, K., Wu, Q., Flavahan, W. A., Levison, B. S., Johansen, M. L., et al. (2014) · Stem Cells · doi:10.1002/stem.1716 · Cited by 259 · see citing works

Actin-binding Proteins Coronin-1a and IBA-1 are Effective Microglial Markers for Immunohistochemistry

Ahmed, Z., Shaw, G., Sharma, V. P., Yang, C., McGowan, E., & Dickson, D. W. (2007) · Journal of Histochemistry &amp; Cytochemistry · doi:10.1369/jhc.6a7156.2007 · Cited by 258 · see citing works

Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

Sanchez-Guajardo, V., Febbraro, F., Kirik, D., & Romero-Ramos, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008784 · Cited by 256 · see citing works

Interleukin‐1β promotes oligodendrocyte death through glutamate excitotoxicity

Takahashi, J., Giuliani, F., Power, C., Imai, Y., & Yong, V. W. (2003) · Annals of Neurology · doi:10.1002/ana.10519 · Cited by 256 · see citing works

Macrophage Response to Peripheral Nerve Injury: The Quantitative Contribution of Resident and Hematogenous Macrophages

Mueller, M., Reif-Leonhard, C., Wacker, K., Ringelstein, E. B., Okabe, M., Hickey, W. F., & Kiefer, R. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000056993.28149.bf · Cited by 256 · see citing works

Development of Imidazoline‐2‐Thiones Based Two‐Photon Fluorescence Probes for Imaging Hypochlorite Generation in a Co‐Culture System

Xu, Q., Heo, C. H., Kim, G., Lee, H. W., Kim, H. M., & Yoon, J. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201500537 · Cited by 247 · see citing works

Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity

Vallières, L., & Sawchenko, P. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05197.2003 · Cited by 245 · see citing works

Influenza Infection Induces Neuroinflammation, Alters Hippocampal Neuron Morphology, and Impairs Cognition in Adult Mice

Jurgens, H. A., Amancherla, K., & Johnson, R. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6389-11.2012 · Cited by 243 · see citing works

Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype

Marshall, S. A., McClain, J. A., Kelso, M. L., Hopkins, D. M., Pauly, J. R., & Nixon, K. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.016 · Cited by 243 · see citing works

Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation

Xu, P., Wang, S.-W., Yu, X., Su, Y., Wang, T., Zhou, W., Zhang, H., Wang, Y., & Liu, R. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.002 · Cited by 245 · see citing works

Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex‐specific manner

Bolton, J. L., Smith, S. H., Huff, N. C., Gilmour, M. I., Foster, W. M., Auten, R. L., & Bilbo, S. D. (2012) · The FASEB Journal · doi:10.1096/fj.12-210989 · Cited by 243 · see citing works

Stab injury and device implantation within the brain results in inversely multiphasic neuroinflammatory and neurodegenerative responses

Potter, K. A., Buck, A. C., Self, W. K., & Capadona, J. R. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/4/046020 · Cited by 239 · see citing works

Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia

Tanaka, R., Komine‐Kobayashi, M., Mochizuki, H., YAMADA, M., Furuya, T., Migita, M., Shimada, T., Mizuno, Y., & Urabe, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00954-5 · Cited by 237 · see citing works

Cien Años de Microglía: Milestones in a Century of Microglial Research

Sierra, A., Paolicelli, R. C., & Kettenmann, H. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.09.004 · Cited by 229 · see citing works

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Alam, M., Ahmed, S., Elasbali, A. M., Adnan, M., Alam, S., Hassan, M. I., & Pasupuleti, V. R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.860508 · Cited by 234 · see citing works

Impaired Synaptic Function in the Microglial KARAP/DAP12-Deficient Mouse

Roumier, A., Béchade, C., Poncer, J. C., Smalla, K., Tomasello, E., Vivier, É., Gundelfinger, E. D., Triller, A., & Bessis, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2251-04.2004 · Cited by 228 · see citing works

Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo

Swinnen, N., Smolders, S., Ávila, A., Notelaers, K., Paesen, R., Ameloot, M. M., Brône, B., Legendre, P., & Rigo, J. (2012) · Glia · doi:10.1002/glia.22421 · Cited by 226 · see citing works

Distinction of Neurons, Glia and Endothelial Cells in the Cerebral Cortex: An Algorithm Based on Cytological Features

García‐Cabezas, M. Á., John, Y. J., Barbas, H., & Zikopoulos, B. (2016) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2016.00107 · Cited by 227 · see citing works

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

Serrano-Pozo, A., Muzikansky, A., Gómez-Isla, T., Growdon, J. H., Betensky, R. A., Frosch, M. P., & Hyman, B. T. (2013) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1097/nen.0b013e3182933788 · Cited by 226 · see citing works

Neuroprotective effects of hydrogen saline in neonatal hypoxia–ischemia rat model

Cai, J., Kang, Z., Liu, K., Liu, W., Li, R., Zhang, J. H., Luo, X., & Sun, X. (2008) · Brain Research · doi:10.1016/j.brainres.2008.11.048 · Cited by 226 · see citing works

Parkinson’s disease as a result of aging

Rodriguez, M., Rodriguez‐Sabate, C., Morales, I., Sanchez, A., & Sabate, M. (2015) · Aging Cell · doi:10.1111/acel.12312 · Cited by 214 · see citing works

An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In Vivo

Kozlowski, C., & Weimer, R. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031814 · Cited by 218 · see citing works

Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer’s disease

Kenkhuis, B., Somarakis, A., Kleindouwel, L. R. T., van Roon-Mom, W. M. C., Höllt, T., & van der Weerd, L. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105684 · Cited by 188 · see citing works

Synaptic Defects in the Spinal and Neuromuscular Circuitry in a Mouse Model of Spinal Muscular Atrophy

Ling, K., Lin, M.-Y., Zingg, B., Feng, Z., & Ko, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015457 · Cited by 215 · see citing works

Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice

Yuan, L., Liu, S., Bai, X., Gao, Y., Liu, G., Wang, X., Liu, D., Li, T., Hao, A., & Wang, Z. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0541-7 · Cited by 213 · see citing works

Immune surveillance of mouse brain perivascular spaces by blood‐borne macrophages

Bechmann, I., Priller, J., Kovac, A. D., Böntert, M., Wehner, T., Fernández‐Klett, F., Bohsung, J., Stuschke, M., Dirnagl, U., & Nitsch, R. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01793.x · Cited by 213 · see citing works

Astrocytes carrying the superoxide dismutase 1 (SOD1 ^G93A ) mutation induce wild-type motor neuron degeneration in vivo

Papadeas, S. T., Kraig, S. E., O'Banion, C., Lepore, A. C., & Maragakis, N. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103141108 · Cited by 213 · see citing works

Embryonic and postnatal development of microglial cells in the mouse retina

Santos, A. M., Calvente, R., Tassi, M., Carrasco, M., Martín‐Oliva, D., Marín‐Teva, J. L., Navascués, J., & Cuadros, M. A. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21538 · Cited by 213 · see citing works

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO

Narayanaswami, V., Dahl, K., Bernard‐Gauthier, V., Josephson, L., Cumming, P. D., & Vasdev, N. (2018) · Molecular Imaging · doi:10.1177/1536012118792317 · Cited by 215 · see citing works

Calcium-Binding Protein Iba-1/AIF-1 in Rat Brain Cells

Kirik, O. V., Sukhorukova, E. G., & Korzhevsky, D. E. (2011) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-011-9391-z · Cited by 9 · see citing works

Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, After Transient Focal Cerebral Ischemia In Rat Brain

DaisukeIto, KortaroTanaka, ShigeakiSuzuki, TomohisaDembo, & YasuoFukuuchi (2001) · Stroke

UC Davis - Immunohistochemistry IBA1 v1Preprint

Rutkowsky, J. M. (2019) · doi:10.17504/protocols.io.y7pfzmn

UC Davis - Immunohistochemistry IBA1 v2Preprint

Rutkowsky, J. (2019) · doi:10.17504/protocols.io.56pg9dn

Intranuclear Accumulation of Iba-1 Protein in Microgliocytes in the Human Brain

Korzhevsky, D. E., Kirik, O. V., Alekseeva, O. S., Sukhorukova, E. G., & Syrtsova, M. A. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0417-z · Cited by 4 · see citing works