Defining a Cancer Dependency Map

Cited by (1,076)

Items 1,001–1,076 of 1,076

  1. Dasatinib inhibits PD-L1 expression via a proteasomal pathway in pancreatic ductal adenocarcinoma cells
    Ching-Chung Ko, Hui-Ying Li, Pei-Ming Yang · 2025 · Journal of Cancer
  2. tRNA thiolation defects disrupt cellular proteostasis and tissue homeostasis in mammals
    Lukas Englmaier, Marta Walczak, Daniel Malzl, Cristian Eggers, F. Eichin, Valentina C. Sladky, Filip Gallob, Y. Tyshchenko, Zarghun Zarif, Thomas Kolbe et al. · 2025 · bioRxiv
  3. Repurposing WHO Essential Antifungals for Cancer Treatment - Protocol for a Systematic Review and Cancer Dependency Map Analysis
    Kieran Cooper, B. Hennessy, C. Osborne · 2025 · HRB Open Research
  4. The Double Life of Shading of Cell 2 (SHOC2): Guardian of Skin Homeostasis and Accomplice of RAS- ERK Signaling
    José M. Rojas · 2025 · Journal of Regenerative Medicine and Biology Research
  5. Comprehensive investigation of the molecular basis of cancer dependencies suggests therapeutic options for breast cancer
    R. Ding, Zhi-Min Shao, Tianjian Yu · 2025 · Cancer Biology and Medicine
  6. Unifying proteomic technologies with ProteinProjector
    Leah V. Schaffer, Mayank Jain, Rami Nasser, Roded Sharan, T. Ideker · 2025 · Bioinformatics Advances
  7. FASTK post-transcriptional regulators – a ‘FAST-tracK’ in mitochondrial gene expression
    Justin M. Van Riper, Bridget J. Corsaro, Monica C. Pillon · 2025 · Biochemical Society Transactions
  8. DeepVul: A Multi-Task Transformer Model for Joint Prediction of Gene Essentiality and Drug Response
    Ala Jararweh, My Nguyen Bach, David Arredondo, Oladimeji S Macaulay, Mikaela Dicome, Luis E. Tafoya, Yue Hu, Kushal Virupakshappa, Genevieve Boland, K. Flaherty et al. · 2025 · bioRxiv
  9. Phenotypic AI-based design of cell-specific small molecule cytotoxics
    Gema Rojas-Granado, Marta Sánchez‐Soto, Jesús Calahorra, María Caballero, Israel Ramos, Martino Bertoni, Patrick Aloy · 2026 · Communications Chemistry
  10. Drug Candidate Identification for Renal Cell Carcinoma via Gene Regulatory Module Analysis and Docking Studies
    Aruna Arumugam Chockalingam, Aninda Astuti, Chia-Wei Weng, Ka‐Lok Ng · 2025 · International Conference on Artificial Intelligence for Medicine, Health and Care (AIxMHC)
  11. Integrating the secretome and interactome to identify novel biomarkers and therapeutic targets in colorectal cancer
    Gabriel Henrique Caxali, Mirian Carolini Esgoti Aal, Catherine Wesselka Garcia Osvaldo, Jakeline Santos Oliveira, Lucas Tadeu Bidinotto, Robson Francisco Carvalho, Flávia Karina Delella · 2025 · Cell Communication and Signaling
  12. COPS5 inhibition synergizes with the antitumor effect of trastuzumab by PTEN upregulation in HER2-amplified gastric cancer
    Sung-Hyun Hwang, Ji-Won Kim, Haeseong Park, A. Aguirre, Kui-Jin Kim, Song-Ji Choi, Woochan Park, Jeongmin Seo, Heejung Chae, M. Kang et al. · 2025 · Gastric Cancer
  13. Development and Application of MiMouse, a Comprehensive Genomic Profiling Panel for Credentialing Mouse Tumor Models
    Kevin Hu, Chia-Jen Liu, Zhaoping Qin, Aaron M. Udager, Marcin P. Cieslik, Scott A. Tomlins · 2025 · Cancer Research Communications
  14. Systems virology at scale
    Cameron D. Griffiths, Andrew J. Sweatt, Kevin A. Janes · 2025 · Current Opinion in Systems Biology
  15. sc2DAT: workflow for targeting tumor subpopulations of single cells
    Giacomo B. Marino, Anna I. Byrd, Nasheath Ahmed, Daniel J. B. Clarke, Avi Ma’ayan · 2024 · Bioinformatics Advances
  16. Reproducible autosomal gene expression changes with loss of typical X and Y complement across tumor types
    S. Plaisier, Robert Phavong, Mason Farmwald, Mariah Lee, Teagen Allen, M. Swamy, Ilsa Rodriguez, MacKenzie Wells, Nadia Phaneuf, S. Massey et al. · 2025 · bioRxiv
  17. A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition
    Paige A. Barta, Leopold Garnar-Wortzel, Timothy R. Bishop, Rachel E. Hayward, Lauren M. Hargis, James B. Shaum, Hui Si Kwok, Brian B. Liau, Benjamin F. Cravatt, Michael A. Erb · 2025 · RSC Chemical Biology
  18. Mechanism-aware inference of response to targeted cancer therapies
    Nilabja Bhattacharjee, S. Peela, Abhishek Halder, Bernadette Mathew, Swarnava Samanta, Sakshi Gujral, Stuti Kumari, S. Panda, Ritwik Ganguly, Gaurav Ahuja et al. · 2025 · bioRxiv
  19. STAMBP as a potential contributor of docetaxel resistance and prognostic biomarker in breast cancer
    Pei‐Yi Chu, Hung-Yu Lin · 2025 · 童綜合醫學雜誌
  20. A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer
    Travis J. Nelson, Ryan M. Kemper, Anna M. Chiarella, Stephany Gonzalez Tineo, Michell D Carroll, Surya P. Tripathi, Brandon J. Clarke, Xu-Fen Yu, Xiaoping Hu, Aidan J. Cooke et al. · 2025 · ACS Pharmacology & Translational Science
  21. ACTL6A regulates the Warburg effect through coordinated activation of AP-1 signaling in head and neck squamous cell carcinoma
    M. Monavarian, Keene Lee, Alistaire R. Sherman, Imran A. Mohammad, Sainiteesh Maddineni, Mao Zhang, Joseph C. Wu, Katrin F. Chua, John Sunwoo, Andrey Finegersh · 2025 · bioRxiv
  22. High-throughput Experimental Validation of Synonymous Mutation Neutrality in the Human Genome
    Yiyun Rao, Ivan Sokirniy, Edward P. O'Brien, Justin R. Pritchard · 2025 · bioRxiv
  23. SUMO E1 covalent allosteric inhibitors upregulate polyamine synthesis via the MAT2A-AdoMetDC axis
    Shuai Zhang, Jinzhu Li, Zhiying Wang, Yutong Jiao, Xiaoyu Shi, Yuanbao Ai, Juanping Wang, Sen Liu · 2025 · Bioorganic Chemistry
  24. Identifying in vivo genetic dependencies of melanocyte and melanoma development
    Sarah C. Perlee, Yilun Ma, Miranda V. Hunter, Jacob B Swanson, Nelly M. Cruz, Zhitao Ming, Julia Xia, Timothée Lionnet, Maura A. McGrail, Richard Mark White · 2024 · eLife
  25. Tyrosine phosphoproteome profiling identifies cell-intrinsic signals limiting the efficacy of tyrosine kinase inhibitor therapies
    C. T. Flower, Forest M. White · 2025 · bioRxiv
  26. Synthetic Lethal Combinations of DNA Repair Inhibitors and Genotoxic Agents to Target High‐Risk Diffuse Large B Cell Lymphoma
    Sara Ovejero, Julie Devin, Laura Alibert, Camille Soun, Yi‐Ching Lin, Laure Dutrieux, Matthieu Abouladzé, Elvira Garcia De Paco, Ouissem Karmous Gadacha, Angelos Constantinou et al. · 2025 · Hematological Oncology
  27. Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
    Brihget Sicairos, Jianhong Zhou, Zhijian Hu, Qingyang Zhang, Wei Q. Shi, Yuchun Du · 2025 · ACS Omega
  28. Endometrial Liquid‐Based Cytology Specimens Preserve High Genome Quality for Molecular Classification After Long‐Term Storage
    T. Akahane, Ikumi Kitazono, Seiya Yokoyama, Yuriko Higashi, Hiroaki Kobayashi, Akihide Tanimoto · 2025 · Diagnostic Cytopathology
  29. macpie: Scalable workflow for high-throughput transcriptomic profiling
    Nenad Bartonicek, Xin Liu, L. Twomey, Michelle Meier, Richard Lupat, S. Craig, David Yoannidis, Jason Li, Tim Semple, Kaylene J. Simpson et al. · 2025 · bioRxiv
  30. Transcriptional patterns of cancer-related genes in primary and metastatic tumours revealed by machine learning
    Faeze Keshavarz-Rahaghi, Erin Pleasance, Steven J.M. Jones · 2025 · BMC Biology
  31. Integrative Analysis of Novel Ferroptosis‐Related Genes Signatures as Prognostic Biomarkers in Ovarian Cancer
    Leilei Cao, Yiqin Ouyang, Wei Lu, Xiao Qi, Zhi-Jie Wang, Jing-Shuai Wang · 2025 · Cancer Reports
  32. The Role of Primate-Specific Genes and Network Dynamics in Cancer Evolution
    Chuan Dong, Su Yang, Zhen Liao, Qian Xu, Haixia Guo, Jianhai Chen, Wen Wei, Shengqian Xia, Zhenshun Cheng, Chengjun Zhang et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  33. The Kinase Inhibitor GNF-7 Is Synthetically Lethal in Topoisomerase 1-Deficient Ewing Sarcoma
    Carly M. Sayers, M. Carter, Hai-Yan Lei, Arnulfo Mendoza, Steven Shema, Xiao-Hu Zhang, Kelli M. Wilson, Lu Chen, Carleen Klumpp-Thomas, C. Thomas et al. · 2025 · Cancers
  34. EssSubgraph improves performance and generalizability of mammalian essential gene prediction with large networks
    Haimei Wen, Susan Carpenter, Karen McGinnis, Andrew Nelson, Keriayn N. Smith, Tian Hong · 2025 · bioRxiv
  35. A pathway-informed mutual exclusivity framework to detect genetic interactions in pediatric cancer
    Anastasia Spinou, Richard Gremmen, Jarno Drost, Patrick Kemmeren · 2025 · BMC Medical Genomics
  36. Platform for Representation and Integration of multimodal Molecular Embeddings
    E. Zheng, Yu Yan, B. Sankar, Ethan Ji, Steven Swee, Irsyad Adam, Ding Wang, A. Pelletier, Alex Bui, Wei Wang et al. · 2025 · arXiv.org
  37. Transcript levels of cellular senescence marker genes are increased based on high expression of gasdermin family of genes in breast cancer
    Çağlar Berkel · 2025 · Genome Instability & Disease
  38. A tighter grip on gene expression.
    Filip Nemčko, Alexander Stark · 2025 · Science
  39. Multi-gradient permutation survival analysis identifies mitosis and immune signatures steadily associated with cancer patient prognosis
    Xin-Lei Cai, Yi Ye, Xiao-Ping Liu, Z. Fang, Luonan Chen, Fei Li, Hong-Bin Ji · 2025 · bioRxiv
  40. Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression
    Carleigh Nesbit, Whitney Martin, A. Czechanski, Candice Byers, Narayanan Raghupathy, Ardian Ferraj, Jason K. Stumpff, L. Reinholdt · 2025 · Scientific Reports
  41. Fast-adapting graph neural network with prior knowledge for drug response prediction across preclinical and clinical data
    Hui Guo, Xiang Lv, Shenghao Li, Dai-Chuan Ma, Yi-Zhou Li, Menglong Li · 2025 · Journal of Pharmaceutical Analysis
  42. Multi‐Omics Analysis and Real‐World Data Validation of Serine Metabolism‐Related Genes in Colorectal Cancer
    Anqi Li, Qihui Wu, Yuanyuan Xu, Yijin Gu, Xuan Wang, Jiaxin Liu, Yan Wang, Jialing Xie, Xiaodan Fu, Yimin Li · 2025 · Journal of Cellular and Molecular Medicine
  43. PMDSynergy: Pre-training-based multi-dimensional fusion model for cancer drug synergy prediction
    Ruoyin Zhang, Siyu Tao, Yimiao Feng, Jie Zheng · 2025 · Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  44. Transcriptome-driven constraint-based modelling reveals metabolic targets for ovarian cancer
    Kate E. Meeson, Joanne C. McGrail, Jean-Marc Schwartz, Stephen S. Taylor · 2025 · bioRxiv
  45. Coenzyme A homeostasis regulates hypoxic signalling via UBFD1 in triple-negative breast cancer
    Paul Grevitt, Óscar Maiques, Kunal Shah, Valle Morales, Emanuela Gadaleta, Martin Dodel, Katiuscia Bianchi, Ivan T. Gout, J. Louise Jones, Claude Chelala et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis
    Takada, Saeko, Bolkan, Bonnie J., O’Connor, MaryJane, Goldberg, Michael, O’Connor, Michael B. · 2025 · PLOS Genetics
  47. Integrating process, proximity, and prediction implicates novel protein and RNA interactions in human Origin Recognition Complex function
    John A. Smolka · 2025 · bioRxiv
  48. MAGELLAN: Automated Generation of Interpretable Computational Models for Biological Reasoning
    Matthew A. Clarke, Charlie George Barker, Yuxin Sun, Theodoros I. Roumeliotis, Jyoti S. Choudhary, Jasmin Fisher · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  49. The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells
    Jie Fang, Jie Fang, Shivendra Singh, Brennan Wells, Qiong Wu, Hongjian Jin, Laura Janke, Shibiao Wan, Jacob A. Steele, Jon P. Connelly et al. · 2025 · eLife
  50. Identification of Target Genes Using Innovative Screening Systems
    Keisuke Sugita, Morito Kurata · 2025 · Pathology International
  51. A structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia
    Luke Jones, Oleksii S. Rukhlenko, Tânia Dias, Hiroaki Imoto, Ciardha Carmody, Kieran Wynne, Boris N. Kholodenko, Jonathan Bond · 2025 · bioRxiv
  52. Exploratory Data Analysis of the In Vitro Effects of Novel Hydrazide-Hydrazone Antioxidants in the Context of In Silico Predictors
    Yordan Yordanov, Virginia Tzankova, Denitsa Stefanova, Maya Georgieva, Diana Tzankova · 2025 · Antioxidants
  53. Hierarchical small molecule inhibition of MYST acetyltransferases
    Xuemin Chen, A. Castroverde, Minervo Perez, R. Holewinski, Kiall F. Suazo, Rashmi Karki, Thorkell Andressen, Benjamin A. Garcia, Jordan L. Meier · 2025 · bioRxiv
  54. FAM46C Expression Sensitizes Multiple Myeloma Cells to PF-543-Induced Cytotoxicity
    A. Miluzio, Federica De Grossi, Marilena Mancino, Stefano Biffo, Nicola Manfrini · 2025 · Biomolecules
  55. The identification of functional regions of MEK1 using CRISPR tiling screens
    Zhiqiang Zhang, Barbara Abreu, Jessica L. Brothwood, John J. Alexander, Martin Sims, John F. Lyons, Joanne M. Munck, Christopher J. Hindley · 2025 · Communications Biology
  56. SAP30 promotes clear cell renal cell carcinoma proliferation and inhibits apoptosis through the MT1G axis
    Wei Guo, Shuwen Wang, Zitong Yang, Yu Dong, Zhinan Xia, Wei Xue, Cheng Zhang · 2025 · European journal of medical research
  57. Exploring the Anti-Tumor Effects of Brusatol in Aggressive B-Cell Lymphomas
    Marta Szmyra, Sandra Haingartner, Sonja Jantscher, Eva Maria Bernhart, Péter Kovács-Hajdu, Veronika Bošková, Nikolaus Krall, Antonella Zupo, Thomas Pircher, Katrin Pansy et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Systemic genome-epigenome analysis captures a lineage-specific super-enhancer for MYB in gastrointestinal adenocarcinoma
    Fuyuan Li, Shangzi Wang, Lian Chen, Ning Jiang, Xingdong Chen, Jin Li · 2025 · Molecular Systems Biology
  59. Global analysis of actionable genomic alterations in thyroid cancer and precision-based pharmacogenomic strategies
    Samantha Espinoza-Ferrao, Gabriela Echeverría‐Garcés, Sebastián Rivera-Orellana, José Bueno‐Miño, Emilia Castellanos-Molina, Melanie Benítez-Núñez, Andrés López‐Cortés · 2025 · Frontiers in Pharmacology
  60. Using cancer profiles to identify synthetic lethal therapeutic targets and predictive biomarkers in cancer gene dependency data
    Laurence H. Pearl, Frances M. G. Pearl · 2026 · Bioinformatics
  61. Menin-MLL1 complex cooperates with NF-Y to promote HCC survival
    Margarita Dzama-Karels, Peyton C. Kuhlers, Mallory Sokolowski, Jacqueline A. Brinkman, John P. Morris, Jesse R. Raab · 2025 · bioRxiv
  62. A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin
    Alex C. Sternisha, Haocheng Li, Jeffrey I. Traylor, Lei Guo, Hyung Jun Ji, Xin Zhao, Kumar Gajendra, Qing Ouyang, Michael Schmidt, Morgan Fleishman et al. · 2025 · bioRxiv
  63. BRCA1 is a molecular correlate of cell proliferation in human brain development and in Group 3 and 4 medulloblastoma
    Ian Cheong, Xinghan Sun, Leo H.K. Lau, Nishka Kishore, Andrea Senff‐Ribeiro, Ander Díaz‐Navarro, Hana Hajari, Ellen Mak, Rhea Ahluwalia, Luca Bianchini et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Fully haplotyped genome assemblies of healthy individuals reveal variability in 5′ss strength and support by splicing regulatory proteins
    J. Ptok, Stephan Theiss, H. Schaal · 2025 · NAR Genomics and Bioinformatics
  65. Integrative Analysis of EGF, OSM, and TGFB Signaling Pathways Reveals Synergistic Mechanisms Driving Cell Motility Through CXCR2 Chemotactic Signaling and CREB Activation
    Ian C. Mclean, Sean M. Gross, Jeremy Copperman, Daniel S. Derrick, Laura M. Heiser · 2025 · bioRxiv
  66. New Kinase Inhibitors That Are Selectively Cytotoxic for Tumor Cells
    D. Skvortsov, I. V. Zhirkina, D. Ipatova, A. R. Pisarev, A. S. Malyshev, Y. A. Ivanenkov, V. G. Kartsev, O. Dontsova · 2025 · Doklady Biochemistry and Biophysics
  67. Targeting an AML-sustaining metabolic node
    Sarada Achyutuni, Jian Xu · 2025 · Blood
  68. Actionable targets in breast cancer: a multi-omics approach to uncover tumor-specific vulnerabilities
    Abdulkadir Elmas · 2025 · Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi
  69. Genome-wide CRISPR knockout screen reveals the landscape of essential genes across the porcine genome
    Thomas Nelson Harvey, Victor Boyartchuk, Maren van Son, Arne Bjørke Gjuvsland, Eli H. Grindflek, Matthew Kent · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  70. Transcriptome Complexity Disentangled: A Regulatory Molecules Approach
    Amir Asiaee, Zachary B. Abrams, Heather H. Pua, Kevin R. Coombes · 2025 · International Journal of Molecular Sciences
  71. Vitamin D receptor expression in germinal centre type diffuse large B-cell lymphoma cells is associated with vitamin D insensitivity
    E. Soilleux, Amanda P. Anderson, Emma Roberts, L. Lyne, K. Wong, H. Spearman, Stefano Casola, A. H. Banham, D. Gascoyne · 2025 · Endocrine Oncology
  72. A clinical drug candidate that triggers non-apoptotic cancer cell death
    Scott J. Dixon, Logan B. Leak, Ziwei Wang, W. Lee, Brianna A. Johnson, Alec Millner, Pin-Joe Ko, Cassandra M. Decosto, Leslie Magtanong, Joan Ritho et al. · 2025 · Research Square
  73. Diverse mechanisms of DDX3Y suppression by DDX3X
    Xiaolu Xu, Shuo Wei · 2025 · bioRxiv
  74. Ku suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansion
    Yimeng Zhu, Angelina Li, Suvrajit Maji, Brian J. Lee, Sophie M Korn, Jake A Gertie, Tyler J. Dorrity, Jianhua Wang, Kyle J. Wang, Amandine Pelletier et al. · 2025 · bioRxiv
  75. Inhibiting BCL2L1 preferentially targets aneuploid cells in acute myeloid leukemia
    Ya Zhao, Wenying Yu, Tingting Xie, Ziyu Xu, Wencui Yang, Kaiyang Zou, Ying Zheng, Fan Yang, Ligang Wu, Xiao Fang · 2026 · Acta Biochimica et Biophysica Sinica
  76. Putting the brakes on cyclin C: a promising strategy to cure B-cell acute lymphoblastic leukemia?
    S. Muddineni, Michael Milyavsky · 2025 · Haematologica