Defining a Cancer Dependency Map

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Items 201–300 of 1,076

1. A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
   Jennifer R. Devlin, Ben P. Martin, Nenad Bartoniček, Keziah Ting, Zheng Fan, Izabela Todorovski, Filip Bjelosevic, Sandra Verschoor, Annette Ciccone, Joseph A. Trapani et al. · 2025 · Molecular Cell
2. The A-C linker controls centriole structural integrity and duplication
   Lorène Bournonville, Marine H. Laporte, Susanne Borgers, Paul Guichard, Virginie Hamel · 2025 · Nature Communications
3. A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients
   Christopher Nardone, Julian Mintseris, Dingwei He, Justine C. Rutter, Benjamin L. Ebert, Steven P. Gygi, Tom A. Rapoport · 2025 · Nature Structural & Molecular Biology
4. Intracellular metabolic gradients dictate dependence on exogenous pyruvate
   Benjamin T. Jackson, Angela M. Montero, Sangita Chakraborty, Julia S. Brunner, Paige K. Arnold, Anna E Bridgeman, Pavlina Krasimirova Todorova, Katrina I. Paras, Lydia W.S. Finley · 2025 · Nature Metabolism
5. Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors
   Michael Launspach, Julia Macos, Shoaib Afzal, Janik Hohmann, Marc L Appis, Maximilian Pilgram, Stefanie Beez, Emily Ohlendorf, Casper F. T. van der Ven, Chahrazad Lachiheb et al. · 2025 · Nature Communications
6. Identification of CD84 as a potent survival factor in acute myeloid leukemia
   Ying-Hui Zhu, Mariam Murtadha, Miaomiao Liu, E. Caserta, Ottavio Napolitano, L. Nguyen, Hua-Feng Wang, M. Moloudizargari, L. Nigam, T. Tandoh et al. · 2025 · Journal of Clinical Investigation
7. CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer
   Shumei Chia, Justine Jia Wen Seow, Rafael Peres da Silva, Chayaporn Suphavilai, Niranjan Shirgaonkar, Maki Murata‐Hori, Xiaoqian Zhang, Elena Yaqing Yong, Jiajia Pan, Matan Thangavelu Thangavelu et al. · 2025 · Cell Reports Medicine
8. Selective USP7 Inhibition Synergizes with MEK1/2 Inhibitor to Enhance Immune Responses and Potentiate Anti–PD-1 Therapy in NRAS-Mutant Melanoma
   Liya Su, Dinghao Wang, Timothy J. Purwin, Sophia Ran, Qi Yang, Qingrun Zhang, Weijia Cai · 2025 · Journal of Investigative Dermatology
9. Impact of mutations on KAT6A enzyme and inhibitory potential of compounds from Withania somnifera using computational approaches
   Cromwel Tepap Zemnou, E. Karim, S. Chtita, F. Zanchi · 2025 · Comput. Biol. Medicine
10. The relationship between ferroptosis and respiratory infectious diseases: a novel landscape for therapeutic approach
    Longyan Hong, Xiangyu Chen, Yiming Liu, Hao Liang, Yinghui Zhao, Pengbo Guo · 2025 · Frontiers in Immunology
11. Precise metabolic dependencies of cancer through deep learning and validations
    Tao Wu, Xiangyu Zhao, Yu Zhang, Die Qiu, K. Diao, Dongliang Xu, Weiliang Wang, Xiaopeng Xiong, Xin-Xiang Li, Xue-Song Liu · 2025 · bioRxiv
12. Anti-SARS-CoV-2 and anticancer properties of triptolide and its derived carbonized nanomaterials.
    Rubina Kousar, Tahira Akhtar, Chin-Jung Lin, Timofey D. Lebedev, Yi-Chuan Li, Chih-Chao Yang, Wei-Jan Wang, Hsiao-Fan Chen, Wen-Chi Su, P. Biswas et al. · 2025 · Cancer Letters
13. Impact of rare non-coding variants on human diseases through alternative polyadenylation outliers
    Xudong Zou, Zhaozhao Zhao, Yu Chen, Kewei Xiong, Zeyang Wang, Shuxin Chen, Hui Chen, Gong‐Hong Wei, Shuhua Xu, Wei Li et al. · 2025 · Nature Communications
14. Identification of modulators of the ALT pathway through a native FISH-based optical screen
    Benura Azeroglu, Simran Khurana, Shih-Chun Wang, Gianna M. Tricola, Shalu Sharma, Camille Jubelin, Ylenia Cortolezzis, Gianluca Pegoraro, Kyle M. Miller, Travis H. Stracker et al. · 2024 · Cell Reports
15. Nuclear Control of Mitochondrial Homeostasis and Venetoclax Efficacy in AML via COX4I1
    Leisi Zhang, Honghai Zhang, Ting-Yu Wang, Ming-Li Li, Anthony K. N. Chan, Hyunjun Kang, L. C. Foong, Qiao Liu, S. Pokharel, Nicole M Mattson et al. · 2024 · Advancement of science
16. Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
    Pendyala, Sriram, Partington, Katie, Bradley, Nicholas, McEwen, Abbye E., Straub, Gwenneth, Kim, Hyeon-Jin, Fayer, Shawn, Holmes, Daniel Lee, Sitko, Katherine A., Garge, Riddhiman K. et al. · 2026 · Cell
17. TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11 -Mutant Tumors to Anti–PD-1 Immunotherapy
    Ahronian, Leanne G., Sahu, Soumyadip, Zhang, Minjie, Patel, Ayushi S., Geng, Ke, Bhattacharya, Reshmee, Falchook, Gerald S., Goldman, Jonathan W., Spira, Alexander I., Punekar, Salman R. et al. · 2025 · Cancer Research
18. RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response
    Shubo Zhao, Chloe S. Palma-Chaundler, Carla M. Engel, Jacqueline Cordes, Daniel Nixdorf, Michael Y. Luo, Selay Kaya, Aldwin Suryo Rahmanto, Diana van den Heuvel, Timur Mackens‐Kiani et al. · 2026 · Molecular Cell
19. GEMap: A comprehensive gene essentiality map for drug discovery
    Sai Tian, Yixue Liang, Jinbo Zhang, Weishan Liang, Jinyuan Lu, Jiajia Ren, Bojian Lin, Ruijun Wu, Chengyang Guo, Weidong Zhang · 2026 · Acta Pharmaceutica Sinica B
20. Medea: An AI agent for therapeutic reasoning across biological contexts
    Pengwei Sui, Michelle M. Li, Brenton P. Munson, Shanghua Gao, Wanxiang Shen, Valentina Giunchiglia, Andrew Nathanael Shen, Yepeng Huang, Zhenglun Kong, Katherine Licon et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
21. Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer
    Zile Fu, Yuanli Song, Fen Liu, Lv Chen, Shangli Cai, Peng Cui, Guoqiang Wang, Wenchuan Xie, Shu Zhang, Li Ding et al. · 2026 · Cancer Cell
22. UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
    Carlos Riechmann, Cara J. Ellison, Jake W Anderson, Kay Hofmann, Peter Sarkies, Paul R. Elliott · 2025 · Nature Structural & Molecular Biology
23. A Novel Integrative Framework for Depression: Combining Network Pharmacology, Artificial Intelligence, and Multi-Omics with a Focus on the Microbiota–Gut–Brain Axis
    Lele Zhang, Kai Chen, Shun Li, Shengjie Kris Liu, Zhenjie Wang · 2025 · Current Issues in Molecular Biology
24. DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance
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25. Mechanisms of Messenger RNA Packaging and Export
    Rupert Faraway, Daniel Zenklusen, Clemens Plaschka · 2025 · Annual Review of Cell and Developmental Biology
26. Development of Orally Bioavailable FTO Inhibitors with Potent Antileukemia Efficacy.
    Teng Yang, Ze Dong, Rong Du, Yiqing Wang, Lu Liu, Yangyang Xue, Xi Zhang, Yong-Gang Liao, J. Gan, Xiao-Xuan Yu et al. · 2025 · Journal of Medicinal Chemistry
27. Bone marrow tumor microenvironment profiling predicts distinct immunosuppressive phenotypes and immunotherapy potential in AML patients
    Leslie Correia da Cruz, Yejin Lee, Ji Yeon Paik, Jeonghye Park, Marc F. Diederich, Claudia Cerella · 2025 · Biomedicine & Pharmacotherapy
28. From Hype to Health Check: Critical Evaluation of Drug Response Prediction Models with DrEval
    J. Bernett, Pascal Iversen, Mario Picciani, Matthias Wilhelm, K. Baum, M. List · 2025 · bioRxiv
29. Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation
    R. Magesh, A. N. Kaur, F. Keller, A. Frederick, T. Tseyang, J. A. Haley, A. M. Rivera-Nieves, Anthony C. Liang, D. Guertin, Jessica B. Spinelli et al. · 2025 · Genes & Development
30. Integrated analysis of scRNA-seq and bulk RNA-seq data identifies BHLHE40 as a key gene in pancreatic cancer progression and gemcitabine resistance.
    Yang Wu, Chun Zhang, Jia-Cheng Huang, Qun Chen, Yufeng Zhang, Feng-Yuan Liu, Dong Xu, Kui-Rong Jiang, Run Shi, Meng-Xing Chen et al. · 2025 · Seminars in Oncology
31. Senataxin prevents replicative stress induced by the Myc oncogene
    Silvia Sberna, Marco Filipuzzi, Nicola Bianchi, Ottavio Croci, Federica Fardella, C. Soriani, S. Rohban, Sara Carnevali, Alessandra Alberta Albertini, Nicola Crosetto et al. · 2025 · Cell Death and Disease
32. Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML
    Yu Zhong, Rou Zhang, Lingzi Lu, Huijian Tan, Yuyu You, Yang Mao, Yan-Qiu Yuan · 2025 · Cell Communication and Signaling
33. PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy
    Xiayun Xu, Ying-Ji Chen, Siqi Fei, Xin-Yue Jiang, Xiao-Ting Zhou, Yi Xue, Yao Li, Shi-Min Zhao, Yan Huang, Chen-Ji Wang · 2025 · Cell Death and Disease
34. Retroelement co-option disrupts the cancer transcriptional programme
    Jane Ho Chun Loong, R. Houston Thompson, Callum Hall, Laura E. Doglio, Judith Pape, Tobias Plowman, George Kassiotis · 2025 · Genome Medicine
35. Multi-omics and single-cell analysis reveals machine learning-based pyrimidine metabolism-related signature in the prognosis of patients with lung adenocarcinoma
    Tong Hu, Run Shi, Yangyue Xu, Tingting Xu, Yuan Fang, Yunru Gu, Zhao-Kai Zhou, Yong-Qian Shu · 2025 · International Journal of Medical Sciences
36. Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis
    Dongkwan Shin, Jeong‐Ryeol Gong, Sang Kwon Jeong, Young-Won Cho, Hwang‐Phill Kim, Tae‐You Kim, Kwang‐Hyun Cho · 2025 · Advanced Science
37. High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors
    Siqi Zheng, Linoy Raz, Lin Zhou, Yael Cohen‐Sharir, Ruifang Tian, Marica Rosaria Ippolito, Sara Gianotti, Ron Saad, René Wardenaar, Mathilde Broekhuis et al. · 2025 · EMBO Reports
38. Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells
    Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina A. Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew V. Jones et al. · 2025 · Cell Death and Disease
39. A tumour-derived organoid biobank maps cancer gene dependencies
    Carmen Herranz‐Ors, Shriram G. Bhosle, A. E. Beck, James G. R. Gilbert, Gabriele Picco, Jose Espejo Valle-Inclán, Francesc Muyas, S. Valentini, A. E. Andres, R. Ansari et al. · 2026 · Nature
40. A compendium of next-generation patient-derived models for diverse cancers
    Dina ElHarouni, Mushriq Al‐Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A. Misek, Heeju Noh, Luca Zanella, Yuen-Yi Tseng, Hayley E. Francies et al. · 2026 · Nature
41. Strategies and mechanisms of precision genome engineering: From gene editing to genome writing
    Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Liu Ls, Y Huang, Ningyun Zhang, Lei Sun et al. · 2026 · iMetaOmics.
42. LASER couples damage sensing to ESCRT assembly for lysosome repair
    Claire S. Goul, Aakriti Jain, Samira Yitiz, Zahra E. Soltani, Serim Yang, Simon Rapp, Martina Spacci, Scot Federman, James Sacco, Huinan Li et al. · 2026 · Nature
43. A disease model resource reveals core principles of tissue-specific cancer evolution
    Sebastian Mueller, Niklas de Andrade Krätzig, Markus Tschurtschenthaler, Miguel G. Silva, Chiara Thordsen, Riccardo Trozzo, Perrine Simon, Frederic Saab, Thorsten Kaltenbacher, Magdalena Żukowska et al. · 2026 · Nature
44. Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle
    Abigail Xie, Julia S. Brunner, Sangita Chakraborty, Angela M. Montero, Anna E Bridgeman, Katrina I. Paras, Ruobing Cui, Maider Fagoaga-Eugui, Monika Komza, Paige K. Arnold et al. · 2026 · Cell
45. Junction-targeting designs limit the application of CRISPR-Cas13d in circular RNA perturbation studies
    Yannick C. Lee-Yow, Raeline Valbuena, Chiara S Richter, Howard Y. Chang, J Engreitz · 2025 · Nucleic Acids Research
46. Drug response in the era of precision medicine: A methodological review
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47. Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers
    Richard C. Centore, Luis Miguel Mendes Soares, Salih Topal, Rishi G. Vaswani, Kana Ichikawa, Zhifang Li, Hong Bo Fan, Jeremy W. Setser, David L. Lahr, Laura E. Zawadzke et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
48. ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC
    Nathan L. Tran, Jiewei Jiang, Mengyao Ma, Gillian E. Gadbois, Kevin Christian Montecillo Gulay, Alyssa L. Verano, Cara R. Schiavon, Elena Rebollo, Haowen Zhou, Chun‐Teng Huang et al. · 2025 · Nature Chemical Biology
49. De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma
    Duo Xu, Yanyun Gao, Shengchen Liu, Shiyuan Yin, Tong Hu, Haibin Deng, Tuo Zhang, Balázs Hegedűs, Thomas M. Marti, Patrick Dorn et al. · 2025 · EMBO Molecular Medicine
50. DOT1L inhibition reprograms innate immunity to potentiate immunomodulatory drug responses in multiple myeloma
    Kazuya Ishiguro, Hiroshi Kitajima, Takeshi Niinuma, Reo Maruyama, Tomohide Tsukahara, Yoshihiko Hirohashi, Akari Takaya, Kohei Kumegawa, Ayano Yoshido, Shohei Sekiguchi et al. · 2025 · Cancer Letters
51. The transcriptomic fingerprint of cancer response to Tumor Treating Fields (TTFields)
    K. Wainer-Katsir, A. Haber, H. Fishman, L. Ding, Michael D. Story, Ren-Fei Du, U. Kahlert, L. Mannarino, F. Mirimao, M. Lupi et al. · 2025 · Cell Death Discovery
52. Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer
    Dongyang Tang, Shiqi Lin, Jingbo Zhou, Josh Haipeng Lei, Fangyuan Shao, Heng Sun, Xiangpeng Chu, Ling Li, Lin He, Yunfeng Qiao et al. · 2025 · Cell Reports Medicine
53. Ribosomal RNA transcription governs splicing through ribosomal protein RPL22
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54. Tegavivint triggers TECR-dependent nonapoptotic cancer cell death
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55. Anlotinib enhances the efficacy of KRAS-G12C inhibitors through c-Myc/ORC2 axis inhibition in non-small cell lung cancer
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56. Pharmacologic degradation of WDR5 suppresses oncogenic activities of SS18::SSX and provides a therapeutic of synovial sarcoma
    Yao Yu, Xufen Yu, Bo Pan, Ho Man Chan, H. Ümit Kanıskan, Jian Jun Jin, Ling Cai, Gang Greg Wang · 2025 · Science Advances
57. Generative prediction of causal gene sets responsible for complex traits
    Benjamin Kuznets-Speck, Buduka K. Ogonor, Thomas P. Wytock, Adilson E. Motter · 2025 · Proceedings of the National Academy of Sciences
58. Plasticity of mitotic cyclins in promoting the G2–M transition
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59. A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma
    Julia Ogden, Robert Sellers, Sudhakar Sahoo, Anthony Oojageer, Anshuman Chaturvedi, Caroline Dive, Carlos Lopez-Garcia · 2025 · Nature Communications
60. Multi-information Fusion Graph Convolutional Network for cancer driver gene identification
    Die Hu, Yan-Bei Liu, Xiao Wang, Lei Geng, Fang Zhang, Z. Xiao, Chun-Wei Lin · 2025 · Pattern Recognition
61. Pooled Tagging and Hydrophobic Targeting of Endogenous Proteins for Unbiased Mapping of Unfolded Protein Responses
    Stephanie E. Sansbury, Yevgeniy V. Serebrenik, Tomer Lapidot, David Geoffrey Smith, George M. Burslem, Ophir Shalem · 2023 · Molecular Cell
62. BH3 mimetics augment cytotoxic T cell killing of acute myeloid leukemia via mitochondrial apoptotic mechanism
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63. The Druggable Transcriptome Project: From Chemical Probes to Precision Medicines
    Matthew David Disney · 2025 · Biochemistry
64. Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition
    Xiangguo E. Shi, Minhua Li, Zian Liu, Jonathan Tiessen, Yuan Li, Jing Zhou, Yudan Zhu, Swetha Mahesula, Ding Qing, Lin Tan et al. · 2025 · Nature Communications
65. High PRMT5 levels, maintained by KEAP1 inhibition, drive chemoresistance in high-grade serous ovarian cancer
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66. Consequences of training data composition for deep learning models in single-cell biology
    Ajay Nadig, Akshaya Thoutam, Madeline Hughes, Anay Gupta, Andrew W. Navia, Nicolò Fusi, Srivatsan Raghavan, Peter S. Winter, Ava P. Amini, Lorin A. Crawford · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
67. The proteomic landscape of diffuse midline glioma highlights the therapeutic potential of non-histone protein methyltransferases
    Arun Kumaran Anguraj Vadivel, Sanja Pajovic, Robert Siddaway, Sabrina Zhu, Stefanie-Grace Sbergio, Olivera Matic, Lauren Phillips, Yong Jia Bu, Mark Nitz, Cynthia E Hawkins · 2025 · Neuro-Oncology
68. Chemoproteomics reveals proteome-wide covalent and non-covalent targets of withaferin A
    Hui-jun Nie, Ying Fu, Shang Long, Jia-yu Wang, Wen-Si Zhao, Lin-hui Zhai, Yin Yang, M. Tan, Hao Hu, Xiao-Hua Chen · 2025 · Acta Pharmacologica Sinica
69. An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
    Marcell Harhai, Mads M. Foged, Christine Zarges, J. Landoni, Sylvain Chollet, Michele Simonelli, Emeline Recazens, M. Lisci, Nora Laban, Suliana Manley et al. · 2025 · bioRxiv
70. SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics
    Stefano Testa, Aastha Pal, Ajay Subramanian, Sushama Varma, Jack Pengfei Tang, Danielle Graham, Sara Arfan, Minggui Pan, Nam Q. Bui, Kristen Nooshin Ganjoo et al. · 2025 · Genome Medicine
71. A graph neural network approach for hierarchical mapping of breast cancer protein communities
    Xiao Zhang, Qian Liu · 2025 · BMC Bioinformatics
72. The combination treatment of RC48 and STAT3 inhibitor acts as a promising therapeutic strategy for basal bladder cancer
    Jingxian Li, Kun Shan, Wei Huang, Qiang Su, Yuanjiong Qi, Zhihong Zhang, Jianqiang Zhu, Eugenie Du · 2025 · Frontiers in Immunology
73. CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects
    Lei Tang, Xin Chen, Jianquan Hou, Xuedong Wei · 2025 · Journal of Translational Medicine
74. Polyamines buffer labile iron to suppress ferroptosis
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75. Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing
    Mehlam Saifudeen, Songli Zhu, Shuguang Liang, Mia M. Eason, Alison Goupil, Deanna Mische, Christian Loc’h, Haiching Ma, Marina Chan, Taranjit S. Gujral · 2026 · Nature Biotechnology
76. Mechanisms and Design Principles of Proteolysis-Targeting Chimeras and Their Emerging Applications
    Nikola Knoll, Nouri Neamati, Aykut Üren · 2026 · ACS Pharmacology & Translational Science
77. Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS–chemokine–myeloid axis
    Bruno Beernaert, Rose L. Jady‐Clark, Parin Shah, Erik Ramon‐Gil, Nora M. Lawson, Zack D Brodtman, Somnath Tagore, Frederik Stihler, A. Carter, Shannique Clarke et al. · 2026 · Science Advances
78. Composite SMG5-SMG6 PIN domain formation is essential for NMD
    Katharina Kurscheidt, Sophie Theunissen, Natalia Pasquali, Kerstin Becker, Volker Boehm, Elena Conti, Niels H. Gehring · 2026 · Nature Communications
79. RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress
    Tyler H. Stanage, Shudong Li, Sandra Segura‐Bayona, Aurora Irene Idilli, Rhona Millar, Graeme Hewitt, Simon J. Boulton · 2026 · Nature Cell Biology
80. Hydrophobic tagging: A promising paradigm for targeted protein degradation
    Lilan Xin, Hongli Wang, Maoze Yang, Zhangxiao Guo, Man Zhu, Terry W. Moore, Chune Dong, Hai‐Bing Zhou · 2025 · Cell Insight
81. Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia
    Amy E. Stewart, Derek K. Zachman, Pol Castellano‐Escuder, Lois M. Kelly, Ben Zolyomi, Michael D. I. Aiduk, Christopher D. Delaney, Ian C. Lock, Claudie Bosc, John Bradley et al. · 2025 · Nature Metabolism
82. p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1–driven ovarian cancers
    Chance C. Sine, Lotte P. Watts, Brianna Fernandez, Nasreen C. Marikar, Jianxin Wang, Erik S. Knudsen, Agnieszka Katarzyna Witkiewicz, Sabrina L. Spencer · 2025 · Science Signaling
83. GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility
    Tsan‐Jan Chen, Chi‐Jen Lo, Meng-Chen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, S D Yang et al. · 2025 · Advanced Science
84. CDK7-targeted therapy effectively disrupts cell cycle progression and oncogenic signaling in head and neck cancer
    María Otero‐Rosales, Miguel Álvarez-González, Irene Pazos, Beatriz de Luxán‐Delgado, Sonia Del Marro, Esperanza Pozo-Agundo, Mar Rodríguez-Santamaría, Ana López-Fernández, María Daniela Corte-Torres, Rocío Granda‐Díaz et al. · 2025 · Signal Transduction and Targeted Therapy
85. Spatial colocalization and molecular crosstalk of myofibroblastic CAFs and tumor cells shape lymph node metastasis in oral squamous cell carcinoma
    Ken Furudate, Shuya Kasai, Tadashi Yoshizawa, Yuya Sasaki, Kohei Fujikura, Shintaro Goto, Ryohei Ito, Koki Takagi, Tomoyuki Tanaka, Hiroshi Kijima et al. · 2025 · PLoS Genetics
86. MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition.
    Gregor A. Lueg, James Zhang, Monica Faronato, A. Gorelik, Wouter W. Kallemeijn, Francesco Falciani, J. Walton, Jack W. Houghton, S. Vannini, E. Poon et al. · 2025 · Cell Reports
87. Integrative genomic identification of therapeutic targets for pancreatic cancer
    Jimmy A. Guo, Dennis H. Gong, Kyle E. Evans, Kazuki Takahashi, Ananya D. Jambhale, Carina Shiau, Patrick Z. Yu, Steven Wang, Wenzhuo Wu, Seema Chugh et al. · 2025 · Cell Reports
88. Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC)
    R. Viswanatha, Samuel Entwisle, Yan-Hui Hu, Ah-Ram Kim, Kelly Reap, Matthew Butnaru, Mujeeb Qadiri, Stephanie E. Mohr, N. Perrimon · 2025 · Nature Communications
89. A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis
    Shawn C. Chafe, Kui Zhai, Nikoo Aghaei, Petar Miletic, Zhi Huang, Kevin R. Brown, Daniel Mobilio, Daniel W Young, Yujin Suk, Shan Grewal et al. · 2025 · Science Translational Medicine
90. Lack of evidence for the transitional cerebellar progenitor
    Kyle S. Smith, Yiran Li, Parthiv Haldipur, Brian L. Gudenas, Kathleen J. Millen, Volker Hovestadt, Paul A. Northcott · 2025 · Nature
91. Exploring synthetic lethality in cancer therapy: CRISPR-Cas9 technology offers new hope
    Yuqi Wu, Yali Wang, Yanbin Wang, Hong Qiu, Xianglin Yuan, Hua Xiong, Yanmei Zou · 2025 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
92. Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells
    Stacia L. Koppenhafer, Elizabeth L. Geary, Mary V. Thomas, Emma E. Croushore, Jessica A.O. Zimmerman, Jenna Marie Gedminas, Dawn E. Quelle, Rebecca D. Dodd, David J. Gordon · 2025 · Cancer Research Communications
93. Deciphering a proliferation-essential gene signature based on CRISPR-Cas9 screening to predict prognosis and characterize the immune microenvironment in HNSCC
    Ke-ling Pang, Pian Li, Xiang-Rong Yao, Wen-Tao Xiao, X. Ren, Jun-Yan He · 2025 · BMC Cancer
94. PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
    Tarik Husremović, Vanessa Meier, Lucas Piëch, Katharina M. Siess, Sumire Antonioli, Irina Grishkovskaya, Nikoleta Kircheva, Silvia Angelova, Karoline Wenzl, Andreas Brandstätter et al. · 2025 · Proceedings of the National Academy of Sciences
95. Comprehensive genomic dependency landscape of a human colon cancer organoid
    Sana Khalili, Atefeh Mohseninia, Changlong Liu, Carolyn E. Banister, Paige Heine, Minou Khazan, Sidney E. Morrison, Prashanth Ravishankar Gokare, Glenn S. Cowley, Barbara A. Weir et al. · 2025 · Communications Biology
96. Genome-wide CRISPR Screening Identifies NFκB and c-MET as Druggable Targets to Sensitize Lenvatinib Treatment in Hepatocellular Carcinoma
    Ting-Chi Rebecca Wan, Lai Wei, Lai-Hung Cheng, Wai Chin, Jialing Shen, For-Fan Chan, Zhijian Kuang, Cun Wang, Carmen Chak-Lui Wong, Chun‐Ming Wong · 2025 · Cellular and Molecular Gastroenterology and Hepatology
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