Defining a Cancer Dependency Map

Cited by (1,076)

Items 501–600 of 1,076

1. Aneuploidy selects for the acquisition of driver genes in breast cancer
   Khalid N. Al‐Zahrani, Ellen R. Langille, Jocelyn Nurtanto, Andreea Obersterescu, Katie Teng, Christopher Lowden, Julien Dessapt, Cynthia H. Chiu, Lauren Caldwell, David P. Cook et al. · 2026 · Nature
2. Hypoxia rescues complex 1-associated disease caused by proteostatic defects
   Ankur Garg, Brandon R. Desousa, Raju Roy, Amy Flis, Skyler Y. Blume, Yohei Abe, Arthur A Melo, Ryan R. Cupo, Gabriela Grigorean, Daniel R. Southworth et al. · 2026 · Nature Metabolism
3. TTF2 processes sites of incomplete DNA replication during mitosis via sister-chromatid exchanges.
   Ryo Fujisawa, Karim P. M. Labib · 2026 · Science
4. Deep Unsupervised Domain Adaptation for Translating Cancer Dependency Maps From Cell Lines to Breast Cancer Tumor Genomics
   Yu Shi, Wei Xu, Pingzhao Hu · 2026 · Genetic Epidemiology
5. Tumor-targeted bispecific antibodies effectively inhibit oncogenic pathways while minimizing toxicity
   Yvonne T. Kschonsak, Wei‐Ching Liang, Joyce Chan, David Kan, Thi Thu Thao Nguyen, Karen Ruiz, Yee-Seir Kee, Wen‐Ting K. Tsai, Hongkang Xi, Марина Москаленко et al. · 2026 · Science Advances
6. Synthetic lethality in cancer: mechanism exploration and therapeutic applications
   Pusong Zhao, Peng Wang, Tianqi Xu, Ligang Chen, Qingge Jia, M H Li · 2026 · Cell Communication and Signaling
7. A Comprehensive Review on CRISPR-Based Screening and Its Applications
   Ali Saber Sichani, Mahmoud Hassani, Fatemeh Gila, Negin Shafieipour, Reza Dabbaghipour, Zahra Heidari, Mohsen Sisakht, Mohammad Hassani, Jafar Fallahi · 2026 · Molecular Biotechnology
8. Gene-guided repurposing identifies dihydroergotamine as a candidate inhibitor of the BCL2–SIVA1 axis in advanced gastric cancer in vitro
   Yu-Liang Huang, Zhi-Xing Lu, Zheng-Yi Shi, Zhengdong Qiu, Xiao-Gang Zhong, Lei Li, Sheng Xu, Yuan Lei, Hai-Hong Huang, Miao Deng et al. · 2026 · Biology Direct
9. Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation
   Sébastien Coassolo, Nairie Michaelian, Timurs Maculins, Caleigh M. Azumaya, Tommy K. Cheung, Jianping Yin, Inna Zilberleyb, Kanika Bajaj Pahuja, Thomas P. Garner, Ted Lau et al. · 2026 · Nature
10. Spatial transcriptomics reveals a molecular tumor budding signature in head and neck cancer
    I. Ourailidis, M. Ball, V. Vogel, Min-hui He, Hairong Wang, Stella Beomseo Kim, Sarah Böning, B. Wollenberg, Klaus-Dietrich Wolff, K. Steiger et al. · 2026 · Genome Medicine
11. Global impact of germline structural variation on the cancer proteome
    Fengju Chen, Yiqun Zhang, Luis F. Paulin, Darshan Shimoga Chandrashekar, Sooryanarayana Varambally, Fritz Joachim Sedlazeck, Chad J. Creighton · 2026 · Nature Communications
12. IL1RAP Antibody–Drug Conjugates Potently Target Primary and Metastatic Diseases in Multiple Oncofusion-Driven Cancers
    Hai‐Feng Zhang, Edouard De Dreuzy, Yue Z. Huang, Seungmin Shin, Qingfeng Huang, Alberto Delaidelli, Xiaqiu Yang, Virginia Adamiak, Andrew G. Lytle, Aarzoo Arzoo et al. · 2026 · Cancer Discovery
13. Functional genomic screens uncover FERMT2 as a critical regulator of YAP/TAZ-driven tumorigenicity
    Arianna Chiesa, Vittoria Poli, Ottavio Croci, Francesca Biagioni, Patricio Fuentes, Mattia Marenda, Ambra Dondi, Simona Rodighiero, Marco Filipuzzi, Silvia Sberna et al. · 2026 · Cell Death and Differentiation
14. Rational design of synthetic proteins using a genome-scale CRISPR screen
    Wells H. Burrell, Simon J. Mueller, Zharko Daniloski, P. Duffy Doyle, Anne Bruun Rovsing, Christopher James, Max Drabkin, Chien-Yu Chou, Hei Yu Annika So, Lyla Katgara et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
15. A comprehensive evaluation of long-read de novo transcriptome assembly
    Feng Yan, Pedro L. Baldoni, J. Lancaster, M. E. Ritchie, Mathew G. Lewsey, Q. Gouil, Nadia M. Davidson · 2026 · Genome Biology
16. LOX Inhibition Disrupts a Collagen–Integrin–MYC Axis to Suppress Progression of Invasive Lobular Carcinoma
    R. L. Flaherty, Flavia Hughes, George Sflomos, Carlos Ronchi, H. Kemp, T. Roumeliotis, Anya A Nicholas, Giovanna Ambrosini, Amelie Ziehme, Sarah Becker et al. · 2026 · Cancer Research
17. Physiologically relevant 3D CRISPR screening enhances mechanistic insight into chemical toxicity compared to 2D screening
    Chanhee Kim, Zhaohan Zhu, Abderrahmane Tagmount, W. Brad Barbazuk, Rhonda L. Bacher, Chris D. Vulpe · 2026 · Toxicology
18. A CRISPR-Cas13d cancer therapeutic enables selective elimination of uveal melanoma
    Daniel Stauber, Lucas Sosnick, Yitong Ma, Sopida Pimcharoen, A. Lawanprasert, N. Murthy, David Myung, L. S. Qi · 2026 · Molecular therapy. Oncology
19. Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis
    Peter Geon Kim, Christopher A. Hergott, Aidan P. Miller, Amy Deik, Meaghan Boileau, Kevin H. Bullock, Kerry A. Pierce, Angelina H. Choy, Wesley Shin, Marie E. McConkey et al. · 2026 · Cell chemical biology
20. Functional landscape of circular RNAs in human cancer cells
    P. Her, Tiantian Li, Ziwei Huang, Xin Xu, Wei-Ning Yang, Moliang Chen, M. Teng, Su-Jun Chen, Yong Zeng, Stanley Liu et al. · 2026 · bioRxiv
21. Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration
    Nikolaos Tsopoulidis, Masaki Yagi, Justin Brumbaugh, S. Ito, Víctor López-Soriano, Robert Morris, Yoseop Yoon, Kathleen A. Messemer, Kuan‐Hung Lin, Eric F. Zaniewski et al. · 2026 · Nature Communications
22. CRISPR screens identify PRMT7 as a therapeutic target to enhance T cell-mediated killing in breast cancer
    Wei Shi, Yi Luo, Yizhuo Wang, J. Burrows, D. Black, Andrew Civitarese, Laura Perlaza-Jiménez, Ping Zhang, Murray Manning, N. Tuano et al. · 2026 · npj Breast Cancer
23. Comprehensive Profiling of N 6 ‐methyladnosine (m 6 A) Readouts Reveals Novel m 6 A Readers That Regulate Human Embryonic Stem Cell Differentiation
    Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui et al. · 2026 · Advanced Science
24. scXDR: drug response prediction across single-cell datasets via heterogeneous network transfer learning
    Guanpeng Qi, Liugen Wang, Mengdi Nan, Yuhan Fu, Qing Ren, Yuan Zhang, Ziyan Sun, Zhixin Shi, Jiayi Lu, Jie Gao · 2026 · Communications Biology
25. Identification of cancer mini-drivers by deciphering selective landscape in the cancer genome
    Xunuo Zhu, Wenyi Zhao, Siqi Wang, Jingwen Yang, Jingqi Zhou, Binbin Zhou, Ji Cao, Bo Yang, Zhan Mei Zhou, Xun Gu · 2025 · Briefings in Bioinformatics
26. Frontiers in Cell-Cycle-Targeting Therapies: Addressing the Heterogeneity of the Cancer Cell Cycle
    Ishaar P. Ganesan, Hiroaki Kiyokawa · 2026 · Cancers
27. ATR inhibitors: from targeting the DNA damage response to exploiting synthetic lethality—A paradigm shift in Cancer therapy
    Xin Hua Zhou, Qi Qin, Huizhi Yao, Yuxing Fu, Linxiao Wang, Wufu Zhu, QiaoLi Lv · 2026 · Bioorganic Chemistry
28. NO/iNOS axis impact on glioma stem cells and temozolomide resistance
    Elsa Hincapié-Arias, Carolina Moughty-Cueto, Juan Manuel Zaloff-Dakoff, Alejandro Mazzón, J. I. Gómez-Escalante, M. Merenzon, Eduardo Seoane, Ezequiel Yasuda, Rodolfo Recalde, M. Socolovsky et al. · 2025 · Journal of molecular medicine
29. The hegemonic EWSR1::ETS oncoprotein overrules core regulatory circuitry principles in Ewing sarcoma
    Sandrine Grossetête, Sakina Zaïdi, Martin F. Orth, Sarah Morice, Karine Laud, Caroline Louis‐Brennetot, Anna Sole Ferre, Virginie Perrin, Florencia Cidre‐Aranaz, Virginie Raynal et al. · 2025 · npj Precision Oncology
30. TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability
    Charlie Moffatt, Ankita Arora, Katherine F. Vaeth, Bryan B. Guzmán, Gurprit Bhardwaj, Audrey Hoelscher, Levi B Gifford, Holger A. Russ, Daniel Dominguez, J. Taliaferro · 2025 · EMBO Journal
31. Off-target autophagy disruption associated with a novel liver toxicity in dogs for a highly basic heterobifunctional protein degrader
    James E. Kath, Rebecca A. Kohnken, Timothy G. Brayman, Junhai Yang, Katharina Haag, Jingyi Gong, Christopher Untucht, Christiane Imhof, Kenneth P. Robinson, Ryan A. McClure et al. · 2025 · Frontiers in Pharmacology
32. Threonyl-tRNA synthetase activates STAT3 by a nontranslational mechanism
    Pallob Barai, Reean Abdullah, Shruti V. Bendre, Erin Weisser, Maxine J van der Donk, Kent L. Wong, Adriana Reyes‐Ordoñez, Erik Russell Nelson, Jie Chen · 2025 · Journal of Biological Chemistry
33. Synergistic Disruption of Survival and Metastatic Potential in Esophageal Adenocarcinoma Cells Through Combined Inhibition of HIF1α and CD73
    Ian Mersich, A. Malmberg, Eahsanul Anik, M. Hassan, U. von Holzen, Brian S J Blagg, Aktar Ali · 2025 · Cancers
34. Computational Phenotypic Drug Discovery for Anticancer Chemotherapy: PTML Modeling of Multi-Cell Inhibitors of Colorectal Cancer Cell Lines
    A. Speck-Planche, M. N. D. S. Cordeiro · 2025 · International Journal of Molecular Sciences
35. Building Ligand‐Responsive Artificial Signaling Pathways Through Programmable Trans ‐Acting RNA Circuits in Mammalian Cells
    Chaoqun Wu, Hong‐Jun Song, Chu Dai, Qiulong Zhang, Xiwen Xing, Liang Xu · 2025 · Angewandte Chemie International Edition
36. A tumor immune microenvironment gene expression signature for predicting prognosis, immunotherapy efficacy, and drug candidates in triple-negative breast cancer
    Li Bai, Ziyu Zhou, Qing-Qing Yu, Zhen Ye, Qing-Zhou Li, Sheng-Rong Li, Cong-Cong Li, Yu Hu, Yun-Jie Hu, Xin-Ran Tai et al. · 2025 · Frontiers in Immunology
37. The Biological and Prognostic Implications of the Nicotinic Acetylcholine Receptor α3, α5, and α7 Subunits in Oral Squamous Cell Carcinoma
    Chi-Maw Lin, Long-Wei Lin, Tseng-Cheng Chen, Yi-Ling Ye, Bor-Luen Chiang · 2025 · Cancer Medicine
38. An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels.
    Rachel P. M. Abrams, R. Donahue, Jessica Ma, Ying Mao, Morgan E. Diolaiti, Alan Ashworth · 2025 · Cell Chemical Biology
39. HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins
    A. Chadburn, Maria Montserrat Aguilar Hernandez, Joanne Dai, M. Harrison, Nicolás M. Reinoso-Vizcaíno, Ashley P. Barry, E. Hocke, Karen Abramson, Vaibhav Jain, Cliburn Chan et al. · 2025 · bioRxiv
40. Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors
    M. Ciccone, Dhivya Anandan, Deeptiman Chatterjee, Chen Chen, Marygrace C. Trousdell, Rebecca Anderson, S. M. Lewis, Mackenzie K. Callaway, Chris Zhao, A. V. Hanasoge Somasundara et al. · 2025 · Nature Communications
41. Modeling response to the KRAS-G12C inhibitor AZD4625 in KRASG12C NSCLC patient-derived xenografts reveals insights into primary resistance mechanisms
    Joshua C. Rosen, Pinjiang Mary Cao, Nhu‐An Pham, Matthew Waas, Quan Li, Katrina Hueniken, Mutian Wang, Roya Navab, Leanne E. Wybenga-Groot, Nikolina Radulovich et al. · 2025 · British Journal of Cancer
42. Quantitative impedance-based characterization of breast cancer cell migration and metastatic potential
    Kyndra S Higgins, C. Gomillion · 2025 · Journal of Biological Engineering
43. EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers
    Manda Magdalena Marić, Sandra Segura‐Bayona, Raviprasad Kuthethur, Tohru Takaki, Valérie Borel, Tyler H. Stanage, Miroslav Penchev Ivanov, Nishita Parnandi, Graeme Hewitt, Rhona Millar et al. · 2025 · Nature Communications
44. MKLNID: Identifying Melanoma-related Pathogenic Genes Through Multiple Kernel Learning and Network Impulsive Dynamics
    Linconghua Wang, Ju Xiang, Zihao Guo, Kai-Xin Zeng, Min Li · 2025 · Interdisciplinary Sciences Computational Life Sciences
45. COPZ1: an example of non-oncogene addiction in human tumors
    T. Di Marco, Debora Vergaro, Angela Greco · 2025 · Frontiers in Pharmacology
46. Revealing genetic drivers of ovarian cancer and chemoresistance: insights from whole-genome CRISPR-knockout library screens
    Tali S. Skipper, Kristie-Ann Dickson, Christopher E. Denes, Matthew A. Waller, Tian Y. D'Araujo, G. Gregory Neely, Nikola A. Bowden, Alen Faiz, Deborah J. Marsh · 2025 · Cellular Oncology
47. Epigenetic synthetic lethality as a cancer therapeutic strategy: synergy of experimental and computational approaches
    Maria Farina-Morillas, Laia Ollé-Monràs, Silvana C. E. Maas, Isabel de Rojas-P, Miguel F. Segura, José Antonio Seoane · 2025 · Epigenomics
48. O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis
    Sean A. Misek, Anna Borgenvik, Daniel Christen, Gloria Kyrila, Alexander Zhang, Sarah Martin Reel, Michelle Boisvert, Ke Xia Cai, Kevin Ning Zhou, Elizabeth Gonzáles et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
49. Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression
    Michael H. Kramer, Stephanie N. Richardson, Yang Li, Tian-Kai Yin, Nichole M. Helton, Daniel R. George, Michelle Cai, S. M. Ramakrishnan, C. Katerndahl, Christopher A. Miller et al. · 2025 · Journal of Clinical Investigation
50. Unraveling the Effects of Epigallocatechin-3-gallate on Hepatocellular Carcinoma Cells: A Comparative Analysis of Monolayer vs Multicellular Tumor Spheroids
    Mariana dos Reis Simpronio, Ana Rita Thomazela Machado, Patrick Wellington da Silva dos Santos, Diego Luís Ribeiro, Lusânia Maria Greggi Antunes, Alexandre F. Aissa · 2025 · ACS Omega
51. PLK4 as a Key Regulator of Neuroblastoma Differentiation and a Promising Therapeutic Target
    Xiang-Dong Tian, Yu-ren Xia, Wen-Chen Gong, Kangwei Zhu, Yu-Long Yang, Zhiqiang Han, Yun Liu, Jie Li, Xin Li, Yu-Chao He et al. · 2025 · International Journal on Biological Sciences
52. AACDR: Integrating Graph Isomorphism Networks and Asymmetric Adversarial Domain Adaptation for Cancer Drug Response Prediction
    Yi Zhang, Ting-Fang Wu, Liang-Peng Nie, Ye-Lu Jiang, Geng Li, Jia Xu, Zhenglong Zhou, Yiwei Chen, Li-Jun Quan, Qiang Lyu · 2025 · Journal of Chemical Information and Modeling
53. M6A-METTL3-dependent nuclear PANC754/PSPC1/H3K4me1 repression complex regulate immune evasive LGALS7 signal to enhance immunotherapy against colorectal cancer
    Jian-Feng Zhang, Guilian Cao, Feng Li, Si Tang, Chenxi Wu, Min Jiang, Jingxin Ye, Shaoqing Ju, Fei Qian, Weifeng Ding · 2025 · Cell Death and Disease
54. Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response
    Kanishk Jain, Pata-Eting Kougnassoukou Tchara, Abid Khan, Amanuel B. Mengistalem, Aidan P. Holland, Christopher N. Bowman, M. Marunde, Tiffany A. Engel, Irina K. Popova, Spencer W. Cooke et al. · 2025 · Nucleic Acids Research
55. Accurate prediction of gene deletion phenotypes with Flux Cone Learning
    Charlotte Merzbacher, Oisin Mac Aodha, Diego A. Oyarzún · 2025 · Nature Communications
56. A manganese metabolism-related gene signature stratifies prognosis and immunotherapy efficacy in kidney cancer
    Yang Liu, Haoyang Ye, Ruoxuan Zhang, Xiao-Long Liu, Ranlu Liu · 2025 · Discover Oncology
57. IMOP-Cancer: identifying mutation order pairs impacting cancer phenotypes
    Yijing Zhang, Shaobo Kang, Renjie Dou, Wanmei Zhang, Yuanyuan Liu, Yang Wu, Dongxue Li, Fangfang Fan, Y. Ping · 2025 · Briefings Bioinform.
58. SL-MERK: Synthetic Lethality Mechanism Explainer based on GraphRAG and Knowledge Graph
    Xueheng Lv, Yimiao Feng, Jie Zheng · 2025 · Annual International Conference of the IEEE Engineering in Medicine and Biology Society
59. No evidence that human GIGYF2 interacts with GRB10: implications for human disease
    Jung-Hyun Choi, Israel Shpilman, Niaz Mahmood, Shaghayegh Farhangmehr, Ulrich Braunschweig, Nathalia Cruz, Jun Luo, R. Ladak, Angelos Pistofidis, J. Ragoussis et al. · 2025 · Life Science Alliance
60. ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancer
    Mirian Gutiérrez, Irene Zamora, R. Iriarte, M. Pajares, Qian Yang, Chen Qian, N. Otegui, J. Fernández-Irigoyen, Enrique Santamaria, N. Alcala et al. · 2025 · Molecular Medicine
61. Specific origin selection and excess functional MCM2–7 loading in ORC-deficient cells
    Yoshiyuki Shibata, Mihaela Peycheva, Etsuko Shibata, Daniel Malzl, Rushad Pavri, Anindya Dutta · 2025 · Nucleic Acids Research
62. Gene and pathway analysis of genome-wide genetic associations of bladder cancer
    Mingjun Shi, Xiangyu Meng, Xuan Xu, Qiao-Li Wang · 2025 · Current Urology
63. The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
    Róbert Zach, Michael Annis, Sandra M. Martin-Guerrero, Abdulrahman Alatawi, Kim Hou Chia, Megan Meredith, Kay Osborn, Nisha Peter, William Pearce, Jessica Booth et al. · 2025 · Nature Communications
64. Energetics of whole genome doubling and genomic instability
    Richard J. Beck, Vural Tagal, Samirkumar B. Amin, Samuel F. Bakhoum, Carlo C. Maley, Roel G.W. Verhaak, Ana P. Gomes, Noemi Andor · 2025 · Cancer Letters
65. Targeting the RARα–Gankyrin–PI3K axis with retinoid analogs to modulate autophagy in breast cancer cells: Computational insights and experimental validation
    Pijush Kanti Khanra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh · 2025 · Computational Biology and Chemistry
66. MYC plus class IIa HDAC inhibition drives mitochondrial dysfunction in non-small cell lung cancer
    Jina Park, Ying-Yu Chen, Jennie J. Cao, Julia An, Ray-Whay Chiu Yen, John D. Outen, Stephen B. Baylin, Michael J. Topper · 2025 · Cell Reports
67. Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture
    Shiella A. Soetomo, Michael F. Sharp, Wayne Crismani · 2025 · PLoS ONE
68. Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway
    Isabel Quintanilla, Benura Azeroglu, Md Abdul Kader Sagar, Travis H. Stracker, Eros Lazzerini Denchi, Gianluca Pegoraro · 2025 · Methods
69. High KYNU Expression Is Associated with Poor Prognosis, KEAP1/STK11 Mutations, and Immunosuppressive Metabolism in Patient-Derived but Not Murine Lung Adenocarcinomas
    Ling Cai, Thomas J. Rogers, Reza Mousavi Jafarabad, Hieu S. Vu, Chendong Yang, Nicole Novaresi, Ana Galán‐Cobo, Luc Girard, Edwin Justin Ostrin, Johannes Francois Fahrmann et al. · 2025 · Cancers
70. Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets
    Rohit Thakur, Mai Xu, Hayley Sowards, Joshuah Yon, Lea Jessop, Timothy Myers, Tongwu Zhang, Raj Chari, Erping Long, Thomas Rehling et al. · 2025 · The American Journal of Human Genetics
71. DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition
    Céline Moison, Rodrigo Mendoza‐Sanchez, Deanne Gracias, Doris A. Schuetz, Jean-François Spinella, Simon Girard, Bounkham Thavonekham, Jalila Chagraoui, Aurélie Durand, Simon Fortier et al. · 2025 · EMBO Reports
72. Biallelic variants in the conserved ribosomal protein chaperone gene PDCD2 are associated with hydrops fetalis and early pregnancy loss
    Anne-Marie Landry-Voyer, T. Holling, Emily Mis, Zabih Mir Hassani, M. Alawi, Weizhen Ji, L. Jeffries, K. Kutsche, François Bachand, S. Lakhani · 2025 · Proceedings of the National Academy of Sciences of the United States of America
73. Molecular signatures bidirectionally link myocardial infarction and lung cancer
    D. Nandi, R. Janardhanan, S. Hannenhalli, P. Agrawal · 2025 · Frontiers in Medicine
74. Nidogen-1, a Player in KMT2A-Rearranged Pediatric Acute Myeloid Leukemia
    Jolien Vanhooren, Larissa Deneweth, Luca Pagliaro, Zhiyao Ren, Mariateresa Giaimo, Raffaella Zamponi, Giovanni Roti, Barbara Depreter, Mattias Hofmans, Barbara De Moerloose et al. · 2025 · International Journal of Molecular Sciences
75. Gene Expression Profiling of Pancreatic Ductal Adenocarcinoma Cells in Hypercapnia Identifies SIAH3 as a Novel Prognostic Biomarker
    Nitzan Zohar, Ryan Maguire, S. Khalilieh, Aditi Jain, Dmitriy Bosykh, Wilbur B. Bowne, H. Lavu, Charles J. Yeo, A. Nevler · 2025 · International Journal of Molecular Sciences
76. Capsule-Based Single-Cell Genome Sequencing
    Dustin Mullaney, Samantha R. Sgrizzi, David Mai, Ian J. Campbell, Yuqi Huang, Andrius Šinkūnas, Daniel Lucas Kerr, Valentino E. Browning, Helen E. Eisenach, Jeremiah Nelson Sims et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
77. Genetic Insights into Breast Cancer in Northeastern Mexico: Unveiling Gene–Environment Interactions and Their Links to Obesity and Metabolic Diseases
    Hugo Leonid Gallardo Blanco, María de Lourdes Garza-Rodríguez, D. Pérez-Ibave, C. H. Burciaga-Flores, V. M. Salinas-Torres, Moisés González-Escamilla, R. Piñeiro-Retif, R. Cerda-Flores, O. Vidal-Gutiérrez, C. Sánchez-Domínguez · 2025 · Cancers
78. PRODE recovers essential and context-essential genes through neighborhood-informed scores
    Thomas Cantore, Paola Gasperini, Riccardo Bevilacqua, Yari Ciani, Sanju Sinha, Eytan Ruppin, Francesca Demichelis · 2025 · Genome biology
79. Multiplexed in vivo base editing identifies functional gene-variant-context interactions
    Jonuelle Acosta, Grace A. Johnson, Samuel I. Gould, Kexin Dong, Yovel Lendner, Diego Detrés, Ondine Atwa, Jari Bulkens, Samuel Gruber, Manuel E. Contreras et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
80. The pioneer transcription factor ELF2 remodels the nucleosome near transcription start sites
    Tianyi Xiao, Caillan Crowe‐McAuliffe, Moritz Ochmann, Yepeng Du, Tianyun Hou, Yinan Chen, Fangjie Zhu, Fatemeh S. Seyednasrollah, Maria Osmala, Sakari Vanharanta et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
81. TRIM33 loss reduces androgen receptor transcriptional output and H2BK120 ubiquitination
    Nils Eickhoff, Janina Janetzko, Nuno Padrão, Sebastian Gregoricchio, Joseph C. Siefert, Liesbeth Hoekman, Simon Linder, Onno B. Bleijerveld, Andries Marinus Bergman, Wilbert T. Zwart · 2025 · Communications Biology
82. Evaluation of Cas13d as a tool for genetic interaction mapping
    Ghanem El Kassem, Jasmine Hillmer, Michael Boettcher · 2025 · Nature Communications
83. Utilising multi-modal data-driven network analysis to identify monotherapy and combinational therapy targets in SOX2-dependent squamous cell lung cancer
    Woochang Hwang, Daniel Kottmann, Wenrui Guo, Méabh MacMahon, Lúcia L. Correia, Sherine Ahmed, Rebecca Harris, Frank M. McCaughan, Namshik Han · 2025 · Communications Chemistry
84. The spectrum of gene intolerance to variation: Insights from a rare disease cohort
    P. Cacheiro, Gabriel Marengo, David U. Gorkin, Kevin A. Peterson, Yonina Loskove, S. Murray, D. Smedley · 2025 · medRxiv
85. Dynamine 3 as a diagnostic and prognostic biomarker in pancreatic cancer: Implications for early detection and targeted therapy
    Fatih Yay, H. Yıldırım, Fatih Kuş, Şuayib Yalçın · 2025 · Biomarkers
86. Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes
    Yihan Wang, Daniel A. Armendariz, Lei Wang, Huan Zhao, Shiqi Xie, Gary C. Hon · 2025 · Genome biology
87. Integrative machine learning approach for identification of new molecular scaffold and prediction of inhibition responses in cancer cells using multi-omics data
    Aman Chandra Kaushik, Shubham Krushna Talware, Mohammad Imran Siddiqi · 2025 · Briefings in Functional Genomics
88. Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex
    Stefano Sellitto, Davide Caredio, Matteo Bimbati, Giovanni Mariutti, Martina Cerisoli, Lukas D. Frick, Vangelis Bouris, Carlos Omar Oueslati Morales, Dalila Laura Vena, Sandesh Neupane et al. · 2026 · PLoS Pathogens
89. WD40 Protein NLE1 as a Novel Diagnostic Biomarker Promoting Hepatocellular Carcinoma Proliferation
    Ru-Tong Zhang, De-Hua Liu, Xiao-Xi Feng, Zhen-Ye Yang, Kai-Guang Zhang · 2025 · Clinical Medicine Insights: Oncology
90. Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities
    Anguraj Sadanandam, Alice C. O’Farrell, Ian S. Miller, Hari PS, Adrian Lärkeryd, Tom Venken, Ingrid Arijs, Eugenia Rosalinda Zanella, Francesca Cottino, Marika Pinnelli et al. · 2026 · Cancer Cell
91. The causal integration ladder: a multilevel evidence framework for therapeutic target evaluation in cervical cancer
    Shishir Singh, M. Srivastava, Pragathi Uppada, Diksha Ameta, Aesha Singh, Monisha Banerjee, Atar Singh Kushwah · 2026 · Frontiers in Systems Biology
92. Synthetic lethality and context-selective DNA-damage response dependencies: from genetic vulnerability to pharmacological translation
    Nayoon Jo, Su‐Jin Kang, Jeongeun Kim, Kwan Hyi Lee, Sunbok Jang · 2026 · Drug Discovery Today
93. OmicsFM brings proteomics into the foundation model era
    Sander Heyndrickx, R. Gabriels, Harikrishnan Ramadasan, L. Martens, Tine Claeys · 2026 · bioRxiv
94. Paediatric therapeutic development workshop on osteosarcoma
    Joseph S. Baxter, Claudia Montiel-Equihua, Jan J. Molenaar, Pablo Berlanga, Michael W. Bishop, Patricia Blanc, Quentin Campbell-Hewson, Michela Casanova, Isidro Cortés‐Ciriano, Brian D. Crompton et al. · 2026 · British Journal of Cancer
95. Integrative multi-omics framework identifies phenotypically impactful driver pathways in glioblastoma multiforme
    Junhua Zhang · 2026 · bioRxiv
96. COMPASS: Component-Wise Inference of Shared and Gene-Specific Perturbation Response
    Huan Liang, Rohit Singh · 2026 · bioRxiv
97. Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics
    Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang et al. · 2026 · MedComm – Biomaterials and Applications
98. RUVBL1 supports TIP60-associated proteasome adaptation and temozolomide resistance in glioblastoma.
    Yang Kong, Wei Zhu, Kun Xue, Ya Gao, Cai-Feng Ma, Shuo Tang, Wei Sun, Guang-Qiang Cui, Xing-Han Tian, Haiying Wang · 2026 · Cellular Signalling
99. Small-molecule activation of the tumor suppressor kinase LKB1 via the pseudokinase STRAD
    Lin Song, Dominique C. Mitchell, Jin Liu, Logan B. Leak, Rigney E. Turnham, LeeAnn Wang, Zheng Wang, Changliang He, Luo Ding, Marc Adler et al. · 2026 · Cell chemical biology
100. dsRNAscan maps human dsRNAome, revealing conservation, intermolecular dsRNA, and correlates of ADAR dependency
     Ryan J. Andrews, Brenda Bass · 2026 · Molecular Cell