A Method for the Acute and Rapid Degradation of Endogenous Proteins

Clift, Dean, McEwan, William A., Labzin, Larisa I., Konieczny, Vera, Mogessie, Binyam, James, Leo C., Schuh, Melina·2017·Cell

DOI 10.1016/j.cell.2017.10.033

Cited by (533)

Items 401–500 of 533

Immediate and Selective Control of Protein Abundance Using the dTAG System
Behnam Nabet, Nathanael S. Gray · 2020 · Royal Society of Chemistry eBooks
New method for endogenous protein degradation
Sarah Crunkhorn · 2017 · Nature Reviews Drug Discovery
The 3rd Antibody Validation meeting: Bath UK 20-21st September 2018
Simon L. Goodman · 2018 · F1000Research
Lysosome Targeting Chimeras (LYTACs) That Engage a Liver-Specific Asialoglycoprotein Receptor for Targeted Protein Degradation
Green Ahn, Steven M. Banik, Caitlyn L. Miller, Nicholas McIlvain Riley, Jennifer R. Cochran, Carolyn Ruth Bertozzi · 2020 · ChemRxiv
Insights and Future Perspectives of Covalent Protein Degraders
Xiaoyu Zhang · 2022 · Wiley eBooks
Distinct Effects of Aducanumab and Lecanemab on Intraneuronal Endogenous Aβ42 and Phosphorylated Tau in Alzheimer’s Disease Treatment
Mingjie Liu, Long Zhu, Fuyun Li, Xiaobang Shi, Yan-Fei Shen, Menglu Liu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Meiosis-specific decoupling of the pericentromere from the kinetochore
Bo Pan, Melania Bruno, Todd S. Macfarlan, Takashi Akera · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy
Jiyeon Leem, Tom Lemonnier, Ani Khutsaidze, Lei Tian, Xiaojun Xing, Suxia Bai, Timothy Nottoli, Binyam Mogessie · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Intracellular antibodies and biodegraders: Beyond small molecules and back again
Davide Cardella, Daniel Sánchez-Guzmán, Terence Howard Rabbitts · 2023 · Current Opinion in Biomedical Engineering
Phenogenetics of cortical granule dynamics during zebrafish oocyte-to-embryo transition
Priscila García-Castro, Isabella Giambó-Falian, Ingrid Carvacho, Ricardo Fuentes · 2025 · Frontiers in Cell and Developmental Biology
Molecular Degraders: A Comprehensive Review of Small Molecule Induced Protein Degradation Strategies
Deepanshu Sindhwani, Kaushal Arora, Pankaj kumar, Prabhakar Kumar Verma, Vivek Vidyadhar Bhosale · 2025 · Current Protein and Peptide Science
Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment
Dilara Koc, Sena Ezgin, Ebru Kavakli, Krishna P. Kota, Edanur Sen, Christopher R. Mahone, Mary Ellen Palko, Lisa H. Cazares, Tolga Can, Lino Tessarollo et al. · 2025 · PLoS Pathogens
FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation
Zirui Zhuang, Ran Li, Bing Wang, Yuxin Meng, Yuancong Li, Junjun Nan, Xin Zhao, Jing Ji · 2025 · ACS Synthetic Biology
Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation
Lijian Shen, Ziyi Liang, Ying Zhang, Jing Wen, Jie Gao · 2025 · MedComm – Biomaterials and Applications
Role of nuclear import proteins in maintaining proteostasis and disease pathogenesis
Xiuling Zhao, Liping Pu, Xuhui Zeng, Junyu Nie · 2026 · Biochemical Pharmacology
PROTACs as novel therapeutics against Mycobacterium tuberculosis: Current progress and future directions
Deepthi Ramesh, Ahammed Ameen Thottasseri · 2026 · European Journal of Medicinal Chemistry
Ubiquitin signatures on aggregating proteins in neurodegeneration
Subhashree Sahoo, Amrita Arpita Padhy, Kummari Shivani, Ashish Misra, Parul Mishra · 2025 · Essays in Biochemistry
TBP regulates transposable element expression in early mouse embryos
Clara Hermant, Carlos Michel Mourra-Díaz, Marlies E. Oomen, Natasha Jansz, Camille Noll, Antoine Canat, Mrinmoy Pal, Tsunetoshi Nakatani, Tamás Schauer, Maria‐Elena Torres‐Padilla · 2026 · The EMBO Journal
Redirecting TRIM21 with TRIMTACs for the targeted degradation of multimeric proteins
Marc A Scemama de Gialluly, Drew Adams · 2026 · FEBS Journal
Targeted protein degradation for fetal hemoglobin induction: a new paradigm in β-hemoglobinopathy therapy
Sanjana Arji, Ziyang Shen, Sabrina Welch, Fadila ElMahdaoui, Ayana Bahadur, Ernie Lee, Hannah Lee, Shang-Chuen Peter Wu, Ekaterina Konshina, Burhanudin Ayubali et al. · 2026 · Biomarker Research
Alternative 3′ UTRs and RNA-binding proteins Ewsr1b, HuR, and Syncrip organize sequential waves of translation to drive embryonic development
Keisuke Sato, Ludivine Fierro, Anyu Suginishi, Takahiro Sanada, Tomoya Kotani · 2026 · Cell Reports
Engineered Lysosome-Targeted Protein Degradation via Hijacking Macropinocytosis
Wen Xu, Henggong Pan, Yalan Han, Ling‐Yan Su, Hejiang Zhou · 2026 · ACS Nano
Anti-capsid nanobodies function as HIV-1 capsid inhibitors by intracellular capsid degradation
Florence M. Stel, Charlotte E. J. Verkuijlen, Esther Willems, Gillian Dekkers, Raimond Heukers, Neeltje A. Kootstra, Teunis B. H. Geijtenbeek · 2026 · Communications Biology
Membrane Protein Clustering as a Key Determinant of Endocytosis: Natural Mechanisms, Nonintentional Transporter Internalization, and Engineered Multivalent Nanocarriers
Toshihiko Tashima · 2026 · Journal of Medicinal Chemistry
Intracellular Delivery of Antibody‐Based Therapeutics for Targeted Oncogenic c‐Myc Degradation in Mammalian Cells and Mice
Lvyang Peng, Jiaoyu Chen, Xia Liu, Jiachang Yan, Yingying Gan, Chen Fang, Jingyan Ge, Shao Qin Yao, Peiyan Yuan · 2026 · Angewandte Chemie International Edition
Targeted Degradation of Mouse Embryo Proteins Using Trim-Away
Thomas Nolte, Steffen Israel, Michele Boiani · 2026 · Methods in molecular biology
Targeted protein degradation dismantles undruggable targets to reverse immune evasion and therapy resistance in cancer
张富荣, Qianheng Wang, Mingxuan Li, Tingting Wang, Ping Lei, Tao Huang, Zhenghao Wu · 2026 · Frontiers in Immunology
Oocyte-specific OMC1 is required for maintaining chromosome cohesion through reproductive life
Sakie Iisaka, Shuhei M. Yoshida, Ryuki Shimada, Tappei Mishina, Sayoko Fujimura, Manami Koshiguchi, Ryuichi Kimura, Shinya Oki, Kimi Araki, Tomoya S. Kitajima et al. · 2026 · Nature Aging
Depleting endogenous proteins
Ada Xin Yee · 2018 · Nature Methods
Perturbation of kinetochore function using GFP-binding protein in fission yeast
Da‐Jie Deng, Qiancheng Xia, Guo‐Song Jia, Fang Suo, Jia-Li Chen, Li Sun, Jinqing Wang, Shuang-Min Wang, Li‐Lin Du, Yamei Wang et al. · 2021 · G3 Genes Genomes Genetics
Ubiquitin-Derived Fragment as a Peptide Linker for the Efficient Cleavage of a Target Protein from a Degron
Yuki Utsugi, Ken Nishimura, Satoshi Yamanaka, Kohei Nishino, Hidetaka Kosako, Tatsuya Sawasaki, Hideyuki Shigemori, Thomas J. Wandless, Yusaku Miyamae · 2024 · ACS Chemical Biology
Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon · 2025 · FEBS Letters
A viral infection-biomimetic strategy for antibody-guided targeted protein degradation
Yuanyuan Yang, Chuanda Zhu, Xiaojun Wang, Lidong Gong, Qiang Ma, Yujie Luo, Hongjun Wang, Dan Lu, Ridong Li, Qiang Zhang et al. · 2025 · Acta Biomaterialia
A Single Transcript Knockdown-Replacement Strategy Employing 5’ UTR Secondary Structures to Precisely Titrate Rescue Protein Translation
Matthew M. Millette, Elizabeth D. Holland, Tanner Tenpas, Erik W. Dent · 2022 · Frontiers in Genome Editing
A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective Towards the Cellular RHOB GTP-Bound Conformation
Nicolas Béry, Laura Keller, Marjorie Soulii, Anne-Laure Iscache, Rémi Gence, Julia Cherier, Stéphanie Cabantous, Olivier Sordet, Isabelle Lajoie‐Mazenc, J.D. Pédelacq et al. · 2018 · SSRN Electronic Journal
Generation of photocaged nanobodies for in vivo applications using genetic code expansion and computationally guided protein engineering
Jack M. O’Shea, Angeliki Goutou, Cyrus R. Sethna, Christopher W. Wood, Sebastian Greiss · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Selective degradation of multimeric proteins via chemically induced proximity to TRIM21
Panrui Lu, Yalong Cheng, Lei Xue, Xintong Ren, Chenglong Chen, Jiao Li, Qingcui Wu, Shan Sun, Junjie Hou, Wei Jia et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
A phosphate-binding pocket in cyclin B3 is essential for XErp1/ Emi2 degradation in meiosis I
Rebecca Demmig, Michael Schäfer, Elijah Johannes, Andreas Heim, Andreas Boland, Thomas U. Mayer · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Degradation of intrinsically disordered proteins using proteolysis targeting nanobody conjugate
Xiaofeng Sun, Dinglan Wu, Chengjian Zhou, Simin Xia, Xi Chen · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Mesoscale landscaping of the TRIM protein family reveals a novel human condensatopathy
Hari Singh, Vineeta Sharma, Jik Nijssen, Andrei Pozniakovsky, Alexander Rubin, Lorrin Liang, David A. Ball, Sunwoo Hong, Victoria C. Gauntner, Guanghao Yu et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Hybrid female sterility due to cohesin protection errors in oocytes
Warif El Yakoubi, Bo Pan, Takashi Akera · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Reciprocal constraint couples architectural protein abundance and pericentromeric satellite expansion
Damian Dudka, Keagan Beeravolu, Michael A. Lampson · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration
Wang, Mingming, VanderVeen, Brandon, Xu, Zhixuan Annie, Xu, Ying, Mintzer, Jacobo, Murphy, Angela, Zhang, Quanguang, Xu, Peisheng · 2026 · Cell Biomaterials
Eaten up from the inside
Karin Kuehnel · 2018 · Nature Chemical Biology
A Targeted Protein Degradation Cell-Based Screening for Intracellular Nanobodies to Assess the Functions of RHOB GTP-Bound Conformation
Nicolas Béry, Laura Keller, Marjorie Soulié, Anne-Laure Iscache, Rémi Gence, Julia Cherier, Stéphanie Cabantous, Olivier Sordet, Isabelle Lajoie‐Mazenc, J.D. Pédelacq et al. · 2018 · SSRN Electronic Journal
Optimization and application of Trim-Away for studying a liquid-like spindle domain in mammalian oocytes
Chun So · 2019
The Necroptosis Effector MLKL drives Small Extracellular Vesicle Release and Tumour Growth in Glioblastoma
Gwennan André‐Grégoire, Tiphaine Douanne, An Thys, Clément Maghe, Kathryn Jacobs, Cyndie Ballu, Kilian Trillet, Ignacio Busnelli, Vincent Hyenne, Jacky G. Goetz et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
A Critical Role for The COP9 Signalosome Subunit 3 as A Gatekeeper of Genome Integrity in 2-Cell Mouse Embryos
Steffen Israel, Hannes C. A. Drexler, Georg Fuellen, Michele Boiani · 2021
Functional and mechanistic studies on engineered antibodies that engage TRIM21
Wen Jie Chin · 2020
Editorial: Special Issue on Mechanics in Development
Timothy E. Saunders, Ivo A. Telley · 2021 · Seminars in Cell and Developmental Biology
Mechanisms of pronuclear migration in mammalian zygotes
Julia Uraji · 2019
Knockoff: Druggable Cleavage of Membrane Proteins
John Rinald, Jason Vevea, Edwin R. Chapman · 2021 · BIO-PROTOCOL
RARE EARTH AND THORIUM CONTENT IN SOILS OF TOMSK REGION
G.E. Pashneva, T. P. Slavnina, V.V. Serebrennikov · 1965 · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
Faculty Opinions recommendation of Major Advances in Targeted Protein Degradation: PROTACs, LYTACs, and MADTACs.
John A. Lowe III · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Membrane Anchorage‐Induced (MAGIC) Knockdown of Non‐synonymous Point Mutations**
Vijay K. Ulaganathan · 2022 · ChemBioChem
Same same but different : a comprehensive functional analysis of SRSF3 and SRSF7 in the regulation of alternative polyadenylation within the 3’ untranslated region
Oliver Daniel Schwich · 2021
Trim-Away in adult animals through Nano-ERASER and its application in cancer therapy
Wang, Mingming, Wang, Junfeng, Wang, Yuzhen, Raja, Manikanda, Gupta, Gourab, Hu, Xiangxiang, Shi, Shanshan, Chen, Hexin, Fan, Daping, Xu, Peisheng · 2023
A Chemically Inducible Organelle Rerouting Assay to Probe Primary Cilium Assembly, Maintenance, and Disassembly in Cultured Cells
F. Basak Turan, Muhammed Erdem Ercan, Elif Nur Firat‐Karalar · 2023 · Methods in molecular biology
An Unconventional Mechanism of IL-1β Secretion that Requires Type I IFN in SLE Monocytes
Simone Caielli, Preetha Balasubramanian, Juan F. Rodríguez-Alcázar, Uthra Balaji, Lauren A. Robinson, Zurong Wan, Jeanine M. Baisch, Cynthia Smitherman, Lynnette Walters, Paola R. Sparagana et al. · 2023 · SSRN Electronic Journal
Antibody-dependent Intracellular neutralisation by TRIM21 is potentiated by HOIP and linear ubiquitin chains
Christopher Green, Konstanze F. Winklhofer, Adam J. Fletcher, Leo C. James, John Skidmore, James A. Duce, William A. McEwan · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Getting Stuff into Th(Em): Protein and Sirna Electroporation of Human Naïve T Cells
Masashi Yukawa, Artem Barski · 2024 · SSRN Electronic Journal
Reconstitution of chromatin reorganization during mammalian oocyte development
Jing Wang, Wang Li, Jing Guo, Xiaoming Xu, Ge Lin, Bin Li, Chun So · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes
Haruna Gekko, Ruri Nomura, Daiki Kuzuhara, Masato Kaneyasu, Genpei Koseki, Deepak Adhikari, Yasuyuki Mio, John Carroll, Tomohiro Kono, Hiroaki Funahashi et al. · 2024 · eLife
Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes
Haruna Gekko, Ruri Nomura, Daiki Kuzuhara, Masato Kaneyasu, Genpei Koseki, Deepak Adhikari, Yasuyuki Mio, John Carroll, Tomohiro Kono, Hiroaki Funahashi et al. · 2025 · eLife
Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes
Haruna Gekko, Ruri Nomura, Daiki Kuzuhara, Masato Kaneyasu, Genpei Koseki, Deepak Adhikari, Yasuyuki Mio, John Carroll, Tomohiro Kono, Hiroaki Funahashi et al. · 2025 · eLife
Peripheral chromatin remodeling at the center of zygotic genome activation
Laure de Chancel, Jean‐Léon Maître · 2025 · Cell Genomics
Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design
Rezart Zhubi, A. Chaikuad, Christian J. Muñoz Sosa, Andreas C. Joerger, Stefan Knapp · 2025 · Journal of Structural Biology X
Chromosome Ageing Occurs at the Primordial Follicle Stage in both Mouse and Human Oocytes
Matilda Bui, Apiwat Moolnangdeaw, Hannes Becher, Shelagh Boyle, Vlastimil Sršeň, Yvonne L. Odey, Richard A. Anderson, Evelyn E. Telfer, Ian R. Adams · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
“Artificial platelet injection system”: a plug-and-play platelet-based lysosome-targeting chimera for targeted protein degradation
Chenming Zou, Haichao Zhu, Yuepeng Tang, Shengrong Guo · 2026 · Bioactive Materials
From inhibition to degradation: Cutting-edge technology in COVID-19 drug discovery
Emmanuel Oluwaseun Adediran, Martin Ikhoyameh, Ololade S Gbadebo · 2025 · Annales Pharmaceutiques Françaises
A novel O-GlcNAcylation at threonine 71 of histone H4 is a component of heterochromatin
Koji Hayakawa, Mitsuko Hirosawa, Daisuke Nara, Nobuyuki Fujiwara, Kunio Shiota, Satoshi Tanaka · 2025 · The Journal of Biochemistry
New modalities: Drugging the undruggable GPCR targets
P. Zawadzki, Piotr P. Graczyk, Jakub Staroń · 2025 · Elsevier eBooks
Cytoskeletal Organization and Dynamics in Female Meiosis and Early Embryogenesis
Andrea Rix, Federica Giannini, Helena van Eck, Binyam Mogessie · 2025 · Springer eBooks
Harnessing nanobodies: Miniature yet mighty tools for cancer and inflammatory disease diagnosis and treatment
Rui Hou, Runhua Zhou, Jingbo Ma, Guangwei Shi, Zhijie Li · 2025 · Elsevier eBooks
Intracellular delivery of full-length antibodies via organ-targeted lipid nanoparticles
Azmain Alamgir, Militsa Yaneva, Mor Sela, Patricia Mora‐Raimundo, Haim Kadosh, Souvik Ghosal, Anas Odeh, Yuval Richtman, Neta Fibeesh, Yael Leichtmann-Bardoogo et al. · 2026 · Proceedings of the National Academy of Sciences
Nucleic acid-encoded antibody gene transfer-next generation of antibody therapies
Kaikai Yu, Geng Xiao, Baichuan Chen, Na Xu, Wensen Liu · 2025 · Drug Delivery
Greatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events
Sylvain Roque, Celia Ben Choug, Cédric Hassen‐Khodja, Suzanne Vigneron, Véronique Legros, Guillaume Chevreux, Benjamin Lacroix, Anna Castro, Thierry Lorca · 2026 · Nature Communications
A synthetic oocyte aging method for uncovering the molecular origins of egg aneuploidy
2025 · Nature Aging
Minute-scale control of ubiquitin-mediated degradation reveals dynamics of bacterial secreted effector-functions
Hao‐Lin Zhang, Yongxia Guo, Bikash Adhikari, Nevenka Dudvarski Stanković, Elmar Wolf, Thomas Rudel · 2026 · Nature Communications
Nanobodies targeting hnRNPA2/B1 and tau
Azady Pirhanov, Cristian Rodriguez, Fatemeh Tashakori-Asfestani, Raven Gonsoulin, Rayne Santiago, Katarnut Tobunluepop, Emmanuella Erhunmwunsee, Sambhavi Puri, Monika Arbaciauskaite, Wu He et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
A novel and critical role of the intracellular Zona Pellucida protein 2 (ZP2) for blastocyst formation in mice
Thomas Nolte, Steffen Israel, Hannes C. A. Drexler, Georg Fuellen, Michele Boiani · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Additional file 2 of Intracellular delivery of anti-BCR/ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells
Guoyun Jiang, Huang, Zhenglan, Ying Yuan, Tao, Kun, Feng, Wenli · 2021 · Figshare
Additional file 1 of Intracellular delivery of anti-BCR/ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells
Guoyun Jiang, Huang, Zhenglan, Ying Yuan, Tao, Kun, Feng, Wenli · 2021 · Figshare
Additional file 5 of Intracellular delivery of anti-BCR/ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells
Guoyun Jiang, Huang, Zhenglan, Ying Yuan, Tao, Kun, Feng, Wenli · 2021 · Figshare
Additional file 6 of Intracellular delivery of anti-BCR/ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells
Guoyun Jiang, Huang, Zhenglan, Ying Yuan, Tao, Kun, Feng, Wenli · 2021 · Figshare
Additional file 4 of Intracellular delivery of anti-BCR/ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells
Guoyun Jiang, Huang, Zhenglan, Ying Yuan, Tao, Kun, Feng, Wenli · 2021 · Figshare
Additional file 2 of The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei
Alyssa N. Coyne, Rothstein, Jeffrey D. · 2021 · Figshare
Additional file 1 of Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021
Wu, Qing, Qian, Wei, Xiaoli Sun, Shaojie Jiang · 2022 · Figshare
Additional file 7 of Intracellular delivery of anti-BCR/ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells
Guoyun Jiang, Huang, Zhenglan, Yuan, Ying, Tao, Kun, Feng, Wenli · 2021 · Figshare
Additional file 3 of Intracellular delivery of anti-BCR/ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells
Guoyun Jiang, Huang, Zhenglan, Ying Yuan, Tao, Kun, Feng, Wenli · 2021 · Figshare
Can Fascaplysins Be Considered Analogs of Indolo[2,3-a]pyrrolo[3,4-c]carbazoles? Comparison of Biosynthesis, Biological Activity and Therapeutic Potential
Maxim E. Zhidkov, Aleksandr M. Popov, Olga A. Soldatkina, Oleg A. Tryapkin, Lyubov N. Kharchenko · 2025 · Marine Drugs
PROTAC-based degradation of catechol-O-methyltransferase for potential treatment of Parkinson’s disease
Haixiao Fang, Panpan Li, Qi Gao, Shubo Du, Jing Gu, Xia Liu, Bo Peng, Hua Bai, Cheng-Wu Zhang, Lin Li et al. · 2026 · Science China Chemistry
Sheddase Targeting Chimeras (SHEDTACs) catalyze membrane target proteolysis
Brett M. Garabedian · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Universal physical principles of protein structural genesis emerge in language-model representation space
Liu Chuanyang, Jiyuan Liu, Xinyuan Qiu, Xiaomin Wu, Wenying Li, Lu Min, Guohao Zhang, Shaowei Zhang, Lingyun Zhu · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Chemoselective Semisynthesis of Covalent Nanobody-Guided Protein Degraders in Neurons
Nam Ky Chu, Nhat T. T. Le, Niyi Samuel Adelakun, Ouada Nebie, Upendra Nayek, Ryejun Na, Julián Meza, Reena Shakya, Marie Butts · 2026 · Research Square
Deubiquitinase USP8 regulates the spindle assembly checkpoint in oocytes
Changyin Zhou (周长银), X -G Zhang, Genlu Xu (许根露), Hui Wang (王慧), Yuting Ran (冉宇婷), Ang Li (李昂), Qing-Yuan Sun (孙青原), Xiang‐Hong Ou · 2026 · Science Advances
Synaptotagmin 5, not synaptotagmin 1, is required for cortical granule exocytosis at fertilization of mouse eggs
Lisa M. Mehlmann, Tracy F. Uliasz, Katie M. Lowther · 2026 · Biology of Reproduction
Age-dependent accumulation of RAD51 on non-damaged chromosomes prevents chromosome segregation in mammalian oocytes
Masaru Ito, Shou Soeda, Tomo Kondo, Asako Furukohri, みどり梶谷, Rina Ogata, Miho Ohsugi, Akira Shinohara · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Nanobody‐Mediated c‐MYC Degradation Inhibits Tumor Cell Progression
Yuanyuan Xue, Hao Jiang, Zhaoyun Zong, Xiaolin Tian, Zelong Miao, Ti Li, Yali Wei, Haiteng Deng · 2026 · MedComm
IAP-based biodegraders can convert necroptosis to apoptosis and eliminate cancer driving protein complexes
Xiuquan Ma, François Vaillant, Veerasikku Gopal Deepagan, Kael L. Schoffer, Farzaneh‐Sadat Rezazadeh‐Shojaee, Jiyi Pang, Christopher A. Baldwin, James M. Murphy, John Silke, Maria C. Tanzer et al. · 2026 · Cell chemical biology