A living biobank of breast cancer organoids captures disease heterogeneity

Sachs, Norman, de Ligt, Joep, Kopper, Oded, Gogola, Ewa, Bounova, Gergana, Weeber, Fleur, Balgobind, Anjali Vanita, Wind, Karin +23 more·2018·Cell

Cited by (1,002)

Items 101–200 of 1,002

  1. Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy
    Vignesh Narasimhan, Josephine A. Wright, Michael Churchill, Tongtong Wang, Rachele Rosati, Tamsin R.M. Lannagan, Laura Vrbanac, Anne B. Richardson, Hiroki Kobayashi, Timothy Jay Price et al. · 2020 · Clinical Cancer Research
  2. Organoid technology in disease modelling, drug development, personalized treatment and regeneration medicine
    Hanxiao Xu, Ying Jiao, Shuang Qin, Weiheng Zhao, Qian Chu, Kongming Wu · 2018 · Experimental Hematology and Oncology
  3. The WNT signaling pathways in wound healing and fibrosis
    Olivier Burgy, Mélanie Königshoff · 2018 · Matrix Biology
  4. Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the future
    Dilara Akhoundova, Mark A. Rubin · 2022 · Cancer Cell
  5. Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapies
    Luc Magré, Monique M. A. Verstegen, Sonja I. Buschow, Luc J. W. van der Laan, Maikel Petrus Peppelenbosch, Jyaysi Desai · 2023 · Journal for ImmunoTherapy of Cancer
  6. Advances in Engineering Human Tissue Models
    Chrysanthi‐Maria Moysidou, Chiara Barberio, Róisı́n M. Owens · 2021 · Frontiers in Bioengineering and Biotechnology
  7. OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics
    Jonathan M. Matthews, Brooke Schuster, Sara Saheb Kashaf, Ping Liu, Rakefet Ben-Yishay, Dana Ishay-Ronen, Evgeny Izumchenko, Le Shen, Christopher R. Weber, Margaret C. Bielski et al. · 2022 · PLoS Computational Biology
  8. Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank
    Zilong Zhou, Lele Cong, Xianling Cong · 2021 · Frontiers in Oncology
  9. 3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis
    Tijmen H. Booij, Leo Price, Erik H.J. Danen · 2019 · SLAS DISCOVERY
  10. Patient-derived tumor organoids for prediction of cancer treatment response
    Peter W. Nagle, John Th. M. Plukker, Christina T. Muijs, Peter van Luijk, Robert Paul Coppes · 2018 · Seminars in Cancer Biology
  11. Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors
    Herpers, Bram, Eppink, Berina, James, Mark I., Cortina, Carme, Cañellas-Socias, Adrià, Boj, Sylvia F., Hernando-Momblona, Xavier, Glodzik, Dominik, Roovers, Rob C., van de Wetering, Marc et al. · 2022 · Nature Cancer
  12. 3D Tumor Models and Their Use for the Testing of Immunotherapies
    Nicolas Boucherit, Laurent Gorvel, Daniel Olive · 2020 · Frontiers in Immunology
  13. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
    Isaac S. Harris, Jennifer E. Endress, Jonathan L. Coloff, Laura M. Selfors, Samuel K. McBrayer, Jennifer M. Rosenbluth, Nobuaki Takahashi, Sabin Dhakal, Vidyasagar Koduri, Matthew G. Oser et al. · 2019 · Cell Metabolism
  14. Hydrogel-based colorectal cancer organoid co-culture models
    Xiaobei Luo, Eliza Li Shan Fong, Chaojun Zhu, Quy Xiao Xuan Lin, Man Xiong, Aimin Li, Tingting Li, Touati Benoukraf, Hanry Yu, Side Liu · 2020 · Acta Biomaterialia
  15. Human organoids: New strategies and methods for analyzing human development and disease
    Nina S. Corsini, Juergen A. Knoblich · 2022 · Cell
  16. Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases
    Masayuki Fujii, Toshiro Sato · 2020 · Nature Materials
  17. Efficient Use of Patient-Derived Organoids as a Preclinical Model for Gynecologic Tumors
    Maru, Yoshiaki, Tanaka, Naotake, Itami, Makiko, Hippo, Yoshitaka · 2019 · Gynecologic Oncology
  18. Patient-derived organoids in precision cancer medicine
    Le Tong, Weiyingqi Cui, Boya Zhang, Pedro Fonseca, Qian Cheng Zhao, Ping Zhang, Beibei Xu, Qisi Zhang, Zhen Li, Brinton A. Seashore-Ludlow et al. · 2024 · Med
  19. Patient-derived Ovarian Cancer Organoids Capture the Genomic Profiles of Primary Tumours Applicable for Drug Sensitivity and Resistance Testing
    Nanki, Yoshiko, Chiyoda, Tatsuyuki, Hirasawa, Akira, Ookubo, Aki, Itoh, Manabu, Ueno, Masaru, Akahane, Tomoko, Kameyama, Kaori, Yamagami, Wataru, Kataoka, Fumio et al. · 2020 · Scientific Reports
  20. Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy
    Jingjing Qu, Farhin Shaheed Kalyani, Li Liu, Tianli Cheng, Lijun Chen · 2021 · 癌症:英文版
  21. Organoid cultures for cancer modeling
    Helen H.N. Yan, April Chan, Frank Pui-Ling Lai, Suet Yi Leung · 2023 · Cell stem cell
  22. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo
    Miao, Yi, Ha, Andrew, de Lau, Wim, Yuki, Kanako, Santos, António J.M., You, Changjiang, Geurts, Maarten H., Puschhof, Jens, Pleguezuelos-Manzano, Cayetano, Peng, Weng Chuan et al. · 2020 · Cell Stem Cell
  23. Heterogeneity within molecular subtypes of breast cancer
    Kevin M. Turner, Syn Kok Yeo, Tammy M. Holm, Elizabeth Shaughnessy, Jun‐Lin Guan · 2021 · American Journal of Physiology-Cell Physiology
  24. Drug screening at single-organoid resolution via bioprinting and interferometry
    Peyton J. Tebon, Bowen Wang, Alexander L Markowitz, Ardalan Davarifar, Brandon L. Tsai, Patrycja Krawczuk, Alfredo E. Gonzalez, Sara Sartini, Graeme F. Murray, Huyen Thi Lam Nguyen et al. · 2023 · Nature Communications
  25. Modeling clear cell renal cell carcinoma and therapeutic implications
    Melissa M. Wolf, W. Kimryn Rathmell, Kathryn Eby Beckermann · 2020 · Oncogene
  26. Metabolic Adaptations in Cancer Stem Cells
    Umesh Prasad Yadav, Tashvinder Singh, Pramit Kumar, Praveen Sharma, Harsimrat Kaur, Sadhana Sharma, Sandeep Singh, Santosh Kumar, Kapil Mehta · 2020 · Frontiers in Oncology
  27. Human organoids: a new dimension in cell biology
    Ruth Lehmann, Connie M. Lee, Erika C. Shugart, Marta Benedetti, R. Alta Charo, Zev J. Gartner, Brigid L.M. Hogan, Juergen A. Knoblich, Celeste M. Nelson, Kevin Wilson · 2019 · Molecular Biology of the Cell
  28. Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells
    Huizhen Sun, Husheng Wang, Xue Wang, Yoichi Aoki, Xinjing Wang, Ziliang Wang, Xi Cheng, Ziliang Wang, Xipeng Wang · 2020 · Theranostics
  29. Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine
    Zarema Gilazieva, Aleksei S. Ponomarev, Catrin Sian Rutland, Albert Anatolyevich Rizvanov, Valeriya V. Solovyeva · 2020 · Cancers
  30. Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids
    Yunuo Mao, Wei Wang, Jingwei Yang, Xin Zhou, Yongqu Lu, Junpeng Gao, Xiao Wang, Lu Wen, Wei Fu, Fuchou Tang · 2023 · Protein & Cell
  31. Characterizing the ecological and evolutionary dynamics of cancer
    Nastaran Zahir, Ruping Sun, Daniel Gallahan, Robert A. Gatenby, Christina N. Curtis · 2020 · Nature Genetics
  32. Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer
    Shenghong Ma, Tracy Tzu-Ling Tang, Gary D. Probst, Andrei William Konradi, Chunyu Jin, Fulong Li, Jorge Silvio Gutkind, Xiang‐Dong Fu, Kun‐Liang Guan · 2022 · Nature Communications
  33. Prospective experimental treatment of colorectal cancer patients based on organoid drug responses
    Salo Ooft, Fleur Weeber, Luuk J. Schipper, Krijn Kristian Dijkstra, Chelsea M. McLean, Sovann Kaing, Joris van de Haar, Warner Prevoo, Erik D. van Werkhoven, Pétur Snæbjörnsson et al. · 2021 · ESMO Open
  34. Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment
    Joe T. Sharick, Christine M. Walsh, Carley M. Sprackling, Cheri A. Pasch, Dan L. Pham, Karla Esbona, Alka Choudhary, Rebeca García‐Varela, Mark E. Burkard, Stephanie M. McGregor et al. · 2020 · Frontiers in Oncology
  35. Tumor organoid models in precision medicine and investigating cancer-stromal interactions
    Xu, Ren, Zhou, Xiaotao, Wang, Shike, Trinkle, Christine · 2021 · Pharmacology & Therapeutics
  36. 3D Cell Cultures: Evolution of an Ancient Tool for New Applications
    Andrea Cacciamali, Riccardo Villa, Silvia Dotti · 2022 · Frontiers in Physiology
  37. Applications of Human Brain Organoids to Clinical Problems
    Han-Chiao Isaac Chen, Hongjun Song, Guo‐li Ming · 2018 · Developmental Dynamics
  38. Patient-Derived Organoids for Precision Cancer Immunotherapy
    Grönholm, Mikaela, Feodoroff, Michaela, Antignani, Gabriella, Martins, Beatriz, Hamdan, Firas, Cerullo, Vincenzo · 2021 · Cancer Research
  39. Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids
    Masayuki Fujii, Hans C. Clevers, Toshiro Sato · 2018 · Gastroenterology
  40. Organoid based personalized medicine: from bench to bedside
    Yaqi Li, Peiyuan Tang, Sanjun Cai, Junjie Peng, Guoqiang Hua · 2020 · Cell Regeneration
  41. Patient-derived organoid (PDO) platforms to facilitate clinical decision making
    Lisa Liu, Lei Yu, Zhichao Li, Wujiao Li, Weiren Huang · 2021 · Journal of Translational Medicine
  42. Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening
    Zhichao Li, Youhui Qian, Wujiao Li, Lisa Liu, Lei Yu, Xia Liu, Guodong Wu, Youyu Wang, Weibin Luo, Fuyuan Fang et al. · 2020 · iScience
  43. The past, present, and future of breast cancer models for nanomedicine development
    Paz Boix-Montesinos, Paula M. Soriano‐Teruel, Ana Armiñán, Mar Orzáez, Maria Jesus Vicent · 2021 · Advanced Drug Delivery Reviews
  44. Mechanical Regulation of Transcription: Recent Advances
    Kaustubh Wagh, Momoko Ishikawa, David A. Garcia, Diana A. Stavreva, Arpita Upadhyaya, Gordon L. Hager · 2021 · Trends in Cell Biology
  45. Human organoids-on-chips for biomedical research and applications
    Hui Wang, Xiufan Ning, Feng Hua Zhao, Hui Zhao, Dong Li · 2024 · Theranostics
  46. Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes
    Bethany M. Barnes, Louisa Nelson, Anthony Tighe, George J. Burghel, I‐Hsuan Lin, Sudha N. Desai, Joanne C. McGrail, Robert David Morgan, Stephen S. Taylor · 2021 · Genome Medicine
  47. Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling
    Priyanshu Shukla, Sriya Yeleswarapu, Marcel Alexander Heinrich, Jai Prakash, Falguni Pati · 2022 · Biofabrication
  48. Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications
    Monize Caiado Decarli, Robson Luis Ferraz do Amaral, Diogo Peres dos Santos, Larissa Bueno Tofani, Eric Takashi Katayama, Rodrigo Alvarenga Rezende, Jorge Vicente Lopes da Silva, Kamilla Swiech, Cláudio Alberto Torres Suazo, Carlos Mota et al. · 2021 · Biofabrication
  49. Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids
    Prince, Elisabeth, Cruickshank, Jennifer, Ba-Alawi, Wail, Hodgson, Kelsey, Haight, Jillian, Tobin, Chantal, Wakeman, Andrew, Avoulov, Alona, Topolskaia, Valentina, Elliott, Mitchell J. et al. · 2022 · Nature Communications
  50. Single‐Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids
    Yan Zhao, Zhixuan Li, Yanjing Zhu, Jing Fu, Xiaofang Zhao, Yani Zhang, Shan Wang, Jianmin Wu, Kaiting Wang, Rui Ting Wu et al. · 2021 · Advanced Science
  51. Patient-Derived Cancer Organoids as Predictors of Treatment Response
    Maikel Verduin, Ann Hoeben, Dirk De Ruysscher, Marc Vooijs · 2021 · Frontiers in Oncology
  52. Cancer Spheroids and Organoids as Novel Tools for Research and Therapy: State of the Art and Challenges to Guide Precision Medicine
    Sanae El Harane, Bochra Zidi, Nadia El Harane, Karl‐Heinz Krause, Thomas Matthes, Olivier Preynat‐Seauve · 2023 · Cells
  53. Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening
    Du, Yuhong, Li, Xingnan, Niu, Qiankun, Mo, Xiulei, Qui, Min, Ma, Tingxuan, Kuo, Calvin J, Fu, Haian · 2020 · Journal of Molecular Cell Biology
  54. Circulating tumor cells in precision oncology: clinical applications in liquid biopsy and 3D organoid model
    Chang Qing Yang, Bai-Rong Xia, Weilin Jin, Ge Lou · 2019 · Cancer Cell International
  55. MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation
    Yuanzhang Fang, Lifei Wang, Changlin Wan, Yifan Sun, Kevin Van der Jeught, Zhuolong Zhou, Tianhan Dong, Ka Man So, Tao Yu, Yujing Li et al. · 2020 · Journal of Clinical Investigation
  56. A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids
    Wojciech Senkowski, Laura Gall-Mas, Matías Marín Falco, Yilin Li, Kari Lavikka, Mette C. Kriegbaum, Jaana Oikkonen, Daria R. Bulanova, Elin J. Pietras, Karolin Voßgröne et al. · 2023 · Developmental Cell
  57. PRMT inhibition induces a viral mimicry response in triple-negative breast cancer
    Qin Wu, David Y. Nie, Wail Ba-Alawi, YiShuai Ji, ZiWen Zhang, Jennifer Cruickshank, Jillian Haight, Felipe E. Ciamponi, Jocelyn Chen, Shili Duan et al. · 2022 · Nature Chemical Biology
  58. Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles
    Helen H N Yan, Hoi Cheong Siu, Siu Lun Ho, Sarah S K Yue, Yang Gao, Wai Yin Tsui, Dessy Chan, April Chan, Jason W.H. Wong, Alice H Y Man et al. · 2020 · Gut
  59. Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
    Kadi Lõhmussaar, Oded Kopper, Jeroen Korving, Harry Begthel, Celien P.H. Vreuls, Johan H. van Es, Hans C. Clevers · 2020 · Nature Communications
  60. Microfluidic Arrays of Breast Tumor Spheroids for Drug Screening and Personalized Cancer Therapies
    Prince, Elisabeth, Kheiri, Sina, Wang, Yihe, Xu, Fei, Cruickshank, Jennifer, Topolskaia, Valentina, Tao, Huachen, Young, Edmond W. K., McGuigan, Alison. P., Cescon, David W. et al. · 2022 · Advanced Healthcare Materials
  61. Cancer research using organoid technology
    Kretzschmar, Kai · 2021 · Journal of Molecular Medicine
  62. Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
    Farin, Henner F., Mosa, Mohammed H., Ndreshkjana, Benardina, Grebbin, Britta M., Ritter, Birgit, Menche, Constantin, Kennel, Kilian B., Ziegler, Paul K., Szabó, Lili, Bollrath, Julia et al. · 2023 · Cancer Discovery
  63. Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification
    Rosemary Millen, Willem W. B. de Kort, Mandy Koomen, Gijs J. F. van Son, Roán Gobits, Bas B. L. Penning de Vries, Harry Begthel, Maurice M.J.M. Zandvliet, Patricia Doornaert, Cornelis P.J. Raaijmakers et al. · 2023 · Med
  64. Designer Self‐Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer
    Zehong Yang, Hongyan Xu, Xiaojun Zhao · 2020 · Advanced Science
  65. The Contribution of Evolutionary Game Theory to Understanding and Treating Cancer
    Benjamin Wölfl, Hedy te Rietmole, Monica Salvioli, Artem Kaznatcheev, Frank Thuijsman, Joel S. Brown, Boudewijn M.T. Burgering, Kateřina Staňková · 2021 · Dynamic Games and Applications
  66. Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysis
    Rui Wang, Yunuo Mao, Wendong Wang, Xin Zhou, Wei Wang, Shuai Gao, Jingyun Li, Lu Wen, Wei Fu, Fuchou Tang · 2022 · Genome biology
  67. The drug-induced phenotypic landscape of colorectal cancer organoids
    Johannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini et al. · 2022 · Nature Communications
  68. Organoids are not organs: Sources of variation and misinformation in organoid biology
    Kim Bak Jensen, Melissa Helen Little · 2023 · Stem Cell Reports
  69. Molecular classification of hormone receptor-positive HER2-negative breast cancer
    Xi Jin, Yi-Fan Zhou, Ding Ma, Shen Zhao, Cai‐Jin Lin, Yi Xiao, Tong Fu, Chenglin Liu, Yiyu Chen, Wen-Xuan Xiao et al. · 2023 · Nature Genetics
  70. Portrait of a cancer: mutational signature analyses for cancer diagnostics
    Van Hoeck, Arne, Tjoonk, Niels H., van Boxtel, Ruben, Cuppen, Edwin · 2019 · BMC Cancer
  71. Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy
    Meghan T. Logun, Xin Wang, Yusha Y. Sun, Stephen Joseph Bagley, Nannan Li, Arati Suvas Desai, Daniel Y. Zhang, MacLean P. Nasrallah, Emily Ling-Lin Pai, Bike Su Oner et al. · 2024 · Cell stem cell
  72. Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025
    Allgayer, Heike, Mahapatra, Samikshya, Mishra, Barnalee, Swain, Biswajit, Saha, Suryendu, Khanra, Sinjan, Kumari, Kavita, Panda, Venketesh K., Malhotra, Diksha, Patil, Nitin S. et al. · 2025 · Molecular Cancer
  73. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment
    Steven Lohard, Nathalie Bourgeois, Laurent Maillet, Fabien Gautier, Aurélie Fétiveau, Hamza Lasla, Frédérique Nguyen, Céline Vuillier, Alison Dumont, Agnès Moreau‐Aubry et al. · 2020 · Nature Communications
  74. Current concepts in tumour-derived organoids
    Ross J Porter, Graeme I. Murray, Mairi H McLean · 2020 · British Journal of Cancer
  75. 3D and organoid culture in research: physiology, hereditary genetic diseases and cancer
    Suarez-Martinez, Elisa, Suazo-Sanchez, Irene, Celis-Romero, Manuel, Carnero, Amancio · 2022 · Cell & Bioscience
  76. Functional precision oncology using patient-derived assays: bridging genotype and phenotype
    Allard W. J. van Renterghem, Joris van de Haar, Emile E. Voest · 2023 · Nature Reviews Clinical Oncology
  77. Patient‐derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR‐T cells <i>in vitro</i>
    Yu, Lei, Li, Zhichao, Mei, Hongbin, Li, Wujiao, Chen, Dong, Liu, Lisa, Zhang, Zhongfu, Sun, Yangyang, Song, Fei, Chen, Wei et al. · 2021 · Clinical &amp; Translational Immunology
  78. Patient‐derived renal cell carcinoma organoids for personalized cancer therapy
    Zhichao Li, Haibo Xu, Lei Yu, Jia Wang, Qian Meng, Hongbing Mei, Zhiming Cai, Wei Chen, Weiren Huang · 2022 · Clinical and Translational Medicine
  79. Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids
    Siqi Wang, Yang Wang, Xiaodong Xun, Changkun Zhang, Xiang Xiao, Qian Cheng, Shihua Hu, Zhao Li, Jiye Zhu · 2020 · Journal of Experimental & Clinical Cancer Research
  80. Cancer stem cells in TNBC
    Zhan Hua, Jason A. White, Jianjun Zhou · 2021 · Seminars in Cancer Biology
  81. Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells
    Guoying Zhou, Ruby Lieshout, Gilles S. van Tienderen, Valeska de Ruiter, Martin E. van Royen, Patrick P.C. Boor, Luc Magré, Jyaysi Desai, Kübra Köten, Yik Y. Kan et al. · 2022 · British Journal of Cancer
  82. Estrogen-related receptors are targetable ROS sensors
    Mathieu Vernier, Catherine R. Dufour, Shawn McGuirk, Charlotte Scholtes, Xiaojing Li, Guillaume Bourmeau, Hellen Kuasne, Morag Park, Julie St‐Pierre, Étienne Audet‐Walsh et al. · 2020 · Genes & Development
  83. 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip
    Li, Wenxiu, Zhou, Zhihang, Zhou, Xiaoyu, Khoo, Bee Luan, Gunawan, Renardi, Chin, Y. Rebecca, Zhang, Liang, Yi, Changqing, Guan, Xinyuan, Yang, Mengsu · 2023 · Advanced Healthcare Materials
  84. Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data
    Ke Liu, Patrick A. Newbury, Benjamin Scott Glicksberg, Billy Zeng, Shreya Paithankar, Eran R. Andrechek, Bin Chen · 2019 · Nature Communications
  85. Anticancer drug discovery using multicellular tumor spheroid models
    Michele Zanoni, Sara Pignatta, Chiara Arienti, Massimiliano Bonafè, Anna Tesei · 2019 · Expert Opinion on Drug Discovery
  86. Modeling and Targeting Alzheimer’s Disease With Organoids
    Angelos Papaspyropoulos, Magda Tsolaki, Nikolaos Foroglou, Αnastasia A. Pantazaki · 2020 · Frontiers in Pharmacology
  87. An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity
    Zhou, Zhuolong, Van der Jeught, Kevin, Fang, Yuanzhang, Yu, Tao, Li, Yujing, Ao, Zheng, Liu, Sheng, Zhang, Lu, Yang, Yang, Eyvani, Haniyeh et al. · 2021 · Nature Biomedical Engineering
  88. Bladder cancer organoids as a functional system to model different disease stages and therapy response
    Martina Minoli, Thomas Cantore, Daniel Hanhart, Mirjam Kiener, Tarcisio Fedrizzi, Federico La Manna, Sofia Karkampouna, Panagiotis Chouvardas, Vera Genitsch, Antonio Rodríguez-Calero et al. · 2023 · Nature Communications
  89. Building consensus on the application of organoid-based drug sensitivity testing in cancer precision medicine and drug development
    Xiang, Dongxi, He, Aina, Zhou, Rong, Wang, Yonggang, Xiao, Xiuying, Gong, Ting, Kang, Wenyan, Lin, Xiaolin, Wang, Xiaochen, PDO-based DST Consortium11 et al. · 2024 · Theranostics
  90. Modeling Cell Communication in Cancer With Organoids: Making the Complex Simple
    Elena Fiorini, Lisa Veghini, Vincenzo Corbo · 2020 · Frontiers in Cell and Developmental Biology
  91. Patient-derived tumor-like cell clusters for drug testing in cancer therapy
    Shenyi Yin, Ruibin Xi, Aiwen Wu, Shu Wang, Yingjie Li, Chaobin Wang, Lei Tang, Yuchao Xia, Di Yang, Juan Li et al. · 2020 · Science Translational Medicine
  92. A pan-cancer organoid platform for precision medicine
    Larsen, Brian M., Kannan, Madhavi, Langer, Lee F., Leibowitz, Benjamin D., Bentaieb, Aicha, Cancino, Andrea, Dolgalev, Igor, Drummond, Bridgette E., Dry, Jonathan R., Ho, Chi-Sing et al. · 2021 · Cell Reports
  93. Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
    Sonam Bhatia, Melissa Kramer, Suzanne Russo, Payal Naik, Gayatri Arun, Kyle Brophy, Peter Andrews, Cheng Fan, Charles M. Perou, Jonathan B. Preall et al. · 2022 · Cancer Research
  94. Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy
    Else Driehuis, Sacha Spelier, Irati Beltrán Hernández, Remco de Bree, Stefan M. Willems, Hans C. Clevers, Sabrina Oliveira · 2019 · Journal of Clinical Medicine
  95. Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma
    Yuanbo Kang, Weihan He, Caiping Ren, Jincheng Qiao, Qiuyong Guo, Jingyu Hu, Hongjuan Xu, Xingjun Jiang, Lei Wang · 2020 · Signal Transduction and Targeted Therapy
  96. Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence
    Emma H. van Schie, Renée van Amerongen · 2020 · Frontiers in Cell and Developmental Biology
  97. The role of tumor microenvironment in drug resistance: emerging technologies to unravel breast cancer heterogeneity
    Vincenzo Salemme, Giorgia Centonze, Lidia Avalle, Dora Natalini, Alessio Piccolantonio, Pietro Arina, Alessandro Morellato, Ugo Ala, Daniela Taverna, Emilia Turco et al. · 2023 · Frontiers in Oncology
  98. Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor-positive breast cancer
    Whittle, James R., Vaillant, François, Surgenor, Elliot, Policheni, Antonia N., Giner, Göknur, Capaldo, Bianca D., Chen, Huei-Rong, Liu, He K., Dekkers, Johanna F., Sachs, Norman et al. · 2020 · Clinical Cancer Research
  99. Mechanically and chemically defined hydrogel matrices for patient-derived colorectal tumor organoid culture
    Ng, Shengyong, Tan, Wai Jin, Pek, Michelle Mi Xue, Tan, Min-Han, Kurisawa, Motoichi · 2019 · Biomaterials
  100. Modeling the Human Body on Microfluidic Chips
    Sasan Jalili‐Firoozinezhad, Cláudia C. Miranda, Joaquim M. S. Cabral · 2021 · Trends in biotechnology