A living biobank of breast cancer organoids captures disease heterogeneity
Sachs, Norman, de Ligt, Joep, Kopper, Oded, Gogola, Ewa, Bounova, Gergana, Weeber, Fleur, Balgobind, Anjali Vanita, Wind, Karin +23 more·2018·Cell
Cited by (1,002)
Items 101–200 of 1,002
- Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized TherapyVignesh Narasimhan, Josephine A. Wright, Michael Churchill, Tongtong Wang, Rachele Rosati, Tamsin R.M. Lannagan, Laura Vrbanac, Anne B. Richardson, Hiroki Kobayashi, Timothy Jay Price et al. · 2020 · Clinical Cancer Research
- Organoid technology in disease modelling, drug development, personalized treatment and regeneration medicineHanxiao Xu, Ying Jiao, Shuang Qin, Weiheng Zhao, Qian Chu, Kongming Wu · 2018 · Experimental Hematology and Oncology
- The WNT signaling pathways in wound healing and fibrosisOlivier Burgy, Mélanie Königshoff · 2018 · Matrix Biology
- Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the futureDilara Akhoundova, Mark A. Rubin · 2022 · Cancer Cell
- Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapiesLuc Magré, Monique M. A. Verstegen, Sonja I. Buschow, Luc J. W. van der Laan, Maikel Petrus Peppelenbosch, Jyaysi Desai · 2023 · Journal for ImmunoTherapy of Cancer
- Advances in Engineering Human Tissue ModelsChrysanthi‐Maria Moysidou, Chiara Barberio, Róisı́n M. Owens · 2021 · Frontiers in Bioengineering and Biotechnology
- OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamicsJonathan M. Matthews, Brooke Schuster, Sara Saheb Kashaf, Ping Liu, Rakefet Ben-Yishay, Dana Ishay-Ronen, Evgeny Izumchenko, Le Shen, Christopher R. Weber, Margaret C. Bielski et al. · 2022 · PLoS Computational Biology
- Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid BiobankZilong Zhou, Lele Cong, Xianling Cong · 2021 · Frontiers in Oncology
- 3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content AnalysisTijmen H. Booij, Leo Price, Erik H.J. Danen · 2019 · SLAS DISCOVERY
- Patient-derived tumor organoids for prediction of cancer treatment responsePeter W. Nagle, John Th. M. Plukker, Christina T. Muijs, Peter van Luijk, Robert Paul Coppes · 2018 · Seminars in Cancer Biology
- Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumorsHerpers, Bram, Eppink, Berina, James, Mark I., Cortina, Carme, Cañellas-Socias, Adrià, Boj, Sylvia F., Hernando-Momblona, Xavier, Glodzik, Dominik, Roovers, Rob C., van de Wetering, Marc et al. · 2022 · Nature Cancer
- 3D Tumor Models and Their Use for the Testing of ImmunotherapiesNicolas Boucherit, Laurent Gorvel, Daniel Olive · 2020 · Frontiers in Immunology
- Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione DepletionIsaac S. Harris, Jennifer E. Endress, Jonathan L. Coloff, Laura M. Selfors, Samuel K. McBrayer, Jennifer M. Rosenbluth, Nobuaki Takahashi, Sabin Dhakal, Vidyasagar Koduri, Matthew G. Oser et al. · 2019 · Cell Metabolism
- Hydrogel-based colorectal cancer organoid co-culture modelsXiaobei Luo, Eliza Li Shan Fong, Chaojun Zhu, Quy Xiao Xuan Lin, Man Xiong, Aimin Li, Tingting Li, Touati Benoukraf, Hanry Yu, Side Liu · 2020 · Acta Biomaterialia
- Human organoids: New strategies and methods for analyzing human development and diseaseNina S. Corsini, Juergen A. Knoblich · 2022 · Cell
- Somatic cell-derived organoids as prototypes of human epithelial tissues and diseasesMasayuki Fujii, Toshiro Sato · 2020 · Nature Materials
- Efficient Use of Patient-Derived Organoids as a Preclinical Model for Gynecologic TumorsMaru, Yoshiaki, Tanaka, Naotake, Itami, Makiko, Hippo, Yoshitaka · 2019 · Gynecologic Oncology
- Patient-derived organoids in precision cancer medicineLe Tong, Weiyingqi Cui, Boya Zhang, Pedro Fonseca, Qian Cheng Zhao, Ping Zhang, Beibei Xu, Qisi Zhang, Zhen Li, Brinton A. Seashore-Ludlow et al. · 2024 · Med
- Patient-derived Ovarian Cancer Organoids Capture the Genomic Profiles of Primary Tumours Applicable for Drug Sensitivity and Resistance TestingNanki, Yoshiko, Chiyoda, Tatsuyuki, Hirasawa, Akira, Ookubo, Aki, Itoh, Manabu, Ueno, Masaru, Akahane, Tomoko, Kameyama, Kaori, Yamagami, Wataru, Kataoka, Fumio et al. · 2020 · Scientific Reports
- Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapyJingjing Qu, Farhin Shaheed Kalyani, Li Liu, Tianli Cheng, Lijun Chen · 2021 · 癌症:英文版
- Organoid cultures for cancer modelingHelen H.N. Yan, April Chan, Frank Pui-Ling Lai, Suet Yi Leung · 2023 · Cell stem cell
- Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In VivoMiao, Yi, Ha, Andrew, de Lau, Wim, Yuki, Kanako, Santos, António J.M., You, Changjiang, Geurts, Maarten H., Puschhof, Jens, Pleguezuelos-Manzano, Cayetano, Peng, Weng Chuan et al. · 2020 · Cell Stem Cell
- Heterogeneity within molecular subtypes of breast cancerKevin M. Turner, Syn Kok Yeo, Tammy M. Holm, Elizabeth Shaughnessy, Jun‐Lin Guan · 2021 · American Journal of Physiology-Cell Physiology
- Drug screening at single-organoid resolution via bioprinting and interferometryPeyton J. Tebon, Bowen Wang, Alexander L Markowitz, Ardalan Davarifar, Brandon L. Tsai, Patrycja Krawczuk, Alfredo E. Gonzalez, Sara Sartini, Graeme F. Murray, Huyen Thi Lam Nguyen et al. · 2023 · Nature Communications
- Modeling clear cell renal cell carcinoma and therapeutic implicationsMelissa M. Wolf, W. Kimryn Rathmell, Kathryn Eby Beckermann · 2020 · Oncogene
- Metabolic Adaptations in Cancer Stem CellsUmesh Prasad Yadav, Tashvinder Singh, Pramit Kumar, Praveen Sharma, Harsimrat Kaur, Sadhana Sharma, Sandeep Singh, Santosh Kumar, Kapil Mehta · 2020 · Frontiers in Oncology
- Human organoids: a new dimension in cell biologyRuth Lehmann, Connie M. Lee, Erika C. Shugart, Marta Benedetti, R. Alta Charo, Zev J. Gartner, Brigid L.M. Hogan, Juergen A. Knoblich, Celeste M. Nelson, Kevin Wilson · 2019 · Molecular Biology of the Cell
- Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cellsHuizhen Sun, Husheng Wang, Xue Wang, Yoichi Aoki, Xinjing Wang, Ziliang Wang, Xi Cheng, Ziliang Wang, Xipeng Wang · 2020 · Theranostics
- Promising Applications of Tumor Spheroids and Organoids for Personalized MedicineZarema Gilazieva, Aleksei S. Ponomarev, Catrin Sian Rutland, Albert Anatolyevich Rizvanov, Valeriya V. Solovyeva · 2020 · Cancers
- Drug repurposing screening and mechanism analysis based on human colorectal cancer organoidsYunuo Mao, Wei Wang, Jingwei Yang, Xin Zhou, Yongqu Lu, Junpeng Gao, Xiao Wang, Lu Wen, Wei Fu, Fuchou Tang · 2023 · Protein & Cell
- Characterizing the ecological and evolutionary dynamics of cancerNastaran Zahir, Ruping Sun, Daniel Gallahan, Robert A. Gatenby, Christina N. Curtis · 2020 · Nature Genetics
- Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancerShenghong Ma, Tracy Tzu-Ling Tang, Gary D. Probst, Andrei William Konradi, Chunyu Jin, Fulong Li, Jorge Silvio Gutkind, Xiang‐Dong Fu, Kun‐Liang Guan · 2022 · Nature Communications
- Prospective experimental treatment of colorectal cancer patients based on organoid drug responsesSalo Ooft, Fleur Weeber, Luuk J. Schipper, Krijn Kristian Dijkstra, Chelsea M. McLean, Sovann Kaing, Joris van de Haar, Warner Prevoo, Erik D. van Werkhoven, Pétur Snæbjörnsson et al. · 2021 · ESMO Open
- Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug TreatmentJoe T. Sharick, Christine M. Walsh, Carley M. Sprackling, Cheri A. Pasch, Dan L. Pham, Karla Esbona, Alka Choudhary, Rebeca García‐Varela, Mark E. Burkard, Stephanie M. McGregor et al. · 2020 · Frontiers in Oncology
- Tumor organoid models in precision medicine and investigating cancer-stromal interactionsXu, Ren, Zhou, Xiaotao, Wang, Shike, Trinkle, Christine · 2021 · Pharmacology & Therapeutics
- 3D Cell Cultures: Evolution of an Ancient Tool for New ApplicationsAndrea Cacciamali, Riccardo Villa, Silvia Dotti · 2022 · Frontiers in Physiology
- Applications of Human Brain Organoids to Clinical ProblemsHan-Chiao Isaac Chen, Hongjun Song, Guo‐li Ming · 2018 · Developmental Dynamics
- Patient-Derived Organoids for Precision Cancer ImmunotherapyGrönholm, Mikaela, Feodoroff, Michaela, Antignani, Gabriella, Martins, Beatriz, Hamdan, Firas, Cerullo, Vincenzo · 2021 · Cancer Research
- Modeling Human Digestive Diseases With CRISPR-Cas9–Modified OrganoidsMasayuki Fujii, Hans C. Clevers, Toshiro Sato · 2018 · Gastroenterology
- Organoid based personalized medicine: from bench to bedsideYaqi Li, Peiyuan Tang, Sanjun Cai, Junjie Peng, Guoqiang Hua · 2020 · Cell Regeneration
- Patient-derived organoid (PDO) platforms to facilitate clinical decision makingLisa Liu, Lei Yu, Zhichao Li, Wujiao Li, Weiren Huang · 2021 · Journal of Translational Medicine
- Human Lung Adenocarcinoma-Derived Organoid Models for Drug ScreeningZhichao Li, Youhui Qian, Wujiao Li, Lisa Liu, Lei Yu, Xia Liu, Guodong Wu, Youyu Wang, Weibin Luo, Fuyuan Fang et al. · 2020 · iScience
- The past, present, and future of breast cancer models for nanomedicine developmentPaz Boix-Montesinos, Paula M. Soriano‐Teruel, Ana Armiñán, Mar Orzáez, Maria Jesus Vicent · 2021 · Advanced Drug Delivery Reviews
- Mechanical Regulation of Transcription: Recent AdvancesKaustubh Wagh, Momoko Ishikawa, David A. Garcia, Diana A. Stavreva, Arpita Upadhyaya, Gordon L. Hager · 2021 · Trends in Cell Biology
- Human organoids-on-chips for biomedical research and applicationsHui Wang, Xiufan Ning, Feng Hua Zhao, Hui Zhao, Dong Li · 2024 · Theranostics
- Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypesBethany M. Barnes, Louisa Nelson, Anthony Tighe, George J. Burghel, I‐Hsuan Lin, Sudha N. Desai, Joanne C. McGrail, Robert David Morgan, Stephen S. Taylor · 2021 · Genome Medicine
- Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modelingPriyanshu Shukla, Sriya Yeleswarapu, Marcel Alexander Heinrich, Jai Prakash, Falguni Pati · 2022 · Biofabrication
- Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applicationsMonize Caiado Decarli, Robson Luis Ferraz do Amaral, Diogo Peres dos Santos, Larissa Bueno Tofani, Eric Takashi Katayama, Rodrigo Alvarenga Rezende, Jorge Vicente Lopes da Silva, Kamilla Swiech, Cláudio Alberto Torres Suazo, Carlos Mota et al. · 2021 · Biofabrication
- Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoidsPrince, Elisabeth, Cruickshank, Jennifer, Ba-Alawi, Wail, Hodgson, Kelsey, Haight, Jillian, Tobin, Chantal, Wakeman, Andrew, Avoulov, Alona, Topolskaia, Valentina, Elliott, Mitchell J. et al. · 2022 · Nature Communications
- Single‐Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor OrganoidsYan Zhao, Zhixuan Li, Yanjing Zhu, Jing Fu, Xiaofang Zhao, Yani Zhang, Shan Wang, Jianmin Wu, Kaiting Wang, Rui Ting Wu et al. · 2021 · Advanced Science
- Patient-Derived Cancer Organoids as Predictors of Treatment ResponseMaikel Verduin, Ann Hoeben, Dirk De Ruysscher, Marc Vooijs · 2021 · Frontiers in Oncology
- Cancer Spheroids and Organoids as Novel Tools for Research and Therapy: State of the Art and Challenges to Guide Precision MedicineSanae El Harane, Bochra Zidi, Nadia El Harane, Karl‐Heinz Krause, Thomas Matthes, Olivier Preynat‐Seauve · 2023 · Cells
- Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screeningDu, Yuhong, Li, Xingnan, Niu, Qiankun, Mo, Xiulei, Qui, Min, Ma, Tingxuan, Kuo, Calvin J, Fu, Haian · 2020 · Journal of Molecular Cell Biology
- Circulating tumor cells in precision oncology: clinical applications in liquid biopsy and 3D organoid modelChang Qing Yang, Bai-Rong Xia, Weilin Jin, Ge Lou · 2019 · Cancer Cell International
- MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentationYuanzhang Fang, Lifei Wang, Changlin Wan, Yifan Sun, Kevin Van der Jeught, Zhuolong Zhou, Tianhan Dong, Ka Man So, Tao Yu, Yujing Li et al. · 2020 · Journal of Clinical Investigation
- A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoidsWojciech Senkowski, Laura Gall-Mas, Matías Marín Falco, Yilin Li, Kari Lavikka, Mette C. Kriegbaum, Jaana Oikkonen, Daria R. Bulanova, Elin J. Pietras, Karolin Voßgröne et al. · 2023 · Developmental Cell
- PRMT inhibition induces a viral mimicry response in triple-negative breast cancerQin Wu, David Y. Nie, Wail Ba-Alawi, YiShuai Ji, ZiWen Zhang, Jennifer Cruickshank, Jillian Haight, Felipe E. Ciamponi, Jocelyn Chen, Shili Duan et al. · 2022 · Nature Chemical Biology
- Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profilesHelen H N Yan, Hoi Cheong Siu, Siu Lun Ho, Sarah S K Yue, Yang Gao, Wai Yin Tsui, Dessy Chan, April Chan, Jason W.H. Wong, Alice H Y Man et al. · 2020 · Gut
- Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoidsKadi Lõhmussaar, Oded Kopper, Jeroen Korving, Harry Begthel, Celien P.H. Vreuls, Johan H. van Es, Hans C. Clevers · 2020 · Nature Communications
- Microfluidic Arrays of Breast Tumor Spheroids for Drug Screening and Personalized Cancer TherapiesPrince, Elisabeth, Kheiri, Sina, Wang, Yihe, Xu, Fei, Cruickshank, Jennifer, Topolskaia, Valentina, Tao, Huachen, Young, Edmond W. K., McGuigan, Alison. P., Cescon, David W. et al. · 2022 · Advanced Healthcare Materials
- Cancer research using organoid technologyKretzschmar, Kai · 2021 · Journal of Molecular Medicine
- Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responsesFarin, Henner F., Mosa, Mohammed H., Ndreshkjana, Benardina, Grebbin, Britta M., Ritter, Birgit, Menche, Constantin, Kennel, Kilian B., Ziegler, Paul K., Szabó, Lili, Bollrath, Julia et al. · 2023 · Cancer Discovery
- Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identificationRosemary Millen, Willem W. B. de Kort, Mandy Koomen, Gijs J. F. van Son, Roán Gobits, Bas B. L. Penning de Vries, Harry Begthel, Maurice M.J.M. Zandvliet, Patricia Doornaert, Cornelis P.J. Raaijmakers et al. · 2023 · Med
- Designer Self‐Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian CancerZehong Yang, Hongyan Xu, Xiaojun Zhao · 2020 · Advanced Science
- The Contribution of Evolutionary Game Theory to Understanding and Treating CancerBenjamin Wölfl, Hedy te Rietmole, Monica Salvioli, Artem Kaznatcheev, Frank Thuijsman, Joel S. Brown, Boudewijn M.T. Burgering, Kateřina Staňková · 2021 · Dynamic Games and Applications
- Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysisRui Wang, Yunuo Mao, Wendong Wang, Xin Zhou, Wei Wang, Shuai Gao, Jingyun Li, Lu Wen, Wei Fu, Fuchou Tang · 2022 · Genome biology
- The drug-induced phenotypic landscape of colorectal cancer organoidsJohannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini et al. · 2022 · Nature Communications
- Organoids are not organs: Sources of variation and misinformation in organoid biologyKim Bak Jensen, Melissa Helen Little · 2023 · Stem Cell Reports
- Molecular classification of hormone receptor-positive HER2-negative breast cancerXi Jin, Yi-Fan Zhou, Ding Ma, Shen Zhao, Cai‐Jin Lin, Yi Xiao, Tong Fu, Chenglin Liu, Yiyu Chen, Wen-Xuan Xiao et al. · 2023 · Nature Genetics
- Portrait of a cancer: mutational signature analyses for cancer diagnosticsVan Hoeck, Arne, Tjoonk, Niels H., van Boxtel, Ruben, Cuppen, Edwin · 2019 · BMC Cancer
- Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapyMeghan T. Logun, Xin Wang, Yusha Y. Sun, Stephen Joseph Bagley, Nannan Li, Arati Suvas Desai, Daniel Y. Zhang, MacLean P. Nasrallah, Emily Ling-Lin Pai, Bike Su Oner et al. · 2024 · Cell stem cell
- Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025Allgayer, Heike, Mahapatra, Samikshya, Mishra, Barnalee, Swain, Biswajit, Saha, Suryendu, Khanra, Sinjan, Kumari, Kavita, Panda, Venketesh K., Malhotra, Diksha, Patil, Nitin S. et al. · 2025 · Molecular Cancer
- STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatmentSteven Lohard, Nathalie Bourgeois, Laurent Maillet, Fabien Gautier, Aurélie Fétiveau, Hamza Lasla, Frédérique Nguyen, Céline Vuillier, Alison Dumont, Agnès Moreau‐Aubry et al. · 2020 · Nature Communications
- Current concepts in tumour-derived organoidsRoss J Porter, Graeme I. Murray, Mairi H McLean · 2020 · British Journal of Cancer
- 3D and organoid culture in research: physiology, hereditary genetic diseases and cancerSuarez-Martinez, Elisa, Suazo-Sanchez, Irene, Celis-Romero, Manuel, Carnero, Amancio · 2022 · Cell & Bioscience
- Functional precision oncology using patient-derived assays: bridging genotype and phenotypeAllard W. J. van Renterghem, Joris van de Haar, Emile E. Voest · 2023 · Nature Reviews Clinical Oncology
- Patient‐derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR‐T cells <i>in vitro</i>Yu, Lei, Li, Zhichao, Mei, Hongbin, Li, Wujiao, Chen, Dong, Liu, Lisa, Zhang, Zhongfu, Sun, Yangyang, Song, Fei, Chen, Wei et al. · 2021 · Clinical & Translational Immunology
- Patient‐derived renal cell carcinoma organoids for personalized cancer therapyZhichao Li, Haibo Xu, Lei Yu, Jia Wang, Qian Meng, Hongbing Mei, Zhiming Cai, Wei Chen, Weiren Huang · 2022 · Clinical and Translational Medicine
- Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoidsSiqi Wang, Yang Wang, Xiaodong Xun, Changkun Zhang, Xiang Xiao, Qian Cheng, Shihua Hu, Zhao Li, Jiye Zhu · 2020 · Journal of Experimental & Clinical Cancer Research
- Cancer stem cells in TNBCZhan Hua, Jason A. White, Jianjun Zhou · 2021 · Seminars in Cancer Biology
- Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cellsGuoying Zhou, Ruby Lieshout, Gilles S. van Tienderen, Valeska de Ruiter, Martin E. van Royen, Patrick P.C. Boor, Luc Magré, Jyaysi Desai, Kübra Köten, Yik Y. Kan et al. · 2022 · British Journal of Cancer
- Estrogen-related receptors are targetable ROS sensorsMathieu Vernier, Catherine R. Dufour, Shawn McGuirk, Charlotte Scholtes, Xiaojing Li, Guillaume Bourmeau, Hellen Kuasne, Morag Park, Julie St‐Pierre, Étienne Audet‐Walsh et al. · 2020 · Genes & Development
- 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐ChipLi, Wenxiu, Zhou, Zhihang, Zhou, Xiaoyu, Khoo, Bee Luan, Gunawan, Renardi, Chin, Y. Rebecca, Zhang, Liang, Yi, Changqing, Guan, Xinyuan, Yang, Mengsu · 2023 · Advanced Healthcare Materials
- Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic dataKe Liu, Patrick A. Newbury, Benjamin Scott Glicksberg, Billy Zeng, Shreya Paithankar, Eran R. Andrechek, Bin Chen · 2019 · Nature Communications
- Anticancer drug discovery using multicellular tumor spheroid modelsMichele Zanoni, Sara Pignatta, Chiara Arienti, Massimiliano Bonafè, Anna Tesei · 2019 · Expert Opinion on Drug Discovery
- Modeling and Targeting Alzheimer’s Disease With OrganoidsAngelos Papaspyropoulos, Magda Tsolaki, Nikolaos Foroglou, Αnastasia A. Pantazaki · 2020 · Frontiers in Pharmacology
- An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicityZhou, Zhuolong, Van der Jeught, Kevin, Fang, Yuanzhang, Yu, Tao, Li, Yujing, Ao, Zheng, Liu, Sheng, Zhang, Lu, Yang, Yang, Eyvani, Haniyeh et al. · 2021 · Nature Biomedical Engineering
- Bladder cancer organoids as a functional system to model different disease stages and therapy responseMartina Minoli, Thomas Cantore, Daniel Hanhart, Mirjam Kiener, Tarcisio Fedrizzi, Federico La Manna, Sofia Karkampouna, Panagiotis Chouvardas, Vera Genitsch, Antonio Rodríguez-Calero et al. · 2023 · Nature Communications
- Building consensus on the application of organoid-based drug sensitivity testing in cancer precision medicine and drug developmentXiang, Dongxi, He, Aina, Zhou, Rong, Wang, Yonggang, Xiao, Xiuying, Gong, Ting, Kang, Wenyan, Lin, Xiaolin, Wang, Xiaochen, PDO-based DST Consortium11 et al. · 2024 · Theranostics
- Modeling Cell Communication in Cancer With Organoids: Making the Complex SimpleElena Fiorini, Lisa Veghini, Vincenzo Corbo · 2020 · Frontiers in Cell and Developmental Biology
- Patient-derived tumor-like cell clusters for drug testing in cancer therapyShenyi Yin, Ruibin Xi, Aiwen Wu, Shu Wang, Yingjie Li, Chaobin Wang, Lei Tang, Yuchao Xia, Di Yang, Juan Li et al. · 2020 · Science Translational Medicine
- A pan-cancer organoid platform for precision medicineLarsen, Brian M., Kannan, Madhavi, Langer, Lee F., Leibowitz, Benjamin D., Bentaieb, Aicha, Cancino, Andrea, Dolgalev, Igor, Drummond, Bridgette E., Dry, Jonathan R., Ho, Chi-Sing et al. · 2021 · Cell Reports
- Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic CharacteristicsSonam Bhatia, Melissa Kramer, Suzanne Russo, Payal Naik, Gayatri Arun, Kyle Brophy, Peter Andrews, Cheng Fan, Charles M. Perou, Jonathan B. Preall et al. · 2022 · Cancer Research
- Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic TherapyElse Driehuis, Sacha Spelier, Irati Beltrán Hernández, Remco de Bree, Stefan M. Willems, Hans C. Clevers, Sabrina Oliveira · 2019 · Journal of Clinical Medicine
- Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinomaYuanbo Kang, Weihan He, Caiping Ren, Jincheng Qiao, Qiuyong Guo, Jingyu Hu, Hongjuan Xu, Xingjun Jiang, Lei Wang · 2020 · Signal Transduction and Targeted Therapy
- Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the EvidenceEmma H. van Schie, Renée van Amerongen · 2020 · Frontiers in Cell and Developmental Biology
- The role of tumor microenvironment in drug resistance: emerging technologies to unravel breast cancer heterogeneityVincenzo Salemme, Giorgia Centonze, Lidia Avalle, Dora Natalini, Alessio Piccolantonio, Pietro Arina, Alessandro Morellato, Ugo Ala, Daniela Taverna, Emilia Turco et al. · 2023 · Frontiers in Oncology
- Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor-positive breast cancerWhittle, James R., Vaillant, François, Surgenor, Elliot, Policheni, Antonia N., Giner, Göknur, Capaldo, Bianca D., Chen, Huei-Rong, Liu, He K., Dekkers, Johanna F., Sachs, Norman et al. · 2020 · Clinical Cancer Research
- Mechanically and chemically defined hydrogel matrices for patient-derived colorectal tumor organoid cultureNg, Shengyong, Tan, Wai Jin, Pek, Michelle Mi Xue, Tan, Min-Han, Kurisawa, Motoichi · 2019 · Biomaterials
- Modeling the Human Body on Microfluidic ChipsSasan Jalili‐Firoozinezhad, Cláudia C. Miranda, Joaquim M. S. Cabral · 2021 · Trends in biotechnology