The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
Open accessAbstract
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0.0014). Distinct patterns of metastatic dissemination were observed, including rapid progression to multiple tissue sites seeded by primary tumors of monoclonal structure. By contrast, we observed attenuated progression in cases characterized by high primary tumor heterogeneity, with metastatic competence acquired gradually and initial progression to solitary metastasis. Finally, we observed early divergence of primitive ancestral clones and protracted latency of up to two decades as a feature of pancreatic metastases.
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Citations
Cites
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“Our observations in this group underpin the role of cytoreductive nephrectomy in removing the ‘‘evolutionary sink of diversity’’ (Gerlinger et al., 2012) and thus minimizing the risk of future metastatic seeding from evolving primary tumors harboring clones of variable metastatic potential.”
Self-citationZehir, A., Benayed, R., Shah, R. H., Syed, A., Middha, S., Kim, H. R., Srinivasan, P., Gao, J., Chakravarty, D., Devlin, S. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4333 · Cited by 3,380 · cited 1×
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Distant metastasis occurs late during the genetic evolution of pancreatic cancer
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Self-citationIntegrative clinical genomics of metastatic cancer
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Cited by
Braun, D. A., Hou, Y., Bakouny, Z., Ficial, M., Sant’ Angelo, M., Forman, J., Ross-Macdonald, P., Berger, A. C., Jegede, O. A., Elagina, L., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0839-y · Cited by 992
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition
Litchfield, K., Reading, J. L., Puttick, C., Thakkar, K., Abbosh, C., Bentham, R., Watkins, T. B. K., Rosenthal, R., Biswas, D., Rowan, A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.002 · Cited by 893
Self-citationIntegrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Clark, D. J., Dhanasekaran, S. M., Petralia, F., Pan, J., Song, X., Hu, Y., da Veiga Leprevost, F., Reva, B., Lih, T.-S. M., Chang, H.-Y., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.007 · Cited by 730
Self-citationLongitudinal molecular trajectories of diffuse glioma in adults
Barthel, F. P., Johnson, K. C., Varn, F. S., Moskalik, A. D., Tanner, G., Kocakavuk, E., Anderson, K. J., Abiola, O., Aldape, K., Alfaro, K. D., et al. (2019) · Nature · doi:10.1038/s41586-019-1775-1 · Cited by 561
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
Mitchell, T. J., Turajlic, S., Rowan, A., Nicol, D., Farmery, J. H. R., O’Brien, T., Martincorena, I., Tarpey, P., Angelopoulos, N., Yates, L. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.020 · Cited by 513
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Metadata
- Authors
- Turajlic, S., Xu, H., Litchfield, K., Rowan, A., Chambers, T., Lopez, J. I., Nicol, D., O’Brien, T., Larkin, J., Horswell, S., Stares, M., Au, L., Jamal-Hanjani, M., Challacombe, B., Chandra, A., Hazell, S., Eichler-Jonsson, C., Soultati, A., Chowdhury, S., Rudman, S., Lynch, J., Fernando, A., Stamp, G., Nye, E., Jabbar, F., Spain, L., Lall, S., Guarch, R., Falzon, M., Proctor, I., Pickering, L., Gore, M., Watkins, T. B. K., Ward, S., Stewart, A., DiNatale, R., Becerra, M. F., Reznik, E., Hsieh, J. J., Richmond, T. A., Mayhew, G. F., Hill, S. M., McNally, C. D., Jones, C., Rosenbaum, H., Stanislaw, S., Burgess, D. L., Alexander, N. R., & Swanton, C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 173
- Issue
- 3
- Pages
- 581-594.e12
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2797282777
- Cited by
- 829
- References
- 11
- FWCI
- 25.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Turajlic, S., Xu, H., Litchfield, K., Rowan, A., Chambers, T., Lopez, J. I., Nicol, D., O’Brien, T., Larkin, J., Horswell, S., Stares, M., Au, L., Jamal-Hanjani, M., Challacombe, B., Chandra, A., Hazell, S., Eichler-Jonsson, C., Soultati, A., Chowdhury, S., . . . Swanton, C. (2018). Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal. Cell. https://doi.org/10.1016/j.cell.2018.03.057
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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