Mapping the Genetic Landscape of Human Cells

Horlbeck, Max A., Xu, Albert, Wang, Min, Bennett, Neal K., Park, Chong Y., Bogdanoff, Derek, Adamson, Britt, Chow, Eric D., Kampmann, Martin, Peterson, Tim R., Nakamura, Ken, Fischbach, Michael A., Weissman, Jonathan S., Gilbert, Luke A.·2018·Cell
DOI 10.1016/j.cell.2018.06.010

Cited by (321)

Items 101–200 of 321

  1. Synthetic lethality in cancer drug discovery: challenges and opportunities
    Emanuel Gonçalves, Colm J. Ryan, David J. Adams · 2025 · Nature Reviews Drug Discovery
  2. Re-defining synthetic lethality by phenotypic profiling for precision oncology
    Yevhen A. Akimov, Tero A. Aittokallio · 2021 · Cell chemical biology
  3. Factorizing polygenic epistasis improves prediction and uncovers biological pathways in complex traits
    David Tang, Jerome Freudenberg, Andy W. Dahl · 2023 · The American Journal of Human Genetics
  4. Application of CHyMErA Cas9-Cas12a combinatorial genome-editing platform for genetic interaction mapping and gene fragment deletion screening
    Michael Aregger, Kun Xing, Thomas Gonatopoulos-Pournatzis · 2021 · Nature Protocols
  5. Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma
    Xiao Chen, Yinglu Li, Fang Zhu, Xinjing Xu, Brian Estrella, Manuel A. Pazos, John T. McGuire, Dimitris Karagiannis, Varun Sahu, Mustafo Mustafokulov et al. · 2023 · Nature Communications
  6. Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise
    So Jung Park, Sung Min Son, António Daniel Barbosa, Lidia Wróbel, Eleanna Stamatakou, Ferdinando Squitieri, Gabriel Balmus, David Chaim Rubinsztein · 2024 · Nature Cell Biology
  7. Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition
    Wenguang G. Liang, Juwina Wijaya, Hui Wei, Alex J. Noble, Jordan M Mancl, Swansea Mo, David E. Lee, John V. Lin King, Man Pan, Chang Liu et al. · 2022 · Nature Communications
  8. In silico biological discovery with large perturbation models
    Djordje Miladinovic, Tobias Höppe, Mathieu Chevalley, Andreas Georgiou, Lachlan Stuart, Arash Mehrjou, Marcus Bantscheff, Bernhard Schölkopf, Patrick Schwab · 2025 · Nature Computational Science
  9. SLKB: synthetic lethality knowledge base
    Birkan Gökbağ, Shan Tang, Kunjie Fan, Lijun Cheng, Lianbo Yu, Yue Zhao, Lang Li · 2023 · Nucleic Acids Research
  10. Context-dependent genetic interactions in cancer
    Luisa Henkel, Benedikt Rauscher, Michael Boutros · 2019 · Current Opinion in Genetics & Development
  11. Engineering novel CRISPRi repressors for highly efficient mammalian gene regulation
    Andrew Kristof, Krithika Karunakaran, Christopher Allen, Paula Mizote, Sophie Briggs, Zixin Jian, Patrick Nash, John Blazeck · 2025 · Genome biology
  12. Considerations in the search for epistasis
    Marleen Balvert, Johnathan Cooper‐Knock, Julian Stamp, Ross Patrick Byrne, Soufiane M. C. Mourragui, Juami H. M. van Gils, Stefania Benónísdóttir, Johannes Schlüter, Kevin Patrick Kenna, Sanne Abeln et al. · 2024 · Genome biology
  13. A multilineage screen identifies actionable synthetic lethal interactions in human cancers
    Samson H. Fong, Brent M. Kuenzi, Nicole M. Mattson, John J. Y. Lee, Kyle S. Sanchez, Ana Bojorquez-Gomez, Kyle M. Ford, Brenton P. Munson, Katherine Licon, Sarah Bergendahl et al. · 2024 · Nature Genetics
  14. Multiple mutations within individual oncogenes
    Yuki Saito, Junji Koya, Keisuke Kataoka · 2020 · Cancer Science
  15. Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity
    Kuoyuan Cheng, Nishanth Ulhas Nair, Joo Sang Lee, Eytan Ruppin · 2021 · Science Advances
  16. High throughput mutagenesis and screening for yeast engineering
    Kendreze L. Holland, John Blazeck · 2022 · Journal of Biological Engineering
  17. Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells
    Sunay Usluer, Pille Hallast, Luca Crepaldi, Yan Zhou, Katie Urgo, Cansu Dinçer, Jing Su, Guillaume G. Noell, Kaur Alasoo, Omar El Garwany et al. · 2023 · Stem Cell Reports
  18. Synthetic lethal connectivity and graph transformer improve synthetic lethality prediction
    Kunjie Fan, Birkan Gökbağ, Shan Tang, Shangjia Li, Yirui Huang, Lingling Wang, Lijun Cheng, Lang Li · 2024 · Briefings in Bioinformatics
  19. Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions
    Scott W. Simpkins, Justin Nelson, Raamesh Deshpande, Sheena Claire Li, Jeff S. Piotrowski, Erin H. Wilson, Abraham Abera Gebre, Hamid Safizadeh, Reika Okamoto, Mami Yoshimura et al. · 2018 · PLoS Computational Biology
  20. Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
    Daniëlle Bianchi, Razvan Borza, Erica De Zan, Guizela Huelsz‐Prince, Sebastian Gregoricchio, Marleen Dekker, Alexander Fish, Abdelghani Mazouzi, Lona John Kroese, Simon Linder et al. · 2025 · Science
  21. Neuromuscular disorders: finding the missing genetic diagnoses
    Katherine E. Koczwara, Nicole J. Lake, Alec M. DeSimone, Monkol Lek · 2022 · Trends in Genetics
  22. A global genetic interaction network by single-cell imaging and machine learning
    Florian Heigwer, Christian Scheeder, Josephine Bageritz, Schayan Yousefian, Benedikt Rauscher, Christina Laufer, Sergi Beneyto‐Calabuig, Maja C. Funk, Vera Peters, Maria Boulougouri et al. · 2023 · Cell Systems
  23. Dual CRISPRi-seq for genome-wide genetic interaction studies identifies key genes involved in the pneumococcal cell cycle
    Julien Dénéréaz, Elise Eray, Bimal Jana, Vincent de Bakker, Horia Todor, Tim van Opijnen, Xue Liu, Jan‐Willem Veening · 2025 · Cell Systems
  24. Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline
    Henry N. Ward, Michael Aregger, Thomas Gonatopoulos-Pournatzis, Maximilian Billmann, Toshiro K. Ohsumi, Kevin R. Brown, Benjamin J. Blencowe, Jason Moffat, Chad L. Myers · 2021 · Nature Protocols
  25. Concurrent outcomes from multiple approaches of epistasis analysis for human body mass index associated loci provide insights into obesity biology
    Sheldon D’Silva, Shreya Chakraborty, Bratati Kahali · 2022 · Scientific Reports
  26. VHL Synthetic Lethality Signatures Uncovered by Genotype-Specific CRISPR-Cas9 Screens
    Ning Sun, Sakina M. Petiwala, Charles Lu, Jessica E. Hutti, Min Hu, Mufeng Hu, Marc H. Domanus, Diya Mitra, Sadiya N. Addo, Christopher P. Miller et al. · 2019 · The CRISPR Journal
  27. Scalable and universal prediction of cellular phenotypes enables in silico experiments
    Yuge Ji, Alejandro Tejada-Lapuerta, Niklas Arndt Schmacke, Zihe Zheng, Xinyue Zhang, Simrah Khan, Ina Rothenaigner, Juliane Tschuck, Kamyar Hadian, Veit Hornung et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Generation of dual-gRNA library for combinatorial CRISPR screening of synthetic lethal gene pairs
    Shan Tang, Xue Wu, Jinghui Liu, Qiongsi Zhang, Xinyi Wang, Shuai Shao, Birkan Gökbağ, Kunjie Fan, Xiaoqi Liu, Fuhai Li et al. · 2022 · STAR Protocols
  29. An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies
    Jing Wang, Yuqi Wen, Yixin Zhang, Zhongming Wang, Yuyang Jiang, Chong Dai, Lianlian Wu, Dongjin Leng, Song He, Xiaochen Bo · 2023 · Journal of Advanced Research
  30. Functional Genomics for Cancer Research: Applications In Vivo and In Vitro
    Thomas A. O’Loughlin, Luke A. Gilbert · 2018 · Annual Review of Cancer Biology
  31. Mitochondrial activity tunes nociceptor resilience to excitotoxicity
    Lin Yuan, Navdeep S. Chandel, David J. Julius · 2025 · Cell
  32. Advances and Challenges in Drug Screening for Cancer Therapy: A Comprehensive Review
    Shohei Motohashi, Eriko Katsuta, Daisuke Ban · 2025 · Bioengineering
  33. Common computational tools for analyzing CRISPR screens
    Medina Colic, Traver Hart · 2021 · Emerging Topics in Life Sciences
  34. Mapping the Genetic Interaction Network of PARP inhibitor Response
    Danny Simpson, Ling Jia, Yangwode Jing, Britt Adamson · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Direct capture of CRISPR guides enables scalable, multiplexed, and multi-omic Perturb-seq
    Replogle, Joseph M., Xu, Albert, Norman, Thomas M., Meer, Elliott J., Terry, Jessica M., Riordan, Daniel, Srinivas, Niranjan, Mikkelsen, Tarjei S., Weissman, Jonathan S., Adamson, Britt · 2018
  36. A High-Content Screen Identifies MicroRNAs That Regulate Liver Repopulation After Injury in Mice
    Adam M. Zahm, Amber W. Wang, Yue Julia Wang, Jonathan Schug, Kirk J. Wangensteen, Klaus H. Kaestner · 2019 · Gastroenterology
  37. Environmental challenge rewires functional connections among human genes
    Benjamin W. Herken, Garrett T. Wong, Thomas M. Norman, Luke A. Gilbert · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Comprehensive Double-Mutant Analysis of the Bacillus subtilis Envelope Using Double-CRISPRi
    Byoung‐Mo Koo, Horia Todor, Jiawei Sun, Jordi van Gestel, John S. Hawkins, Cameron C. Hearne, Amy B. Banta, Kerwyn Casey Huang, Jason M. Peters, Carol A. Gross · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  39. ZNF574 is a Quality Control Factor For Defective Ribosome Biogenesis Intermediates
    Jared F. Akers, Michael LaScola, Adrian Bothe, Hanna Suh, Carmen Jung, Zachary D. Stolp, Tanushree Ghosh, Liewei L. Yan, Yuming Wang, Michelle Macurak et al. · 2024 · Molecular Cell
  40. Comprehensive genetic interaction analysis of the Bacillus subtilis envelope using double-CRISPRi
    Byoung‐Mo Koo, Horia Todor, Jiawei Sun, Jordi van Gestel, John S. Hawkins, Cameron C. Hearne, Amy B. Banta, Kerwyn Casey Huang, Jason M. Peters, Carol A. Gross · 2025 · Cell Systems
  41. Large-scale datasets uncovering cell signalling networks in cancer: context matters
    Sumana Sharma, Evangelia Petsalaki · 2019 · Current Opinion in Genetics & Development
  42. Analyzing CRISPR screens in non-conventional microbes
    Varun Trivedi, Adithya Ramesh, Ian R. Wheeldon · 2023 · Journal of Industrial Microbiology & Biotechnology
  43. CRISPR/Cas-based devices for mammalian synthetic biology
    Tackhoon Kim, Timothy K. Lu · 2019 · Current Opinion in Chemical Biology
  44. In vivo CRISPR screening for novel noncoding RNA functional targets in glioblastoma models
    Frank Joseph Attenello, Kathleen Tsung, Isaac Bishara, Yong‐Hwee Eddie Loh, Thomas C. Chen · 2021 · Journal of Neuroscience Research
  45. Gene-gene interactions at GWAS loci modulate lipid plasma levels and cellular uptake of low-density lipoprotein
    M. Zimoń, Yunfeng Huang, Anthi Trasta, Jiangjiang Liu, Jimmy Z. Liu, Chia-Yen Chen, Rainer Pepperkok, Bernd Klaus, Christopher D. Whelan, David Sexton et al. · 2020 · Nature Communications
  46. Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function
    Neal K. Bennett, Hiroki J. Nakaoka, Danny Laurent, Ross A. Okimoto, Yoshitaka J. Sei, Andrew Horvai, Trever Grant Bivona, Johanna ten Hoeve, Thomas G. Graeber, Ken Nakamura et al. · 2022 · PLoS Biology
  47. Importance of genetic screens in precision oncology
    Antonio Mulero‐Sánchez, Ziva Pogacar, Loredana Vecchione · 2019 · ESMO Open
  48. CRISPRi: a way to integrate iPSC-derived neuronal models
    Sarah N. J. Franks, Rachel Heon‐Roberts, Brent James Ryan · 2024 · Biochemical Society Transactions
  49. dCas9 techniques for transcriptional repression in mammalian cells: Progress, applications and challenges
    Yuanyuan Li, Liquan Zhou · 2021 · BioEssays
  50. Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference
    S. John Liu, Max A. Horlbeck, Jonathan S. Weissman, Daniel A. Lim · 2020 · Methods in molecular biology
  51. Using cryo-EM to understand the assembly pathway of respiratory complex I
    Eike Laube, Jonathan Schiller, Volker Zickermann, Janet Vonck · 2024 · Acta Crystallographica Section D Structural Biology
  52. Towards a CRISPeR understanding of homologous recombination with high-throughput functional genomics
    Samuel B. Hayward, Alberto Ciccia · 2021 · Current Opinion in Genetics & Development
  53. Pathway-driven analysis of synthetic lethal interactions in cancer using perturbation screens
    Mina Karimpour, Mehdi Totonchi, Mehrdad Behmanesh, Hesam Montazeri · 2023 · Life Science Alliance
  54. Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway
    Erica De Zan, Ruud G.P.M. van Stiphout, Bianca V. Gapp, Vincent A. Blomen, Thijn R. Brummelkamp, Sebastian M. B. Nijman · 2020 · Science Signaling
  55. Impact of CRISPR in cancer drug discovery
    Jason Moffat, Alexis C. Komor, Lawrence Lum · 2024 · Science
  56. A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments
    Boyang Zhao, Yiyun Rao, Scott M. Leighow, Edward P. O’Brien, Luke A. Gilbert, Justin R. Pritchard · 2022 · Nature Communications
  57. ASTER: A Method to Predict Clinically Relevant Synthetic Lethal Genetic Interactions
    Herty Liany, Aishwarya Jayagopal, Dachuan Huang, Jing Quan Lim, Nur Izzah NBH, Anand Devaprasath D. Jeyasekharan, Choon Kiat Ong, Vaibhav Rajan · 2024 · IEEE Journal of Biomedical and Health Informatics
  58. Nonparametric Bayesian multiarmed bandits for single-cell experiment design
    Federico Camerlenghi, Bianca Dumitrascu, Federico Ferrari, Barbara Elizabeth Engelhardt, Stefano Favaro · 2020 · The Annals of Applied Statistics
  59. A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin
    Sean M. Santos, John L. Hartman · 2019 · Cancer & Metabolism
  60. Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platform
    Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori Wilson, Ryan Steger, Annabel K. Sangree, Medina Colic, Sidney H. Wang, John G. Doench, Traver Hart · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  61. CRISPR /Cas Technology in Disease Prevention and Control of Aquatic Animals
    Nan Lin, Jiexin Zhang, Yilei Wang, Ziping Zhang · 2024 · Reviews in Aquaculture
  62. Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles
    Maximilian Billmann, Michael Costanzo, Xiang Zhang, Arshia Zernab Hassan, Mahfuzur Rahman, Kevin R. Brown, Katherine S. Chan, Amy H.Y. Tong, Carles Pons, Henry N. Ward et al. · 2026 · Cell
  63. Identification of a cholesterol metabolism-related prognostic signature for multiple myeloma
    Na Zhao, Chunxia Qu, Yang Yan, Huihui Li, Yueyue Li, Hongbo Zhu, Zhiguo Long · 2023 · Scientific Reports
  64. Chemical-genetic CRISPR-Cas9 screens in human cells using a pathway-specific library
    Frances V Hundley, David Paul Toczyski · 2021 · STAR Protocols
  65. Genetic landscape of T cells identifies synthetic lethality for T-ALL
    Connor P. O’Meara, Lucía Guerri, Divine-Fondzenyuy Lawir, Fernando Mateos, Mary Iconomou, Norimasa Iwanami, Cristian Soza‐Ried, Katarzyna Sikora, Iliana Siamishi, Orlando B. Giorgetti et al. · 2021 · Communications Biology
  66. Translational drug–interaction corpus
    Shijun Zhang, Heng‐Yi Wu, Lei Wang, Gongbo Zhang, Luis Mateus Rocha, Hagit Shatkay, Lang Li · 2022 · Database
  67. Extracting complementary insights from molecular phenotypes for prioritization of disease-associated mutations
    Shayne D. Wierbowski, Robert Fragoza, Siqi Liang, Haiyuan Yu · 2018 · Current Opinion in Systems Biology
  68. Synthetic Lethality in Lung Cancer—From the Perspective of Cancer Genomics
    Iwao Shimomura, Yusuke Yamamoto, Takahiro Ochiya · 2019 · Medicines
  69. Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome
    András Horváth, Gergely Róna, Michele Pagano, Philip W. Jordan · 2020 · BMC Molecular and Cell Biology
  70. Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality
    Arti Navare, Fred David Mast, Jean Paul Olivier, Thierry Bertomeu, Maxwell Lewis Neal, Lindsay N. Carpp, Alexis Kaushansky, Jasmin Coulombe‐Huntington, Mike Tyers, John D. Aitchison · 2022 · The Journal of Cell Biology
  71. A systematic genetic interaction map of human solute carriers assigns a role to SLC25A51/MCART1 in mitochondrial NAD uptake
    Enrico Girardi, Giuseppe Fiume, Ulrich Goldmann, Celine Sin, Felix Müller, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Benedikt Agerer, Felix Kartnig et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  72. Large-scale mapping of environmental-genetic interactions illustrates the dynamic nature of cell-cycle and DNA repair regulation
    Benjamin W. Herken, Garrett T. Wong, Anna Mäkiniemi, Emma K. Lundberg, Thomas M. Norman, Luke A. Gilbert · 2026 · Molecular Cell
  73. Comprehensive synergy mapping links a BAF- and NSL-containing “supercomplex” to the transcriptional silencing of HIV-1
    Zichong Li, Steven G. Deeks, Mélanie Ott, Warner C. Greene · 2023 · Cell Reports
  74. Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer
    Tackhoon Kim, Byung-Sun Park, Soobeen Heo, Heeju Jeon, Jaeyeal Kim, Donghwa Kim, Sang Kook Lee, So‐Youn Jung, Sun‐Young Kong, Timothy K. Lu · 2024 · eLife
  75. CSSLdb: Discovery of cancer-specific synthetic lethal interactions based on machine learning and statistic inference
    Yuyang Dou, Yujie Ren, Xinmiao Zhao, Jiaming Jin, Shizheng Xiong, Lulu Luo, Xinru Xu, Xueni Yang, Jiafeng Yu, Li Guo et al. · 2024 · Computers in Biology and Medicine
  76. Computational Methods for Analysis of Large-Scale CRISPR Screens
    Xueqiu Lin, Augustine Chemparathy, Marie F. La Russa, Timothy Daley, Lei S. Qi · 2020 · Annual Review of Biomedical Data Science
  77. ASTER: A Method to Predict Clinically Actionable Synthetic Lethal Genetic Interactions
    Herty Liany, Anand Devaprasath D. Jeyasekharan, Vaibhav Rajan · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  78. CRISPRi-TnSeq: A genome-wide high-throughput tool for bacterial essential-nonessential genetic interaction mapping
    Bimal Jana, Xue Liu, Julien Dénéréaz, Hongshik Park, Dmitry R. Leshchiner, Bruce Liu, Clément Gallay, Jan‐Willem Veening, Tim van Opijnen · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  79. Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistry
    Caroline M. Wilson, Greg C. Pommier, Daniel D. Richman, Nicholas A. Sambold, Jeffrey A. Hussmann, Jonathan S. Weissman, Luke A. Gilbert · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  80. Comprehensive resistance profiling of chronic myeloid leukaemia associated ABL1 variants against five tyrosine kinase inhibitors using prime editing
    Y. J. Jung, Goosang Yu, Hyeong-Cheol Oh, Jueng-Hu Lee, Eunhye Jeon, Juhyeon Bae, Taebo Sim, Seokjoong Kim · 2025 · Nature Biomedical Engineering
  81. Multi-level characteristics recognition of cancer core therapeutic targets and drug screening for a broader patient population
    张德楠, Yangguang Su, Ying Wang, Zhuo Qu, Jiaxin Liu, Xuekun Ren, Xiujie Chen · 2023 · Frontiers in Pharmacology
  82. The nucleolar phase of signal recognition particle assembly
    Amani Issa, Florence Schlotter, Justine Flayac, Jing Chen, Ludivine Wacheul, Manon Philippe, Lucas Sardini, Lalia Mostefa, Franck Vandermoere, Édouard Bertrand et al. · 2024 · Life Science Alliance
  83. Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability
    Prashant K. Mishra, Wei-Chun Au, Pedro G. Castiñeira, Nazrin Ali, John Stanton, Lars Boeckmann, Yoshimitsu Takahashi, Michael Costanzo, Charles M. Boone, Kerry Bloom et al. · 2023 · Molecular Biology of the Cell
  84. Lethal clues to cancer-cell vulnerability
    Felix Yi-Chung Feng, Luke A. Gilbert · 2019 · Nature
  85. A landscape of synergistic drug combinations in non-small-cell lung cancer
    Nishanth Ulhas Nair, Patricia Greninger, Adam A. Friedman, Arnaud Amzallag, Eliane Cortez, Avinash D Sahu, Joo Sang Lee, Anahita Dastur, Regina K. Egan, Ellen Murchie et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  86. A global genetic interaction map of a human cell reveals conserved principles of genetic networks
    Maximilian Billmann, Michael Costanzo, Xiang Zhang, Arshia Zernab Hassan, Mahfuzur Rahman, Kevin R. Brown, Katherine Chan, Amy H.Y. Tong, Carles Pons, Henry N. Ward et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  87. Very long-chain fatty acids drive 1-deoxySphingolipid toxicity
    Adam Majcher, Gergely Karsai, Elkhan Yusifov, Martina Schaettin, Ermanno Malagola, Péter Horváth, Jinmei Li, Sofía Rodriguez-Gallardo, Kuniyoshi Shimizu, Gai Zhibo et al. · 2025 · Nature Communications
  88. Predicting genetic interactions, cell line dependencies and drug sensitivities with variational graph auto-encoder
    Asia Gervits, Roded Sharan · 2022 · Frontiers in Bioinformatics
  89. Application of CRISPR-Cas9 Screening Technologies to Study Mitochondrial Biology in Healthy and Disease States
    David M. Sharon, Steven M. Chan · 2019 · Advances in experimental medicine and biology
  90. Mapping cancer genetics at single-cell resolution
    Luke A. Gilbert · 2020 · Science Translational Medicine
  91. Toolboxes for plant systems biology research
    Jihyun Park, Gözde S. Demirer, Lily S. Cheung · 2022 · Current Opinion in Biotechnology
  92. Multi-omics Sampling-based Graph Transformer for Synthetic Lethality Prediction
    Xusheng Zhao, Hao Liu, Qiong Dai, Hao Ming Peng, Xu Bai, Huailiang Peng · 2023 · IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
  93. Genetically Encoded Fluorescence Barcodes Allow for Single-Cell Analysis via Spectral Flow Cytometry
    Xiaoming Lu, Daniel J. Pritko, Megan Abravanel, Jonah R. Huggins, Oluwaferanmi Ogunleye, Tirthankar Biswas, Katia C. Ashy, Semaj K. Woods, Mariclaire W.T. Livingston, Mark Blenner et al. · 2025 · ACS Synthetic Biology
  94. Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor immune composition
    Maxime Dhainaut, Samuel A. Rose, Güray Aktürk, Aleksandra Wroblewska, Eun Sook Park, Sebastian Rune Nielsen, Mark Buckup, Vladimir Roudko, Luisanna Pia, Jessica Le Bérichel et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  95. MiT4SL: multi-omics triplet representation learning for cancer cell line-adapted prediction of synthetic lethality
    Siyu Tao, Yimiao Feng, Yang Yang, Min Wu, Jie Zheng · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  96. RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS
    Avinash V. Dharmadhikari, Maria Alba Abad, Sheraz Khan, Reza Maroofian, Tristan T. Sands, Farid Ullah, Itaru Samejima, Yanwen Shen, Martin A. Wear, Kiara E. Moore et al. · 2025 · Nature Communications
  97. Protein-protein interactions are a major source of epistasis in genetic interaction networks
    Xavier Castellanos-Girouard, Adrian W.R. Serohijos, Stephen W. Michnick · 2026 · Nature Communications
  98. Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response
    Helen E King, Savannah O’Connell, Daisy Kavanagh, Sofia Mason, Cerys S. McCool, Javier Fernández-Chamorro, Christine Louise Chaffer, Susan J. Clark, Helaine Graziele Santos Vieira, Timothy Sterne-Weiler et al. · 2026 · Nucleic Acids Research
  99. Keeping it centered: decoding the activities that regulate yeast histone H3 variant Cse4 and confine it to centromeres
    Martina Greco, Joanna Klim, Peter De Wulf · 2026 · Frontiers in Cell and Developmental Biology
  100. Biochemistry and genetics are coming together to improve our understanding of genotype to phenotype relationships
    Judith Notbohm, Tina Perica · 2024 · Current Opinion in Structural Biology