Fischbach, Michael A.

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 10,100

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

Sharma, S. V., Lee, D. Y., Li, B., Quinlan, M. P., Takahashi, F., Maheswaran, S., McDermott, U., Azizian, N., Zou, L., Fischbach, M. A., et al. (2010) · Cell

Cancer Cells and MetastasisEpigenetics and DNA Methylation

Cited by 2,770

Bile acid metabolites control TH17 and Treg cell differentiation

Hang, S., Paik, D., Yao, L., Kim, E., Trinath, J., Lu, J., Ha, S., Nelson, B. N., Kelly, S. P., Wu, L., et al. (2019) · Nature

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 1,457

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

Dodd, D., Spitzer, M. H., Van Treuren, W., Merrill, B. D., Hryckowian, A. J., Higginbottom, S. K., Le, A., Cowan, T. M., Nolan, G. P., Fischbach, M. A., et al. (2017) · Nature

Gut microbiota and healthTryptophan and brain disorders

Cited by 1,425

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Nemet, I., Saha, P. P., Gupta, N., Zhu, W., Romano, K. A., Skye, S. M., Cajka, T., Mohan, M. L., Li, L., Wu, Y., et al. (2020) · Cell

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

Cited by 784

Small molecules from the human microbiota

Donia, M. S., & Fischbach, M. A. (2015) · Science

Microbial Natural Products and BiosynthesisGut microbiota and health

Cited by 760

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S., & Fischbach, M. A. (2014) · Cell Host & Microbe

Gut microbiota and healthTryptophan and brain disorders

Cited by 732

A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics

Donia, M. S., Cimermancic, P., Schulze, C. J., Wieland Brown, L. C., Martin, J., Mitreva, M., Clardy, J., Linington, R. G., & Fischbach, M. A. (2014) · Cell

Microbial Natural Products and BiosynthesisAntimicrobial Peptides and Activities

Cited by 705

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

Sato, Y., Atarashi, K., Plichta, D. R., Arai, Y., Sasajima, S., Kearney, S. M., Suda, W., Takeshita, K., Sasaki, T., Okamoto, S., et al. (2021) · Nature

Gut microbiota and healthSteroid Chemistry and Biochemistry

Cited by 632

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

Funabashi, M., Grove, T. L., Wang, M., Varma, Y., McFadden, M. E., Brown, L. C., Guo, C., Higginbottom, S., Almo, S. C., & Fischbach, M. A. (2020) · Nature

Steroid Chemistry and BiochemistryMicrobial Natural Products and Biosynthesis

Cited by 590

A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes

Scharschmidt, T. C., Vasquez, K. S., Truong, H.-A., Gearty, S. V., Pauli, M. L., Nosbaum, A., Gratz, I. K., Otto, M., Moon, J. J., Liese, J., et al. (2015) · Immunity

T-cell and B-cell ImmunologyDermatology and Skin Diseases

Cited by 586

Metagenomic compendium of 189,680 DNA viruses from the human gut microbiome

Nayfach, S., Páez-Espino, D., Call, L., Low, S. J., Sberro, H., Ivanova, N. N., Proal, A. D., Fischbach, M. A., Bhatt, A. S., Hugenholtz, P., et al. (2021) · Nature Microbiology

Bacteriophages and microbial interactionsGenomics and Phylogenetic Studies

Cited by 580

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

Stinear, T. P., Seemann, T., Harrison, P. F., Jenkin, G. A., Davies, J. K., Johnson, P. D. R., Abdellah, Z., Arrowsmith, C., Chillingworth, T., Churcher, C., et al. (2008) · Genome Research

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 570

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

Constantinides, M. G., Link, V. M., Tamoutounour, S., Wong, A. C., Perez-Chaparro, P. J., Han, S.-J., Chen, Y. E., Li, K., Farhat, S., Weckel, A., et al. (2019) · Science

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 567

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

Needham, B. D., Funabashi, M., Adame, M. D., Wang, Z., Boktor, J. C., Haney, J., Wu, W.-L., Rabut, C., Ladinsky, M. S., Hwang, S.-J., et al. (2022) · Nature

Gut microbiota and healthTryptophan and brain disorders

Cited by 489

A biosynthetic pathway for a prominent class of microbiota-derived bile acids

Devlin, A. S., & Fischbach, M. A. (2015) · Nature Chemical Biology

Gut microbiota and healthSteroid Chemistry and Biochemistry

Cited by 448

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., et al. (2018) · Cell Host & Microbe

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 436

The natural history of antibiotics

Clardy, J., Fischbach, M. A., & Currie, C. R. (2009) · Current Biology

Microbial Natural Products and BiosynthesisAntibiotic Resistance in Bacteria

Cited by 402

How pathogenic bacteria evade mammalian sabotage in the battle for iron

Fischbach, M. A., Lin, H., Liu, D. R., & Walsh, C. T. (2006) · Nature Chemical Biology

Escherichia coli research studiesBacterial Genetics and Biotechnology

Cited by 321

The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2

Fischbach, M. A., Lin, H., Zhou, L., Yu, Y., Abergel, R. J., Liu, D. R., Raymond, K. N., Wanner, B. L., Strong, R. K., Walsh, C. T., et al. (2006) · Proceedings of the National Academy of Sciences

Escherichia coli research studiesBacterial Genetics and Biotechnology

Cited by 319

Mapping the Genetic Landscape of Human Cells

Horlbeck, M. A., Xu, A., Wang, M., Bennett, N. K., Park, C. Y., Bogdanoff, D., Adamson, B., Chow, E. D., Kampmann, M., Peterson, T. R., et al. (2018) · Cell

CRISPR and Genetic EngineeringBioinformatics and Genomic Networks

Cited by 319

Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade

Sun, S., Luo, L., Liang, W., Yin, Q., Guo, J., Rush, A. M., Lv, Z., Liang, Q., Fischbach, M. A., Sonnenburg, J. L., et al. (2020) · Proceedings of the National Academy of Sciences

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 277

What lives on our skin: ecology, genomics and therapeutic opportunities of the skin microbiome

Scharschmidt, T. C., & Fischbach, M. A. (2013) · Drug Discovery Today: Disease Mechanisms

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 215

Engineered skin bacteria induce antitumor T cell responses against melanoma

Chen, Y. E., Bousbaine, D., Veinbachs, A., Atabakhsh, K., Dimas, A., Yu, V. K., Zhao, A., Enright, N. J., Nagashima, K., Belkaid, Y., et al. (2023) · Science

Immunotherapy and Immune ResponsesBacterial Cancer Therapy

Cited by 191