The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment
Open accessAbstract
Chromosomal instability (CIN) is a hallmark of human cancer and it is associated with poor prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome segregation during mitosis leading to structural and numerical chromosomal abnormalities. In addition to generating genomic heterogeneity that acts as a substrate for natural selection, CIN promotes inflammatory signaling by introducing double-stranded DNA into the cytosol, engaging the cGAS-STING anti-viral pathway. These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment in the course of immune editing and evasion.
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Cites
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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
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Cited by
The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer
Kwon, J., & Bakhoum, S. F. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0761 · Cited by 1,293
Self-citationIntratumor Heterogeneity: The Rosetta Stone of Therapy Resistance
Marusyk, A., Janiszewska, M., & Polyak, K. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.03.007 · Cited by 1,009
Context is everything: aneuploidy in cancer
Ben-David, U., & Amon, A. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-019-0171-x · Cited by 665
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Zhang, S., Xiao, X., Yi, Y., Wang, X., Zhu, L., Shen, Y., Lin, D., & Wu, C. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01848-7 · Cited by 399
cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers
Hong, C., Schubert, M., Tijhuis, A. E., Requesens, M., Roorda, M., van den Brink, A., Ruiz, L. A., Bakker, P. L., van der Sluis, T., Pieters, W., et al. (2022) · Nature · doi:10.1038/s41586-022-04847-2 · Cited by 371
Metadata
- Authors
- Bakhoum, S. F., & Cantley, L. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 174
- Issue
- 6
- Pages
- 1347-1360
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2891405227
- Cited by
- 717
- References
- 111
- FWCI
- 22.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
