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Cited by 538

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Intelligent Image-Activated Cell Sorting

Open access
Nitta, Nao, Sugimura, Takeaki, Isozaki, Akihiro, Mikami, Hideharu, Hiraki, Kei, Sakuma, Shinya, Iino, Takanori, Arai, Fumihito, Endo, Taichiro, Fujiwaki, Yasuhiro, Fukuzawa, Hideya, Hase, Misa, Hayakawa, Takeshi, Hiramatsu, Kotaro, Hoshino, Yu, Inaba, Mary, Ito, Takuro, Karakawa, Hiroshi, Kasai, Yusuke, Koizumi, Kenichi, Lee, SangWook, Lei, Cheng, Li, Ming, Maeno, Takanori, Matsusaka, Satoshi, Murakami, Daichi, Nakagawa, Atsuhiro, Oguchi, Yusuke, Oikawa, Minoru, Ota, Tadataka, Shiba, Kiyotaka, Shintaku, Hirofumi, Shirasaki, Yoshitaka, Suga, Kanako, Suzuki, Yuta, Suzuki, Nobutake, Tanaka, Yo, Tezuka, Hiroshi, Toyokawa, Chihana, Yalikun, Yaxiaer, Yamada, Makoto, Yamagishi, Mai, Yamano, Takashi, Yasumoto, Atsushi, Yatomi, Yutaka, Yazawa, Masayuki, Di Carlo, Dino, Hosokawa, Yoichiroh, Uemura, Sotaro, Ozeki, Yasuyuki, Goda, Keisuke·2018·Cell
DOI 10.1016/j.cell.2018.08.028
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Abstract

A fundamental challenge of biology is to understand the vast heterogeneity of cells, particularly how cellular composition, structure, and morphology are linked to cellular physiology. Unfortunately, conventional technologies are limited in uncovering these relations. We present a machine-intelligence technology based on a radically different architecture that realizes real-time image-based intelligent cell sorting at an unprecedented rate. This technology, which we refer to as intelligent image-activated cell sorting, integrates high-throughput cell microscopy, focusing, and sorting on a hybrid software-hardware data-management infrastructure, enabling real-time automated operation for data acquisition, data processing, decision-making, and actuation. We use it to demonstrate real-time sorting of microalgal and blood cells based on intracellular protein localization and cell-cell interaction from large heterogeneous populations for studying photosynthesis and atherothrombosis, respectively. The technology is highly versatile and expected to enable machine-based scientific discovery in biological, pharmaceutical, and medical sciences.

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Metadata

Authors
Nitta, N., Sugimura, T., Isozaki, A., Mikami, H., Hiraki, K., Sakuma, S., Iino, T., Arai, F., Endo, T., Fujiwaki, Y., Fukuzawa, H., Hase, M., Hayakawa, T., Hiramatsu, K., Hoshino, Y., Inaba, M., Ito, T., Karakawa, H., Kasai, Y., Koizumi, K., Lee, S., Lei, C., Li, M., Maeno, T., Matsusaka, S., Murakami, D., Nakagawa, A., Oguchi, Y., Oikawa, M., Ota, T., Shiba, K., Shintaku, H., Shirasaki, Y., Suga, K., Suzuki, Y., Suzuki, N., Tanaka, Y., Tezuka, H., Toyokawa, C., Yalikun, Y., Yamada, M., Yamagishi, M., Yamano, T., Yasumoto, A., Yatomi, Y., Yazawa, M., Di Carlo, D., Hosokawa, Y., Uemura, S., Ozeki, Y., & Goda, K.
Venue
Cell
Publisher
Elsevier BV
Published
2018-09
Volume
175
Issue
1
Pages
266-276.e13
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2018.08.028
OpenAlex
W2888971284
Cited by
538
References
51
FWCI
30.51
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Intelligent Image-Activated Cell Sorting. https://app.cochat.ai/papers/10.1016/j.cell.2018.08.028
The paper
Nitta, N., Sugimura, T., Isozaki, A., Mikami, H., Hiraki, K., Sakuma, S., Iino, T., Arai, F., Endo, T., Fujiwaki, Y., Fukuzawa, H., Hase, M., Hayakawa, T., Hiramatsu, K., Hoshino, Y., Inaba, M., Ito, T., Karakawa, H., Kasai, Y., . . . Goda, K. (2018). Intelligent Image-Activated Cell Sorting. Cell. https://doi.org/10.1016/j.cell.2018.08.028

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.