Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

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  65. Determination of intracellular 2-hydroxyglutarate enantiomers using two-dimensional liquid chromatography
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  79. Epithelial-to-mesenchymal transition activates Bcat1 expression to promote recurrent tumor growth
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  80. A hybrid [18F]fluoropivalate PET-multiparametric MRI to detect and characterise brain tumour metastases based on a permissive environment for monocarboxylate transport
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  90. Ivosidenib for the treatment of relapsed or refractory acute myeloid leukemia with an IDH1 mutation
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  94. Branched-chain amino acid transaminases as promising targets in tumor therapy
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  95. Targeting the Keap1/Nrf2 axis in cancer: molecular mechanisms and pharmacological interventions
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  96. The Distribution and Significance of IDH Mutations in Gliomas
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  97. FYN-mediated phosphorylation of BCKDK at Y151 promotes GBM proliferation by increasing the oncogenic metabolite N-acetyl-L-alanine
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  98. Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection
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  100. It takes two to tango: IDH mutation and glutaminase inhibition in glioma
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