Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
McBrayer, Samuel K., Mayers, Jared R., DiNatale, Gabriel J., Shi, Diana D., Khanal, Januka, Chakraborty, Abhishek A., Sarosiek, Kristopher A., Briggs, Kimberly J., Robbins, Alissa K., Sewastianik, Tomasz, Shareef, Sarah J., Olenchock, Benjamin A., Parker, Seth J., Tateishi, Kensuke, Spinelli, Jessica B., Islam, Mirazul, Haigis, Marcia C., Looper, Ryan E., Ligon, Keith L., Bernstein, Bradley E., Carrasco, Ruben D., Cahill, Daniel P., Asara, John M., Metallo, Christian M., Yennawar, Neela H., Vander Heiden, Matthew G., Kaelin, William G.·2018·Cell
Cited by (361)
Items 201–300 of 361
- Mutant IDH1 inhibitors activate pSTAT3-Y705 leading to an increase in BCAT1 and YKL-40 levels in mutant IDH1-expressing cellsDebanjan Bhattacharjee, Balabhaskararao Kancharana, Nishant Jain · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant GliomaVictor Ruiz‐Rodado, Tomohiro Seki, Tyrone Dowdy, Adrian Lita, Meili Zhang, Sue Han, Chunzhang Yang, Murali Krishna Cherukuri, Mark R. Gilbert, Mioara Larion · 2020 · Cancers
- Critical role of antioxidant programs in enzalutamide-resistant prostate cancerEliot B. Blatt, Karla Parra, Antje Neeb, Lorenzo Buroni, Denisa Bogdan, Wei Yuan, Yunpeng Gao, Collin Gilbreath, Alec Paschalis, Suzanne Carreira et al. · 2023 · Oncogene
- Metabolic Profiles Point Out Metabolic Pathways Pivotal in Two Glioblastoma (GBM) Cell Lines, U251 and U-87MGFilipa Martins, David van der Kellen, Luís G. Gonçalves, Jacinta Serpa · 2023 · Biomedicines
- Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitorsYosuke Kitagawa, Ami Kobayashi, Daniel P. Cahill, Hiroaki Wakimoto, Shota Tanaka · 2024 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Integrative Analysis of Metabolomic and Transcriptomic Data Reveals Metabolic Alterations in Glioma PatientsYingying Shi, Daling Ding, Liwei Liu, Zhuolun Li, Lihua Zuo, Lin Zhou, Qiuzheng Du, Ziwei Jing, Xiaojian Zhang, Zhi Sun · 2021 · Journal of Proteome Research
- Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in TreatmentColin Moriarty, Natasha Gupta, Debanjan Bhattacharya · 2025 · Cell Biology International
- Metabolism in the tumor microenvironment: implications for pathogenesis and therapeuticsJonas Aakre Wik, Emma Riiser Berge, Kristine Stromsnes, Bjørn Steen Skålhegg · 2025 · Frontiers in Immunology
- Metabolic Rewiring in Adult-Type Diffuse GliomasJong‐Whi Park · 2023 · International Journal of Molecular Sciences
- BCAA metabolism in cancer progression and therapy resistance: The balance between fuel and cell signalingZhou Yi, Jiahui Kou, Wenjin Li, Yuyao Wang, Xingxing Su, Hongguang Zhang · 2025 · Frontiers in Pharmacology
- Integration and Intersection of Cancer Metabolism with Epigenetic Pathways in GliomasSiva Kumar Natarajan, Matthew J Pun, James Haggerty-Skeans, Sriram Venneti · 2025 · Annual Review of Pathology Mechanisms of Disease
- Gut microbiota-derived l-theanine promotes host branched-chain amino acid catabolismYouxia Wang, Bingnan Liu, Ziyi Han, Peng Bin, Wenjie Tang, Jian Fu, Ifen Hung, Chunxue Liu, Hong Wei, Liangpeng Ge et al. · 2026 · Nature Microbiology
- The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approachesEmily Gruber, Lev M. Kats · 2023 · Biochemical Society Transactions
- Metabolic remodeling in astrocytes: Paving the path to brain tumor developmentMyriam Jaraíz-Rodríguez, Lucia del Prado, Eduardo Balsa · 2023 · Neurobiology of Disease
- Metabolism: an important player in glioma survival and developmentNing Wang, Yiru Yuan, Tianhao Hu, Huizhe Xu, Haozhe Piao · 2024 · Discover Oncology
- Clinical Targeting of Altered Metabolism in High-Grade GliomaAndrew J. Scott, Costas Andreas Lyssiotis, Daniel Richard Wahl · 2021 · The Cancer Journal
- Identifying Differential Expression Genes and Prognostic Signature Based on Subventricular Zone Involved GlioblastomaQing Yuan, Fuxing Zuo, Hong‐Qing Cai, Hai-Peng Qian, Jinghai Wan · 2022 · Frontiers in Genetics
- From Metabolism to Genetics and Vice Versa: The Rising Role of Oncometabolites in Cancer Development and TherapyEmanuela Di Gregorio, Gianmaria Miolo, Asia Saorin, Agostino Steffan, Giuseppe Corona · 2021 · International Journal of Molecular Sciences
- Managing GSH elevation and hypoxia to overcome resistance of cancer therapies using functionalized nanocarriersNelly M. Dabbour, Ahmed M. Salama, Thoria Donia, Radwa T. Al-Deeb, Abdullah M. Abd Elghane, Karima H. Badry, Samah A. Loutfy · 2021 · Journal of Drug Delivery Science and Technology
- Nuclear IMPDH Filaments in Human GliomasNarges Ahangari, David G. Muñoz, Josée Coulombe, Douglas A. Gray, Elizabeth C. Engle, Long Cheng, John Woulfe · 2021 · Journal of Neuropathology & Experimental Neurology
- A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigueBrennan J. Wadsworth, Marina Leiwe, Eleanor Minogue, Pedro P. Cunha, Viktor Engman, Carolin Brombach, Christos Asvestis, Shiv K. Sah‐Teli, Emilia Marklund, Peppi Koivunen et al. · 2023 · eLife
- Stable isotope-resolved metabolomics analyses of metabolic phenotypes reveal variable glutamine metabolism in different patient-derived models of non-small cell lung cancer from a single patientConnor Jarrett Kinslow, Michael Bousamra ll, Yihua Cai, Jun Yan, Pawel Lorkiewicz, Ahmad Al‐Attar, Jinlian Tan, Richard M. Higashi, Andrew N. Lane, Teresa W.‐M. Fan · 2024 · Metabolomics
- Metabolic functions of misunderstood D-2-hydroxyglutarateYidong Liu, Zhaoqi Kang, Wen Zhang, Cuiqing Ma, Ping Xu, Chao Gao · 2024 · The Innovation Life
- Alpha-Lipoic Acid Prevents Side Effects of Therapeutic Nanosilver without Compromising Cytotoxicity in Experimental Pancreatic CancerXuefeng An, Li Liu, Michael Schaefer, Bin Yan, Christian Scholz, Stefan Hillmer, Kangtao Wang, Yiqiao Luo, Huihui Ji, Jury Gladkich et al. · 2021 · Cancers
- (2R,3S)-Dihydroxybutanoic Acid Synthesis as a Novel Metabolic Function of Mutant Isocitrate Dehydrogenase 1 and 2 in Acute Myeloid LeukemiaJeffrey R. Idle, Katja Seipel, Ulrike Bacher, Thomas Pabst, Diren Beyoğlu · 2020 · Cancers
- l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer modelsAnirban Kundu, Garrett J. Brinkley, Hyeyoung Nam, Suman Karki, Richard L. Kirkman, Madhuparna Pandit, Eun‐Hee Shim, Hayley Widden, Juan Liu, Yasaman Heidarian et al. · 2024 · Journal of Clinical Investigation
- Suppressing PD-L1 Expression via AURKA Kinase Inhibition Enhances Natural Killer Cell-Mediated Cytotoxicity against GlioblastomaTrang Thi Thu Nguyen, Qiuqiang Gao, Jeong-Yeon Mun, Zhe Zhu, Chang Shu, Aaron Naim, Meri Rogava, Benjamin Izar, Mike‐Andrew Westhoff, Georg Karpel‐Massler et al. · 2024 · Cells
- IDH Mutant Cholangiocarcinoma: Pathogenesis, Management, and Future TherapiesAlexander Bray, Vaibhav Sahai · 2025 · Current Oncology
- IDH mutant high-grade gliomasSantosh Valvi, Maryam Fouladi, Michael J. Fisher, Nicholas G. Gottardo · 2025 · Frontiers in Molecular Neuroscience
- Association between altered metabolism and genetic mutations in human gliomaHannah Pearl, Candace C. Fleischer · 2023 · Cancer Reports
- Molecular Profiling and Targeted Therapies in GliomasYuli Felistia, Patrick Yung Wen · 2023 · Current Neurology and Neuroscience Reports
- Mechanism analysis and targeted therapy of IDH gene mutation in gliomaXingyuan Ma · 2025 · American Journal of Cancer Research
- Combination strategies to target metabolic flexibility in cancerJelena Krstić, Katharina Schindlmaier, Andreas Prokesch · 2022 · International review of cytology
- Multi-omics analysis identifies BCAT2 as a potential pan-cancer biomarker for tumor progression and immune microenvironment modulationQixuan Cao, Jie Fan, Jian Zou, Wei Wang · 2024 · Scientific Reports
- Integrated analysis of transcriptional and metabolic responses to mitochondrial stressLiam P. Kelley, Songhua Hu, Sarah A. Boswell, Peter Karl Sorger, Alison Epstein Ringel, Marcia C. Haigis · 2025 · Cell Reports Methods
- Glutaminase 1 inhibitors: Therapeutic potential, mechanisms of action, and clinical perspectivesHui Wang, Xiandeng Li, Haitao Hu, Zhan Gao · 2025 · Biochemical Pharmacology
- Branched chain amino acids and their aberrant metabolism in cancerMorgan L. Brown, Xuanyan Cai, Marie Celeste Simon · 2025 · Trends in cancer
- Mitochondrial VHL rewires cell metabolism in hypoxiaGuobang Li, Wenfeng Pan, Long Wu, Zhiliang Cai, Haoming Chen, Xingui Wu, Tiantian Yu, Kun Liao, Hui Zhang, 温星桥 et al. · 2025 · Cell Metabolism
- C-13 Hyperpolarized MR Spectroscopy for Metabolic Imaging of Brain TumorsPavithra Viswanath, Yan Li, Sabrina M. Ronen · 2019 · Springer eBooks
- Delivery of PARP inhibitors through 2HG-incorporated liposomes for synergistically targeting DNA repair in cancerZhangyi Luo, Yixian Huang, Shangyu Chen, Bei Zhang, Haozhe Huang, Sheida Dabiri, Yuang Chen, Anju Zhang, Alexis R. Andreas, Song Li · 2024 · Cancer Letters
- BCAT1 contributes to the development of TKI-resistant CMLYu Jiang, Difan Zhang, Xiaoxiao He, Chiqi Chen, Li Xie, Ligen Liu, Zhuo Yu, Ya‐Ping Zhang, Junke Zheng, Dan Huang · 2024 · Cellular Oncology
- Oncogenic Mechanisms and Therapeutic Targeting of Metabolism in Leukemia and LymphomaMaximilian F. Stahl, Zachary Drew Epstein-Peterson, Andrew M. Intlekofer · 2020 · Cold Spring Harbor Perspectives in Medicine
- IDH1 mutation inhibits differentiation of astrocytes and glioma cells with low oxoglutarate dehydrogenase expression by disturbing α-ketoglutarate-related metabolism and epigenetic modificationYuanlin Zhao, Ying Li Yang, Risheng Yang, Chao Sun, Xing Gao, Xiwen Gu, Yuan Yuan, Ya-Ting Nie, Shenhui Xu, Ruili Han et al. · 2024 · Life Metabolism
- Reprogrammed mitochondria: a central hub of cancer cell metabolismFabio Ciccarone, Maria Rosa Ciriolo · 2024 · Biochemical Society Transactions
- Unveiling the role of RNA methylation in glioma: Mechanisms, prognostic biomarkers, and therapeutic targetsQichen Xu, Chunsong Yang, Liyun Wang, Jing Zhou · 2024 · Cellular Signalling
- Brain tumour histopathology through the lens of deep learning: A systematic reviewChun Kiet Vong, Alan Wang, Mike Dragunow, Thomas Park, Vickie Shim · 2025 · Computers in Biology and Medicine
- Unveiling the Maze: Branched-Chain Amino Acids Fueling the Dynamics of Cancer Metabolism and ProgressionKai Xu, Pratham Viral Shah, Dhruvi Makhanasa, Md. Wasim Khan · 2025 · Cancers
- State of the art: glioma-associated epilepsy—bridging tumor biology and epileptogenesisIris Divé, Anna‐Luisa Luger, Dorothea Muench, Katharina Johanna Weber, Joachim P. Steinbach, Felix Rosenow, Frank Winkler, Pia Susann Zeiner · 2025 · Neurological Research and Practice
- Ferroptosis in AML: nanoparticles, biomarkers, and immune rewiring for therapeutic breakthroughsFarzaneh Tavakoli, Mohammad A. Araskhan, Fatemeh Karimpour, Hamed Soleimani Samarkhazan, Hoda Hasheminasab, Elham Roshandel, Nader Vazifeh Shiran, Ali Dehghanifard, Mohammad Hossein Mohammadi · 2025 · Discover Oncology
- LncRNA PSMB8-AS1 increases glioma malignancy via the miR-382-3p/BCAT1 axisHaibo Liu, Jie Zhang, Jiamin Li, Xiaoying Cao, Kai Yu, Xun Xia, Zongxi Li, Fengbo Wang · 2023 · Translational Oncology
- Low-Grade GliomasDavid Schiff · 2024 · Neurology
- Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemiaQiangqiang Shao, Jedrzej Wykretowicz, Nan Hu, Karan Bedi, Mohamed Rizk, Isabella A. Malek, Surinder Kumar, David B. Lombard, Kerby Shedden, David A. Scott et al. · 2024 · Leukemia
- IDH-Mutant GliomasKensuke Tateishi, Tetsuya Yamamoto · 2019 · IntechOpen eBooks
- idh-1 neomorphic mutation confers sensitivity to vitamin B12 in Caenorhabditis elegansOlga Ponomarova, Alyxandra N. Starbard, Alexandra C. Belfi, Amanda V Anderson, Meera V. Sundaram, Albertha J.M. Walhout · 2024 · Life Science Alliance
- TET enzymes: Involvement in cancer development and therapeutical perspectivesTarik Aanniz, Meriem El Fessikh, Jihane Touhtouh, Sara Aboulaghras, Nasreddine El Omari, Asaad Khalid, Ashraf N. Abdalla, Mohammed Rizwan Amanullah, Bey Hing Goh, Learn−Han Lee et al. · 2025 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Metabolism and therapeutic response in acute myeloid leukemia with IDH1/2 mutationsLudovic Gabellier, Enzo Bosetta, Maël Heiblig, Jean‐Emmanuel Sarry · 2025 · Trends in cancer
- Nanotechnology-driven strategies in postoperative cancer treatment: innovations in drug delivery systemsJunjie Zhou, Yan-Chuan Feng, Min-Long Zhao, Qi Guo, Xibo Zhao · 2025 · Frontiers in Pharmacology
- Generation of induced neural stem cells with inducible IDH1R132H for analysis of glioma development and drug testingKamila Rosiak, Dagmara Grot, Piotr Rieske · 2020 · PLoS ONE
- Tumor evolution-targeted nanomedicineEVTLingpu Zhang, Jia‐Zhen Yang, Dongsheng Tang, Hanchen Zhang, Jianxun Ding, Haihua Xiao · 2022 · Scientia Sinica Chimica
- The role of branched-chain aminotransferase 1 in driving glioblastoma cell proliferation and invasion varies with tumor subtypeMaria Fala, Susana R�os, Ashley Sawle, Jyotsna Upendra Rao, Anastasia Tsyben, Laura Tronci, Christian Frezza, Richard James Mair, Kevin Michael Brindle · 2023 · Neuro-Oncology Advances
- In vivo characterization of physiological and metabolic changes related to isocitrate dehydrogenase 1 mutation expcression by multiparametric MRI and MRS in a rat model with orthotopically grafted human‐derived glioblastoma cell linesAlexandra Clément, Matthieu Doyen, Florence Fauvelle, Gabriela Hossu, Bailiang Chen, Muriel Barberi‐Heyob, Alex Hirtz, Vasile Stupar, Zohra Lamiral, Celso Pouget et al. · 2021 · NMR in Biomedicine
- Conditional Covalent Lethality Driven by Oncometabolite AccumulationMinervo Perez, Kellie D. Nance, Daniel W. Bak, Supuni Thalalla Gamage, Susana Sarai Najera, Amy N. Conte, William Marston Linehan, Eranthie Weerapana, Jordan L. Meier · 2022 · ACS Chemical Biology
- Mitochondria transfer in glioblastomaSimon Storevik, Mina Thue Augustsson, Shannon Sherwin Moreino, Hanjo Köppe, Dionysios Christos Watson, Defne Bayık, Carolina De La Pena Fernandez, Amanda M Serapiglia, Nikhil Panicker, Justin Durla Lathia et al. · 2026 · Neuro-Oncology
- Association between accumulation of 2-hydroxyglutarate detected by MR spectroscopy and preoperative seizure in IDH-mutant gliomaHiroaki Nagashima, Kazuhiro Tanaka, Shunsuke Yamanishi, Mitsuru Hashiguchi, Hirofumi Iwahashi, Takiko Uno, Yuichiro Somiya, Masato Komatsu, Tomoo Itoh, Ryohei Sasaki et al. · 2024 · Journal of neurosurgery
- Determination of intracellular 2-hydroxyglutarate enantiomers using two-dimensional liquid chromatographyTakuma Ohtawa, Ayuna Hattori, Muneki Isokawa, Masashi Harada, Takashi Funatsu, Takahiro Ito, Makoto Tsunoda · 2021 · Journal of Chromatography Open
- Leveraging insights into cancer metabolism—a symposium reportJennifer Cable, Lydia W.S. Finley, Benjamin P. Tu, Gary J. Patti, Trudy G. Oliver, Santosha Adipudi Vardhana, Miyeko Mana, Russell Erick Ericksen, Sanika Khare, Ralph J. DeBerardinis et al. · 2019 · Annals of the New York Academy of Sciences
- Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choiceMilan R. Savani, Bingbing Li, Bailey C. Smith, Wen Gu, Yi Xiao, Gerard Baquer, Tracey E. Shipman, Skyler Oken, Namya Manoj, Lauren G. Zacharias et al. · 2026 · Nature Metabolism
- Rewiring amino acids in cancerYiqing Zhang, Jianxin Lyu, Hezhi Fang · 2025 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Targeting Metabolic Vulnerabilities in Glioblastoma: a Framework for Multi-node Combination TherapyVishal Gokani, Anuhya Kotta, Venkata Repaka, Sukanya Rauniyar, Evan Noch · 2026 · Current Oncology Reports
- Neuro-tumor-immune crosstalk in pancreatic cancer: Mechanisms and therapeutic insights.Jian-Guo Jin, Bin He, Xiang Wang, Yuqian Zhang, Huiming You, Sirui Mo, Duancheng Guo, Saimeng Shi · 2026 · Biochimica et biophysica acta. Reviews on cancer
- Ivosidenib and Vorasidenib Decrease Intratumoral 2-Hydroxyglutarate and Total Choline Levels in Patients with Lower-Grade Glioma: An In Vivo MR Spectroscopy StudyDunja Simičić, Şeyma Alçiçek, Lindsay Blair, Max A. Saint-Germain, Helge J. Zöllner, Zsombor Ritter, Jaishri O'Neill Blakeley, Christopher W. Davies‐Jenkins, Matthias Holdhoff, John Laterra et al. · 2026 · Clinical Cancer Research
- Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside ApplicationsYuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang · 2026 · MedComm
- Current and emerging therapies in IDH-mutant gliomaVihang Nakhate, Gilbert Youssef, Patrick Yung Wen · 2026 · Neurotherapeutics
- Metabolism-Associated DNA Methylation Signature Stratifies Lower-Grade Glioma Patients and Predicts Response to ImmunotherapyGuozheng Yang, Dezhi Shan, Rongrong Zhao, Gang Li · 2022 · Frontiers in Cell and Developmental Biology
- Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cellsTatsuya Morishima, Koichi Takahashi, Desmond Wai Loon Chin, Yuxin Wang, Kenji Tokunaga, Yuichiro Arima, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa · 2023 · Cancer Science
- A glutamatergic biomarker panel enables differentiating Grade 4 gliomas/astrocytomas from brain metastasesFalko Lange, Richard Gade, Anne Einsle, Katrin Porath, Gesine Reichart, Claudia Maletzki, Björn Schneider, Christian Henker, Daniel Dubinski, Michael Linnebacher et al. · 2024 · Frontiers in Oncology
- To enhance the ex vivo expansion of CAR-NK-92 cells by regulating intracellular redox statusHuimin Huang, Guofeng Zhang, Yuanyuan Zhao, Wen‐Song Tan, Haibo Cai · 2024 · Process Biochemistry
- Targeting Tumor Metabolism to Overcome RadioresistanceDaniel Richard Wahl, Michael S. Petronek, Ramachandran Rashmi, John M. Floberg, Bryan G. Allen, Julie Kristina Schwarz · 2020 · Cancer drug discovery and develogment/Cancer drug discovery and development
- Epithelial-to-mesenchymal transition activates Bcat1 expression to promote recurrent tumor growthDouglas B. Fox, James V. Alvarez · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- A hybrid [18F]fluoropivalate PET-multiparametric MRI to detect and characterise brain tumour metastases based on a permissive environment for monocarboxylate transportS. Islam, Marianna Inglese, Preetha Aravind, Tara D. Barwick, Francesco Angelo Mauri, Laura McLeavy, Erik Årstad, J. Wang, Ignazio Puccio, L. Hung et al. · 2025 · European Journal of Nuclear Medicine and Molecular Imaging
- ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistanceZhengyang Zhang, Jie Gao, Xiang Liao, Zining Zhang, Xiongfeng Cao, Yi Gong, Wenlong Chen, Lirong Zhang, Hsiang‐i Tsai, Dongqing Wang et al. · 2025 · Cell Death and Differentiation
- Leveraging cancer metabolism to translate into effective therapeuticsJie Xu, Linlin Guo, Yi Wang, Xiaoping Li, Ping Yi, Chunming Cheng · 2025 · Seminars in Cancer Biology
- IDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal CarcinomaYuheng Zhao, Chunxian Ou, Huimin Huang, Yujue Wang, Jiaxi Shen, Yaoyi Li, Qing‐Mei He, Zeteng Han, Yuer Xie, Tianyun Zhong et al. · 2026 · Cancer Research
- Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunityQixiang Ma, Ru Zhao, Jiangxue Han, Wen-Ying Zhu, Mi‐die Xu, Xiao-Yan Zhang, Guoquan Yan, Wenyu Wen, Guang-Chun Han, Min Luo et al. · 2026 · Nature Immunology
- Emerging roles of ferroptosis in modulating the immune landscape of glial tumoursMichael Argenziano, Taruna V. Neelakantan, Colin P. Sperring, Oluwaseyi O. Adeuyan, Dominique M. O. Higgins, Jeffrey N. Bruce, Betty Y.S. Kim, Athanassios Dovas, Peter Canoll, Michael K. Lim et al. · 2026 · Nature Cell Biology
- Metabolic models predict fotemustine and the combination of eflornithine/rifamycin and adapalene/cannabidiol for the treatment of gliomasAli Kishk, Maria Pires Pacheco, Tony Heurtaux, Thomas Sauter · 2024 · Briefings in Bioinformatics
- Discovery of Aloperine as a Potential Antineoplastic Agent for Cholangiocarcinoma Harboring Mutant IDH1Xingkang Wu, Yang Li, Chenchen Han, Shi-Fei Li, Xuemei Qin · 2024 · International Journal of Molecular Sciences
- A lanthanide complexes-based endoplasmic reticulum-targetable probe for ratiometric time-gated luminescence detection and imaging of reactive sulfur species in vitro and in vivoTao Wang, Bo Song, Deshu Kong, Wenzhu Zhang, Jingli Yuan · 2025 · Journal of Rare Earths
- Metabolic biomarkers of radiotherapy response in plasma and tissue of an IDH1 mutant astrocytoma mouse modelVictor Ruiz‐Rodado, Tyrone Dowdy, Adrian Lita, Tamalee R. Kramp, Meili Zhang, Dorela D. Shuboni‐Mulligan, Christel C. Herold‐Mende, Terri S. Armstrong, Mark R. Gilbert, Kevin A. Camphausen et al. · 2022 · Frontiers in Oncology
- Ivosidenib for the treatment of relapsed or refractory acute myeloid leukemia with an IDH1 mutationFlorence Pasquier, Claude Chahine, Christophe Marzac, Stéphane de Botton · 2020 · Expert Review of Precision Medicine and Drug Development
- Potential of Polyphenolic Nutraceuticals in the Management of Glioblastoma MultiformeSwati Devendra Raysing, Ashish Prakash Gorle · 2022 · Current Nutraceuticals
- Targeting IDH2 promotes antitumor immunity through epigenetic activation of cGAS-STING pathwayJiangjiang Li, Xinghua Zhen, Lulu Liu, Xueling Yan, Lingzhi Wu, Xiangjian Luo, Pumin Zhang · 2025 · Lung Cancer
- Ammonia in cancer: dual roles and therapeutic strategiesJinhui Wei, Yue Chen, Qiang Li, Fuxin Huang, Chuanzhao Zhang, Baohua Hou, Shanzhou� Huang · 2025 · Cancer Cell International
- Branched-chain amino acid transaminases as promising targets in tumor therapyWen Zhang, Jie Shen, Xuanyin Ding, Hele Liu, Xu Wang, Dan Feng · 2026 · Frontiers in Cell and Developmental Biology
- Targeting the Keap1/Nrf2 axis in cancer: molecular mechanisms and pharmacological interventionsYangchen Xia, Ziyang Xu, Xun Yuan, Qian Chu · 2025 · Investigational New Drugs
- The Distribution and Significance of IDH Mutations in GliomasNu Thien Nhat Tran · 2022 · IntechOpen eBooks
- FYN-mediated phosphorylation of BCKDK at Y151 promotes GBM proliferation by increasing the oncogenic metabolite N-acetyl-L-alanineLing Zou, Wei Wang, Wenda Huang, Xiaofang Ni, Wensheng Li, Yue Cheng, Qin Tian, Lin Liu, Feng Zhu, Qiuhong Duan · 2024 · Heliyon
- Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detectionWenhao Li, Zhihao Wang, Siliang Chen, Mingrong Zuo, Yufan Xiang, Yunbo Yuan, Yuze He, Shuxin Zhang, Yanhui Liu · 2024 · Frontiers in Oncology
- α-Ketoglutarate promotes amino acid depletion and suppresses B-cell lymphoma growth and developmentCarine Jaafar, Purushoth Ethiraj, Zhijun Qiu, An‐Ping Lin, Pedro S. S. M. Ferrari, Ricardo C.T. Aguiar · 2025 · Blood
- It takes two to tango: IDH mutation and glutaminase inhibition in gliomaQing Hua Zhang · 2018 · Science Translational Medicine