Spinelli, Jessica B.

The multifaceted contributions of mitochondria to cellular metabolism

Spinelli, J. B., & Haigis, M. C. (2018) · Nature Cell Biology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,935

Accumulation of succinate controls activation of adipose tissue thermogenesis

Mills, E. L., Pierce, K. A., Jedrychowski, M. P., Garrity, R., Winther, S., Vidoni, S., Yoneshiro, T., Spinelli, J. B., Lu, G. Z., Kazak, L., et al. (2018) · Nature

Adipose Tissue and MetabolismLipid metabolism and biosynthesis

Cited by 539

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

Spinelli, J. B., Yoon, H., Ringel, A. E., Jeanfavre, S., Clish, C. B., & Haigis, M. C. (2017) · Science

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 468

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., et al. (2016) · Cell Metabolism

Mitochondrial Function and PathologyT-cell and B-cell Immunology

Cited by 429

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

McBrayer, S. K., Mayers, J. R., DiNatale, G. J., Shi, D. D., Khanal, J., Chakraborty, A. A., Sarosiek, K. A., Briggs, K. J., Robbins, A. K., Sewastianik, T., et al. (2018) · Cell

Cancer, Hypoxia, and MetabolismGlioma Diagnosis and Treatment

Cited by 368

Fumarate is a terminal electron acceptor in the mammalian electron transport chain

Spinelli, J. B., Rosen, P. C., Sprenger, H.-G., Puszynska, A. M., Mann, J. L., Roessler, J. M., Cangelosi, A. L., Henne, A., Condon, K. J., Zhang, T., et al. (2021) · Science

Mitochondrial Function and PathologyCancer, Hypoxia, and Metabolism

Cited by 221

Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer

Brown, K. K., Spinelli, J. B., Asara, J. M., & Toker, A. (2017) · Cancer Discovery

Biochemical and Molecular ResearchCancer, Hypoxia, and Metabolism

Cited by 198