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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

Open access
André, Pascale, Denis, Caroline, Soulas, Caroline, Bourbon-Caillet, Clarisse, Lopez, Julie, Arnoux, Thomas, Bléry, Mathieu, Bonnafous, Cécile, Gauthier, Laurent, Morel, Ariane, Rossi, Benjamin, Remark, Romain, Breso, Violette, Bonnet, Elodie, Habif, Guillaume, Guia, Sophie, Lalanne, Ana Ines, Hoffmann, Caroline, Lantz, Olivier, Fayette, Jérôme, Boyer-Chammard, Agnès, Zerbib, Robert, Dodion, Pierre, Ghadially, Hormas, Jure-Kunkel, Maria, Morel, Yannis, Herbst, Ronald, Narni-Mancinelli, Emilie, Cohen, Roger B., Vivier, Eric·2018·Cell
DOI 10.1016/j.cell.2018.10.014
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Abstract

Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of patients respond to these immunotherapies. Here, we report that blocking the inhibitory NKG2A receptor enhances tumor immunity by promoting both natural killer (NK) and CD8 + T cell effector functions in mice and humans. Monalizumab, a humanized anti-NKG2A antibody, enhanced NK cell activity against various tumor cells and rescued CD8 + T cell function in combination with PD-x axis blockade. Monalizumab also stimulated NK cell activity against antibody-coated target cells. Interim results of a phase II trial of monalizumab plus cetuximab in previously treated squamous cell carcinoma of the head and neck showed a 31% objective response rate. Most common adverse events were fatigue (17%), pyrexia (13%), and headache (10%). NKG2A targeting with monalizumab is thus a novel checkpoint inhibitory mechanism promoting anti-tumor immunity by enhancing the activity of both T and NK cells, which may complement first-generation immunotherapies against cancer.

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Metadata

Authors
André, P., Denis, C., Soulas, C., Bourbon-Caillet, C., Lopez, J., Arnoux, T., Bléry, M., Bonnafous, C., Gauthier, L., Morel, A., Rossi, B., Remark, R., Breso, V., Bonnet, E., Habif, G., Guia, S., Lalanne, A. I., Hoffmann, C., Lantz, O., Fayette, J., Boyer-Chammard, A., Zerbib, R., Dodion, P., Ghadially, H., Jure-Kunkel, M., Morel, Y., Herbst, R., Narni-Mancinelli, E., Cohen, R. B., & Vivier, E.
Venue
Cell
Publisher
Elsevier BV
Published
2018-12
Volume
175
Issue
7
Pages
1731-1743.e13
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2018.10.014
OpenAlex
W2902856530
Cited by
1,221
References
5
FWCI
41.16
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells. https://app.cochat.ai/papers/10.1016/j.cell.2018.10.014
The paper
André, P., Denis, C., Soulas, C., Bourbon-Caillet, C., Lopez, J., Arnoux, T., Bléry, M., Bonnafous, C., Gauthier, L., Morel, A., Rossi, B., Remark, R., Breso, V., Bonnet, E., Habif, G., Guia, S., Lalanne, A. I., Hoffmann, C., Lantz, O., . . . Vivier, E. (2018). Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells. Cell. https://doi.org/10.1016/j.cell.2018.10.014

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.