Functional exhaustion of antiviral lymphocytes in COVID-19 patients
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In December 2019, a novel coronavirus was first reported in Wuhan, China. 1 It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is responsible for coronavirus disease 2019 (COVID-19). Up to 28 February 2020, 79,394 cases have been confirmed according to China’s National Health Commission. Outside China, the virus has spread rapidly to over 36 countries and territories.
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In ex vivo studies, NK cells from patients with COVID-19 displayed impaired cytotoxicity.
“In ex vivo studies, NK cells from patients with COVID-19 displayed impaired cytotoxicity (64, 65)”
From SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients (2021) · cites this paper as [64]
NK cells were shown to be decreased in patients with COVID-19 in association with disease severity.
“NK cells were shown to be decreased in patients with COVID-19 in association with disease severity (64).”
From SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients (2021) · cites this paper as [64]
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Activation or exhaustion of CD8+ T cells in patients with COVID-19
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Viral persistence, reactivation, and mechanisms of long COVID
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T Cells: Warriors of SARS-CoV-2 Infection
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Is pregnancy a risk factor of COVID-19?
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Retracted
- Authors
- Zheng, M., Gao, Y., Wang, G., Song, G., Liu, S., Sun, D., Xu, Y., & Tian, Z.
- Affiliations
- First Affiliated Hospital of Anhui Medical University (CN)
- Anhui Medical University (CN)
- University of Science and Technology of China (CN)
- Corresponding author
- Zheng, Meijuan
- Xu, Yuanhong
- Tian, Zhigang
- Venue
- Cellular & Molecular Immunology
- Published
- 2020-03-19
- Volume
- 17
- Issue
- 5
- Pages
- 533-535
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- PMC
- PMC7091858
- OpenAlex
- W3011508332
- Cited by
- 1,768
- References
- 11
- Citations by year
- 2026: 26 · 2025: 63 · 2024: 119 · 2023: 186 · 2022: 329 · 2021: 514 · 2020: 531
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cellular and Molecular Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81788101, 81771685)
- Chinese Academy of Sciences (XDB29030000, 81788101)
- Anhui Medical University (YJGG202002)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- COVID-19 pandemic, SARS-CoV-2, T cell exhaustion, T cell dysfunction
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Antiviral Agents, Hepatitis C, Humans, Killer Cells, Natural, Pneumonia, Viral, Coronavirus Infections, Pandemics
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