Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

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Items 501–600 of 636

1. Irisin as a predictor of bone metabolism in Han Chinese Young Men with pre-diabetic individuals
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2. Irisin in ischemic stroke, Alzheimer’s disease and depression: a Narrative Review
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3. Examining a role for irisin in treating cerebral ischemia
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4. Irisin Is a Potential Novel Biomarker and Therapeutic Target Against Kidney Diseases
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6. Irisin Research Landscape (2012–2024): A Bibliometric and Visual Analysis of Evolving Hotspots and Future Trends
   Lijia Gao, Wen Sun, Hongwei Shi, Weijie Zhu, Haidong Wang, Juan Wang · 2025 · Biologics
7. Therapeutic Potential of Irisin in Neurodegenerative Diseases
   Sania Muzaffar, Alpna Tyagi, Subbiah Pugazhenthi · 2025 · International Journal of Molecular Sciences
8. Irisin reduces neurodegeneration and neuroinflammation in the 6-hydroxydopamine rat model of Parkinson’s disease
   Nicole M. Kamidai, Luiz Roberto Britto, Ana Flávia Fernandes Ferreira · 2026 · Brain Research Bulletin
9. Therapeutic potential of exerkines in neurodegenerative and mental disorders: a narrative review
   Suwol Yang, Hye-Won Sang, Seoyeon Kim, Eun‐Jeong Cho, Youngju Choi, Dong‐Woo Kang, Young Charles Jang, Dong-Ho Park, Hyo‐Bum Kwak, Jang Soo Yook · 2026 · Frontiers in Physiology
10. Metabolic Myokines and Adipokines in the Follicular Microenvironment: Implications for Oocyte Competence and IVF Outcomes
    Charalampos Voros, Fotios G. Chatzinikolaou, George K. Papadimas, Ioannis Papapanagiotou, Athanasios Karpouzos, Aristotelis-Marios Koulakmanidis, Diamantis Athanasiou, Kyriakos Bananis, Antonia Iliana Athanasiou, Aikaterini V. Athanasiou et al. · 2026 · International Journal of Molecular Sciences
11. Protective effects of irisin in sarcopenia: a promising treatment
    Yixiao Chen, Guoqing Li, Feng Gao, Ruijiang Li, Minghui Yang, Yufeng Ge, Xinbao Wu · 2026 · Journal of Orthopaedic Translation
12. Bone, muscle, and sarcopenia
    Kristen M. Beavers, Monica C. Serra, Ashley A. Weaver, Denise K. Houston · 2020 · Elsevier eBooks
13. Extracellular HSP90 warms up integrins for an irisin workout
    Dimitra Bourboulia, Mark R. Woodford, Mehdi Mollapour · 2023 · Cell Metabolism
14. Irisin at the Croasroad of Autophagy and BNDF Signaling for Neuroplasticity Regulation
    Elmira A. Anderzhanova, Татьяна Александровна Воронина · 2023 · Neurochemical Journal
15. Impact of Nutritional Status of Patients with Head and Neck Squamous Cell Carcinoma on the Expression Profile of Ghrelin, Irisin, and Titin
    Agata Andruszko, Jarosław Szydlowski, Beniamin Oskar Grabarek, Katarzyna Mazur, Tomasz Sirek, Piotr Ossowski, Mieszko Kozikowski, Konrad Kaminiów, Ariadna Zybek‐Kocik, Jacek Banaszewski · 2024 · Cancers
16. Methods to predict heart failure in diabetes patients
    Alexander Е. Berezin, Tetiana A. Berezina, Uta Charlotte Hoppe, Michael Lichtenauer, Alexander A. Berezin · 2024 · Expert Review of Endocrinology & Metabolism
17. Connecting bone metastasis, adipose tissue and adipokines: How does physical activity fit?
    Paola Maroni, Marta Gomarasca, Michela Signo, Giovanni Lombardi · 2024 · Advanced Exercise and Health Science
18. Folding and Misfolding Dynamics of Irisin Protein Revealed by Single-Molecule Magnetic Tweezers
    Jiashu Xu, Hao Sun, Zhuwei Zhang, Zilong Guo, Shimin Le, Hu Chen · 2024 · The Journal of Physical Chemistry Letters
19. Relationship of irisin and apelin levels with sarcopenia and body composition in community-dwelling older adults: a paired case–control study
    Liangchuan Zhang, Yating Peng, Yaling Qie, Jia Guo, Yuan Kong, Xue Zhang, Zetian Li, Hong Jia · 2025 · Applied Physiology, Nutrition, and Metabolism
20. Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway
    Lijun Fang, Wenqiang Li, Hua Zhao, Wei Wang, Hongmei Gao, Pengqi Wang, Xinzhi Zhang, Ruijuan Lv, Feng Xu, Jiazheng Chen et al. · 2025 · Biochemical Pharmacology
21. Effect of the Myokine Irisin on Circadian Rhythm of Voluntary Locomotor Activity in Rats
    Alexey N. Inyushkin, С. И. Павленко, T. S. Isakova, Anastasia Konashenkova, A. A. Inyushkin, A. A. Inyushkin · 2025 · Journal of Evolutionary Biochemistry and Physiology
22. Can the inhibition of glycogen synthase kinase 3 mimic the physiological effects of exercise on muscle and other organs?
    Briana L. Hockey, Jessica L. Braun, Rene Vandenboom, Paul J. LeBlanc, Rebecca E. K. MacPherson, Val Andrew Fajardo · 2025 · Advanced Exercise and Health Science
23. Muscles and bones
    Eisuke Hiruma · 2022 · Elsevier eBooks
24. Construction, Purification, and Biological Characterization of Plant-Made Human Recombinant Irisin
    Eun Bi Ma, Kyungmin Min, Minhee Park, Hyangju Kang, Bo-Hwa Choi, Eun‐Ju Sohn, Joo Young Huh · 2024 · Drug Targets and Therapeutics
25. Irisin’s Mechanism of Action and Levels in Physiological and Pathological Conditions
    Nafez Abu Tarboush, Tala Alsharaeh, Ibrahim Alawaisheh · 2024 · Jordan Medical Journal
26. Chemical composition alterations in rat brain hypothalamus induced by irisin administration using spectroscopic and machine learning techniques
    Zozan Güleken, Huri Dedeakayoğulları, Esra Kutlu, Zeynep Ceylan, J. Cebulski, Joanna Depciuch · 2024 · Analytical Biochemistry
27. Evolutionary Insights into Irisin/FNDC5: Roles in Aging and Disease from Drosophila to Mammals
    Kiwon Lee, Myungjin Kim · 2025 · Biomolecules
28. Irisin: muscle’s novel player in endoplasmic reticulum stress and disease
    Joel Rimson Pinto, K. Deepika Bhat, Bipasha Bose, Sudheer Shenoy P · 2025 · Molecular and Cellular Biochemistry
29. Physical exercise for obesity and T2DM mitigation in polycystic ovary syndrome: the role of adipose tissue
    Matheus Pedro Santos, Anna Karenina Azevedo‐Martins, Anderson Oliveira Rodrigues, Nayara S. S. Aquino, Fabiana S. Evangelista · 2025 · Metabolism and Target Organ Damage
30. Irisin and its role in the reproductive physiology: a review
    Francine Alves, Solano Dantas Martins, Maria Alice Felipe Oliveira, Valdevane Rocha Araújo · 2025 · Brazilian Journal of Biology
31. Beneficial effects of aerobic exercises on multiple myeloma: Mechanisms and clinical observations
    Siyao He, Jingjing Wen, Zhongqing Zou, Linfeng Li, Xiaohui Zhao, Xiang Liu, Hongmei Luo, Jingcao Huang, Ziyue Mi, Yue Zhang et al. · 2025 · International Journal of Cancer
32. Liu-Jun-Zi decoction alleviates metabolic dysfunction-associated steatohepatitis by modulating myogenic irisin mediated skeletal muscle-liver crosstalk
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33. Effects of whole-body vibration training on inflammatory markers and lipid profiles in adults: a systematic review and meta-analysis of randomized controlled trials
    Yan Pan, Ping Luo, J. Pang · 2025 · Frontiers in Immunology
34. Irisin regulates the phosphorylation of glucocorticoid receptor Ser212 and Ser234 and mediates glucocorticoid-induced muscle atrophy in mice
    Jingjing Yang, Pu Zhang, Yina An, Shuyu Tan, Siqi Sun, Yifan Liu, Lin Zhu, Haidong Wang, Ting Gao, Yanjun Dong · 2025 · Communications Biology
35. Epigenetic insights of Olympic champions: nuclear and mitochondrial DNA methylation and regulators of aging
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36. Irisin inhibits adipogenic differentiation of bone marrow mesenchymal stem cells through the SIRT1/RANBP2/FTO signaling axis and protects against osteoporosis
    Junfei Chen, Jincheng Liu, Qingyang Fu, Mingyu Xu, Xu Zhai, Le Li, Wanlong Xu, Xinhui Wu, Kaidi Wang, Haipeng Si · 2026 · Cell Death Discovery
37. Exercise modality–dependent non-hypertrophic anabolic adaptations in skeletal muscle of rats with type 2 diabetes
    Yi-dan Zhang, Xiang-xing Zhao, Xia Liu · 2026 · Frontiers in Physiology
38. Exerkines in diabetic retinopathy: from mechanisms to therapeutic prospects
    Juming Zhu · 2026 · Frontiers in Endocrinology
39. Integrin αVβ5 regulates myoblast proliferation and differentiation in sarcopenia mice treated with FNDC5 gene delivery
    Guoxi Gao, Qiyang Wang, YuQiong Zhang, MingHong Shao, Yiming Liang, Shumin Zhou, Sheng Lu · 2026 · Skeletal Muscle
40. Glucagon-like peptide-1 receptor agonists ameliorate polycystic ovarian syndrome in mice by regulating the irisin level and activating the BMP4-Smad signaling pathway
    Yueying Yang, Chuanhao Xiong, Xiaohui Wei, Xuejiao Wang, Kong Feijuan, Yu Hu, Wei Li, Yuhang Ma, Xiaoying Ding · 2026 · Biology of Reproduction
41. Treadmill exercise mediates the neuroprotective effect in post-stroke depression rats through the PGC-1α/FNDC5/irisin pathway
    Dandan Xie, Lu Chen, Mingming Ma, Ruixue Guan, Chengyan Han · 2026 · Behavioural Brain Research
42. Sex specific effects of irisin on the skeleton
    Anika Shimonty, Lynda Faye Bonewald · 2026 · Bone Research
43. Bridging Space and Military Nutrition: Energy Balance Challenges and Countermeasures in Extreme Environments
    Nicole M. Sekel, Stefan M. Pasiakos · 2026 · Journal of Nutrition
44. Irisin maintains ER homeostasis and activates AMPK via integrin αVβ5 to attenuate CSE + LPS-induced emphysema and inflammation
    Zina Bai, Tongxinwei Sun, Zelin Chen, Siqin Han, Yumei Li, Xiaopeng Zhang, Cuiqing Ma, Yahong Chen, Ping Jiang, Xixin Yan et al. · 2026 · Respiratory Research
45. High-intensity interval training modulates APP expression and reduces neuronal apoptosis in a β-amyloid-induced model of Alzheimer’s disease: hippocampal evidence
    Welton Daniel Nogueira Godinho, Francisco Sérgio Lopes Vasconcelos Filho, Cícero Matheus Lima Amaral, Maria Izabel Florindo Guedes, Guilherme Lisboa de Serpa, Adriano César Carneiro Loureiro, Vânia Marilande Ceccatto, Paula Matias Soares · 2026 · Experimental Brain Research
46. Dose-dependent tandem responses of osteoblasts during osteogenesis
    Yuwei Zhang, Lizhen Wang, Hongyan Kang, Chia-Ying James Lin, Yubo Fan · 2023 · Medicine in Novel Technology and Devices
47. Research Progress of Irisin in Obesity and Related Metabolic Diseases
    怡宁 张 · 2023 · Advances in Clinical Medicine
48. Obesity-mediated insulin resistance in target tissues: role of adiponectin, fetuin-A, and irisin
    Sutapa Mukherjee, Snehasis Das, Dipanjan Chattopadhyay, Satinath Mukhopadhyay · 2024 · Elsevier eBooks
49. Muscle Exercise
    Ewa Ziemann · 2024 · Springer eBooks
50. Irisin at the Crossroad of Autophagy and BNDF Signaling for Neuroplasticity Regulation
    Эльмира Алиякбяровна Андяржанова, Татьяна Александровна Воронина · 2023 · Нейрохимия
51. Irisin modulates granulosa cell function in chicken ovarian follicles: Effects on viability, gene expression, and progesterone secretion
    Dorota Katarzyńska‐Banasik, Anna Kozubek, Kinga Kowalik, Andrzej Sechman · 2025 · Animal Reproduction Science
52. Irisin: A bright or a dark future?
    André Pereira, André Costa-Pinho, Davide Maurício Carvalho, J. Costa Maia, Paula Freitas · 2019 · Revista Portuguesa de Endocrinologia Diabetes e Metabolismo
53. The interplay between bone, muscle and adipose tissue — is there a role for potential new metabolic biomarker?
    Wojciech J. Bilinski, Przemysław Tomasz Paradowski, Grażyna Sypniewska · 2019 · Medical Research Journal
54. [Research progress on mechanism of myokines regulating bone tissue cells].
    Hongcheng Peng, Zhen Hua, Huilin Yang, Jianwei Wang · 2021 · PubMed Central
55. What the discovery of irisin receptor means to bone
    Guobin Li, Na Cao, Peng Shang, Huiyun Xu · 2020 · Archives of Physiology and Biochemistry
56. Different Sclerostin Response to Cycling and Running at the Same Exercise Intensity
    Nitzan Dror, Joseph M. Carbone, Fadia Haddad, Bareket Falk, Panagiota Klentrou, Shlomit Radom‐Aizik · 2021 · Research Square
57. Systemic Factors Affect Bone Health in SMA Type II Patients and a Mouse Model of SMA
    Fiorella Carla Grandi, Sonia Pezet, A. Arnould, Sabrina Mazzucchi, Elèna Gidaja, Stéphanie Astord, Maud Chapart, Stéphane Vasseur, Alessandra Ricupero, Matteo Ernu et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
58. Osteocytes: More Than Just Mechanosensory Cells
    Matthew Prideaux, Lynda Faye Bonewald · 2020 · Elsevier eBooks
59. MUNARI, con M de MODERNO: la producción gráfica y artística del escritor
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60. The role of international retailing in the first and second global economy
    Nicholas Alexander, Anne Marie Doherty, Andrew Godley, Haiming Hang · 2011
61. Irisin/FNDC5: A Novel Player in Musculoskeletal Health
    2020 · Journal of Human Physiology
62. Osteosarcopenia
    Ben Kirk, Jesse Zanker, Steven Phu, Gustavo Duque · 2021
63. Sedanter, sağlıklı, genç erkek bireylerde akut tüm vücut titreşim egzersizinin serum irisin seviyelerine etkileri
    Mukaddes Mergen Dalyanoğlu, Emine Kılıç-Toprak, Fatma Ünver, Yasin Özdemir, Ebru Tekin, Z. Melek BOR KÜÇÜKATAY · 2022 · Pamukkale Medical Journal
64. Irisin
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65. The role of a recently discovered peptide—irisin—in physiological and pathological processes
    Marta Bagłaj-Oleszczuk, Alina Jankowska‐Konsur · 2022 · Postępy Higieny i Medycyny Doświadczalnej
66. Irisin: The Bony Builder Flexes Its Muscles
    Mathieu Ferron · 2022 · Diabetes
67. Expression and Function of Synthetic Dimeric Exercise-Induced Cytokine Irisin-Irisin
    Fengying LIU, Yide HUANG, Jia LIN, Xuequn CHEN, Qingshui Wang, Yao LIN · 2023 · Rehabilitation Medicine
68. STEM CELLS AND THEIR PARACRINE FACTORS
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69. THE PARTICIPATION OF IRISIN IN THE MECHANISMS OF WEIGHT LOSS IN OBESITY
    Yu. M. Panchenko, Svitlana Drozdovska · 2023 · Bulletin of Problems Biology and Medicine
70. Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner
    Anika Shimonty, Fabrizio Pin, Matthew Prideaux, Gang Peng, Joshua R. Huot, Hyeonwoo Kim, Clifford james Rosen, Bruce M. Spiegelman, Lynda Faye Bonewald · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
71. Can irisin be developed as the molecular evolutionary clock based on the origin and functions?
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72. Irisin and Metastatic Melanoma: Selective Anti-Invasiveness Activity in BRAF Wild-Type Cells
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73. The the role of eight weeks of combined high-intensity interval training in modulating intrahepatic FNDC5 protein and irisin levels in male rats with non-alcoholic steatohepatitis
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74. Influence of Omega-3 Fatty Acids on Energy Metabolism and Bone Turnover
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75. Decreased Circulating Irisin Levels is Associated with Mortality Risk in Heart Failure Patients with Reduced Ejection Fraction
    Xian Guo, Ying Gu, jiaying gao, Xiaoming Xu, Rutao Wang, Wenjun Yan, Xinxin Wang, Peini Xue, Lei A. Wang, Jin F et al. · 2025 · SSRN Electronic Journal
76. Irisin Modulates IFNT Signaling in Bovine Luteal Cells
    Ana Paula da Silva, Karine de Vargas Aires, Suzana Rossato Feltrin, Leonardo Guedes de Andrade, Julia Vieira Cambuí, Clacir Staudt, L.F. Schütz, Christopher Alan Price, Valério Marques Portela, Alfredo Quites Antoniazzi · 2025 · Molecular Reproduction and Development
77. Pancatalytic biomaterials enable inflammation-related disease intervention
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78. Physical exercise and irisin: managing obesity and related comorbidities
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79. The Combination of Acerola and Mango Ginger Promotes Beiging of 3T3–L1 Adipocytes
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80. Irisin deficiency exacerbates cardiac dysfunction and enhances hemorrhage injury in hemorrhage/resuscitation
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81. Developing Subcutaneous Formulations for Irisin as a Potential Therapeutic
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82. Depletion of mmu-miR-185 enhances osteocyte connectivity and suppresses bone fragility through the interaction between ARL8B and RAB5A
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83. Correlation between Irisin and Bone Metabolism
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84. Myokine-Mediated Muscle-Kidney Crosstalk
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85. Additional file 2 of Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3
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86. Additional file 1 of Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3
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87. Additional file 5 of Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3
    Xue, Chunling, Li, Xuechun, Ba, Li, Yamei Shen, Zhao Sun, Gu, Junjie, Yang, Ying, Han, Qin, Zhao, Robert Chunhua · 2022 · Figshare
88. Additional file 1 of mir-150-5p inhibits the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by targeting irisin to regulate the p38/MAPK signaling pathway
    Qi, Jia-long, Zhang, Zhi-dong, Zhou Dong, Shan, Tao, Yin, Zong-sheng · 2024 · Figshare
89. Additional file 4 of Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3
    Xue, Chunling, Li, Xuechun, Ba, Li, Yamei Shen, Zhao Sun, Gu, Junjie, Yang, Ying, Han, Qin, Zhao, Robert Chunhua · 2022 · Figshare
90. Additional file 6 of Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3
    Xue, Chunling, Li, Xuechun, Ba, Li, Yamei Shen, Zhao Sun, Gu, Junjie, Yang, Ying, Han, Qin, Zhao, Robert Chunhua · 2022 · Figshare
91. Additional file 3 of Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3
    Xue, Chunling, Li, Xuechun, Ba, Li, Yamei Shen, Zhao Sun, Gu, Junjie, Yang, Ying, Han, Qin, Zhao, Robert Chunhua · 2022 · Figshare
92. Additional file 1 of Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy
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93. Enhanced gait following NW-RSA training links to reduced myostatin and improved L-arginine metabolites in older women with preserved vitamin D
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94. Treadmill running modulates infrapatellar fat pad remodeling in osteoarthritic rats in an intensity-dependent manner
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95. Central Irisin Administration Attenuates Hypothalamic TLR4/MyD88-Mediated Neuroinflammatory Signaling in Diet-Induced Obese Mice
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96. Irisin Mitigates Myocardial Hypoxia/Reoxygenation Injury by Preserving Mitochondrial Redox Homeostasis via the UCP2-SOD2 Axis
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97. Osteocyte biology
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98. FNDC5/irisin ameliorates diabetes-associated cognitive dysfunction via αVβ5-cAMP signaling to regulate oxidative stress, neuroinflammation and synaptic plasticity
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99. Altérations de la fonction motrice induites par une restriction sensorimotrice précoce chez le rat : implication du dialogue muscle-cerveau
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