The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface
Open accessAbstract
SUMMARY Here we describe the discovery of a naturally occurring human antibody (Ab) FluA-20 that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and that reacts with most influenza A viruses. Structural characterization of FluA-20 with H1 and H3 head domains revealed a novel epitope in the HA trimer interface, suggesting previously unrecognized dynamic features of the trimeric HA protein. The critical HA residues recognized by FluA-20 remain conserved across most subtypes of influenza A viruses, which explains the Ab’s extraordinary breadth. The Ab rapidly disrupted the integrity of HA protein trimers, inhibited cell-to-cell spread of virus in culture, and protected mice against challenge with viruses of H1N1, H3N2, H5N1 or H7N9 subtypes when used as prophylaxis or therapy. The FluA-20 Ab reveals an exceedingly conserved protective determinant in the influenza HA head domain trimer interface that is an unexpected new target for anti-influenza therapeutics and vaccines.
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Metadata
- Authors
- Bangaru, S., Lang, S., Schotsaert, M., Vanderven, H. A., Zhu, X., Kose, N., Bombardi, R., Finn, J. A., Kent, S. J., Gilchuk, P., Gilchuk, I., Turner, H. L., García-Sastre, A., Li, S., Ward, A. B., Wilson, I. A., & Crowe, J. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 177
- Issue
- 5
- Pages
- 1136-1152.e18
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2945681432
- Cited by
- 245
- References
- 9
- FWCI
- 20.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bangaru, S., Lang, S., Schotsaert, M., Vanderven, H. A., Zhu, X., Kose, N., Bombardi, R., Finn, J. A., Kent, S. J., Gilchuk, P., Gilchuk, I., Turner, H. L., García-Sastre, A., Li, S., Ward, A. B., Wilson, I. A., & Crowe, J. E. (2019). A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface. Cell. https://doi.org/10.1016/j.cell.2019.04.011
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