A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins
Abstract
An antibody able to broadly neutralize both group 1 and group 2 influenza A viruses—and its target epitope—are identified.
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Neutralizing antibodies that target the stem region of group 2 HA have been identified through screens of large B cell libraries after vaccination or infection that neutralize both group 1 and group 2 influenza A viruses.
“Neutralizing antibodies that target the stem region of group 2 HA have been identified through screens of large B cell libraries after vaccination or infection that neutralize both group 1 and group 2 influenza A viruses34,35.”
From Design of protein-binding proteins from the target structure alone (2022) · cites this paper as [34]
There was a clear reorientation of the oligosaccharide at Asn38 compared with the unbound HK68/H3 structure.
“There was a clear reorientation of the oligosaccharide at Asn38 compared with the unbound HK68/H3 structure (Fig. 5a and Extended Data Fig. 10a; this has also been observed in HK68/H3 HA structures bound to stem region neutralizing antibodies34,35).”
From Design of protein-binding proteins from the target structure alone (2022) · cites this paper as [34]
Binding of the H3 binder to both H1 and H3 HA is competed by the stem region that binds the neutralizing antibody FI6v3.
“The binding to both H1 and H3 HA is competed by the stem region that binds the neutralizing antibody FI6v3 (ref. 34) on the yeast surface (Extended Data Fig. 10c), which indicates that the binder attaches the HA at the targeted site.”
From Design of protein-binding proteins from the target structure alone (2022) · cites this paper as [34]
Wibmer et al. reported loss of neutralization of 501Y.V2 by the NTD-specific mAb 4A8, likely driven by the R246I mutation.
“Wibmer et al.34 have also recently reported the loss of neutralization of 501Y.V2 by the NTD-specific mAb 4A8, likely driven by the R246I mutation.”
From Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies (2021) · cites this paper as [34]
Wang et al. also showed reduced neutralisation by mRNA vaccine sera against E484K bearing pseudovirus.
“Wang et al also showed reduced neutralisation by mRNA vaccine sera against E484K bearing pseudovirus34.”
From Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies (2021) · cites this paper as [34]
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Self-citation
- Authors
- Corti, D., Voss, J., Gamblin, S. J., Codoni, G., Macagno, A., Jarrossay, D., Vachieri, S. G., Pinna, D., Minola, A., Vanzetta, F., Silacci, C., Fernandez-Rodriguez, B. M., Agatic, G., Bianchi, S., Giacchetto-Sasselli, I., Calder, L., Sallusto, F., Collins, P., Haire, L. F., Temperton, N., Langedijk, J. P. M., Skehel, J. J., & Lanzavecchia, A.
- Affiliations
- Institute for Research in Biomedicine (CH)
- National Institute for Medical Research (GB)
- Medical Research Council (MRC) National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
- Humabs BioMed SA, 6500 Bellinzona, Switzerland.
- University of Kent (GB)
- Pepscan (Netherlands) (NL)
- ETH Zurich (CH)
- Corresponding author
- Corti, Davide
- Voss, Jarrod
- Codoni, Giosiana
- Skehel, John J.
- Lanzavecchia, Antonio
- ORCID
- Venue
- Science
- Published
- 2011-08-12
- Volume
- 333
- Issue
- 6044
- Pages
- 850-856
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002632348
- Cited by
- 1,203
- References
- 41
- Citations by year
- 2026: 52 · 2025: 61 · 2024: 38 · 2023: 53 · 2022: 62 · 2021: 81 · 2020: 89 · 2019: 78 · 2018: 84 · 2017: 83 · 2016: 82 · 2015: 86 · 2014: 110 · 2013: 128 · 2012: 98
- FWCI
- 84.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Greenwich Academic Literature Archive (University of Greenwich) (submittedVersion)
- Kent Academic Repository (University of Kent) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- broadly neutralizing antibodies, influenza A virus, hemagglutinin, monoclonal antibodies, plasma cells, passive immunization, conserved epitopes, antibody structure, vaccine design, H1 subtype, H3 subtype
- MeSH terms
- Animals, Antibodies, Viral, Antibody Specificity, Epitopes, Antigens, Viral, Cells, Cultured, Cross Reactions, Ferrets, Glycosylation, Humans, Immunization, Passive, Immunoglobulin Variable Region, Influenza, Human, Models, Molecular, Molecular Sequence Data, Orthomyxoviridae Infections, Influenza A virus, Influenza B virus, Plasma Cells, Protein Structure, Secondary, Crystallography, X-Ray, Hemagglutinin Glycoproteins, Influenza Virus, Mice, Influenza A Virus, H1N1 Subtype, Protein Multimerization, Antibodies, Neutralizing, Hydrophobic and Hydrophilic Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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