The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription
Open accessAbstract
SUMMARY Increasing evidence suggests that transcriptional control and chromatin activities at large involve regulatory RNAs, which likely enlist specific RNA-binding proteins (RBPs). Although multiple RBPs have been implicated in transcription control, it has remained unclear how extensively RBPs directly act on chromatin. We embarked on a large-scale RBP ChIP-seq analysis, revealing widespread RBP presence in active chromatin regions in the human genome. Like transcription factors (TFs), RBPs also show strong preference for hotspots in the genome, particularly gene promoters, where their association is frequently linked to transcriptional output. Unsupervised clustering reveals extensive co-association between TFs and RBPs, as exemplified by YY1, a known RNA-dependent TF, and RBM25, an RBP involved in splicing regulation. Remarkably, RBM25 depletion attenuates all YY1-dependent activities, including chromatin binding, DNA looping, and transcription. We propose that various RBPs may enhance network interaction through harnessing regulatory RNAs to control transcription.
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Cites
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Structural basis for inactivation of PRC2 by G-quadruplex RNA
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Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms
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Sequential verification of transcription by Integrator and Restrictor
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Metadata
- Authors
- Xiao, R., Chen, J.-Y., Liang, Z., Luo, D., Chen, G., Lu, Z. J., Chen, Y., Zhou, B., Li, H., Du, X., Yang, Y., San, M., Wei, X., Liu, W., Lécuyer, E., Graveley, B. R., Yeo, G. W., Burge, C. B., Zhang, M. Q., Zhou, Y., & Fu, X.-D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 178
- Issue
- 1
- Pages
- 107-121.e18
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2954785163
- Cited by
- 395
- References
- 13
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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