The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity
Open accessAbstract
Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to their unique ability to initiate T cell responses and direct their differentiation into effector lineages. Classical DCs have been divided into two subsets, cDC1 and cDC2, based on phenotypic markers and their distinct abilities to prime CD8 and CD4 T cells. While the transcriptional regulation of the cDC1 subset has been well characterized, cDC2 development and function remain poorly understood. By combining transcriptional and chromatin analyses with genetic reporter expression, we identified two principal cDC2 lineages defined by distinct developmental pathways and transcriptional regulators, including T-bet and RORγt, two key transcription factors known to define innate and adaptive lymphocyte subsets. These novel cDC2 lineages were characterized by distinct metabolic and functional programs. Extending our findings to humans revealed conserved DC heterogeneity and the presence of the newly defined cDC2 subsets in human cancer.
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Metadata
- Authors
- Brown, C. C., Gudjonson, H., Pritykin, Y., Deep, D., Lavallée, V.-P., Mendoza, A., Fromme, R., Mazutis, L., Ariyan, C., Leslie, C., Pe’er, D., & Rudensky, A. Y.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 179
- Issue
- 4
- Pages
- 846-863.e24
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2981900400
- Cited by
- 601
- References
- 99
- FWCI
- 18.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Brown, C. C., Gudjonson, H., Pritykin, Y., Deep, D., Lavallée, V.-P., Mendoza, A., Fromme, R., Mazutis, L., Ariyan, C., Leslie, C., Pe’er, D., & Rudensky, A. Y. (2019). Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity. Cell. https://doi.org/10.1016/j.cell.2019.09.035
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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