The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells
Open accessAbstract
The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. The responsive stem cell that mediates this process is unclear, in part because of a lack of in vitro models that recapitulate key epithelial changes that occur in vivo during damage and repair. Here, we identify a Hopx + colitis-associated regenerative stem cell (CARSC) population that functionally contributes to mucosal repair in mouse models of colitis. Hopx + CARSCs, enriched for fetal-like markers, transiently arose from hypertrophic crypts known to facilitate regeneration. Importantly, we established a long-term, self-organizing two-dimensional (2D) epithelial monolayer system to model the regenerative properties and responses of Hopx + CARSCs. This system can reenact the "homeostasis-injury-regeneration" cycles of epithelial alterations that occur in vivo . Using this system, we found that hypoxia and endoplasmic reticulum stress, insults commonly present in inflammatory bowel diseases, mediated the cyclic switch of cellular status in this process.
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
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Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510
Hypoxia-inducible factors and the response to hypoxic stress
Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380
Hypoxia signalling through mTOR and the unfolded protein response in cancer
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Intestinal label-retaining cells are secretory precursors expressing Lgr5
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Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
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Nikolaev, M., Mitrofanova, O., Broguiere, N., Geraldo, S., Dutta, D., Tabata, Y., Elci, B., Brandenberg, N., Kolotuev, I., Gjorevski, N., et al. (2020) · Nature · doi:10.1038/s41586-020-2724-8 · Cited by 755
Metastasis-Initiating Cells and Ecosystems
Massagué, J., & Ganesh, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0010 · Cited by 372
Elmentaite, R., Ross, A. D. B., Roberts, K., James, K. R., Ortmann, D., Gomes, T., Nayak, K., Tuck, L., Pritchard, S., Bayraktar, O. A., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.11.010 · Cited by 316
Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities
Iliev, I. D., Ananthakrishnan, A. N., & Guo, C.-J. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01163-0 · Cited by 249
Organoids in gastrointestinal diseases: From experimental models to clinical translation
Günther, C., Winner, B., Neurath, M. F., & Stappenbeck, T. S. (2022) · Gut · doi:10.1136/gutjnl-2021-326560 · Cited by 145
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Metadata
- Authors
- Wang, Y., Chiang, I.-L., Ohara, T. E., Fujii, S., Cheng, J., Muegge, B. D., Ver Heul, A., Han, N. D., Lu, Q., Xiong, S., Chen, F., Lai, C.-W., Janova, H., Wu, R., Whitehurst, C. E., VanDussen, K. L., Liu, T.-C., Gordon, J. I., Sibley, L. D., & Stappenbeck, T. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 179
- Issue
- 5
- Pages
- 1144-1159.e15
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2985983100
- Cited by
- 200
- References
- 17
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wang, Y., Chiang, I.-L., Ohara, T. E., Fujii, S., Cheng, J., Muegge, B. D., Ver Heul, A., Han, N. D., Lu, Q., Xiong, S., Chen, F., Lai, C.-W., Janova, H., Wu, R., Whitehurst, C. E., VanDussen, K. L., Liu, T.-C., Gordon, J. I., Sibley, L. D., & Stappenbeck, T. S. (2019). Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells. Cell. https://doi.org/10.1016/j.cell.2019.10.015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
