Hypoxia signalling through mTOR and the unfolded protein response in cancer

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · see citing works

Signal integration in the endoplasmic reticulum unfolded protein response

Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,308 · see citing works

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181 · see citing works

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works

Autophagy: process and functionPreprint

Mizushima, N. (2007) · Genes & Development · doi:10.1101/gad.1599207 · Cited by 3,967 · see citing works

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844 · see citing works

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336 · see citing works

Defining the role of mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833 · see citing works

Exploiting tumour hypoxia in cancer treatment

Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828 · see citing works

Molecular regulation of vessel maturation

Jain, R. K. (2003) · Nature Medicine · doi:10.1038/nm0603-685 · Cited by 2,515 · see citing works

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300 · see citing works

The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy

Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. A. (1953) · The British Journal of Radiology · doi:10.1259/0007-1285-26-312-638 · Cited by 2,158 · see citing works

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G., Mukherjee, C., Shi, Y., Gélinas, C., Fan, Y., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.06.001 · Cited by 2,013 · see citing works

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumPreprint

Marciniak, S. J., Yun, C. Y., Oyadomari, S., Novoa, I., Zhang, Y., Jungreis, R., Nagata, K., Harding, H. P., & Ron, D. (2004) · Genes & Development · doi:10.1101/gad.1250704 · Cited by 2,004 · see citing works

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumPreprint

Zinszner, H., Kuroda, M., Wang, X., Batchvarova, N., Lightfoot, R. T., Remotti, H. E., Stevens, J. L., & Ron, D. (1998) · Genes & Development · doi:10.1101/gad.12.7.982 · Cited by 1,996 · see citing works

Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01453-06 · Cited by 1,832 · see citing works

Role of autophagy in cancer

Mathew, R., Karantza-Wadsworth, V., & White, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2254 · Cited by 1,798 · see citing works

Reinitiation involving upstream ORFs regulates <i>ATF4</i> mRNA translation in mammalian cells

Vattem, K. M., & Wek, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400541101 · Cited by 1,696 · see citing works

Untitled work

(2000) · PubMed · Cited by 1,445 · see citing works

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes &amp; Development · doi:10.1101/gad.1256804 · Cited by 1,384 · see citing works

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

Scheuner, D. L., Song, B., McEwen, E. L., Liu, C., Laybutt, D. R., Gillespie, P. J., Saunders, T. L., Bonner‐Weir, S., & Kaufman, R. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00265-9 · Cited by 1,355 · see citing works

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

Laughner, E., Taghavi, P., Chiles, K., Mahon, P. C., & Semenza, G. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.3995-4004.2001 · Cited by 1,256 · see citing works

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

Hudson, C. C., Liu, M., Chiang, G. G., Otterness, D. M., Loomis, D. C., Kaper, F., Giaccia, A. J., & Abraham, R. T. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.20.7004-7014.2002 · Cited by 1,186 · see citing works

Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1

Maiuri, M. C., Toumelin-Braizat, G. L., Criollo, A., Rain, J., Gautier, F., Juin, P. P., Tasdemir, E., Pierron, G., Troulinaki, K., Tavernarakis, N., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601689 · Cited by 1,107 · see citing works

A MicroRNA Signature of Hypoxia

Kulshreshtha, R., Ferracin, M., Wojcik, S. E., Garzon, R., Alder, H., Agosto-Perez, F. J., Davuluri, R., Liu, C.-G., Croce, C. M., Negrini, M., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01395-06 · Cited by 1,055 · see citing works

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Dewhirst, M. W., Cao, Y., & Moeller, B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2397 · Cited by 1,022 · see citing works

Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response

Bernales, S., McDonald, K. L., & Walter, P. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040423 · Cited by 1,009 · see citing works

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

Lu, P. D., Harding, H. P., & Ron, D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408003 · Cited by 1,006 · see citing works

Regulation of cap-dependent translation by eIF4E inhibitory proteins

Richter, J. D., & Sonenberg, N. (2005) · Nature · doi:10.1038/nature03205 · Cited by 972 · see citing works

ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R. J., Kominami, E., & Momoi, T. (2007) · Cell Death &amp; Differentiation · doi:10.1038/sj.cdd.4401984 · Cited by 934 · see citing works

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

Fasanaro, P., D'Alessandra, Y., Di Stefano, V., Melchionna, R., Romani, S., Pompilio, G., Capogrossi, M. C., & Martelli, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800731200 · Cited by 912 · see citing works

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885 · see citing works

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesisPreprint

Karantza‐Wadsworth, V., Patel, S. A., Kravchuk, O., Chen, G., Mathew, R., Jin, S., & White, E. (2007) · Genes & Development · doi:10.1101/gad.1565707 · Cited by 841 · see citing works

Loss of <i>PTEN</i> facilitates HIF-1-mediated gene expression

Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Gottschalk, A. R., Ryan, H. E., Johnson, R. S., Jefferson, A. B., et al. (2000) · Genes &amp; Development · doi:10.1101/gad.14.4.391 · Cited by 840 · see citing works

HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation

Gordan, J. D., Thompson, C. B., & Simon, M. C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.07.006 · Cited by 806 · see citing works

HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

Gordan, J. D., Bertout, J. A., Hu, C.-J., Diehl, J. A., & Simon, M. C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.006 · Cited by 781 · see citing works

Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium

Høyer-Hansen, M. H., & Jäättelä, M. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402200 · Cited by 765 · see citing works

ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

Bi, M., Naczki, C., Koritzinsky, M., Fels, D. R., Blais, J. D., Hu, N., Harding, H. P., Novoa, I., Varia, M. A., Raleigh, J. A., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600777 · Cited by 732 · see citing works

The role of the unfolded protein response in tumour development: friend or foe?

Ma, Y., & Hendershot, L. M. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1505 · Cited by 712 · see citing works

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

Sowter, H., Ratcliffe, P. J., Watson, P. H., Greenberg, A. H., & Harris, A. L. (2001) · PubMed · Cited by 711 · see citing works

Hypoxia regulates TSC1/2–mTOR signaling and tumor suppression through REDD1-mediated 14–3–3 shuttling

DeYoung, M. P., Horak, P., Sofer, A., Sgroi, D., & Ellisen, L. W. (2008) · Genes &amp; Development · doi:10.1101/gad.1617608 · Cited by 710 · see citing works

Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

Koumenis, C., Naczki, C., Koritzinsky, M., Rastani, S., Diehl, J. A., Sonenberg, N., Koromilas, A. E., & Wouters, B. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7405-7416.2002 · Cited by 688 · see citing works

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway

Isaacs, J. S., Jung, Y.-J., Mimnaugh, E. G., Martinez, A., Cuttitta, F., & Neckers, L. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204733200 · Cited by 663 · see citing works

hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

Camps, C., Buffa, F. M., Colella, S., Moore, J., Sotiriou, C. P., Sheldon, H., Harris, A. L., Gleadle, J., & Ragoussis, J. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1755 · Cited by 658 · see citing works

MiRNA-Directed Regulation of VEGF and Other Angiogenic Factors under Hypoxia

Zhong, H., Lv, Q., Ye, W., Wong, C.-K. A., Cai, G., Gu, D., Ji, Y., Zhao, C., Wang, J., Yang, B. B., et al. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000116 · Cited by 655 · see citing works

Protein quality control in the early secretory pathway

Anelli, T., & Sitia, R. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601974 · Cited by 623 · see citing works

The interplay between MYC and HIF in cancer

Dang, C. V., Kim, J., Gao, P., & Yustein, J. T. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2274 · Cited by 614 · see citing works

Hypoxia-induced energy stress regulates mRNA translation and cell growth

Liu, L., Cash, T. P., Jones, R. G., Keith, B., Thompson, C. B., & Simon, M. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.010 · Cited by 607 · see citing works

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

Thomas, G. V., Tran, C., Mellinghoff, I. K., Welsbie, D. S., Chan, E., Fueger, B., Czernin, J., & Sawyers, C. L. (2006) · Nature Medicine · doi:10.1038/nm1337 · Cited by 604 · see citing works

XBP1 Is Essential for Survival under Hypoxic Conditions and Is Required for Tumor Growth

Romero‐Ramírez, L., Cao, H., Nelson, D. W., Hammond, E. M., Lee, A., Yoshida, H., Mori, K., Glimcher, L. H., Denko, N. C., Giaccia, A. J., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1606 · Cited by 570 · see citing works

Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis.

Huang, S., & Harari, P. M. (2000) · PubMed · Cited by 555 · see citing works

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

Brugarolas, J. B., Vazquez, F., Reddy, A., Sellers, W. R., & Kaelin, W. G. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00187-9 · Cited by 528 · see citing works

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

Hardwick, J. S., Kuruvilla, F. G., Tong, J. K., Shamji, A. F., & Schreiber, S. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14866 · Cited by 523 · see citing works

Hypoxia-inducible Factor 1α Is Regulated by the Mammalian Target of Rapamycin (mTOR) via an mTOR Signaling Motif

Land, S. C., & Tee, A. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611782200 · Cited by 507 · see citing works

Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

Mazure, N. M., Chen, E. Y., Laderoute, K. R., & Giaccia, A. J. (1997) · Blood · doi:10.1182/blood.v90.9.3322 · Cited by 498 · see citing works

Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia

Stein, I., Itin, A., Einat, P., Skaliter, R., Grossman, Z., & Keshet, E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3112 · Cited by 498 · see citing works

Autophagy in chronically ischemic myocardium

Yan, L., Vatner, D. E., Kim, S., Ge, H., Masurekar, M. R., Massover, W. H., Yang, G., Matsui, Y., Sadoshima, J., & Vatner, S. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506843102 · Cited by 497 · see citing works

A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets

Arsham, A. M., Howell, J. J., & Simon, M. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212770200 · Cited by 463 · see citing works

Delineation of a Negative Feedback Regulatory Loop That Controls Protein Translation during Endoplasmic Reticulum Stress

Ma, Y., & Hendershot, L. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301107200 · Cited by 458 · see citing works

Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1

Sofer, A., Lei, K., Johannessen, C. M., & Ellisen, L. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.5834-5845.2005 · Cited by 449 · see citing works

Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress

Blais, J. D., Filippenko, V., Bi, M., Harding, H. P., Ron, D., Koumenis, C., Wouters, B. G., & Bell, J. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7469-7482.2004 · Cited by 447 · see citing works

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

Özcan, U., Özcan, L., Yılmaz, E., Düvel, K., Şahin, M., Manning, B. D., & Hotamışlıgil, G. S. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.023 · Cited by 434 · see citing works

The FAD- and O2-Dependent Reaction Cycle of Ero1-Mediated Oxidative Protein Folding in the Endoplasmic Reticulum

Tu, B. P., & Weissman, J. S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00696-2 · Cited by 433 · see citing works

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

Erler, J. T., Cawthorne, C. J., Williams, K. J., Koritzinsky, M., Wouters, B. G., Wilson, C., Miller, C., Demonacos, C., Stratford, I. J., & Dive, C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2875-2889.2004 · Cited by 400 · see citing works

The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

Peng, T., Golub, T. R., & Sabatini, D. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5575-5584.2002 · Cited by 397 · see citing works

PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR

Bernardi, R., Guernah, I., Jin, D. K., Grisendi, S., Alimonti, A., Teruya‐Feldstein, J., Cordon‐Cardo, C., Simon, M. C., Rafii, S., & Pandolfi, P. P. (2006) · Nature · doi:10.1038/nature05029 · Cited by 379 · see citing works

Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy

Adhami, F., Liao, G., Morozov, Y. M., Schloemer, A. J., Schmithorst, V. J., Lorenz, J. N., Dunn, R. S., Vorhees, C. V., Wills-Karp, M. A., Degen, J. L., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051066 · Cited by 375 · see citing works

SR 4233 (Tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

Brown, J. M. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.220 · Cited by 367 · see citing works

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

Koritzinsky, M., Magagnin, M. G., van den Beucken, T., Seigneuric, R., Savelkouls, K. G. M., Dostie, J., Pyronnet, S., Kaufman, R. J., Weppler, S. A., Voncken, J. W., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600998 · Cited by 364 · see citing works

Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3

Azad, M. B., Chen, Y., Henson, E. S., Cizeau, J., McMillan‐Ward, E., Israels, S. J., & Gibson, S. B. (2008) · Autophagy · doi:10.4161/auto.5278 · Cited by 355 · see citing works

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway

Denoyelle, C., Abou-Rjaily, G., Bezrookove, V., Verhaegen, M., Johnson, T. M., Fullen, D. R., Pointer, J. N., Gruber, S. B., Su, L. D., Nikiforov, M. A., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1471 · Cited by 349 · see citing works

miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer

Giannakakis, A., Sandaltzopoulos, R., Greshock, J. D., Liang, S., Huang, J., Hasegawa, K., Li, C., O’Brien-Jenkins, A., Katsaros, D., Weber, B. L., et al. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.2.5297 · Cited by 341 · see citing works

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L

Papandreou, I., Lim, A. L., Laderoute, K., & Denko, N. C. (2008) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2008.84 · Cited by 334 · see citing works

A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.

Braunstein, S., Karpisheva, K., Pola, C., Goldberg, J., Hochman, T., Yee, H., Cangiarella, J., Arju, R., Formenti, S., & Schneider, R. (2007) · Molecules and Cells · doi:10.1016/j.molcel.2007.10.019 · Cited by 320 · see citing works

Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo

Gills, J. J., LoPiccolo, J., Tsurutani, J., Shoemaker, R. H., Best, C. J. M., Abu-Asab, M. S., Borojerdi, J. P., Warfel, N. A., Gardner, E. R., Danish, M., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0161 · Cited by 320 · see citing works

Antiangiogenic Potential of the Mammalian Target of Rapamycin Inhibitor Temsirolimus

Bufalo, D. D., Ciuffreda, L., Trisciuoglio, D., Desideri, M., Cognetti, F., Zupi, G., & Milella, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2825 · Cited by 318 · see citing works

Hypoxia-inducible Factor-1α mRNA Contains an Internal Ribosome Entry Site That Allows Efficient Translation during Normoxia and Hypoxia

Lang, K. J. D., Kappel, A., & Goodall, G. J. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0017 · Cited by 314 · see citing works

Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.

Mabjeesh, N. J., Post, D. E., Willard, M. T., Kaur, B., Meir, E. G. V., Simons, J. W., & Zhong, H. (2002) · PubMed · Cited by 299 · see citing works

ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase

平田, 晃. (2004) · Medical Entomology and Zoology · Cited by 296 · see citing works

Perk-Dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress

Blais, J. D., Addison, C., Edge, R. E., Falls, T. J., Zhao, H., Wary, K. K., Koumenis, C., Harding, H. P., Ron, D., Holčı́k, M., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01145-06 · Cited by 295 · see citing works

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in DrosophilaPreprint

Reiling, J. H., & Hafen, E. (2004) · Genes & Development · doi:10.1101/gad.322704 · Cited by 291 · see citing works

Bortezomib Mediates Antiangiogenesis in Multiple Myeloma via Direct and Indirect Effects on Endothelial Cells

Roccaro, A. M., Hideshima, T., Raje, N. S., Kumar, S. K., Ishitsuka, K., Yasui, H., Shiraishi, N., Ribatti, D., Nico, B., Vacca, A., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1195 · Cited by 283 · see citing works

High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma

HEBERT, C. A., Norris, K., Scheper, M. A., Nikitakis, N. G., & Sauk, J. J. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-5 · Cited by 274 · see citing works

Bnip3 Mediates the Hypoxia-induced Inhibition on Mammalian Target of Rapamycin by Interacting with Rheb

Li, Y., Wang, Y., Kim, E., Beemiller, P., Wang, C. Y., Swanson, J. A., You, M., & Guan, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705231200 · Cited by 269 · see citing works

Up-regulation of Protein-disulfide Isomerase in Response to Hypoxia/Brain Ischemia and Its Protective Effect against Apoptotic Cell Death

Tanaka, S., Uehara, T., & Nomura, Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10388 · Cited by 267 · see citing works

ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase.

Hirata, A., Ogawa, S.-I., Kometani, T., Kuwano, T., Naito, S., Kuwano, M., & Ono, M. (2002) · PubMed · Cited by 258 · see citing works

A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin

Browne, G. J., & Proud, C. G. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2986-2997.2004 · Cited by 256 · see citing works

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay

Ferraiuolo, M. A., Basak, S., Dostie, J., Murray, E. L., Schoenberg, D. R., & Sonenberg, N. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504039 · Cited by 255 · see citing works

Hypoxia Inhibits Protein Synthesis through a 4E-BP1 and Elongation Factor 2 Kinase Pathway Controlled by mTOR and Uncoupled in Breast Cancer Cells

Connolly, E., Braunstein, S., Formenti, S., & Schneider, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3955-3965.2006 · Cited by 233 · see citing works

Targeting hypoxia cell signaling for cancer therapy

Melillo, G. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9059-x · Cited by 230 · see citing works

IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth In vivo

Drogat, B., Auguste, P., Nguyên, D. T., Bouchecareilh, M., Pineau, R., Nalbantoglu, J. N., Kaufman, R. J., Chevet, É., Bikfalvi, A., & Moenner, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3235 · Cited by 221 · see citing works

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

Köditz, J., Nesper, J., Wottawa, M., Stiehl, D. P., Camenisch, G., Franke, C., Myllyharju, J., Wenger, R. H., & Katschinski, D. M. (2007) · Blood · doi:10.1182/blood-2007-06-094441 · Cited by 214 · see citing works

A novel shuttling protein, 4E‐T, mediates the nuclear import of the mRNA 5′ cap‐binding protein, eIF4E

Dostie, J., Ferraiuolo, M. A., Pause, A., Adam, S. A., & Sonenberg, N. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.3142 · Cited by 206 · see citing works

Protein Kinase Cθ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum

Sakaki, K., Wu, J., & Kaufman, R. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710209200 · Cited by 179 · see citing works

Anoxic induction of ATF-4 through HIF-1–independent pathways of protein stabilization in human cancer cells

Ameri, K., Lewis, C. E., Raida, M. K., Sowter, H., Hai, T., & Harris, A. L. (2003) · Blood · doi:10.1182/blood-2003-06-1859 · Cited by 178 · see citing works

Expression and splicing of the unfolded protein response gene XBP‐1 are significantly associated with clinical outcome of endocrine‐treated breast cancer

Davies, M. P. A., Barraclough, D. L., Stewart, C. E., Joyce, K. A., Eccles, R. M., Barraclough, R., Rudland, P. S., & Sibson, D. R. (2008) · International Journal of Cancer · doi:10.1002/ijc.23479 · Cited by 178 · see citing works

HIV Protease Inhibitors Block Akt Signaling and Radiosensitize Tumor Cells Both In vitro and In vivo

Gupta, A. K., Cerniglia, G. J., Mick, R., McKenna, W. G., & Muschel, R. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1220 · Cited by 174 · see citing works

Ero1-Lα plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer

May, D., Itin, A., Gal, O., Kalinski, H., Feinstein, E., & Keshet, E. (2005) · Oncogene · doi:10.1038/sj.onc.1208325 · Cited by 167 · see citing works

The HIF pathway in cancer

Maxwell, P. H. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.03.001 · Cited by 167 · see citing works

Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.

Edinger, A. L., Linardic, C. M., Chiang, G. G., Thompson, C. B., & Abraham, R. T. (2003) · PubMed · Cited by 162 · see citing works

Nelfinavir Down-regulates Hypoxia-Inducible Factor 1α and VEGF Expression and Increases Tumor Oxygenation: Implications for Radiotherapy

Pore, N., Gupta, A., Cerniglia, G. J., Jiang, Z., Bernhard, E. J., Evans, S. M., Koch, C. J., Hahn, S. M., & Maity, A. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1239 · Cited by 157 · see citing works

Inhibition of Tumor Endothelial ERK Activation, Angiogenesis, and Tumor Growth by Sorafenib (BAY43-9006)

Murphy, D. A., Makonnen, S., Lassoued, W., Feldman, M. D., Carter, C., & Lee, W. M. F. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050711 · Cited by 156 · see citing works

Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response

Zhang, K., & Kaufman, R. J. (2005) · Handbook of Experimental Pharmacology · doi:10.1007/3-540-29717-0_3 · Cited by 152 · see citing works

Effect of Bortezomib on Human Neuroblastoma Cell Growth, Apoptosis, and Angiogenesis

Brignole, C., Marimpietri, D., Pastorino, F., Nico, B., Paolo, D. D., Cioni, M., Piccardi, F., Cilli, M., Pezzolo, A., Corrias, M. V., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj309 · Cited by 149 · see citing works

CCI-779 Inhibits Rhabdomyosarcoma Xenograft Growth by an Antiangiogenic Mechanism Linked to the Targeting of mTOR/Hif-1α/VEGF Signaling

Wan, X., Shen, N., Mendoza, A., Khanna, C., & Helman, L. J. (2006) · Neoplasia · doi:10.1593/neo.05820 · Cited by 148 · see citing works

HIV-1 Protease Inhibitors Nelfinavir and Atazanavir Induce Malignant Glioma Death by Triggering Endoplasmic Reticulum Stress

Pyrko, P., Kardosh, A., Wang, W., Xiong, W., Schönthal, A. H., & Chen, T. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0796 · Cited by 140 · see citing works

BNIP3 Expression Is Linked with Hypoxia-Regulated Protein Expression and with Poor Prognosis in Non–Small Cell Lung Cancer

Giatromanolaki, A. N., Koukourakis, M. I., Sowter, H., Sivridis, E., Gibson, S. B., Gatter, K. C., & Harris, A. L. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0076 · Cited by 135 · see citing works

The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1‐Lα

Gess, B., Hofbauer, K., Wenger, R. H., Lohaus, C., Meyer, H. E., & Kurtz, A. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03590.x · Cited by 132 · see citing works

Mxi1 is induced by hypoxia in a HIF-1–dependent manner and protects cells from c-Myc-induced apoptosis

Corn, P. G., Ricci, M., Scata, K. A., Arsham, A. M., Simon, M. C., Dicker, D. T., & El‐Deiry, W. S. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.11.2299 · Cited by 128 · see citing works

Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF

Guba, M. O., Yezhelyev, M., Eichhorn, M., Schmid, G., Ischenko, I., Papyan, A., Graeb, C., Seeliger, H., Geissler, E. K., Jauch, K., et al. (2005) · Blood · doi:10.1182/blood-2004-09-3540 · Cited by 127 · see citing works

The HIV Protease Inhibitor Nelfinavir Downregulates Akt Phosphorylation by Inhibiting Proteasomal Activity and Inducing the Unfolded Protein Response

Gupta, A., Li, B., Cerniglia, G. J., Ahmed, M. S., Hahn, S. M., & Maity, A. M. (2007) · Neoplasia · doi:10.1593/neo.07124 · Cited by 125 · see citing works

The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells

Murphy, B. J., Laderoute, K. R., Short, S., & Sutherland, R. J. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.241 · Cited by 125 · see citing works

The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

Luwor, R. B., Lü, Y., Li, X., Mendelsohn, J. M., & Fan, Z. (2005) · Oncogene · doi:10.1038/sj.onc.1208625 · Cited by 122 · see citing works

Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism

Young, R. M., Wang, S.-J., Gordan, J. D., Ji, X., Liebhaber, S. A., & Simon, M. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710079200 · Cited by 121 · see citing works

Assessing IRES activity in the HIF-1α and other cellular 5′ UTRs

Bert, A. G., Grépin, R., Vadas, M. A., & Goodall, G. J. (2006) · RNA · doi:10.1261/rna.2320506 · Cited by 121 · see citing works

Proteasomal Inhibition Attenuates Transcriptional Activity of Hypoxia-Inducible Factor 1 (HIF-1) via Specific Effect on the HIF-1α C-Terminal Activation Domain

Kaluz, S., Kaluzová, M., & Stanbridge, E. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00552-06 · Cited by 108 · see citing works

BNIP3 as a Progression Marker in Primary Human Breast Cancer; Opposing Functions inIn situVersus Invasive Cancer

Tan, E. Y., Campo, L., Han, C., Turley, H., Pezzella, F., Gatter, K. C., Harris, A. L., & Fox, S. B. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1466 · Cited by 91 · see citing works

HIV Protease Inhibitors Decrease VEGF/HIF-1α Expression and Angiogenesis in Glioblastoma Cells

Pore, N., Gupta, A., Cerniglia, G. J., & Maity, A. M. (2006) · Neoplasia · doi:10.1593/neo.06535 · Cited by 90 · see citing works

IRE1-Independent Gain Control of the Unfolded Protein Response

Leber, J. H., Bernales, S., & Walter, P. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020235 · Cited by 87 · see citing works

Mutations in the PI3K/PTEN/TSC2 Pathway Contribute to Mammalian Target of Rapamycin Activity and Increased Translation under Hypoxic Conditions

Kaper, F., Dornhöfer, N., & Giaccia, A. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3375 · Cited by 85 · see citing works

Treatment of HER-2/ neu Overexpressing Breast Cancer Xenograft Models with Trastuzumab (Herceptin) and Gefitinib (ZD1839): Drug Combination Effects on Tumor Growth, HER-2/ neu and Epidermal Growth Factor Receptor Expression, and Viable Hypoxic Cell Fraction

Warburton, C., Dragowska, W. H., Gelmon, K. A., Chia, S., Yan, H., Masin, D., Denyssevych, T., Wallis, A. E., & Bally, M. B. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0244 · Cited by 83 · see citing works

Efficient translation of mouse hypoxia-inducible factor-1α under normoxic and hypoxic conditions

Görlach, A., Camenisch, G., Kvietikova, I., Vogt, L., Wenger, R. H., & Gassmann, M. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00172-x · Cited by 76 · see citing works

The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft.

Delmas, C., End, D. W., Rochaix, P., Favre, G., Toulas, C., & Moyal, E. C. (2003) · PubMed · Cited by 70 · see citing works

Hypoxia sensing and pathways of cytosolic Ca2+ increases

Toescu, E. C. (2004) · Cell Calcium · doi:10.1016/j.ceca.2004.02.019 · Cited by 67 · see citing works

Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts

Vlahovic, G., Ponce, A. M., Rabbani, Z. N., Salahuddin, F. K., Zgonjanin, L., Spasojević, I., Vujaskovic, Z., & Dewhirst, M. W. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603941 · Cited by 64 · see citing works

Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1α

Lü, Y., Liang, K., Li, X., & Fan, Z. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-63 · Cited by 63 · see citing works

Regulation of protein synthesis in human cells exposed to extreme hypoxia.

Kraggerud, S. M., Sandvik, J. A., & Pettersen, E. O. (1995) · PubMed · Cited by 63 · see citing works

Suppression of the Hypoxia-Inducible Factor-1 Response in Cervical Carcinoma Xenografts by Proteasome Inhibitors

Birle, D. C., & Hedley, D. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2722 · Cited by 58 · see citing works

Phosphorylation of eIF2α is required for mRNA translation inhibition and survival during moderate hypoxia

Koritzinsky, M., Rouschop, K. M. A., van den Beucken, T., Magagnin, M. G., Savelkouls, K. G. M., Lambin, P., & Wouters, B. G. (2007) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2007.04.031 · Cited by 55 · see citing works

Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imaging

Solomon, B., Binns, D., Roselt, P. D., Weibe, L. I., McArthur, G. A., Cullinane, C. M., & Hicks, R. J. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0066 · Cited by 50 · see citing works

The mTOR target 4E‐BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency

Magagnin, M. G., van den Beucken, T., Sergeant, K., Lambin, P., Koritzinsky, M., Devreese, B., & Wouters, B. (2008) · Proteomics · doi:10.1002/pmic.200700551 · Cited by 49 · see citing works

Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: Possible role for thrombosis

Weppler, S. A., Krause, M., Żyromska, A., Lambin, P., Baumann, M. A., & Wouters, B. G. (2006) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2006.11.004 · Cited by 49 · see citing works

Rates of Oxygen Consumption for Proliferating and Quiescent Cells Isolated from Multicellular Tumor Spheroids

Freyer, J. P. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2468-7_44 · Cited by 47 · see citing works

Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer

Huynh, H. T., Teo, C. C. M., & Soo, K. C. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0237 · Cited by 47 · see citing works

Hypoxia and Regulation of Messenger RNA Translation

Koritzinsky, M., & Wouters, B. G. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)35013-1 · Cited by 46 · see citing works

Oxygen regulated 80 kDa protein and glucose regulated 78 kDa protein are identical

Roll, D., Murphy, B., Laderoute, K. R., Sutherland, R. M., & Smith, H. C. (1991) · Molecular and Cellular Biochemistry · doi:10.1007/bf00227480 · Cited by 43 · see citing works

BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1α pathway and prognosis

Giatromanolaki, A. N., Koukourakis, M. I., Gatter, K. C., Harris, A. L., & Sivridis, E. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.046680 · Cited by 41 · see citing works

Enhanced synthesis of specific proteins, RNA, and DNA caused by hypoxia and reoxygenation

Wilson, R. E., & Sutherland, R. M. (1989) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(89)90895-x · Cited by 39 · see citing works

Herceptin Down-Regulates HER-2/neu and Vascular Endothelial Growth Factor Expression and Enhances Taxol-Induced Cytotoxicity of Human Ewing's Sarcoma Cells In vitro and In vivo

Guan, H., Jia, S.-F., Zhou, Z., Stewart, J., & Kleinerman, E. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0777 · Cited by 39 · see citing works

Induction of murine HRD1 in experimental cerebral ischemia

Qi, X., Okuma, Y., Hosoi, T., Kaneko, M., & Nomura, Y. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.07.013 · Cited by 24 · see citing works

Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress

Magagnin, M. G., Sergeant, K., van den Beucken, T., Rouschop, K. M. A., Jutten, B., Seigneuric, R., Lambin, P., Devreese, B. V., Koritzinsky, M., & Wouters, B. G. (2007) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2007.04.027 · Cited by 23 · see citing works

Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors

Hardee, M. E., Eapen, R. J., Rabbani, Z. N., Dreher, M. R., Marks, J. R., Blackwell, K., & Dewhirst, M. W. (2008) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-008-0729-3 · Cited by 20 · see citing works

Farnesyltransferase inhibitor effects on prostate tumor micro-environment and radiation survival

Shi, Y., Wu, J., Mick, R., Cerniglia, G. J., Moyal, E. C., Rhim, J. S., Koch, C. J., & Bernhard, E. J. (2004) · The Prostate · doi:10.1002/pros.20122 · Cited by 14 · see citing works

Regulation of cancer cell metabolism

Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744 · see citing works

Reactive oxygen species in cancer

Liou, G., & Störz, P. (2010) · Free Radical Research · doi:10.3109/10715761003667554 · Cited by 3,394 · see citing works

Targeting hypoxia in cancer therapy

Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172 · see citing works

Hypoxia-inducible factors and the response to hypoxic stress

Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380 · see citing works

mTOR signaling at a glance

Laplante, M., & Sabatini, D. (2009) · Journal of Cell Science · doi:10.1242/jcs.051011 · Cited by 2,317 · see citing works

The impact of O2 availability on human cancer

Bertout, J. A., Patel, S. A., & Simon, M. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2540 · Cited by 1,365 · see citing works

Regulation of autophagy by ROS: physiology and pathology

Scherz-Shouval, R., & Elazar, Z. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.07.007 · Cited by 1,263 · see citing works

Life and death partners: apoptosis, autophagy and the cross-talk between them

Eisenberg‐Lerner, A., Bialik, S., Simon, H.-U., & Kimchi, A. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.33 · Cited by 1,183 · see citing works

Pathophysiology of placental-derived fetal growth restriction

Burton, G. J., & Jauniaux, E. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.577 · Cited by 1,070 · see citing works

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

McKeown, S. R. (2014) · The British Journal of Radiology · doi:10.1259/bjr.20130676 · Cited by 1,050 · see citing works

Tackling the cancer stem cells — what challenges do they pose?

Pattabiraman, D. R., & Weinberg, R. A. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4253 · Cited by 985 · see citing works

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40027 · Cited by 829 · see citing works

Translational control in cancer

Silvera, D., Formenti, S. C., & Schneider, R. J. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2824 · Cited by 820 · see citing works

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

Chen, X., Iliopoulos, D., Zhang, Q. H., Tang, Q., Greenblatt, M. B., Hatziapostolou, M., Lim, E., Tam, W. L., Ni, M., Chen, Y., et al. (2014) · Nature · doi:10.1038/nature13119 · Cited by 817 · see citing works

The unfolded protein response in immunity and inflammation

Grootjans, J., Kaser, A., Kaufman, R., & Blumberg, R. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.62 · Cited by 766 · see citing works

Translational Regulation of Gene Expression during Conditions of Cell Stress

Spriggs, K. A., Bushell, M., & Willis, A. E. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.028 · Cited by 721 · see citing works

Placental Origins of Chronic Disease

Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works

The Role of Hypoxia in Development of the Mammalian Embryo

Dunwoodie, S. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.11.008 · Cited by 651 · see citing works

Endothelium—role in regulation of coagulation and inflammation

van Hinsbergh, V. W. M. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0285-5 · Cited by 594 · see citing works

Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars

Li, M., Tian, S., Jin, L. G., Zhou, G., Li, Y., Zhang, Y., Wang, T., Yeung, C. K. L., Chen, L., Ma, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2811 · Cited by 553 · see citing works

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534 · see citing works

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

Pacchiano, F., Carta, F., McDonald, P. C., Lou, Y., Vullo, D., Scozzafava, A., Dedhar, S., & Supuran, C. T. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101541x · Cited by 530 · see citing works

Role of hypoxia in the hallmarks of human cancer

Ruan, K., Song, G., & Ouyang, G. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22214 · Cited by 485 · see citing works

The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond

Pastoreková, S., & Gillies, R. J. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09799-0 · Cited by 463 · see citing works

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

Qin, L., Wang, Z., Tao, L., & Wang, Y. (2010) · Autophagy · doi:10.4161/auto.6.2.11062 · Cited by 435 · see citing works

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury

Jiang, M., Liu, K., Luo, J., & Dong, Z. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090594 · Cited by 375 · see citing works

The endoplasmic reticulum stress response in aging and age-related diseases

Brown, M. K., & Naidoo, N. N. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00263 · Cited by 372 · see citing works

Nutrient Sensing, Metabolism, and Cell Growth Control

Yuan, H.-X., Xiong, Y., & Guan, K. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.019 · Cited by 357 · see citing works

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

Phan, T. H. G., Paliogiannis, P., Nasrallah, G. K., Giordo, R., Eid, A. H., Fois, A. G., Zinellu, A., Mangoni, A. A., & Pintus, G. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03693-7 · Cited by 355 · see citing works

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

Fluegen, G., Avivar‐Valderas, A., Wang, Y., Padgen, M. R., Williams, J. K., Nobre, A. R., Calvo, V., Cheung, J. F., Bravo‐Cordero, J. J., Entenberg, D. R., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3465 · Cited by 331 · see citing works

Generating specificity and diversity in the transcriptional response to hypoxia

Lendahl, U., Lee, K. L., Yang, H. H., & Poellinger, L. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2665 · Cited by 330 · see citing works

MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

Favaro, E., Ramachandran, A., McCormick, R., Gee, H., Blancher, C., Crosby, M., Devlin, C., Blick, C., Buffa, F., Li, J.-L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010345 · Cited by 324 · see citing works

Pathophysiological implications of hypoxia in human diseases

Chen, P.-S., Chiu, W.-T., Hsu, P.-L., Lin, S.-C., Peng, I.-C., Wang, C.-Y., & Tsai, S.-J. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00658-7 · Cited by 318 · see citing works

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

Appenzeller‐Herzog, C., & Hall, M. N. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.02.006 · Cited by 316 · see citing works

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

Cho, S. H., Raybuck, A. L., Stengel, K. R., Wei, M., Beck, T. C., Volanakis, E. J., Thomas, J. W., Hiebert, S. W., Haase, V. H., & Boothby, M. R. (2016) · Nature · doi:10.1038/nature19334 · Cited by 307 · see citing works

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond

Tam, S. Y., Wu, V., & Law, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00486 · Cited by 304 · see citing works

MicroRNA-34a: a potential therapeutic target in human cancer

Li, X. J., Ren, Z. J., & Tang, J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.270 · Cited by 286 · see citing works

HIF1A Overexpression Is Associated with Poor Prognosis in a Cohort of 731 Colorectal Cancers

Baba, Y., Nosho, K., Shima, K., Irahara, N., Chan, A. T., Meyerhardt, J. A., Chung, D. C., Giovannucci, E. L., Fuchs, C. S., & Ogino, S. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090972 · Cited by 284 · see citing works

Protein Kinases and Phosphatases in the Control of Cell Fate

Bononi, A., Agnoletto, C., Marchi, E. D., Marchi, S., Patergnani, S., Bonora, M., Giorgi, C., Missiroli, S., Poletti, F., Rimessi, A., et al. (2011) · Enzyme Research · doi:10.4061/2011/329098 · Cited by 283 · see citing works

Targeting the Tumor Microenvironment: From Understanding Pathways to Effective Clinical Trials

Hua, F., & DeClerck, Y. A. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0661 · Cited by 282 · see citing works

Hypoxia induced EMT: A review on the mechanism of tumor progression and metastasis in OSCC

Joseph, J. P., Harishankar, M. K., Pillai, A. A., & Devi, A. (2018) · Oral Oncology · doi:10.1016/j.oraloncology.2018.03.004 · Cited by 281 · see citing works

Development of HIF‐1 inhibitors for cancer therapy

Onnis, B., Rapisarda, A., & Melillo, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00876.x · Cited by 268 · see citing works

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

Chang, Q., Jurišica, I., Do, T., & Hedley, D. W. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4049 · Cited by 267 · see citing works

Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer

Cho, J.-W., Hong, M. H., Ha, S., Kim, Y., Cho, B. C., Lee, I., & Kim, H. R. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00493-8 · Cited by 267 · see citing works

Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α

McInturff, A. M., Cody, M. J., Elliott, E. A., Glenn, J. W., Rowley, J. W., Rondina, M. T., & Yost, C. C. (2012) · Blood · doi:10.1182/blood-2012-01-405993 · Cited by 265 · see citing works

Cancer Stem Cells, Hypoxia and Metastasis

Hill, R. P., Marie-Egyptienne, D. T., & Hedley, D. W. (2009) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2008.12.002 · Cited by 240 · see citing works

Endoplasmic reticulum stress in pulmonary fibrosis

Burman, A., Tanjore, H., & Blackwell, T. S. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.015 · Cited by 238 · see citing works

Hypoxia-activated prodrugs: paths forward in the era of personalised medicine

Hunter, F. W., Wouters, B. G., & Wilson, W. R. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.79 · Cited by 230 · see citing works

Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress

Dewhirst, M. W. (2009) · Radiation Research · doi:10.1667/rr1926.1 · Cited by 228 · see citing works

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

Nagelkerke, A., Bussink, J., Mujčić, H., Wouters, B. G., Lehmann, S., Sweep, F. C. G. J., & Span, P. N. (2013) · Breast Cancer Research · doi:10.1186/bcr3373 · Cited by 223 · see citing works

Cancer Cell MetabolismPreprint

Cairns, R. A., Harris, I. S., McCracken, S. A., & Mak, T. W. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.012856 · Cited by 223 · see citing works

Tumor hypoxia as a driving force in genetic instability

Luoto, K. R., Kumareswaran, R., & Bristow, R. G. (2013) · Genome Integrity · doi:10.1186/2041-9414-4-5 · Cited by 222 · see citing works

A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis

Sparrow, D. B., Chapman, G., Smith, A., Mattar, M. Z., Major, J., O׳Reilly, V. C., Saga, Y., Zackai, E. H., Dormans, J. P., Alman, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.054 · Cited by 220 · see citing works

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

Ebbesen, P., Pettersen, E. O., Gorr, T. A., Jobst, G., Williams, K. J., Kieninger, J., Wenger, R. H., Pastoreková, S., Dubois, L. J., Lambin, P., et al. (2009) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360902784425 · Cited by 220 · see citing works

Differential Roles of GSK-3β During Myocardial Ischemia and Ischemia/Reperfusion

Zhai, P., Sciarretta, S., Galeotti, J., Volpe, M., & Sadoshima, J. (2011) · Circulation Research · doi:10.1161/circresaha.111.249532 · Cited by 218 · see citing works

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

Vasseur, S., Afzal, S., Tardivel‐Lacombe, J., Park, D. S., Iovanna, J., & Mak, T. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812745106 · Cited by 214 · see citing works

Plasticity of disseminating cancer cells in patients with epithelial malignancies

Bednarz‐Knoll, N., Alix‐Panabières, C., & Pantel, K. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9370-z · Cited by 214 · see citing works

Autophagy in cancer development, immune evasion, and drug resistance

Niu, X., You, Q., Hou, K., Tian, Y., Wei, P., Zhu, Y., Gao, B., Ashrafizadeh, M., Aref, A. R., Kalbasi, A., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101170 · Cited by 217 · see citing works

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stressPreprint

Young, R. M., Ackerman, D., Quinn, Z. L., Mancuso, A., Gruber, M., Liu, L., Giannoukos, D. N., Bobrovnikova-Marjon, E. V., Diehl, J. A., Keith, B., et al. (2013) · Genes & Development · doi:10.1101/gad.198630.112 · Cited by 214 · see citing works

Acetyl-11-Keto-β-Boswellic Acid Inhibits Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2–Mediated Angiogenesis

Pang, X., Yi, Z., Zhang, X., Sung, B., Qu, W., Lian, X., Aggarwal, B. B., & Liu, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0755 · Cited by 212 · see citing works

Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib

Broxterman, H. J., Gotink, K. J., & Verheul, H. M. W. (2009) · Drug Resistance Updates · doi:10.1016/j.drup.2009.07.001 · Cited by 206 · see citing works

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

Xi, H., Kurtoğlu, M., Liu, H., Wangpaichitr, M., You, M., Liu, X., Savaraj, N., & Lampidis, T. J. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1391-0 · Cited by 204 · see citing works

Hypoxic tumor microenvironment: Opportunities to develop targeted therapies

Patel, A., & Sant, S. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.04.005 · Cited by 203 · see citing works

Hypoxia signaling pathways: modulators of oxygen-related organelles

Schönenberger, M. J. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00042 · Cited by 199 · see citing works

Autophagy: Regulation and role in disease

Meijer, A. J., & Codogno, P. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360903044068 · Cited by 199 · see citing works

Angiogenesis in prostate cancer: onset, progression and imaging

Russo, G., Mischi, M., Scheepens, W. A., de la Rosette, J. J. M. C. H., & Wijkstra, H. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2012.11444.x · Cited by 196 · see citing works

Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

Wang, Y., Chiang, I.-L., Ohara, T. E., Fujii, S., Cheng, J., Muegge, B. D., Heul, A. V., Han, N. D., Lu, Q., Xiong, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.015 · Cited by 196 · see citing works

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

Dubois, L. J., Lieuwes, N. G., Maresca, A., Thiry, A., Supuran, C. T., Scozzafava, A., Wouters, B. G., & Lambin, P. (2009) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2009.06.019 · Cited by 195 · see citing works

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

Singh, A. K., Kashyap, M. P., Tripathi, V., Singh, S., Garg, G., & Rizvi, S. I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0129-3 · Cited by 195 · see citing works

Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy

Kouidhi, S., Ayed, F. B., & Elgaaïed, A. B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00353 · Cited by 193 · see citing works

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

Cai, D., & Liu, T. (2012) · Aging · doi:10.18632/aging.100431 · Cited by 189 · see citing works

Hypoxia and Selective Autophagy in Cancer Development and Therapy

Daskalaki, I., Gkikas, I., & Tavernarakis, N. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00104 · Cited by 188 · see citing works

Patient-derived tumor organoids for prediction of cancer treatment response

Nagle, P. W., Plukker, J. T. M., Muijs, C. T., van Luijk, P., & Coppes, R. P. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.06.005 · Cited by 181 · see citing works

Endoplasmic Reticulum Stress in the Kidney as a Novel Mediator of Kidney Injury

Inagi, R. (2009) · Nephron Experimental Nephrology · doi:10.1159/000210573 · Cited by 180 · see citing works

Effects of Chemotherapy on the Immune System: Implications for Cancer Treatment and Patient Outcomes

Sharma, A., Jasrotia, S., & Kumar, A. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02781-2 · Cited by 180 · see citing works

Role of the VEGF/VEGFR Axis in Cancer Biology and Therapy

Rapisarda, A., & Melillo, G. (2012) · Advances in cancer research · doi:10.1016/b978-0-12-386503-8.00006-5 · Cited by 180 · see citing works

Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate

Rafalski, V. A., Mancini, E., & Brunet, A. (2012) · Journal of Cell Science · doi:10.1242/jcs.114827 · Cited by 179 · see citing works

Endoplasmic reticulum stress as a progression factor for kidney injury

Inagi, R. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.11.006 · Cited by 176 · see citing works

Predicting tumour radiosensitivity to deliver precision radiotherapy

Price, J., Prabhakaran, A., & West, C. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00709-y · Cited by 176 · see citing works

Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia

Rapisarda, A., & Melillo, G. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.64 · Cited by 175 · see citing works

Lessons from patient-derived xenografts for better in vitro modeling of human cancer

Choi, S. Y. C., Lin, D., Gout, P. W., Collins, C. C., Xu, Y., & Wang, Y. Z. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.09.009 · Cited by 174 · see citing works

Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells

Du, R., Sun, W., Xia, L., Zhao, A., Yu, Y., Zhao, L., Wang, H., Huang, C., & Sun, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030771 · Cited by 171 · see citing works

Molecular targeting of hypoxia in radiotherapy

Rey, S., Schito, L., Koritzinsky, M., & Wouters, B. G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.10.002 · Cited by 171 · see citing works

Tanshinone IIA protects against heart failure post-myocardial infarction via AMPKs/mTOR-dependent autophagy pathway

Zhang, X., Wang, Q., Wang, X., Chen, X., Shao, M., Zhang, Q., Guo, D., Yan, W. S., Li, C., Wang, W., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108599 · Cited by 171 · see citing works

Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances

Strashilov, S. A., & Yordanov, A. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126395 · Cited by 169 · see citing works

Regulation and Function of Protein Kinases and Phosphatases

Cheng, H.-C., Qi, R., Paudel, H., & Zhu, H.-J. (2011) · Enzyme Research · doi:10.4061/2011/794089 · Cited by 147 · see citing works

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

Kreuzaler, P. A., Panina, Y., Segal, J., & Yuneva, M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.021 · Cited by 151 · see citing works

Biology of Hypoxia

Span, P. N., & Bussink, J. (2015) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2014.10.002 · Cited by 162 · see citing works

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

Radogna, F., Dicato, M. A., & Diederich, M. F. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.12.018 · Cited by 162 · see citing works

Molecular mechanisms of hypoxia in cancer

Challapalli, A., Carroll, L. S., & Aboagye, E. O. (2017) · Clinical and Translational Imaging · doi:10.1007/s40336-017-0231-1 · Cited by 161 · see citing works

Hypothalamic inflammation: a double‐edged sword to nutritional diseases

Cai, D., & Liu, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06388.x · Cited by 159 · see citing works

Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease

LANGEN, R. C. J., Gosker, H. R., Remels, A. H. V., & Schols, A. M. W. J. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.015 · Cited by 159 · see citing works

Oncogenic regulation of tumor metabolic reprogramming

Tarrado‐Castellarnau, M., de Atauri, P., & Cascante, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10911 · Cited by 159 · see citing works

Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects

Shang, R., Qu, S., & Wang, D. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i45.9933 · Cited by 156 · see citing works

mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression

Huber, T. B., Walz, G., & Kuehn, E. W. (2010) · Kidney International · doi:10.1038/ki.2010.457 · Cited by 155 · see citing works

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke

Speer, R. E., Karuppagounder, S. S., Basso, M., Sleiman, S. F., Kumar, A., Brand, D., Smirnova, N., Gazaryan, I. G., Khim, S. J., & Ratan, R. R. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.026 · Cited by 155 · see citing works

Prognostic Significance of Carbonic Anhydrase IX Expression in Cancer Patients: A Meta-Analysis

van Kuijk, S. J. A., Yaromina, A., Houben, R. M. A., Niemans, R., Lambin, P., & Dubois, L. J. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00069 · Cited by 154 · see citing works

Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic

Shah, F., Logsdon, D. P., Messmann, R. A., Fehrenbacher, J. C., Fishel, M. L., & Kelley, M. R. (2017) · npj Precision Oncology · doi:10.1038/s41698-017-0023-0 · Cited by 153 · see citing works

Hypoxia, HIFs and bone development

Araldi, E., & Schipani, E. (2010) · Bone · doi:10.1016/j.bone.2010.04.606 · Cited by 150 · see citing works

Cellular and molecular mechanisms in the hypoxic tissue: role of HIF‐1 and ROS

Zepeda, A. B., Pessoa, A., Castillo, R. L., Figueroa, C. A., Pulgar, V. M., & Farías, J. G. (2013) · Cell Biochemistry and Function · doi:10.1002/cbf.2985 · Cited by 149 · see citing works

Regulation of Autophagy Through Multiple Independent Hypoxic Signaling Pathways

Rouschop, K. M. A., & Wouters, B. G. (2009) · Current Molecular Medicine · doi:10.2174/156652409788167131 · Cited by 115 · see citing works

Targeting Hypoxic Adaptations of Cancer Cells: Molecular Mechanisms and Therapeutic Opportunities

Tang, C., & Yu, J. Q. (2014) · Springer eBooks · doi:10.1007/978-94-017-9421-3_14

Hypoxia Mediated Signaling Pathways

Chan, D. A., Koong, A. C., & Giaccia, A. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00269-2

Hypoxia Signaling and the Metastatic Phenotype

Mujčić, H., Hill, R. P., Koritzinsky, M., & Wouters, B. G. (2014) · Current Molecular Medicine · doi:10.2174/1566524014666140603115831 · Cited by 30 · see citing works

Mutual Regulation of Hypoxia-Inducible Factor and Mammalian Target of Rapamycin as a Function of Oxygen Availability

Knaup, K. X., Jozefowski, K., Schmidt, R., Bernhardt, W. M., Weidemann, A., Jürgensen, J. S., Warnecke, C., Eckardt, K., & Wiesener, M. S. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0288 · Cited by 56 · see citing works