Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
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Two niches with distinct characteristics work in tandem.
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Interconversion between reserve and active intestinal stem cell populations occurs.
“interconversion of reserve and active intestinal stem cell (ISC) populations has also been observed previously25,28–30.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [28]
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- Authors
- Takeda, N., Jain, R., LeBoeuf, M. R., Wang, Q., Lu, M. M., & Epstein, J. A.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Takeda, Norifumi
- Jain, Rajan
- Epstein, Jonathan A.
- Venue
- Science
- Published
- 2011-12-09
- Volume
- 334
- Issue
- 6061
- Pages
- 1420-1424
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3705713
- OpenAlex
- W2017828716
- Cited by
- 742
- References
- 28
- Citations by year
- 2026: 18 · 2025: 33 · 2024: 37 · 2023: 41 · 2022: 46 · 2021: 50 · 2020: 44 · 2019: 51 · 2018: 62 · 2017: 48 · 2016: 56 · 2015: 59 · 2014: 60 · 2013: 70 · 2012: 64
- FWCI
- 39.11
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL071546, U01HL100405)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32AR007465)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- intestinal stem cells, HOPX, crypt base columnar cells, stem cell niche, stem cell lineage, quiescent stem cells, label-retaining cells, intestinal epithelium
- MeSH terms
- Animals, Cell Cycle, Cell Differentiation, Cells, Cultured, Epithelial Cells, Intestinal Mucosa, Intestine, Small, Models, Biological, Tamoxifen, Homeodomain Proteins, Cell Lineage, Paneth Cells, Multipotent Stem Cells, Cell Proliferation, Mice, Stem Cell Niche
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