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Cited by 758

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart

Open access
Asp, Michaela, Giacomello, Stefania, Larsson, Ludvig, Wu, Chenglin, Fürth, Daniel, Qian, Xiaoyan, Wärdell, Eva, Custodio, Joaquin, Reimegård, Johan, Salmén, Fredrik, Österholm, Cecilia, Ståhl, Patrik L., Sundström, Erik, Åkesson, Elisabet, Bergmann, Olaf, Bienko, Magda, Månsson-Broberg, Agneta, Nilsson, Mats, Sylvén, Christer, Lundeberg, Joakim·2019·Cell
DOI 10.1016/j.cell.2019.11.025
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Abstract

The process of cardiac morphogenesis in humans is incompletely understood. Its full characterization requires a deep exploration of the organ-wide orchestration of gene expression with a single-cell spatial resolution. Here, we present a molecular approach that reveals the comprehensive transcriptional landscape of cell types populating the embryonic heart at three developmental stages and that maps cell-type-specific gene expression to specific anatomical domains. Spatial transcriptomics identified unique gene profiles that correspond to distinct anatomical regions in each developmental stage. Human embryonic cardiac cell types identified by single-cell RNA sequencing confirmed and enriched the spatial annotation of embryonic cardiac gene expression. In situ sequencing was then used to refine these results and create a spatial subcellular map for the three developmental phases. Finally, we generated a publicly available web resource of the human developing heart to facilitate future studies on human cardiogenesis.

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Research works printed but not linked: 2

  1. Lin, 1990, Myoglobin content and citrate synthase activity in different parts of the normal human heart, J. Appl. Physiol., 69, 899, 10.1152/jappl.1990.69.3.899 · doi:10.1152/jappl.1990.69.3.899
  2. Moncada, 2019, Integrating single-cell RNA-Seq with spatial transcriptomics in pancreatic ductal adenocarcinoma using multimodal intersection analysis, bioRxiv

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Metadata

Authors
Asp, M., Giacomello, S., Larsson, L., Wu, C., Fürth, D., Qian, X., Wärdell, E., Custodio, J., Reimegård, J., Salmén, F., Österholm, C., Ståhl, P. L., Sundström, E., Åkesson, E., Bergmann, O., Bienko, M., Månsson-Broberg, A., Nilsson, M., Sylvén, C., & Lundeberg, J.
Venue
Cell
Publisher
Elsevier BV
Published
2019-12
Volume
179
Issue
7
Pages
1647-1660.e19
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2019.11.025
OpenAlex
W2996171578
Cited by
758
References
61
FWCI
23.85
Type
journal article
Language
en
Open access
bronze
Licence
Funders
Formas (2017-01066_3)

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CoChat. (2026). Citation check: A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart. https://app.cochat.ai/papers/10.1016/j.cell.2019.11.025
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Asp, M., Giacomello, S., Larsson, L., Wu, C., Fürth, D., Qian, X., Wärdell, E., Custodio, J., Reimegård, J., Salmén, F., Österholm, C., Ståhl, P. L., Sundström, E., Åkesson, E., Bergmann, O., Bienko, M., Månsson-Broberg, A., Nilsson, M., Sylvén, C., & Lundeberg, J. (2019). A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart. Cell. https://doi.org/10.1016/j.cell.2019.11.025

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.