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Cited by 417

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells

Open access
Wu, Huijuan, Yu, Yuanyuan, Huang, Huanwei, Hu, Yucheng, Fu, Siling, Wang, Zheng, Shi, Mengting, Zhao, Xi, Yuan, Jie, Li, Jiao, Yang, Xueyi, Bin, Ennan, Wei, Dong, Zhang, Hongbin, Zhang, Jin, Yang, Chun, Cai, Tao, Dai, Huaping, Chen, Jingyu, Tang, Nan·2020·Cell
DOI 10.1016/j.cell.2019.11.027
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Abstract

Fibrosis can develop in most organs and causes organ failure. The most common type of lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung periphery and then progresses toward the lung center, eventually causing respiratory failure. Little is known about the mechanisms underlying the pathogenesis and periphery-to-center progression of the disease. Here we discovered that loss of Cdc42 function in alveolar stem cells (AT2 cells) causes periphery-to-center progressive lung fibrosis. We further show that Cdc42-null AT2 cells in both post-pneumonectomy and untreated aged mice cannot regenerate new alveoli, resulting in sustained exposure of AT2 cells to elevated mechanical tension. We demonstrate that elevated mechanical tension activates a TGF-β signaling loop in AT2 cells, which drives the periphery-to-center progression of lung fibrosis. Our study establishes a direct mechanistic link between impaired alveolar regeneration, mechanical tension, and progressive lung fibrosis.

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Metadata

Authors
Wu, H., Yu, Y., Huang, H., Hu, Y., Fu, S., Wang, Z., Shi, M., Zhao, X., Yuan, J., Li, J., Yang, X., Bin, E., Wei, D., Zhang, H., Zhang, J., Yang, C., Cai, T., Dai, H., Chen, J., & Tang, N.
Venue
Cell
Publisher
Elsevier BV
Published
2020-01
Volume
180
Issue
1
Pages
107-121.e17
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2019.11.027
OpenAlex
W2988699331
Cited by
417
References
52
FWCI
29.16
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells. https://app.cochat.ai/papers/10.1016/j.cell.2019.11.027
The paper
Wu, H., Yu, Y., Huang, H., Hu, Y., Fu, S., Wang, Z., Shi, M., Zhao, X., Yuan, J., Li, J., Yang, X., Bin, E., Wei, D., Zhang, H., Zhang, J., Yang, C., Cai, T., Dai, H., Chen, J., & Tang, N. (2020). Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells. Cell. https://doi.org/10.1016/j.cell.2019.11.027

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.