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Cited by 499Endometrial and Cervical Cancer TreatmentsAdvanced Proteomics Techniques and ApplicationsOvarian cancer diagnosis and treatment

The DOI matches its Crossref record; 187 of the 188 references it cites were found in a registry or an index.

Proteogenomic Characterization of Endometrial Carcinoma

Open access
Dou, Yongchao, Kawaler, Emily A., Cui Zhou, Daniel, Gritsenko, Marina A., Huang, Chen, Blumenberg, Lili, Karpova, Alla, Petyuk, Vladislav A., Savage, Sara R., Satpathy, Shankha, Liu, Wenke, Wu, Yige, Tsai, Chia-Feng, Wen, Bo, Li, Zhi, Cao, Song, Moon, Jamie, Shi, Zhiao, Cornwell, MacIntosh, Wyczalkowski, Matthew A., Chu, Rosalie K., Vasaikar, Suhas, Zhou, Hua, Gao, Qingsong, Moore, Ronald J., Li, Kai, Sethuraman, Sunantha, Monroe, Matthew E., Zhao, Rui, Heiman, David, Krug, Karsten, Clauser, Karl, Kothadia, Ramani, Maruvka, Yosef, Pico, Alexander R., Oliphant, Amanda E., Hoskins, Emily L., Pugh, Samuel L., Beecroft, Sean J.I., Adams, David W., Jarman, Jonathan C., Kong, Andy, Chang, Hui-Yin, Reva, Boris, Liao, Yuxing, Rykunov, Dmitry, Colaprico, Antonio, Chen, Xi Steven, Czekański, Andrzej, Jędryka, Marcin, Matkowski, Rafał, Wiznerowicz, Maciej, Hiltke, Tara, Boja, Emily, Kinsinger, Christopher R., Mesri, Mehdi, Robles, Ana I., Rodriguez, Henry, Mutch, David, Fuh, Katherine, Ellis, Matthew J., DeLair, Deborah, Thiagarajan, Mathangi, Mani, D.R., Getz, Gad, Noble, Michael, Nesvizhskii, Alexey I., Wang, Pei, Anderson, Matthew L., Levine, Douglas A., Smith, Richard D., Payne, Samuel H., Ruggles, Kelly V., Rodland, Karin D., Ding, Li, Zhang, Bing, Liu, Tao, Fenyö, David, Agarwal, Anupriya, Anurag, Meenakshi, Avtonomov, Dmitry, Birger, Chet, Birrer, Michael J., Boca, Simina M., Bocik, William E., Borate, Uma, Borucki, Melissa, Burke, Meghan C., Cai, Shuang, Calinawan, Anna, Carr, Steven A., Carter, Sonya, Castro, Patricia, Cerda, Sandra, Chaikin, Michelle, Chan, Daniel W., Chan, Doug, Charamut, Alyssa, Chen, Feng, Chen, Jin, Chen, Lijun, Chen, Lin S., Chesla, David, Chheda, Milan G., Chinnaiyan, Arul M., Chowdhury, Shrabanti, Cieslik, Marcin P., Clark, David J., Cottingham, Sandra, Culpepper, Houston, Day, Jacob, De Young, Stephanie, Demir, Emek, Dhanasekaran, Saravana Mohan, Dhir, Rajiv, Domagalski, Marcin J., Dottino, Peter, Druker, Brian, Duffy, Elizabeth, Dyer, Maureen, Edwards, Nathan J., Edwards, Robert, Elburn, Kim, Field, Jayson B., Francis, Alicia, Gabriel, Stacey, Geffen, Yifat, Geiszler, Daniel, Gillette, Michael A., Godwin, Andrew K., Grady, Pamela, Hannick, Linda, Hariharan, Pushpa, Hilsenbeck, Sue, Hindenach, Barbara, Hoadley, Katherine A., Hong, Runyu, Hostetter, Galen, Hsieh, James J., Hu, Yingwei, Ittmann, Michael M., Jaehnig, Eric, Jewell, Scott D., Ji, Jiayi, Jones, Corbin D., Karabon, Renee, Ketchum, Karen A., Khan, Munziba, Kim, Beom-Jun, Krek, Azra, Krubit, Tanya, Kumar-Sinha, Chandan, Leprevost, Felipe D., Lewis, Michael, Li, Qing Kay, Li, Yize, Liu, Hongwei, Lubinski, Jan, Ma, Weiping, Madan, Rashna, Malc, Ewa, Malovannaya, Anna, Mareedu, Sailaja, Markey, Sanford P., Marrero-Oliveras, Annette, Martignetti, John, McDermott, Jason, McGarvey, Peter B., McGee, John, Mieczkowski, Piotr, Modugno, Francesmary, Montgomery, Rebecca, Newton, Chelsea J., Omenn, Gilbert S., Paulovich, Amanda G., Perou, Amy M., Petralia, Francesca, Piehowski, Paul, Polonskaya, Larisa, Qi, Liqun, Richey, Shannon, Robinson, Karna, Roche, Nancy, Rohrer, Daniel C., Schadt, Eric E., Schnaubelt, Michael, Shi, Yan, Skelly, Tara, Sokoll, Lori J., Song, Xiaoyu, Stein, Stephen E., Suh, James, Tan, Donghui, Tansil, Darlene, Teo, Guo Ci, Thangudu, Ratna R., Tognon, Cristina, Traer, Elie, Tyner, Jeffrey, Um, Ki Sung, Valley, Dana R., Vatanian, Negin, Vats, Pankaj, Velvulou, Uma, Vernon, Michael, Wang, Liang-Bo, Wang, Ying, Webster, Alex, Westbrook, Thomas, Wheeler, David, Whiteaker, Jeffrey R., Wilson, George D., Zakhartsev, Yuriy, Zelt, Robert, Zhang, Hui, Zhang, Yuping, Zhang, Zhen, Zhao, Grace·2020·Cell
DOI 10.1016/j.cell.2020.01.026PMC PMC7233456
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Abstract

We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. We also characterized aspects of the tumor immune landscape, including immunogenic alterations, neoantigens, common cancer/testis antigens, and the immune microenvironment, all of which can inform immunotherapy decisions. Collectively, our multi-omic analyses provide a valuable resource for researchers and clinicians, identify new molecular associations of potential mechanistic significance in the development of endometrial cancers, and suggest novel approaches for identifying potential therapeutic targets.

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Authors
Dou, Y., Kawaler, E. A., Cui Zhou, D., Gritsenko, M. A., Huang, C., Blumenberg, L., Karpova, A., Petyuk, V. A., Savage, S. R., Satpathy, S., Liu, W., Wu, Y., Tsai, C.-F., Wen, B., Li, Z., Cao, S., Moon, J., Shi, Z., Cornwell, M., Wyczalkowski, M. A., Chu, R. K., Vasaikar, S., Zhou, H., Gao, Q., Moore, R. J., Li, K., Sethuraman, S., Monroe, M. E., Zhao, R., Heiman, D., Krug, K., Clauser, K., Kothadia, R., Maruvka, Y., Pico, A. R., Oliphant, A. E., Hoskins, E. L., Pugh, S. L., Beecroft, S. J. I., Adams, D. W., Jarman, J. C., Kong, A., Chang, H.-Y., Reva, B., Liao, Y., Rykunov, D., Colaprico, A., Chen, X. S., Czekański, A., Jędryka, M., Matkowski, R., Wiznerowicz, M., Hiltke, T., Boja, E., Kinsinger, C. R., Mesri, M., Robles, A. I., Rodriguez, H., Mutch, D., Fuh, K., Ellis, M. J., DeLair, D., Thiagarajan, M., Mani, D. R., Getz, G., Noble, M., Nesvizhskii, A. I., Wang, P., Anderson, M. L., Levine, D. A., Smith, R. D., Payne, S. H., Ruggles, K. V., Rodland, K. D., Ding, L., Zhang, B., Liu, T., Fenyö, D., Agarwal, A., Anurag, M., Avtonomov, D., Birger, C., Birrer, M. J., Boca, S. M., Bocik, W. E., Borate, U., Borucki, M., Burke, M. C., Cai, S., Calinawan, A., Carr, S. A., Carter, S., Castro, P., Cerda, S., Chaikin, M., Chan, D. W., Chan, D., Charamut, A., Chen, F., Chen, J., Chen, L., Chen, L. S., Chesla, D., Chheda, M. G., Chinnaiyan, A. M., Chowdhury, S., Cieslik, M. P., Clark, D. J., Cottingham, S., Culpepper, H., Day, J., De Young, S., Demir, E., Dhanasekaran, S. M., Dhir, R., Domagalski, M. J., Dottino, P., Druker, B., Duffy, E., Dyer, M., Edwards, N. J., Edwards, R., Elburn, K., Field, J. B., Francis, A., Gabriel, S., Geffen, Y., Geiszler, D., Gillette, M. A., Godwin, A. K., Grady, P., Hannick, L., Hariharan, P., Hilsenbeck, S., Hindenach, B., Hoadley, K. A., Hong, R., Hostetter, G., Hsieh, J. J., Hu, Y., Ittmann, M. M., Jaehnig, E., Jewell, S. D., Ji, J., Jones, C. D., Karabon, R., Ketchum, K. A., Khan, M., Kim, B.-J., Krek, A., Krubit, T., Kumar-Sinha, C., Leprevost, F. D., Lewis, M., Li, Q. K., Li, Y., Liu, H., Lubinski, J., Ma, W., Madan, R., Malc, E., Malovannaya, A., Mareedu, S., Markey, S. P., Marrero-Oliveras, A., Martignetti, J., McDermott, J., McGarvey, P. B., McGee, J., Mieczkowski, P., Modugno, F., Montgomery, R., Newton, C. J., Omenn, G. S., Paulovich, A. G., Perou, A. M., Petralia, F., Piehowski, P., Polonskaya, L., Qi, L., Richey, S., Robinson, K., Roche, N., Rohrer, D. C., Schadt, E. E., Schnaubelt, M., Shi, Y., Skelly, T., Sokoll, L. J., Song, X., Stein, S. E., Suh, J., Tan, D., Tansil, D., Teo, G. C., Thangudu, R. R., Tognon, C., Traer, E., Tyner, J., Um, K. S., Valley, D. R., Vatanian, N., Vats, P., Velvulou, U., Vernon, M., Wang, L.-B., Wang, Y., Webster, A., Westbrook, T., Wheeler, D., Whiteaker, J. R., Wilson, G. D., Zakhartsev, Y., Zelt, R., Zhang, H., Zhang, Y., Zhang, Z., & Zhao, G.
Affiliations
  • Baylor College of Medicine (US)
  • NYU Langone Health (US)
  • Pacific Northwest National Laboratory (US)
  • Washington University in St. Louis (US)
  • Broad Institute (US)
  • The University of Texas MD Anderson Cancer Center (US)
  • Gladstone Institutes (US)
  • Brigham Young University (US)
  • University of Michigan (US)
  • Icahn School of Medicine at Mount Sinai (US)
  • University of Miami (US)
  • Wroclaw Medical University (PL)
  • Poznan University of Medical Sciences (PL)
  • National Cancer Institute (US)
  • Frederick National Laboratory for Cancer Research (US)
  • University of South Florida (US)
Corresponding author
  • Rodland, Karin D.
  • Ding, Li
  • Zhang, Bing
  • Liu, Tao
  • Fenyö, David
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
2020-02
Volume
180
Issue
4
Pages
729-748.e26
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2020.01.026
PMC
PMC7233456
OpenAlex
W3006211741
Cited by
485
References
188
Citations by year
2026: 47 · 2025: 67 · 2024: 82 · 2023: 93 · 2022: 80 · 2021: 82 · 2020: 33
FWCI
45.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
Funders
School of Medicine, New York University
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
  • Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
  • Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
Keywords
endometrial cancer, proteogenomics, endometrioid carcinoma, serous carcinoma, p53 pathway, Wnt/β-catenin signaling, circular RNA, epithelial-mesenchymal transition, histone acetylation, tumor immune microenvironment, neoantigens, cancer-testis antigens, immunotherapy, therapeutic target, tumor subtypes
MeSH terms
Acetylation, Animals, Antigens, Neoplasm, Carcinoma, Female, Humans, Phosphorylation, Protein Processing, Post-Translational, Signal Transduction, Gene Expression Regulation, Neoplastic, Endometrial Neoplasms, Microsatellite Repeats, Proteome, Feedback, Physiological, MicroRNAs, Genomic Instability, Mice, Epithelial-Mesenchymal Transition, Transcriptome

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