The DOI matches its Crossref record; 272 of the 272 references it cites were found in a registry or an index.
Toll-like Receptors and the Control of Immunity
Open accessAbstract
The study of innate immunity and its link to inflammation and host defense encompasses diverse areas of biology, ranging from genetics and biophysics to signal transduction and physiology. Central to our understanding of these events are the Toll-like receptors (TLRs), an evolutionarily ancient family of pattern recognition receptors. Herein, we describe the mechanisms and consequences of TLR-mediated signal transduction with a focus on themes identified in the TLR pathways that also explain the operation of other immune signaling pathways. These themes include the detection of conserved microbial structures to identify infectious agents and the use of supramolecular organizing centers (SMOCs) as signaling organelles that ensure digital cellular responses. Further themes include mechanisms of inducible gene expression, the coordination of gene regulation and metabolism, and the influence of these activities on adaptive immunity. Studies in these areas have informed the development of next-generation therapeutics, thus ensuring a bright future for research in this area.
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“TLR9 activation induces the assembly of a supramolecular organizing center called the myddosome, involving MyD88 and multiple members of the serine threonine kinase family IRAK [82,83].”
From Risk mitigation of immunogenicity: a key to personalized retinal gene therapy (2021) · cites this paper as [83]
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Metadata
- Authors
- Fitzgerald, K. A., & Kagan, J. C.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Boston Children's Hospital (US)
- Corresponding author
- Fitzgerald, Katherine A.
- Kagan, Jonathan C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 180
- Issue
- 6
- Pages
- 1044-1066
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC9358771
- OpenAlex
- W3012283572
- Cited by
- 2,168
- References
- 272
- Citations by year
- 2026: 299 · 2025: 392 · 2024: 428 · 2023: 386 · 2022: 343 · 2021: 244 · 2020: 73
- FWCI
- 25.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 383 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Keywords
- Toll-like receptors, innate immunity, pattern recognition receptors, inducible gene expression, adaptive immunity, inflammation, host defense, therapeutics
- MeSH terms
- Animals, Humans, Immunity, Innate, Inflammation, Organelles, Signal Transduction, Toll-Like Receptors, Adaptive Immunity
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