Toll-like Receptors and the Control of Immunity

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996

Mutations affecting segment number and polarity in Drosophila

Nüsslein‐Volhard, C., & Wieschaus, E. F. (1980) · Nature · doi:10.1038/287795a0 · Cited by 4,370

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224

Gut microbiome and health: mechanistic insights

de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut · doi:10.1136/gutjnl-2021-326789 · Cited by 2,388

Pattern recognition receptors in health and diseases

Li, D., & Wu, M. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00687-0 · Cited by 1,961

Macrophages as tools and targets in cancer therapy

Mantovani, A., Allavena, P., Marchesi, F., & Garlanda, C. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00520-5 · Cited by 1,807

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

Ciesielska, A., Matyjek, M., & Kwiatkowska, K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03656-y · Cited by 1,420

Targeting HER2-positive breast cancer: advances and future directions

Swain, S. M., Shastry, M., & Hamilton, E. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00579-0 · Cited by 1,160

Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity

Duan, T., Du, Y., Xing, C., Wang, H. Y., & Wang, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.812774 · Cited by 1,080

Activation and evasion of type I interferon responses by SARS-CoV-2

Lei, X., Dong, X., Ma, R., Wang, W., Xiao, X., Tian, Z., Wang, C., Wang, Y., Li, L., Ren, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17665-9 · Cited by 980

Anti-Inflammatory Action and Mechanisms of Resveratrol

Meng, T., Xiao, D., Muhammed, A., Deng, J., Chen, L., & He, J. (2021) · Molecules · doi:10.3390/molecules26010229 · Cited by 743

Immune determinants of COVID-19 disease presentation and severity

Brodin, P. (2021) · Nature Medicine · doi:10.1038/s41591-020-01202-8 · Cited by 670

Hallmarks of Health

López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499

Molecular mechanisms of early plant pattern-triggered immune signaling

DeFalco, T. A., & Zipfel, C. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.07.029 · Cited by 475

TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation

Irizarry-Caro, R. A., McDaniel, M. M., Overcast, G. R., Jain, V. G., Troutman, T. D., & Pasare, C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009778117 · Cited by 472

Immunology of aging: the birth of inflammaging

Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08899-6 · Cited by 464

Signaling pathways of chronic kidney diseases, implications for therapeutics

Yuan, Q., Tang, B., & Zhang, C. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01036-5 · Cited by 508

Toll-Like Receptors (TLRs), NOD-Like Receptors (NLRs), and RIG-I-Like Receptors (RLRs) in Innate Immunity. TLRs, NLRs, and RLRs Ligands as Immunotherapeutic Agents for Hematopoietic Diseases

Wicherska‐Pawłowska, K., Wróbel, T., & Rybka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413397 · Cited by 451

Pathogenesis of pneumonia and acute lung injury

Long, M. E., Mallampalli, R. K., & Horowitz, J. C. (2022) · Clinical Science · doi:10.1042/cs20210879 · Cited by 418

Detection of Viral Infections by Innate Immunity

Carty, M., Guy, C., & Bowie, A. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114316 · Cited by 427

Immunomodulatory activities of polysaccharides from Ganoderma on immune effector cells

Ren, L., Zhang, J., & Zhang, T. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127933 · Cited by 354

A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)

Siddiqui, S., Mateen, S., Ahmad, R., & Moin, S. (2022) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-022-02625-7 · Cited by 404

Antiviral activity of bacterial TIR domains via immune signalling molecules

Ofir, G., Herbst, E., Baroz, M., Cohen, D., Millman, A., Doron, S., Tal, N., Malheiro, D. B. A., Malitsky, S., Amitai, G., et al. (2021) · Nature · doi:10.1038/s41586-021-04098-7 · Cited by 339

Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke

Endres, M., Moro, M. Á., Nolte, C. H., Dames, C., Buckwalter, M. S., & Meisel, A. (2022) · Circulation Research · doi:10.1161/circresaha.121.319994 · Cited by 359

Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review

Su, M., Tang, T. F., Tang, W., Yu, L., Wang, L., & Liu, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1243834 · Cited by 357

A Comprehensive Review of Risk Factors for Venous Thromboembolism: From Epidemiology to Pathophysiology

Pastori, D., Cormaci, V. M., Marucci, S., Franchino, G., Sole, F. D., Capozza, A., Fallarino, A., Corso, C., Valeriani, E., Menichelli, D., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043169 · Cited by 376

Toll‐Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility

Sameer, A. S., & Nissar, S. (2021) · BioMed Research International · doi:10.1155/2021/1157023 · Cited by 323

Pattern recognition receptors: function, regulation and therapeutic potential

Chen, R., Zou, J., Chen, J., Zhong, X. Y., Kang, R., & Tang, D. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02264-1 · Cited by 392

Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment

Xu, Z., Chen, Y., Ma, L., Chen, Y., Liu, J., Guo, Y., Yu, T., Zhang, L., Zhu, L., & Shu, Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.046 · Cited by 337

Cancer vaccines: Building a bridge over troubled waters

Sellars, M., Wu, C. J., & Fritsch, E. F. (2022) · Cell · doi:10.1016/j.cell.2022.06.035 · Cited by 332

Role of the cGAS–STING pathway in systemic and organ-specific diseases

Skopelja‐Gardner, S., An, J., & Elkon, K. B. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00589-6 · Cited by 318

Regulation of the nucleic acid-sensing Toll-like receptors

Lind, N. A., Rael, V. E., Pestal, K., Liu, B., & Barton, G. M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00577-0 · Cited by 308

A second-generation M1-polarized CAR macrophage with antitumor efficacy

Lei, A., Yu, H., Lu, S., Lu, H., Ding, X., Tan, T., Zhang, H., Zhu, M., Tian, L., Wang, X., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01687-8 · Cited by 326

Early glycolytic reprogramming controls microglial inflammatory activation

Cheng, J., Zhang, R., Xu, Z., Ke, Y., Sun, R., Yang, H., Zhang, X., Zhen, X., & Zheng, L.-T. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02187-y · Cited by 295

Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice

Ni, H., Wang, Y., Yao, K., Wang, L., Huang, J., Xiao, Y., Chen, H., Liu, B., Yang, C. Y., & Zhao, J. (2024) · Nature Communications · doi:10.1038/s41467-023-43650-z · Cited by 306

Calcium Signaling Mechanisms Across Kingdoms

Luan, S., & Wang, C. (2021) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120219-035210 · Cited by 278

Polarization of Tumor-Associated Macrophages by Nanoparticle-Loaded Escherichia coli Combined with Immunogenic Cell Death for Cancer Immunotherapy

Wei, B., Pan, J., Yuan, R., Shao, B., Wang, Y., Guo, X., & Zhou, S. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c00209 · Cited by 263

Regulatory role of short-chain fatty acids in inflammatory bowel disease

Zhang, Z., Zhang, H., Chen, T., Shi, L., Wang, D., & Tang, D. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00869-5 · Cited by 291

Harnessing innate immune pathways for therapeutic advancement in cancer

Hu, A.-K., Sun, L., Lin, H., Liao, Y., Yang, H., & Mao, Y. Q. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01765-9 · Cited by 286

Toll-Like Receptors: General Molecular and Structural Biology

Behzadi, P., García‐Perdomo, H. A., & Karpiński, T. M. M. (2021) · Journal of Immunology Research · doi:10.1155/2021/9914854 · Cited by 267

Innate immune evasion strategies of SARS-CoV-2

Minkoff, J. M., & tenOever, B. R. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00839-1 · Cited by 267

Bacillus cereus: Epidemiology, Virulence Factors, and Host–Pathogen Interactions

Tuipulotu, D. E., Mathur, A., Ngo, C., & Man, S. M. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.09.003 · Cited by 244

Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses

Chen, Y., Lin, J., Zhao, Y., Ma, X., & Yi, H. (2021) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2000808 · Cited by 260

Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

Chen, L., Qin, H., Zhao, R., Zhao, X., Lin, L., Chen, Y., Lin, Y., Li, Y., Qin, Y., Li, Y., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abc2816 · Cited by 240

Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization

Zhou, Z., Deng, T., Tao, M., Lin, L., Sun, L., Song, X., Gao, D., Li, J., Wang, Z., Wang, X., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122141 · Cited by 242

Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

Shi, S., Chen, Y., Luo, Z., Nie, G., & Dai, Y. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01077-5 · Cited by 251

Exploiting innate immunity for cancer immunotherapy

Yi, M., Li, T., Niu, M., Mei, Q., Zhao, B., Chu, Q., Dai, Z., & Wu, K. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01885-w · Cited by 250

Targeting innate immune pathways for cancer immunotherapy

Cao, L. L., & Kagan, J. C. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.018 · Cited by 234

Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206 + macrophages IL-10 activation

Jia, D., Wang, Q.-W., Hu, Y., He, J., Ge, Q., Qi, Y., Chen, L.-Y., Zhang, Y., Fan, L., Lin, Y., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2145843 · Cited by 222

Tumor-associated myeloid cells: diversity and therapeutic targeting

Mantovani, A., Marchesi, F., Jaillon, S., Garlanda, C., & Allavena, P. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00613-4 · Cited by 230

Phagocytic microglia and macrophages in brain injury and repair

Yu, F., Wang, Y., Stetler, R. A., Leak, R. K., Hu, X., & Chen, J. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13899 · Cited by 213

The Multiple Roles of Interferon Regulatory Factor family in Health and Disease

Wang, L., Zhu, Y., Zhang, N., Xian, Y., Tang, Y., Ye, J., Reza, F., He, G., Wen, X., & Jiang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01980-4 · Cited by 178

The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease

Mukherjee, T., Kumar, N., Chawla, M., Philpott, D. J., & Basak, S. (2024) · Science Signaling · doi:10.1126/scisignal.adh1641 · Cited by 213

How Do Sensory Neurons Sense Danger Signals?

Donnelly, C. R., Ouyang, C., & Ji, R. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.07.008 · Cited by 200

Acinetobacter baumannii: An Ancient Commensal with Weapons of a Pathogen

Sarshar, M., Behzadi, P., Scribano, D., Palamara, A. T., & Ambrosi, C. (2021) · Pathogens · doi:10.3390/pathogens10040387 · Cited by 194

Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

Zhao, X., Zhao, R., & Nie, G. (2022) · Nature Protocols · doi:10.1038/s41596-022-00713-7 · Cited by 198

The RING finger protein family in health and disease

Cai, C., Tang, Y., Zhai, J., & Zheng, C. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01152-2 · Cited by 204

The Release of Peripheral Immune Inflammatory Cytokines Promote an Inflammatory Cascade in PCOS Patients via Altering the Follicular Microenvironment

Liu, Y., Liu, H., Li, Z., Fan, H., Yan, X., Liu, X., Xuan, J., Feng, D., & Wei, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.685724 · Cited by 202

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS

Trowbridge, J. J., & Starczynowski, D. T. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201544 · Cited by 189

OMV Vaccines and the Role of TLR Agonists in Immune Response

Mancini, F., Rossi, O., Necchi, F., & Micoli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124416 · Cited by 178

Dendritic cell maturation in cancer

Moon, C. Y., Belabed, M., Park, M. D., Mattiuz, R., Puleston, D. J., & Mérad, M. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-024-00787-3 · Cited by 189

Direct activation of a bacterial innate immune system by a viral capsid protein

Zhang, T., Tamman, H., Wallant, K. C. ’., Kurata, T., LeRoux, M., Srikant, S., Brodiazhenko, T., Čepauskas, A., Talavera, A., Martens, C., et al. (2022) · Nature · doi:10.1038/s41586-022-05444-z · Cited by 174

A. Muciniphila Suppresses Colorectal Tumorigenesis by Inducing TLR2/NLRP3-Mediated M1-Like TAMs

Fan, L., Xu, C., Ge, Q., Lin, Y., Wong, C. C., Qi, Y., Ye, B., Lian, Q., Zhuo, W., Si, J., et al. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-1019 · Cited by 178

Viruses inhibit TIR gcADPR signalling to overcome bacterial defence

Leavitt, A., Yirmiya, E., Amitai, G., Lu, A., Garb, J., Herbst, E., Morehouse, B. R., Hobbs, S. J., Antine, S. P., Sun, Z.-Y. J., et al. (2022) · Nature · doi:10.1038/s41586-022-05375-9 · Cited by 171

Targeting macrophages in hematological malignancies: recent advances and future directions

Li, W., Wang, F., Guo, R., Bian, Z., & Song, Y. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01328-x · Cited by 174

Advances in the study of macrophage polarization in inflammatory immune skin diseases

Xia, T., Fu, S.-P., Yang, R., Kang, Y., Lei, W., Yang, Y., Zhang, Q., Zhao, Y., Jiang, Y. Y., Yu, L., et al. (2023) · Journal of Inflammation · doi:10.1186/s12950-023-00360-z · Cited by 184

Histone lactylation: from tumor lactate metabolism to epigenetic regulation

Yu, X., Yang, J., Xu, J., Pan, H., Wang, W. J., Yu, X., & Shi, S. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.91492 · Cited by 187

Inducible antibacterial responses in macrophages

Sweet, M. J., Ramnath, D., Singhal, A., & Kapétanovic, R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01080-y · Cited by 171

COVID 19: a clue from innate immunity

Birra, D., Benucci, M., Landolfi, L., Merchionda, A., Loi, G., Amato, P., Licata, G., Quartuccio, L., Triggiani, M., & Moscato, P. (2020) · Immunologic Research · doi:10.1007/s12026-020-09137-5 · Cited by 155

pH sensing at the intersection of tissue homeostasis and inflammation

Hajjar, S., & Zhou, X. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.08.008 · Cited by 165

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia

Rausch, V., Sala, V., Penna, F., Porporato, P. E., & Ghigo, A. (2021) · Oncogenesis · doi:10.1038/s41389-020-00288-6 · Cited by 149

Signaling pathways in macrophages: molecular mechanisms and therapeutic targets

Li, M., Wang, M., Wen, Y., Zhang, H., Zhao, G., & Gao, Q. (2023) · MedComm · doi:10.1002/mco2.349 · Cited by 165

Shared TIR enzymatic functions regulate cell death and immunity across the tree of life

Essuman, K., Milbrandt, J., Dangl, J. L., & Nishimura, M. T. (2022) · Science · doi:10.1126/science.abo0001 · Cited by 144

Exposure to polystyrene microplastics triggers lung injury via targeting toll-like receptor 2 and activation of the NF-κB signal in mice

Cao, J., Xu, R., Geng, Y., Xu, S., & Guo, M. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121068 · Cited by 152

Can SARS-CoV-2 Virus Use Multiple Receptors to Enter Host Cells?

Gadanec, L. K., McSweeney, K. R., Qaradakhi, T., Ali, B. A., Zulli, A., & Apostolopoulos, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22030992 · Cited by 147

IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial

Ackerman, L., Acloque, G., Bacchelli, S., Schwartz, H., Feinstein, B. J., Stella, P. L., Alavi, A., Gollerkeri, A. M., Davis, J., Campbell, V., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02635-7 · Cited by 146

Control of adaptive immunity by pattern recognition receptors

Carroll, S. L., Pasare, C., & Barton, G. M. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.014 · Cited by 155

Targeting toll-like receptor 7/8 for immunotherapy: recent advances and prospectives

Sun, H., Li, Y., Zhang, P., Xing, H., Zhao, S. Q., Song, Y., Wan, D., & Yu, J. (2022) · Biomarker Research · doi:10.1186/s40364-022-00436-7 · Cited by 150

Inflammaging: The ground for sarcopenia?

Liang, Z., Zhang, T., Liu, H., Li, Z., Peng, L., Wang, C., & Wang, T. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111931 · Cited by 156

Single-Cell RNA Sequencing Reveals the Heterogeneity of Tumor-Associated Macrophage in Non-Small Cell Lung Cancer and Differences Between Sexes

Yang, Q., Zhang, H., Wei, T., Lin, A., Sun, Y., Luo, P., & Zhang, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.756722 · Cited by 144

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

Orzalli, M. H., Prochera, A., Payne, L., Smith, A., Garlick, J. A., & Kagan, J. C. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.012 · Cited by 136

Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex

Wang, J., Xue, X., Zhao, X., Luo, L., Liu, J., Dai, S., Zhang, F., Wu, R., Liu, Y., Peng, C. Y., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.08.006 · Cited by 142

Necroptosis: A Novel Pathway in Neuroinflammation

Yu, Z., Jiang, N., Su, W., & Zhuo, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.701564 · Cited by 134

Tumor-Associated Macrophages: A Potential Target for Cancer Therapy

Tan, Y., Wang, M., Zhang, Y., Ge, S., Zhong, F., Xia, G., & Sun, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.693517 · Cited by 138

Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines

Sartorius, R., Trovato, M., Manco, R., D’Apice, L., & Berardinis, P. D. (2021) · npj Vaccines · doi:10.1038/s41541-021-00391-8 · Cited by 140

Modulation of Macrophage Immunometabolism: A New Approach to Fight Infections

Gauthier, T., & Chen, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.780839 · Cited by 137

Toll-like receptor 9 agonists and combination therapies: strategies to modulate the tumour immune microenvironment for systemic anti-tumour immunity

Dongye, Z., Li, J., & Wu, Y. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01876-6 · Cited by 138

DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease

Chen, J., Wang, T., Li, X., Gao, L., Wang, K., Cheng, M., Zeng, Z., Chen, L., Shen, Y., & Wen, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01881-6 · Cited by 143

Regulation of innate immune signaling by IRAK proteins

Pereira, M. C. A., & Gazzinelli, R. T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133354 · Cited by 134

Mutual regulation of metabolic processes and proinflammatory NF-κB signaling

Kracht, M., Müller‐Ladner, U., & Schmitz, M. L. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.07.027 · Cited by 129

Traditional application and modern pharmacological research of Eucommia ulmoides Oliv.

Huang, L., Lyu, Q., Zheng, W., Yang, Q., & Cao, G. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00482-7 · Cited by 133

Innate immune detection of lipid oxidation as a threat assessment strategy

Zhivaki, D., & Kagan, J. C. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00618-8 · Cited by 129

The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways

Pereira, M. C. A., Durso, D. F., Bryant, C. E., Kurt‐Jones, E. A., Silverman, N. S., Golenbock, D. T., & Gazzinelli, R. T. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111225 · Cited by 127

Recent Advances in the Development of Toll-like Receptor Agonist-Based Vaccine Adjuvants for Infectious Diseases

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