Fitzgerald, Katherine A

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature

Inflammasome and immune disordersAtherosclerosis and Cardiovascular Diseases

Cited by 4,026

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 3,065

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology

Inflammasome and immune disordersAutophagy in Disease and Therapy

Cited by 3,049

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature

Inflammasome and immune disordersinterferon and immune responses

Cited by 2,627

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 2,441

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,282

Toll-like Receptors and the Control of Immunity

Fitzgerald, K. A., & Kagan, J. C. (2020) · Cell

Immune Response and InflammationInflammasome and immune disorders

Cited by 2,168

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

Woo, S.-R., Fuertes, M. B., Corrales, L., Spranger, S., Furdyna, M. J., Leung, M. Y. K., Duggan, R., Wang, Y., Barber, G. N., Fitzgerald, K. A., et al. (2014) · Immunity

interferon and immune responsesImmunotherapy and Immune Responses

Cited by 1,917

IFI16 is an innate immune sensor for intracellular DNA

Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., et al. (2010) · Nature Immunology

interferon and immune responsesImmune Response and Inflammation

Cited by 1,643

DNA sensing by the cGAS–STING pathway in health and disease

Motwani, M., Pesiridis, S., & Fitzgerald, K. A. (2019) · Nature Reviews Genetics

interferon and immune responsesImmune Response and Inflammation

Cited by 1,467

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology

Immune Response and InflammationAdvanced Glycation End Products research

Cited by 1,372

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology

Inflammasome and immune disordersAutophagy in Disease and Therapy

Cited by 1,367

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,353

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Rathinam, V. A. K., Jiang, Z., Waggoner, S. N., Sharma, S., Cole, L. E., Waggoner, L., Vanaja, S. K., Monks, B. G., Ganesan, S., Latz, E., et al. (2010) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,331

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

Sheedy, F. J., Grebe, A., Rayner, K. J., Kalantari, P., Ramkhelawon, B., Carpenter, S. B., Becker, C. E., Ediriweera, H. N., Mullick, A. E., Golenbock, D. T., et al. (2013) · Nature Immunology

Inflammasome and immune disordersAtherosclerosis and Cardiovascular Diseases

Cited by 935

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

Harris, J., Hartman, M., Roche, C., Zeng, S. G., O'Shea, A., Sharp, F. A., Lambe, E. M., Creagh, E. M., Golenbock, D. T., Tschopp, J., et al. (2011) · Journal of Biological Chemistry

Inflammasome and immune disordersAutophagy in Disease and Therapy

Cited by 794

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

Rathinam, V. A. K., Vanaja, S. K., Waggoner, L., Sokolovska, A., Becker, C., Stuart, L. M., Leong, J. M., & Fitzgerald, K. A. (2012) · Cell

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 729

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

El Kasmi, K. C., Qualls, J. E., Pesce, J. T., Smith, A. M., Thompson, R. W., Henao-Tamayo, M., Basaraba, R. J., König, T., Schleicher, U., Koo, M.-S., et al. (2008) · Nature Immunology

Immune Response and InflammationTuberculosis Research and Epidemiology

Cited by 646

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

Mishra, B. B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., & Sassetti, C. M. (2013) · Nature Immunology

Inflammasome and immune disordersTuberculosis Research and Epidemiology

Cited by 571

Mechanisms of inflammasome activation: recent advances and novel insights

Vanaja, S. K., Rathinam, V. A. K., & Fitzgerald, K. A. (2015) · Trends in Cell Biology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 499

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

Schoenemeyer, A., Barnes, B. J., Mancl, M. E., Latz, E., Goutagny, N., Pitha, P. M., Fitzgerald, K. A., & Golenbock, D. T. (2005) · Journal of Biological Chemistry

interferon and immune responsesImmune Response and Inflammation

Cited by 411

Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS

Reinert, L. S., Lopušná, K., Winther, H., Sun, C., Thomsen, M. K., Nandakumar, R., Mogensen, T. H., Meyer, M., Vægter, C., Nyengaard, J. R., et al. (2016) · Nature Communications

interferon and immune responsesHerpesvirus Infections and Treatments

Cited by 397

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

Jakobsen, M. R., Bak, R. O., Andersen, A., Berg, R. K., Jensen, S. B., Jin, T., Laustsen, A., Hansen, K., Østergaard, L., Fitzgerald, K. A., et al. (2013) · Proceedings of the National Academy of Sciences

interferon and immune responsesHIV Research and Treatment

Cited by 344

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Liehl, P., Zuzarte-Luís, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K. K., Carret, C., Lassnig, C., et al. (2014) · Nature Medicine

interferon and immune responsesMalaria Research and Control

Cited by 313