The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Impact of GPCR Structures on Drug Discovery
Open accessAbstract
Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of these drug candidates have entered clinical trials. Given the length of time required for a drug to reach the market, there are no documented examples of licensed drugs being developed with the aid of a structure, but this is likely to change as current efforts come to fruition.
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Cites
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Synthon-based ligand discovery in virtual libraries of over 11 billion compounds
Sadybekov, A. A., Sadybekov, A. V., Liu, Y., Iliopoulos-Tsoutsouvas, C., Huang, X.-P., Pickett, J., Houser, B., Patel, N., Tran, N. K., Tong, F., et al. (2022) · Nature · doi:10.1038/s41586-021-04220-9 · Cited by 417
Multi‐state modeling of G‐protein coupled receptors at experimental accuracy
Heo, L., & Feig, M. (2022) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.26382 · Cited by 215
Structures of the σ2 receptor enable docking for bioactive ligand discovery
Alon, A., Lyu, J., Braz, J. M., Tummino, T. A., Craik, V., O’Meara, M. J., Webb, C. M., Radchenko, D. S., Moroz, Y. S., Huang, X.-P., et al. (2021) · Nature · doi:10.1038/s41586-021-04175-x · Cited by 211
Sala, D., Hildebrand, P. W., & Meiler, J. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1121962 · Cited by 80
Metadata
- Authors
- Congreve, M., de Graaf, C., Swain, N. A., & Tate, C. G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 181
- Issue
- 1
- Pages
- 81-91
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3014501695
- Cited by
- 375
- References
- 100
- FWCI
- 14.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
