The DOI matches its Crossref record; 252 of the 252 references it cites were found in a registry or an index.
Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
Open accessAbstract
The view that sleep is essential for survival is supported by the ubiquity of this behavior, the apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep loss can be lethal. The cause of this lethality is unknown. Here we show, using flies and mice, that sleep deprivation leads to accumulation of reactive oxygen species (ROS) and consequent oxidative stress, specifically in the gut. ROS are not just correlates of sleep deprivation but drivers of death: their neutralization prevents oxidative stress and allows flies to have a normal lifespan with little to no sleep. The rescue can be achieved with oral antioxidant compounds or with gut-targeted transgenic expression of antioxidant enzymes. We conclude that death upon severe sleep restriction can be caused by oxidative stress, that the gut is central in this process, and that survival without sleep is possible when ROS accumulation is prevented. VIDEO ABSTRACT.
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In the citing paper
“severe sleep loss causes accumulation of ROS in the gut (but not the brain) of both flies and mice, which was associated with death of the flies”
From Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis (2020) · cites this paper as [225]
In the citing paper
“all these effects could be prevented by oral administration of antioxidant compounds or through gut-targeted transgenic expression of antioxidant enzymes.”
From Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis (2020) · cites this paper as [225]
In the citing paper
“the antioxidant components of coffee (like melatonin, one of the antioxidant compounds used in the mentioned study by Rogulja and collaborators, [225]) may prevent accumulation of ROS in the gut and avoid the deleterious effect of voluntary sleep restriction.”
From Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis (2020) · cites this paper as [225]
In the citing paper
“sleep deprivation caused mice and flies death through the accumulation of reactive oxygen species (ROS) in the gut [20]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway (2023) · cites this paper as [20]
Citations
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Liang, B., Zhong, Y., Huang, Y., Lin, X., Liu, J., Lin, L., Hu, M., Jiang, J., Dai, M., Wang, B., et al. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-021-00414-1 · Cited by 508
Hulse, B. K., Haberkern, H., Franconville, R., Turner-Evans, D., Takemura, S.-Y., Wolff, T., Noorman, M., Dreher, M., Dan, C., Parekh, R., et al. (2021) · eLife · doi:10.7554/elife.66039 · Cited by 392
Oxidative eustress: On constant alert for redox homeostasis
Sies, H. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101867 · Cited by 353
Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals
Sang, D., Lin, K., Yang, Y., Ran, G., Li, B., Chen, C., Li, Q., Ma, Y., Lu, L., Cui, X., et al. (2023) · Cell · doi:10.1016/j.cell.2023.10.025 · Cited by 281
Wang, Y., Chen, Y., Zhang, X., Lu, Y., & Chen, H. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104248 · Cited by 265
Metadata
- Authors
- Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D.
- Affiliations
- Harvard University (US)
- Corresponding author
- Rogulja, Dragana
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 181
- Issue
- 6
- Pages
- 1307-1328.e15
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3033924751
- Cited by
- 541
- References
- 252
- Citations by year
- 2026: 79 · 2025: 127 · 2024: 109 · 2023: 92 · 2022: 63 · 2021: 53 · 2020: 18
- FWCI
- 18.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pew Charitable Trusts
- New York Stem Cell Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, reactive oxygen species, oxidative stress, intestine, antioxidant enzymes, lifespan, oral antioxidants, Drosophila, mice
- MeSH terms
- Animals, Antioxidants, Drosophila, Male, Mice, Inbred CBA, Mice, Inbred C57BL, Sleep, Sleep Deprivation, Reactive Oxygen Species, Oxidative Stress, Gastrointestinal Tract, Mice
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