TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Molgora, Martina, Esaulova, Ekaterina, Vermi, William, Hou, Jinchao, Chen, Yun, Luo, Jingqin, Brioschi, Simone, Bugatti, Mattia +13 more·2020·Cell

Cited by (657)

Items 101–200 of 657

  1. Tumor microenvironment and immunotherapy for triple-negative breast cancer
    Zi-Jie Guo, Zi-Yu Zhu, Xi-Xi Lin, Shenkangle Wang, Yi-Hong Wen, Lin-Bo Wang, Li-Li Zhi, Ji-Chun Zhou · 2024 · Biomarker Research
  2. A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma
    Adele M. Alchahin, Shenglin Mei, Ιωάννα Τσέα, Taghreed Hirz, Youmna Sami Kfoury, Douglas M. Dahl, Chin‐Lee Wu, Alexander O. Subtelny, Shulin Wu, David T. Scadden et al. · 2022 · Nature Communications
  3. Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment
    Sayali Onkar, Jian Cui, Jian Zou, Carly Cardello, Anthony Richard Cillo, Mostofa Rafid Uddin, April Sagan, Marion Joy, Hatice U. Osmanbeyoglu, Katherine L. Pogue–Geile et al. · 2023 · Nature Cancer
  4. Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing–Assisted Multiomics Analysis
    Xuanwen Bao, Qiong Li, Jinzhang Chen, Diyu Chen, Chanqi Ye, Xiaomeng Dai, Yanfang Wang, Xin Li, Xiaoxiang Rong, Fei Cheng et al. · 2022 · Cancer Immunology Research
  5. Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models
    Filippo Birocchi, Melania Cusimano, Federico Rossari, Stefano Beretta, Paola M. V. Rancoita, Anna Ranghetti, Stefano Colombo, Barbara Costa, Peter E. Angel, Francesca Sanvito et al. · 2022 · Science Translational Medicine
  6. Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling
    Ido Yofe, Tomer Landsberger, Adam Yalin, Isabelle Solomon, Cristóbal Costoya, Dafne Franz Demane, Mansi Shah, Eyal David, Chamutal Borenstein, Oren Barboy et al. · 2022 · Nature Cancer
  7. Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome
    Gabriela Rapozo Guimarães, Giovanna Resk Maklouf, Cristiane Esteves Teixeira, Leandro de Oliveira Santos, Nayara Gusmão Tessarollo, Nayara Evelin de Toledo, Alessandra Freitas Serain, Cristóvão Antunes de Lanna, Marco Antônio M. Pretti, Jéssica Gonçalves Vieira da Cruz et al. · 2024 · Nature Communications
  8. TREM2: A new player in the tumor microenvironment
    Martina Molgora, Yizhou A. Liu, Marco Colonna, Marina Cella · 2023 · Seminars in Immunology
  9. Macrophage diversity in human cancers: New insight provided by single-cell resolution and spatial context
    Militsa A. Rakina, Irina Larionova, Julia G. Kzhyshkowska · 2024 · Heliyon
  10. TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity
    Cui, Huachun, Banerjee, Sami, Xie, Na, Hussain, Musaddique, Jaiswal, Ashish, Liu, Hongli, Kulkarni, Tejaswini, Antony, Veena B., Liu, Rui-Ming, Colonna, Marco et al. · 2025 · Nature Communications
  11. Function of TREM1 and TREM2 in Liver-Related Diseases
    Huifang Sun, Jianguo Feng, Liling Tang · 2020 · Cells
  12. Targeting tumor-associated macrophages for successful immunotherapy of ovarian carcinoma
    Iva Truxová, David Cibula, Radek Špíšek, Jitka Palich Fucikova · 2023 · Journal for ImmunoTherapy of Cancer
  13. TREM2/β-catenin attenuates NLRP3 inflammasome-mediated macrophage pyroptosis to promote bacterial clearance of pyogenic bacteria
    Wang, Yi, Cao, Can, Zhu, Yanting, Fan, Huifeng, Liu, Qiaojuan, Liu, Yiting, Chen, Kang, Wu, Yongjian, Liang, Siping, Li, Meiyu et al. · 2022 · Cell Death & Disease
  14. Targeting macrophages: a novel treatment strategy in solid tumors
    Mengmeng Liu, Lina Liu, Yongping Song, Wei Li, Linping Xu · 2022 · Journal of Translational Medicine
  15. Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2
    Yu Chen, Eleonora Maries Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jinchao Hou, Kai Schlepckow, Simone Degan, Lindsey A. Chew et al. · 2024 · The Journal of Experimental Medicine
  16. Macrophages and T cells in metabolic disorder-associated cancers
    Daniel Taranto, D. Kloosterman, L. Akkari · 2024 · Nature Reviews. Cancer
  17. TREM2 marks tumor-associated macrophages
    Kyohei Nakamura, Mark John Smyth · 2020 · Signal Transduction and Targeted Therapy
  18. TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer’s Disease: Lessons Learned from Transcriptomics
    Feng Xue, Heng Du · 2021 · Cells
  19. Timing and location dictate monocyte fate and their transition to tumor-associated macrophages
    Garett Dunsmore, Wei Guo, Ziyi Li, David Alejandro Bejarano, Rhea Pai, Katharine Lu Yang, Immanuel Kwok, Leonard Tan, Melissa Shu Feng Ng, Carlos de la Calle‐Fabregat et al. · 2024 · Science Immunology
  20. Cytocidal macrophages in symbiosis with CD4 and CD8 T cells cause acute diabetes following checkpoint blockade of PD-1 in NOD mice
    Hao Hu, Pavel N. Zakharov, Orion J. Peterson, Emil R. Unanue · 2020 · Proceedings of the National Academy of Sciences
  21. Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
    Yan Tang, David J. Kwiatkowski, Elizabeth P. Henske · 2022 · Nature Communications
  22. The tumour microenvironment in pancreatic cancer — new clinical challenges, but more opportunities
    Heng‐Chung Kung, Kevin Zheng, Jacquelyn W. Zimmerman, Lei Zheng · 2025 · Nature Reviews Clinical Oncology
  23. Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes
    Laura Ardighieri, Francesco Missale, Mattia Bugatti, Luisa Benerini Gatta, Irene Pezzali, Matilde Monti, Stefano Gottardi, Laura Zanotti, Eliana Bignotti, Antonella Ravaggi et al. · 2021 · Frontiers in Immunology
  24. Exploring the Impact of TREM2 in Tumor-Associated Macrophages
    Darya Khantakova, Simone Brioschi, Martina Molgora · 2022 · Vaccines
  25. Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti–PD-1 resistance
    Ashwin Ajith, Kenza Mamouni, Daniel David Horuzsko, Abu Musa, Amiran Dzutsev, Jennifer R. Fang, Ahmed Chadli, Xingguo Zhu, Iryna Lebedyeva, Giorgio Trinchieri et al. · 2023 · Journal of Clinical Investigation
  26. Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions
    Shenglin Mei, Adele M. Alchahin, Ιωάννα Τσέα, Youmna Sami Kfoury, Taghreed Hirz, Nathan Elias Jeffries, Ting Zhao, Yanxin Xu, Hanyu Zhang, Hirak Sarkar et al. · 2024 · Genome Medicine
  27. Turning enemies into allies—reprogramming tumor-associated macrophages for cancer therapy
    Martina Molgora, Marco Colonna · 2021 · Med
  28. Reprogramming of Hepatic Metabolism and Microenvironment in Nonalcoholic Steatohepatitis
    Liangyou Rui, Jiandie D. Lin · 2022 · Annual Review of Nutrition
  29. Sopa: a technology-invariant pipeline for analyses of image-based spatial omics
    Quentin Blampey, Kevin Mulder, Margaux Gardet, Stergios Christodoulidis, Charles‐Antoine Dutertre, Fabrice André, Florent Ginhoux, Paul-Henry Cournède · 2024 · Nature Communications
  30. Targeting tumour-reprogrammed myeloid cells: the new battleground in cancer immunotherapy
    Francesco De Sanctis, Annalisa Adamo, Stefania Canè, Stefano Ugel · 2022 · Seminars in Immunopathology
  31. Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes
    Yoshihiro Komohara, Daisuke Kurotaki, Hirotake Tsukamoto, Yuko Miyasato, Hiromu Yano, Cheng Pan, Yutaka Yamamoto, Yukio Fujiwara · 2023 · Cancer Science
  32. TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti–PD-1 tumor immunotherapy
    Di Luccia, Blanda, Molgora, Martina, Khantakova, Darya, Jaeger, Natalia, Chang, Hao-Wei, Czepielewski, Rafael S., Helmink, Beth A., Onufer, Emily J., Fachi, José L., Bhattarai, Bishan et al. · 2024 · Science Immunology
  33. Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
    Adriana M. Mujal, Alexis J. Combes, Arjun A. Rao, Mikhail Binnewies, Bushra Samad, Jessica Tsui, Alexandre Boissonnas, Joshua L. Pollack, Rafael José Argüello, Maxwell V. Meng et al. · 2022 · Cancer Immunology Research
  34. Immunotherapy in soft tissue and bone sarcoma: unraveling the barriers to effectiveness
    Myrofora Panagi, Pampina Pilavaki, Anastasia Constantinidou, Triantafyllos Stylianopoulos · 2022 · Theranostics
  35. Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma
    Mekenzie Peshoff, Pravesh Gupta, Shivangi Oberai, Rakesh Trivedi, Hiroshi G. Katayama, Prashanth Chakrapani, Minghao Dang, Simona Migliozzi, Joy Gumin, Divya B Kadri et al. · 2024 · Neuro-Oncology
  36. Lactation-associated macrophages exist in murine mammary tissue and human milk
    Dilay Cansever, Ekaterina Petrova, Sinduya Krishnarajah, Caroline Mussak, Christina A. Welsh, Wiebke Mildenberger, Kevin Mulder, Victor Kreiner, E. Roussel, Sebastian A. Stifter et al. · 2023 · Nature Immunology
  37. Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation
    Hannah Theobald, David Alejandro Bejarano, Natalie Katzmarski, Jessica Haub, Jonas Schulte-Schrepping, Jiangyan Yu, Kevin E. Bassler, A. L. Ament, Collins Osei-Sarpong, Federica Piattini et al. · 2024 · Nature Immunology
  38. Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
    Christopher A Alvarez-Breckenridge, Samuel C. Markson, Jackson H. Stocking, Naema Nayyar, Matt Lastrapes, Matthew R. Strickland, Albert Eusik Kim, Magali A. de Sauvage, Ashish Dahal, Juliana M. Larson et al. · 2022 · Cancer Immunology Research
  39. Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells
    Ada Gabriela Blidner, Camila Agustina Bach, Pablo A. García, Joaquin Pedro Merlo, Alejandro J. Cagnoni, Nadia Bannoud, Montana N Manselle Cocco, Juan M. Pérez‐Sáez, Nicolás A. Pinto, Nicolás I. Torres et al. · 2025 · Immunity
  40. Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1–Dependent Myeloid Cells
    Lee-Ann Van de Velde, Emma Kaitlynn Allen, Jeremy Chase Crawford, Taylor Leigh Wilson, Clifford S. Guy, Marion Russier, Leonie Zeitler, Armita Bahrami, David Finkelstein, S. William Pelletier et al. · 2021 · Cancer Research
  41. Mapping Breast Cancer Microenvironment Through Single-Cell Omics
    Zhenya Tan, Kan Chen, Minqiong Sun, Fan Yang, Mandy Wong, Siying Wang, Hong Zheng · 2022 · Frontiers in Immunology
  42. Macrophage and monocyte subsets as new therapeutic targets in cancer immunotherapy
    Birgit Fendl, Anna Sophie Berghoff, Matthias Preusser, B. Maier · 2023 · ESMO Open
  43. Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer
    K. Hu, Nicholas F. Kuhn, Tristan Courau, Jessica L. Tsui, B. Samad, Patrick K. Ha, J. Kratz, A. Combes, M. Krummel · 2023 · Cell Stem Cell
  44. Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
    Samarth Hegde, B. Giotti, Brian Y. Soong, Laszlo Halasz, Jessica Le Berichel, Maximilian M. Schaefer, Benoît Kloeckner, R. Mattiuz, Matthew D. Park, A. Magen et al. · 2025 · Nature
  45. Immunosuppressive landscape in hepatocellular carcinoma revealed by single-cell sequencing
    Yi Bai, Dapeng Chen, Chuanliang Cheng, Zhongmin Li, Hao Chi, Yuliang Zhang, Xiaoyu Zhang, Shaohai Tang, Qiang Zhao, Yamin Zhang et al. · 2022 · Frontiers in Immunology
  46. The therapeutic potential of TREM2 in cancer
    Elysa M. Wolf, B. Fingleton, A. Hasty · 2022 · Frontiers in Oncology
  47. Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors
    Ángel F. Álvarez-Prado, Roeltje R. Maas, Klara Soukup, Florian Klemm, Mara Kornete, Fanny S. Krebs, Vincent Zoete, Sabina Berezowska, Jean‐Philippe Brouland, Andreas Felix Hottinger et al. · 2023 · Cell Reports Medicine
  48. TREM2 Depletion in Pancreatic Cancer Elicits Pathogenic Inflammation and Accelerates Tumor Progression via Enriching IL-1β+ Macrophages
    Daowei Yang, Xinlei Sun, Hua Wang, Ignacio Ivan Wistuba, Huamin Wang, Anirban Maitra, Yang Chen · 2025 · Gastroenterology
  49. Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma
    William H. Tomaszewski, Jessica Waibl Polania, Molly A. Chakraborty, Jonathan Perera, Jeremy J. Ratiu, Alexandra M. Hoyt-Miggelbrink, Donald Patrick McDonnell, Mustafa Khasraw, David M. Ashley, Peter Edward Fecci et al. · 2022 · Nature Communications
  50. At the Interface of Tumor-Associated Macrophages and Fibroblasts: Immune-Suppressive Networks and Emerging Exploitable Targets
    Timperi, Eleonora, Croizer, Hugo, Khantakova, Darya, Rana, Mhaidly, Molgora, Martina, Guerriero, Jennifer L., Mechta-Grigoriou, Fatima, Romano, Emanuela · 2024 · Clinical Cancer Research
  51. Tumor-Derived Myeloid Cell Chemoattractants and T Cell Exclusion in Pancreatic Cancer
    Robert H. Vonderheide, Adham Sean Bear · 2020 · Frontiers in Immunology
  52. Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential
    Rodrigo Carlessi, Elena Denisenko, Ebru Boslem, Julia Köhn‐Gaone, Nathan Main, N. Dianah B. Abu Bakar, Gayatri D. Shirolkar, Matthew Jones, Aaron B. Beasley, Daniel Poppe et al. · 2023 · Cell Genomics
  53. Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas
    Wenshu Tang, Cario W.S. Lo, Wei Ma, Annie Tsz-Wai Chu, Amy H.Y. Tong, Brian Hon‐Yin Chung · 2024 · Cell & Bioscience
  54. NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment
    Carlos de la Calle‐Fabregat, Josep Calafell-Segura, Margaux Gardet, Garett Dunsmore, Kevin Mulder, Laura Ciudad, Aymeric Silvin, Joaquim Moreno‐Càceres, Angel Luis Corbí, Cristina Muñoz‐Pinedo et al. · 2024 · Science Advances
  55. Targeting the Tumor Microenvironment: A Close Up of Tumor-Associated Macrophages and Neutrophils
    Massimo Russo, Claudia Nastasi · 2022 · Frontiers in Oncology
  56. A Population of TIM4+FOLR2+ Macrophages Localized in Tertiary Lymphoid Structures Correlates to an Active Immune Infiltrate Across Several Cancer Types
    Mattia Bugatti, Marco Bergamini, Francesco Missale, Matilde Monti, Laura Ardighieri, Irene Pezzali, Sara Picinoli, Nicoletta Caronni, Yoann Missolo-Koussou, Julie Helft et al. · 2022 · Cancer Immunology Research
  57. TREM2 scFv‐Engineering Escherichia coli Displaying Modulation of Macrophages to Boost Cancer Radio‐Immunotherapy
    Yifan Wang, Anqi Dong, Jianping Man, Hua Chen, Wenhao Shen, Lei Wang, Hongli Yang, Lin Hu, Kai Yang · 2025 · Advanced Materials
  58. Metabolism archetype cancer cells induce protumor TREM2+ macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma
    Tianhao Chu, Gui‐Qi Zhu, Zheng Tang, Wei‐Feng Qu, Rui Yang, Haiting Pan, Yì Wáng, Ruilin Tian, Leilei Chen, Zhiqi Guan et al. · 2025 · Nature Communications
  59. Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy
    Qicong Luo, Zinan Dong, Wen Xie, Xiaoteng Fu, Lingyun Lin, Qiang Zeng, Yinggang Chen, Guodong Ye, Maoli Chen, Huiyu Hu et al. · 2023 · Cell Reports
  60. ZEB2 is a master switch controlling the tumor-associated macrophage program
    Fadi Sheban, Truong San Phan, Ken Xie, Florian Ingelfinger, Chamutal Gur, Yuval Shapir Itai, Ronnie Blecher‐Gonen, Chunsong Yu, Roberto Avellino, Paulina Chalan et al. · 2025 · Cancer Cell
  61. Tumor associated macrophage in HPV+ tumors: Between immunosuppression and inflammation
    Laurent Gorvel, Daniel Olive · 2022 · Seminars in Immunology
  62. Efferocytosis by macrophages in physiological and pathological conditions: regulatory pathways and molecular mechanisms
    Yan-Ran Sheng, Wen-Ting Hu, Si-Man Chen, Xiao-Yong Zhu · 2024 · Frontiers in Immunology
  63. Vax-Innate: improving therapeutic cancer vaccines by modulating T cells and the tumour microenvironment
    Faezzah Baharom, Dalton Hermans, Lélia Delamarre, Robert A. Seder · 2024 · Nature reviews. Immunology
  64. Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung adenocarcinoma
    Yifeng Ren, Qiong Ma, Xiao Feng Zeng et al. · 2024 · Molecular Cancer
  65. An integrated overview of the immunosuppression features in the tumor microenvironment of pancreatic cancer
    Jinglong Guo, Siyue Wang, Qi Gao · 2023 · Frontiers in Immunology
  66. What Happens to the Immune Microenvironment After PD-1 Inhibitor Therapy?
    Qingyi Wang, Bin Xie, Shuang Liu, Ying Shi, Yongguang Tao, Desheng Xiao, Wenxiang Wang · 2021 · Frontiers in Immunology
  67. Fibroblast growth factor receptor 3 mutation attenuates response to immune checkpoint blockade in metastatic urothelial carcinoma by driving immunosuppressive microenvironment
    Yuxuan Song, Yun Peng, Caipeng Qin, Yulong Wang, Wenbo Yang, Yiqing Du, Tao Xu · 2023 · Journal for ImmunoTherapy of Cancer
  68. Immune Dysregulation in Obesity
    Zewen Jiang, Chihiro Tabuchi, Sarah G. Gayer, Sagar P. Bapat · 2025 · Annual Review of Pathology Mechanisms of Disease
  69. TREM2 is associated with tumor immunity and implies poor prognosis in glioma
    Mingchen Yu, Yuanhao Chang, You Zhai, Bo Pang, Peng Wang, Guanzhang Li, Tao Jiang, Fan Zeng · 2023 · Frontiers in Immunology
  70. Tumor-Infiltrating Myeloid Cells Co-Express TREM1 and TREM2 and Elevated TREM-1 Associates With Disease Progression in Renal Cell Carcinoma
    Jill W. Ford, Marieli Gonzalez-Cotto, Alexander W. Macfarlane, Suraj Peri, O. M. Zack Howard, Jeffrey J. Subleski, Karen J Ruth, Mohammed Haseebuddin, Tahseen Al‐Saleem, Youfeng Yang et al. · 2022 · Frontiers in Oncology
  71. The role of tumor-associated macrophages in oral squamous cell carcinoma
    Yiwen Xue, Xiao Jie Song, Siyu Fan, Runzhi Deng · 2022 · Frontiers in Physiology
  72. Colorectal Cancer Immunotherapy: State of the Art and Future Directions
    Cornista, Alyssa Mauri, Giolito, Maria Virginia, Baker, Kristi, Hazime, Hajar, Dufait, Inès, Datta, Jashodeep, Khumukcham, Saratchandra Singh, De Ridder, Mark, Roper, Jatin, Abreu, Maria T. et al. · 2023 · Gastro Hep Advances
  73. Advanced insights on tumor-associated macrophages revealed by single-cell RNA sequencing: The intratumor heterogeneity, functional phenotypes, and cellular interactions
    Sen Yang, Mengyi Wang, Yuze Hua, Jiayi Li, Huaijin Zheng, Ming Cui, Nan Huang, Qiaofei Liu, Quan Liao · 2024 · Cancer Letters
  74. Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages
    Rui Sun, Chao Lei, Zhishan Xu, Xuemei Gu, Liu Huang, Liang Chen, Yi Tan, Min Peng, Kavitha Yaddanapudi, Leah J. Siskind et al. · 2024 · Nature Communications
  75. Myeloid Trem2 ameliorates the progression of metabolic dysfunction-associated steatotic liver disease by regulating macrophage pyroptosis and inflammation resolution
    Wenjie Yu, Yu Zhang, Linfeng Sun, Wei Huang, Xiangdong Li, Nan L. Xia, Xuejiao Chen, Likalamu Pascalia Wikana, Yuhao Xiao, Minhao Chen et al. · 2024 · Metabolism
  76. Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways
    Yunji Yan, Shengwei Bai, Hongxi Han, Junqiang Dai, Liang Niu, Hongyu Wang, Qiang Dong, Hang Yin, Guoqiang Yuan, Yawen Pan · 2024 · Cell Communication and Signaling
  77. Macrophages: Targets for next-generation cancer immunotherapy
    Xiaoqi Sun, Matthew D. Park, Miriam Mérad, Brian D. Brown · 2026 · Cancer Cell
  78. Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy
    Kleeman, Sam O., Thakir, Tuba Mansoor, Demestichas, Breanna, Mourikis, Nicholas, Loiero, Dominik, Ferrer, Miriam, Bankier, Sean, Riazat-Kesh, Yosef J.R.A., Lee, Hassal, Chantzichristos, Dimitrios et al. · 2023 · Cell Genomics
  79. Immunosuppressive Cell Subsets and Factors in Myeloid Leukemias
    Julian Swatler, Laura Turos-Korgul, Ewa Kozłowska, Katarzyna Piwocka · 2021 · Cancers
  80. Multifunctional nanoparticles precisely reprogram the tumor microenvironment and potentiate antitumor immunotherapy after near-infrared-II light-mediated photothermal therapy
    Yanni Ge, Jiaojiao Zhang, Kai Jin, Ziqiang Ye, Wei Wang, Zhuxian Zhou, Juan Ye · 2023 · Acta Biomaterialia
  81. Targeting tumor‑associated macrophages: Critical players in tumor progression and therapeutic strategies (Review)
    Pengfei Su, Ou Li, Kun Ke, Zhichen Jiang, Jianzhang Wu, Yuanyu Wang, Yiping Mou, Weiwei Jin · 2024 · International Journal of Oncology
  82. Targeted and immuno-based therapies in sarcoma: mechanisms and advances in clinical trials
    Fan Tang, Yan Tie, Yu-Quan Wei, Chongqi Tu, Xiawei Wei · 2021 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  83. Identification of TREM2-positive tumor-associated macrophages in esophageal squamous cell carcinoma: implication for poor prognosis and immunotherapy modulation
    Hongmu Li, Miao Yu, Leqi Zhong, Songjie Feng, Yue Xu, Lu Tang, Chun Jing Wu, Xianzhou Zhang, Ling Gu, Hengyi Diao et al. · 2023 · Frontiers in Immunology
  84. Pre-existing effector T-cell levels and augmented myeloid cell composition denote response to CDK4/6 inhibitor palbociclib and pembrolizumab in hormone receptor-positive metastatic breast cancer
    Colt A. Egelston, Weihua Guo, Susan Elaine Yost, Jin Sun Lee, David L. Rose, Christian Avalos, Jian Ye, Paul Henry Frankel, Daniel D. Schmolze, James Ross Waisman et al. · 2021 · Journal for ImmunoTherapy of Cancer
  85. Blockading a new NSCLC immunosuppressive target by pluripotent autologous tumor vaccines magnifies sequential immunotherapy
    Hong Wu, Hongyan Li, Yiqiang Liu, Jingchen Liang, Qianshi Liu, Zhigang Xu, Zhongzhu Chen, Kun Zhang, Kun Zhang, Chuan Shan Xu · 2021 · Bioactive Materials
  86. TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content
    Sinem Günalp, Derya Göksu Helvaci, Aysenur Oner, Ahmet Bursalı, Alessandra Jordano Conforte, Hüseyin Güner, Gökhan Karakülah, Éva Szegezdi, Duygu Sağ · 2023 · Frontiers in Immunology
  87. TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages
    Xuezhen Chen, Yue Zhao, Yimin Huang, Kaichuan Zhu, Fan Zeng, Junyi Zhao, Huaqiu Zhang, Xinzhou Zhu, Helmut Kettenmann, Xianyuan Xiang · 2023 · Glia
  88. Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes
    Adam Al‐Diwani, Nicholas M. Provine, Andrew G. Murchison, Rhiannon Laban, Owen Swann, Ivan G. Koychev, Fintan Sheerin, Sandro Dá Mesquita, Amanda Heslegrave, Henrik Zetterberg et al. · 2024 · Brain
  89. Scavenger Receptor CD36 in Tumor-Associated Macrophages Promotes Cancer Progression by Dampening Type-I IFN Signaling
    Ziyan Zoe Xu, Alexandra Kuhlmann-Hogan, Shihao Xu, Hubert Tseng, Dan Chen, Shirong Tan, Ming Hua Sun, Victoria Tripple, Marcus Bosenberg, Kathryn Miller‐Jensen et al. · 2024 · Cancer Research
  90. IL-1β+ macrophages and the control of pathogenic inflammation in cancer
    Nicoletta Caronni, Federica La Terza, Luca Frosio, Renato Ostuni · 2025 · Trends in Immunology
  91. Defining and targeting tumor-associated macrophages in malignant mesothelioma
    Licun Wu, Mikihiro Kohno, Junichi Murakami, Amin Zia, Jonathan Allen, Hana Yun, Meilin Chan, Cristina Baciu, Mingyao Liu, Véronique Serre‐Beinier et al. · 2023 · Proceedings of the National Academy of Sciences
  92. Metabolism in tumor-associated macrophages
    Jie Li, Gina M. DeNicola, Brian Ruffell · 2022 · International review of cytology
  93. Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer
    Qiaohua Wang, Yongjian Wu, Guanmin Jiang, Xi Huang · 2024 · Journal of Experimental & Clinical Cancer Research
  94. Heterogeneity of glioblastoma stem cells in the context of the immune microenvironment and geospatial organization
    Aryeh Silver, Diana Feier, Tanya Ghosh, Maryam Rahman, Jianping Huang, Matthew R. Sarkisian, Loic P. Deleyrolle · 2022 · Frontiers in Oncology
  95. TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy
    Qiu, Hui, Shao, Zhiying, Wen, Xin, Jiang, Jinghua, Ma, Qinggong, Wang, Yan, Huang, Long, Ding, Xin, Zhang, Longzhen · 2021 · Frontiers in Immunology
  96. Dietary fat and lipid metabolism in the tumor microenvironment
    Swagata Goswami, Qiming Zhang, Cigdem Elif Celik, Ethan M. Reich, Ömer H. Yilmaz · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  97. CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases
    Tao Shi, Wei Liu, Yuting Luo, Kaijie Liang, Shiji Ren, Xueru Song, Fangcen Liu, Chun Lu, Daniel Hirschhorn, Hanbing Wang et al. · 2025 · Cancer Cell
  98. Functional diversity of disorder-specific macrophages involved in various diseases
    Yuichi Mitsui, Takashi Satoh · 2025 · Inflammation and Regeneration
  99. Tumor-associated macrophages, dendritic cells, and neutrophils: biological roles, crosstalk, and therapeutic relevance
    Mingyi Shen, Yanhua Du, Youqiong Ye · 2021 · Medical Review
  100. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders
    Han Gao, Jiawei Di, Bettina Hjelm Clausen, Nanxiang Wang, Xizhong Zhu, Tianlun Zhao, Yanyu Chang, Mao Pang, Yang Yang, Ronghan He et al. · 2023 · Cell Reports