TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Molgora, Martina, Esaulova, Ekaterina, Vermi, William, Hou, Jinchao, Chen, Yun, Luo, Jingqin, Brioschi, Simone, Bugatti, Mattia, Omodei, Andrea Salvatore, Ricci, Biancamaria, Fronick, Catrina, Panda, Santosh K., Takeuchi, Yoshiko, Gubin, Matthew M., Faccio, Roberta, Cella, Marina, Gilfillan, Susan, Unanue, Emil R., Artyomov, Maxim N., Schreiber, Robert D., Colonna, Marco·2020·Cell

DOI 10.1016/j.cell.2020.07.013

Cited by (657)

Items 301–400 of 657

Construction of Durvalumab/carbon nanotube/PEI/aptamer-siRNA chimera for the immunotherapy of hepatocellular carcinoma
Niu Qiang, Lv Wei, Yan Tao, Wang Jin, Yan Bin, Zhou DingHua · 2022 · Biomedical Materials
TREM2 knockdown improves the therapeutic effect of PD-1 blockade in hepatocellular carcinoma
Qinyu Wang, Kang Zheng, Dong Tan, Gang Liang · 2022 · Biochemical and Biophysical Research Communications
Self-modifying NanoEnhancers facilitating lysosomal escape for cGAS-STING cascading activation in tumor immunotherapy
Yanni Ge, Yuheng Bao, An Shao, Kai Jin, Zhengwei Mao, Weijun Tong, Juan Ye · 2024 · Nano Today
Parkin modulates the hepatocellular carcinoma microenvironment by regulating PD-1/PD-L1 signalling
Guiqin Ye, Xin Sun, Jiuzhou Li, Maomao Pu, Jianbin Zhang · 2025 · Journal of Advanced Research
Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review
Alessandra Cesano, Ryan C. Augustin, Luigi Barrea, Davide Bedognetti, Tullia Carmela Bruno, Alberto Carturan, Christian Hammer, Winson S. Ho, Jakob Nikolas Kather, Tomas Kirchhoff et al. · 2025 · Journal for ImmunoTherapy of Cancer
Therapeutic targeting of tumor-associated macrophages
Rikke Kongsgaard Rasmussen, Anders Etzerodt · 2021 · Advances in pharmacology
Shared Gene Expression and Immune Pathway Changes Associated with Progression from Nevi to Melanoma
Elizabeth S. Borden, Anngela C. Adams, Kenneth H. Buetow, Melissa Ann Wilson, Julie E. Bauman, Clara N. Curiel‐Lewandrowski, H.‐H. Sherry Chow, Bonnie LaFleur, Karen Taraszka Hastings · 2021 · Cancers
Pathogenesis and therapeutic applications of microglia receptors in Alzheimer’s disease
Jiao Fu, RuoXuan Wang, JiHui He, Xiaojing Liu, Xinxin Wang, JuMing Yao, Ye Liu, Chongzhao Ran, Qingsong Ye, Yan He · 2025 · Frontiers in Immunology
Myeloid Trem2 Dynamically Regulates the Induction and Resolution of Hepatic Ischemia-Reperfusion Injury Inflammation
Sheng Han, Xiangdong Li, Nan L. Xia, Yu Zhang, Wenjie Yu, Jie Li, Chenyu Jiao, Ziyi Wang, Liyong Pu · 2023 · International Journal of Molecular Sciences
High PHD Finger Protein 19 (PHF19) expression predicts poor prognosis in colorectal cancer: a retrospective study
Pengfei Li, Jie Sun, Yuanyuan Ruan, Lujun Song · 2021 · PeerJ
Regulation of signal transduction pathways in colorectal cancer: implications for therapeutic resistance
Yeelon Yeoh, Teck Yew Low, Nadiah Abu, Pey Yee Lee · 2021 · PeerJ
Interplay between the complement system and other immune pathways in the tumor microenvironment
Cecília Garlanda, Monica Dambra, Elena Illica Magrini · 2025 · Seminars in Immunology
Multi-omics dissection of tumor microenvironment-mediated drug resistance: mechanisms and therapeutic reprogramming
Fanghua Chen, Yu Fu, Gaigai Bai, Junjun Qiu, Keqin Hua · 2025 · Frontiers in Pharmacology
Hepatic Zonation in MASLD: Old Question, New Challenge in the Era of Spatial Omics
Erika Paolini, Miriam Longo, Marica Meroni, Paola Dongiovanni · 2025 · International Journal of Molecular Sciences
Sarcoma Immunotherapy: Confronting Present Hurdles and Unveiling Upcoming Opportunities
Sehan Jeong, Sharmin Afroz, Donghyun Kang, Jeonghwan Noh, Jooyeon Suh, June Hyuk Kim, Hye Jin You, Hyun Guy Kang, Yi‐Jun Kim, Jin‐Hong Kim · 2023 · Molecules and Cells
On the Biology and Therapeutic Modulation of Macrophages and Dendritic Cells in Cancer
Matthew D. Park, Meriem Belabed, Steven T. Chen, Pauline Hamon, Samarth Hegde, Raphaël Mattiuz, Thomas Urban Marron, Miriam Mérad · 2023 · Annual Review of Cancer Biology
124I-Labeled Immuno-PET Targeting hTREM2 for the Diagnosis of Gastric Carcinoma
Dai Shi, Zhan Xu, Yuan Cheng, Qingyu Lin, Zhan Si, Wenhui Fu, Tingting Yang, Hongcheng Shi, Dengfeng Cheng · 2023 · Molecular Pharmaceutics
IL-4-STAT6-induced high Siglec-G/10 expression aggravates the severe immune suppressive tumor microenvironment and impedes the efficacy of immunotherapy in head and neck squamous cell carcinoma
Wenyi Yang, Zhaoyang Guo, Houyu Ju, Yusheng Lu, Yifan Fei, Yuanchen Yin, Guoxin Ren, Ming Yan, Chaofeng Han, Jingzhou Hu · 2025 · Journal for ImmunoTherapy of Cancer
Single-cell to pre-clinical evaluation of Trem2 , Folr2 , and Slc7a7 as macrophage-associated biomarkers for atherosclerosis
Tiit Örd, Senthil Palani, Judith Giroud‐Gerbetant, Susanna Bodoy, Tapio Lönnberg, Henri Niskanen, Aarthi Ravindran, Lari Holappa, Melody Chemaly, Mari Taipale et al. · 2025 · Cardiovascular Research
Single-cell pair-wise relationships untangled by composite embedding model
Sishir Subedi, Yongjin Park · 2023 · iScience
Potential therapeutic targets in myeloid cell therapy for overcoming chemoresistance and immune suppression in gastrointestinal tumors
Jiawei Fan, Jianshu Zhu, He Zhu, Hong Xu · 2024 · Critical Reviews in Oncology/Hematology
Single‐cell and spatial omics unravel the spatiotemporal biology of tumour border invasion and haematogenous metastasis
Xifu Cheng, Yuke Cao, Xiangyi Liu, Yuanheng Li, Qing Li, Dian Gao, Qiongfang Yu · 2024 · Clinical and Translational Medicine
PI3K/AKT/mTOR Targeting in Colorectal Cancer Radiotherapy: A Systematic Review
Seyedeh Nasibeh Mousavikia, Leili Darvish, Ali Ahmadizad Firouzjaei · 2025 · Journal of Gastrointestinal Cancer
Adaptive resistance in tumors to anti-PD-1 therapy through re-immunosuppression by upregulation of GPNMB expression
Xiaoqing Xu, Kun Xie, Bingyu Li, Lijun Xu, Lei Huang, Yan Feng, Chenyu Pi, Jingming Zhang, Tao Huang, Ming Jiang et al. · 2021 · International Immunopharmacology
Promising immunotherapeutic targets in lung cancer based on single-cell RNA sequencing
Qianqian Xue, Wenbei Peng, Siyu Zhang, Xiao‐Shan Wei, Linlin Ye, Zihao Wang, Xuan Xiang, Pei Zhang, Qiong Zhou · 2023 · Frontiers in Immunology
Interactions between glioblastoma and myeloid cells
Yuting Li, Yu‐Hong Chen, Kaiyong Cai, Yujuan Qin, Xi Wang, Bo Zhang, Lin Shi, Zonglin He, Jiasheng Wang, Jiecun Long et al. · 2025 · Frontiers in Cell and Developmental Biology
Macrophage Polarization in the Tumor Microenvironment of Hepatocellular Carcinoma: From Mechanistic Insights to Translational Therapies
Xiaoqing Fu, Mingquan Pang, Zhixin Wang, Haijiu Wang · 2025 · Cancer Control
Bidirectional Regulation in the Tumour Microenvironment: The Interaction Between Tumour‐Associated Macrophages and T Cells Reshapes the Paradigm of Cancer Immunotherapy
Yuting Li, Lufang Wang · 2026 · Immunology
CTLA‐4 inhibition facilitates follicular T and B cell interaction and the production of tumor‐specific antibodies
Areum Jo, Dasom Jeong, Hye Hyeon Eum, Nayoung Kim, Minsu Na, Huiram Kang, Hae‐Ock Lee · 2023 · International Journal of Cancer
The Pathogenesis in Alzheimer's Disease: TREM2 as a Potential Target
Guangtong Liu, Linlin Zhang, Yongzhao Fan, Wenliang Ji · 2023 · Journal of Integrative Neuroscience
Immunity in malignant brain tumors: Tumor entities, role of immunotherapy, and specific contribution of myeloid cells to the brain tumor microenvironment
Jenny Christine Kienzler, Burkhard Becher · 2023 · European Journal of Immunology
IL36G-producing neutrophil-like monocytes promote cachexia in cancer
Yoshihiro Hayashi, Yasushige Kamimura-Aoyagi, Sayuri Nishikawa, Rena Noka, Rika Iwata, Asami Iwabuchi, Yushin Watanabe, Natsumi Matsunuma, Kanako Yuki, Hiroki Kobayashi et al. · 2024 · Nature Communications
Targeting immune checkpoints on myeloid cells: current status and future directions
Chuhan Ma, Yang Li, Min Li, Chao Lv, Yu Tian · 2025 · Cancer Immunology Immunotherapy
Tumour‐Associated Macrophages in Oral Squamous Cell Carcinoma
Akhilanand Chaurasia, Carel Brigi, Arwa Daghrery, Farah Asa’ad, Francesca Spirito, Akira Hasuike, Patricia González‐Alva, Dave D. Kojic, Revan Birke Koca Ünsal, Gowri Sivaramakrishnan · 2025 · Oral Diseases
The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis
Vladimir Wischnewski, Paola Guerrero Aruffo, Matteo Massara, Roeltje R. Maas, Klara Soukup, Johanna A. Joyce · 2025 · Cell Reports
TREM2 facilitates gastric cancer progression and immune evasion via inhibiting TRIM21-mediated STAT1 degradation in tumor-associated macrophages
Zihao Zhang, Kuan Yu, Yifan Cao, Peiyi Xie, Leihao Wang, Zhenbin Shen, Jing Qin · 2025 · Cell Death and Disease
A CD276-Targeted Antibody-Drug Conjugate to Treat Non-Small Lung Cancer (NSCLC)
Jiashuai Zhang, Zhuoxin “Zora” Zhou, Kai Chen · 2023 · Cells
Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages
Qing Wang, Yining Cao, Songyi Ye, Maoyuan Ding, Wenliang Ge, Yuejin Liang, Jinling Chen · 2024 · PLoS Pathogens
Tissue‐Resident Macrophages in Cancer: Friend or Foe?
Jianhua Chi, Qinglei Gao, Dan Liu · 2024 · Cancer Medicine
Age-Associated Modulation of TREM1/2-Expressing Macrophages Promotes Melanoma Progression and Metastasis
Marzia Scortegagna, Rabi Murad, Parinaz Bina, Yongmei Feng, Rebecca A. Porritt, Alexey V. Terskikh, Xiao Tian, Peter D. Adams, Kristiina Vuori, Ze’ev A. Ronai · 2025 · Cancer Research
Myeloid Cells TREM Down Anti-tumor Responses
Aimée R. Bugler-Lamb, Martin Guilliams · 2020 · Cell
The Chromatin-Oxygen Sensor Gene KDM5C Associates with Novel Hypoxia-Related Signatures in Glioblastoma Multiforme
Denise Drongitis, Lucia Verrillo, Pasqualino De Marinis, Pasquale Orabona, Agnese Caiola, Giacinto Turitto, Alessandra Alfieri, Sara Bruscella, Marisa Gentile, Vania Moriello et al. · 2022 · International Journal of Molecular Sciences
Immuno-Contexture and Immune Checkpoint Molecule Expression in Mismatch Repair Proficient Colorectal Carcinoma
Mauro Giacomelli, Matilde Monti, Diego Cesare Pezzola, Silvia Lonardi, Mattia Bugatti, Francesco Missale, Rossella Cioncada, Laura Melocchi, Viviana Giustini, Vincenzo Villanacci et al. · 2023 · Cancers
Good CARMA : Turning bad tumor‐resident myeloid cells good with chimeric antigen receptor macrophages
Christopher M. Snyder, Saar I. Gill · 2023 · Immunological Reviews
Single-Cell Sequencing, an Advanced Technology in Lung Cancer Research
Hao Wang, Die Meng, Haoyue Guo, Chenglong Sun, Peixin Chen, Minlin Jiang, Yi Xu, Jia Yu, Qiyu Fang, Jun Zhu et al. · 2021 · OncoTargets and Therapy
Cell surface receptors TREM2, CD14 and integrin α M β 2 drive sinking engulfment in phosphatidylserine-mediated phagocytosis
Daan Vorselen, Roarke A. Kamber, Ramon Lorenzo D. Labitigan, Aaron Paul van Loon, Eric Peterman, Melissa K. Delgado, Sijie Lin, Jeffrey P. Rasmussen, Michael Cory Bassik, Julie A. Theriot · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy
Federico Giovannoni, Craig A. Strathdee, Camilo Faust Akl, Brian M. Andersen, Zhaorong Li, Hong‐Gyun Lee, María Florencia Torti, Joseph M. Rone, Pere Duart-Abadía, Martina Molgora et al. · 2025 · Nature Cancer
Myeloid cells in the era of cancer immunotherapy: Top 3 unanswered questions
Mehdi Chaib, Ubaid A. Tanveer, Liza Makowski · 2023 · Pharmacology & Therapeutics
TREM-1 and TREM-2 as therapeutic targets: clinical challenges and perspectives
Alexander B. Sigalov · 2024 · Frontiers in Immunology
Remodeling the Tumor Myeloid Landscape to Enhance Antitumor Antibody Immunotherapies
Khiyam Hussain, Mark Steven Cragg, Stephen A. Beers · 2021 · Cancers
Neoantigen vaccine and neoantigen‐specific cell adoptive transfer therapy in solid tumors: Challenges and future directions
Yanwei Shen, Lu Yu, Xiaoli Xu, Shaojun Yu, Zhuo Yu · 2022 · Cancer Innovation
TREM2 Is a Prognostic Biomarker and Correlated with an Immunosuppressive Microenvironment in Thyroid Cancer
Jing Wang, Zhendong Li · 2022 · Disease Markers
The immunoregulatory effect of the TREM2-agonist Sulfavant A in human allogeneic mixed lymphocyte reaction
Giusi Barra, Carmela Gallo, Dalila Carbone, Marcello Ziaco, Mario dell’Isola, Mario Affuso, Emiliano Manzo, Genoveffa Nuzzo, Laura Fioretto, Giuliana d’Ippolito et al. · 2023 · Frontiers in Immunology
Biophysical heterogeneity of myeloid-derived microenvironment to regulate resistance to cancer immunotherapy
Jie Zhao, Yiting Dong, Yundi Zhang, Jie Wang, Zhijie Wang · 2022 · Advanced Drug Delivery Reviews
Predictive value of tumor microenvironment on pathologic response to neoadjuvant chemotherapy in patients with undifferentiated pleomorphic sarcomas
Jean‐Philippe Guégan, Nathan El-Ghazzi, Julien Vibert et al. · 2024 · Journal of Hematology & Oncology
FIG4 downregulation-arrested autophagy-lysosomal degradation of IL-18 drives lipid-associated macrophage polarization and immunotherapy resistance in triple-negative breast cancer
Fada Xia, Xudong Zhu, X Li, Qiaoli Yi, Shangjun Zhou, Jiayu Wang, Xia Wang, Kejing Zhang, Cheng Zhan, Hailin Tang et al. · 2026 · Cancer Letters
Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft models
Maria Eugénia Marques Da Costa, Robin Droit, Pierre Khneisser, Anne Gomez‐Brouchet, Tiphaine Adam de Beaumais, Marie Nolla, Nicolas Signolles, Jacob Torrejon-Diaz, Bérangère Lombard, Damarys Loew et al. · 2023 · Frontiers in Oncology
Lipid metabolism in the immune niche of tumor-prone liver microenvironment
Jintian Chen, Thomas Ting-Hei Chan, Jingying Zhou · 2023 · Journal of Leukocyte Biology
TAM-tastic: from resistance to resilience in cancer
Jie Ting Low, Ping‐Chih Ho, Mai Matsushita · 2024 · Trends in Pharmacological Sciences
Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation
Xiaoman Ju, Eva Maria Putz, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong, Biping Deng et al. · 2025 · Nature Communications
Deciphering metabolic reprogramming of immune cells within the tumor microenvironment
Yinping Wang, Weijie Chen, Zida Wang, Siwen Cai, Xinnan Zhao, Jingsi Jin, Ting Gao, Junwen Qu · 2025 · Journal of Translational Medicine
Targeting immunosuppressive myeloid cells via implant-mediated slow release of small molecules to prevent glioblastoma recurrence
Yannik Kaiser, Christopher Garris, Eliana Marinari, Hyung Shik Kim, Juhyun Oh, Martin Pédard, Elias A. Halabi, Moonhyun Choi, Sepideh Parvanian, Rainer H. Köhler et al. · 2025 · Nature Biomedical Engineering
Guiding immunotherapy combinations: Who gets what?
Michelle Ferreira, Jennifer Hsing Choe · 2021 · Advanced Drug Delivery Reviews
A Pathologically Friendly Strategy for Determining the Organ‐specific Spatial Tumor Microenvironment Topology in Lung Adenocarcinoma Through the Integration of snRandom‐seq and Imaging Mass Cytometry
Xuqi Sun, Xiao Teng, Chuan Liu, Weihong Tian, Jinlin Cheng, Shuqiang Hao, Yuzhi Jin, Libing Hong, Yongqiang Zheng, Xiaomeng Dai et al. · 2024 · Advanced Science
Cancer metastasis linked to macrophage size, shape, and metabolism
Peter J. Murray · 2020 · The Journal of Experimental Medicine
Understanding tissue-resident macrophages unlocks the potential for novel combinatorial strategies in breast cancer
Manjusha Biswas · 2024 · Frontiers in Immunology
Biological and clinical role of TREM2 in liver diseases
Ke Ma, Shouliang Guo, Jin Li, Tao Wei, Tingbo Liang · 2024 · Hepatology Communications
Integrated immunogenomic analyses of high-grade serous ovarian cancer reveal vulnerability to combination immunotherapy
Raphael Gronauer, Leonie Madersbacher, Pablo Monfort‐Lanzas, Gabriel Floriani, Susanne Sprung, Alain Gustave Zeimet, Christian Marth, Heidi Fiegl, Hubert Hackl · 2024 · Frontiers in Immunology
Comprehensive immune ageing reveals TREM2/TIM3 myeloid cells drive brain immune evasion
Berta Segura‐Collar, Lucía Mondéjar-Ruescas, Denisse Alcivar-López, María Garranzo‐Asensio, Pablo Mata-Martínez, Ramón García‐Escudero, Aurelio Hernández‐Laín, Juan Manuel Sepúlveda-Sánchez, Ángel Pérez‐Núñez, Jesús Ávila et al. · 2025 · EBioMedicine
Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment
Máté Kiss, László Halász, Éva Hadadi, Wilhelm K. Berger, Petros Tzerpos, Szilárd Póliska, Daliya Kancheva, Aurélie AG Gabriel, Romina Mora Barthelmess, Ayla Debraekeleer et al. · 2025 · Genome Medicine
MEN1 deficiency stabilizes PD‐L1 and promotes tumor immune evasion of lung cancer
Cuncun Zhang, Ningning Sun, Qing-Ze Fei, Linlin Peng, Chengyu Wei, Xiangyu Liu, Sainan Miao, Mengqi Chai, Fang Wang, Di Wang et al. · 2024 · Cancer Science
Therapeutic utility of immunosuppressive TREM2+ macrophages: an important step forward in potentiating the immune checkpoint inhibitors
Fulya Koksalar Alkan, Hasan Körkaya · 2020 · Signal Transduction and Targeted Therapy
Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry
Wei Meng, Yoshiko Takeuchi, Jeffrey P. Ward, Hussein Sultan, Cora D. Arthur, Elaine R. Mardis, Maxim N. Artyomov, Cheryl F. Lichti, Robert D. Schreiber · 2024 · Cancer Immunology Research
Association of Sympathovagal Imbalance with Increased Inflammation and Impaired Adaptive Immunity in Bladder Cancer Patients
Iveta Mikolášková, Milan Zvarík, Kinga Szabóová, Elena Tibenská, Vladimı́ra Ďurmanová, Magda Suchánková, Boris Kollárik, Patrik Hesko, Patrik Palacka, Mária Bucová et al. · 2024 · International Journal of Molecular Sciences
New insights into combined immunotherapy for hepatocellular carcinoma associated with liver cirrhosis
Yufan Liu, Kexin Cong, Qiao Li, Dan Zhang, Jiyao Sheng · 2025 · Frontiers in Immunology
Meningeal blood vessel blockage enhances anti-glioblastoma immunity
Yixin Gao, Yushan Peng, Jiying Cheng, Xinyu Zhang, Jian Zhong, Chenfei Lu, Xudong Xing, Yanxing Lai, Huixin Sun, Xuechao Zeng et al. · 2026 · Cell
Decoding the CAF–TAM axis: multi-omics dissection and therapeutic targeting of stromal–immune crosstalk in the tumor microenvironment
Yage Fu, Mei Li, Shiwang Wu, Jingsi Wang, Shan Wang · 2026 · Cell Death and Disease
Acute and Chronic Macrophage Differentiation Modulates TREM2 in a Personalized Alzheimer’s Patient-Derived Assay
Nicoleta Carmen Cosma, Neriman Eren, Berk Üsekes, Susanna Gerike, Isabella Heuser, Oliver Peters, Julian Hellmann‐Regen · 2023 · Cellular and Molecular Neurobiology
SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer
Jiahua Yu, Shijun Yu, Jin Bai, Zhe Zhu, Yong Gao, Yandong Li · 2024 · Cancer Gene Therapy
Combined single-cell RNA-seq and bulk RNA-seq to analyze the expression and role of TREM2 in bladder cancer
Xingxing Zhang, Yuelin Du, Wei Xiong, Panfeng Shang · 2022 · Medical Oncology
Preclinical Evaluation of 99mTc-MAG3-5-Fab Targeting TREM2 in Lung Cancer Mouse Models: A Comparison with 99mTc-MAG3-5-F(ab′)2
Dai Shi, Wenhui Fu, Hui Ru Tan · 2023 · Molecular Pharmaceutics
Pexidartinib and standard neoadjuvant therapy in the adaptively randomized I-SPY2 trial for early breast cancer
Hope S. Rugo, MJ Campbell, Christina S. F. Yau, Amy Jo Chien, Anne Marie Wallace, Claudine J. Isaacs, Judy Caroline Boughey, Hyo Sook Han, Meredith Buxton, Julia L. Clennell et al. · 2024 · Breast Cancer Research and Treatment
Emerging Strategies of Cell and Gene Therapy Targeting Tumor Immune Microenvironment
Runtian Wang, Xiaorui Duan, Jian Li, Cheng Zhang, Lin Shen · 2025 · Clinical Cancer Research
Astragalus injection antagonizes the efficacy of anti-PD-1 against melanoma through down-regulating MHC-II expression
Rui Lei, Qiao Li, Ruilong Wang, Zhuo Kui Wu, Qing Kong, Suqing Liu, Zhuyu Luo, Xiao Liu, Xiaohua Zhu, Jinfeng Wu · 2025 · Journal of Ethnopharmacology
Myeloid TGF-β signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis
Ziyi Meng, Xiaoxue Qiu, Zhimin Chen, Yu-Tung Lee, Linkang Zhou, You Lu, Tongyu Liu, Siming Li, Benjamin Lévi, Katherine Ann Gallagher et al. · 2025 · JHEP Reports
Endoplasmic Reticulum Stress‐Induced triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Downregulation Exacerbates Platelet Activation and Myocardial Infarction in Patients With Coronary Artery Disease
Xiaowen Wu, Guanxing Pan, Lin Chang, Yulong Zhang, Yangyang Liu, Wei Zhang, Yifan Guo, Ge Zhang, Haoxuan Zhong, Zhiyong Qi et al. · 2025 · Journal of the American Heart Association
Positive and negative roles of myeloid cells in cancer immunotherapy
Jaroslav Žák, Judith A. Varner · 2025 · Journal for ImmunoTherapy of Cancer
TREM2‐Mediated Cholesterol Efflux in Macrophages Inhibits Anti‐Tumor Immunity via Limitation of CD4 + T and NK Cells
Yunhan Wang, Weina Yu, Xinxin Wang, Qitai Zhao, Qingyang Lei, Aitian Li, Shasha Liu, Tian Wang, Li Yang, Yi Zhang · 2025 · Advanced Science
The role of tumor-associated macrophages in cancer development and their significance as prognostic markers
Arash Salmaninejad, Sepideh Mehrpour Layeghi, Zeinab Falakian, Parisa Safari Foroushani, Shahin Golestani, Farzad Pourghazi, Sepehr Kobravi, Meysam Yousefi · 2026 · Clinical and Experimental Medicine
Identification of inflammatory lipid-associated macrophages in human carotid atherosclerosis
Kory J. Lavine · 2023 · Nature Cardiovascular Research
Crosstalk between peripheral immunity and central nervous system in Alzheimer’s disease
Han-Chen Yang, Qi Qin, Meng Wang, Yunsi Yin, Ruiyang Li, Yi Tang · 2023 · Cellular Immunology
Analysis of macrophage polarization and regulation characteristics in ovarian tissues of polycystic ovary syndrome
Yue Yuan, Yan Mao, Liu Yang, Yilin Wang, Xuehong Zhang · 2024 · Frontiers in Medicine
Identification of PANoptosis-based signature for predicting the prognosis and immunotherapy response in AML
Lu Zhang, Yanan Yu, Guiqing Li, Jiachun Li, Xiaolin Ma, Jiao Ren, Na Liu, Songyue Guo, Jinwei Cai, Jinwei Cai · 2024 · Heliyon
Comments on the ambiguity of selected surface markers, signaling pathways and omics profiles hampering the identification of myeloid-derived suppressor cells
Manfred Bernhard Lutz, I Eckert · 2021 · Cellular Immunology
Myeloid Immune Cells CARrying a New Weapon Against Cancer
Rodrigo Nalio Ramos, Samuel Campanelli Freitas Couto, Théo Gremen Mimary de Oliveira, Paulo Henrique dos Santos Klinger, Tárcio Teodoro Braga, Eduardo Magalhães Rego, José Alexandre Marzagão Barbuto, Vanderson Rocha · 2021 · Frontiers in Cell and Developmental Biology
Liver Metastasis Modulate Responses of Suppressive Macrophages and Exhausted T Cells to Immunotherapy Revealed by Single Cell Sequencing
Qiming Zhang, Siyuan Liu, Yedan Liu, Dev M. Bhatt, Juan Estrada, Brian Belmontes, Xianwen Ren, Jude R. Canon, Wenjun Ouyang · 2022 · Advanced Genetics
Isolating and Targeting a Highly Active, Stochastic Dendritic Cell Subpopulation for Improved Immune Responses
Peter Deak, Bradley Studnitzer, Trevor Wai-Ming Ung, Rachel C. Steinhardt, Melody A. Swartz, Aaron Palmer Esser-Kahn · 2022 · Cell Reports
It takes two to tango: the role of tumor-associated macrophages in T cell-directed immune checkpoint blockade therapy
Fadi Sheban · 2023 · Frontiers in Immunology
Amyloids and brain cancer: molecular linkages and crossovers
Shalini Singh, Vibhuti Joshi, Arun Upadhyay · 2023 · Bioscience Reports
Molecular mechanisms and clinical relevance of endothelial cell cross-talk in clear cell renal cell carcinoma
Elin Sjöberg · 2024 · Upsala Journal of Medical Sciences