TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Cited by (657)

Items 201–300 of 657

  1. Clinical impact of anti-inflammatory microglia and macrophage phenotypes at glioblastoma margins
    Imran Noorani, Kastytis Šidlauskas, Sean Pellow, Reece Savage, Jeannette L Norman, David S. Chatelet, Mark Fabian, Paul Grundy, Jeng Ching, James A. R. Nicoll et al. · 2023 · Brain Communications
  2. Tumour-associated macrophages: versatile players in the tumour microenvironment
    Zoey Zeyuan Ji, Max Kam‐Kwan Chan, Alex Siu Wing Chan, Kam Tong Leung, Xiaohua Jiang, Ka‐Fai To, Yi Wu, Patrick Ming‐Kuen Tang · 2023 · Frontiers in Cell and Developmental Biology
  3. Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages
    Yingzheng Xu, Hannah Hillman, Michael Chang, Fanta Barrow, Stoyan Ivanov, Xavier S. Revelo, Jesse W. Williams · 2025 · Communications Biology
  4. Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy
    Michelle von Locquenghien, Pascale Zwicky, Ken Xie, Diego Adhemar Jaitin, Fadi Sheban, Adam Yalin, Florian Uhlitz, Chamutal Gur, Reut Sharet-Eshed, Eyal David et al. · 2025 · Cell
  5. MIF is a critical regulator of mononuclear phagocytic infiltration in hepatocellular carcinoma
    Yunxi Liao, Chenyang Wu, Li Yang, Jinhua Wen, Dongyu Zhao · 2023 · iScience
  6. Single cell analyses reveal the PD-1 blockade response-related immune features in hepatocellular carcinoma
    Yao Li, Fengwei Li, Lei Xu, Xiaodong Shi, Hui Xue, Jianwei Liu, Shilei Bai, Yeye Wu, Yang Zhao, Feng Xue et al. · 2024 · Theranostics
  7. Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche
    Haensel, Daniel, Daniel, Bence, Gaddam, Sadhana, Pan, Cory, Fabo, Tania, Bjelajac, Jeremy, Jussila, Anna R., Gonzalez, Fernanda, Li, Nancy Yanzhe, Chen, Yun et al. · 2023 · Nature Communications
  8. Blocking CX3CR1+ Tumor-Associated Macrophages Enhances the Efficacy of Anti-PD1 Therapy in Hepatocellular Carcinoma
    Xiaonan Xiang, Kai Wang, Hui Zhang, Haibo Mou, Zhixiong Shi, Yaoye Tao, Hongliang Song, Zhengxing Lian, Shuai Wang, Di Lu et al. · 2024 · Cancer Immunology Research
  9. Single‐cell transcriptome analysis deciphers the CD74‐mediated immune evasion and tumour growth in lung squamous cell carcinoma with chronic obstructive pulmonary disease
    Denian Wang, Sixiang Li, Zhi Yang, Chunyan Yu, Peng-Fei Wu, Ying Yang, Rui Zhang, Qingyan Li, Jian Yang, Hongchun Li et al. · 2024 · Clinical and Translational Medicine
  10. Unravelling monocyte functions: from the guardians of health to the regulators of disease
    Alexander Mildner, Ki-Wook Kim, Simon Yona · 2024 · Discovery Immunology
  11. Unraveling the role of M2 TAMs in ovarian cancer dynamics: a systematic review
    Ya-Ping Wang, Caixia Ma, Xiabing Li, Fangfang Yang, Na Wang, Gaili Ji, Qing Liu, Hong Zhu, Shengnan Xu, Hongyu Li · 2025 · Journal of Translational Medicine
  12. Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
    Sayuri Miyauchi, Kei‐ichiro Arimoto, Mengdan Liu, Yue Zhang, Dong‐Er Zhang · 2023 · Cell Reports
  13. sTREM2 is a plasma biomarker for human NASH and promotes hepatocyte lipid accumulation
    Vishal M Kothari, Christopher E. Savard, Jingjing Tang, Sum P. Lee, Savitha Subramanian, Shari Wang, Laura J. den Hartigh, Karin Bornfeldt, George N. Ioannou · 2023 · Hepatology Communications
  14. The Yin Yang of Complement and Cancer
    Seppo Meri, Elena Illica Magrini, Alberto Mantovani, Cecília Garlanda · 2023 · Cancer Immunology Research
  15. A novel polysaccharide isolated from Coriolus versicolor polarizes M2 macrophages into an M1 phenotype and reversesits immunosuppressive effect on tumor microenvironment
    Sixue Bi, Yongshuai Jing, Xuehui Cui, Yitong Gong, Junli Zhang, Xiaofei Feng, Zhen Shi, Qiusheng Zheng, Defang Li · 2024 · International Journal of Biological Macromolecules
  16. Molecular maps of synovial cells in inflammatory arthritis using an optimized synovial tissue dissociation protocol
    Sam G. Edalat, Reto Gerber, Miranda Houtman, Janine Lückgen, Rui Lourenço Teixeira, Maria Del Pilar Palacios Cisneros, Tamara Pfanner, Tadeja Kuret, Nadja Ižanc, Raphael Micheroli et al. · 2024 · iScience
  17. Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer
    Mindy Kim Graham, Rulin Wang, Roshan V. Chikarmane, Bulouere Abel, Ajay M. Vaghasia, Anuj Gupta, Qizhi Zheng, Jessica L Hicks, Polina Sysa‐Shah, Xin Pan et al. · 2024 · Nature Communications
  18. Metabolism and macrophages in the tumor microenvironment
    Hannah Yang, Chan Kim, Weiping Zou · 2024 · Current Opinion in Immunology
  19. Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to intervention
    Hancheng Wu, Jing Li, Ruilin Yao, Jing Liu, Lili Su, Wenjie You · 2025 · Theranostics
  20. Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth
    Jaime Mateus-Tique, Ashwitha Lakshmi, Bhavya Singh, Rhea Iyer, Alfonso R. Sánchez-Paulete, Chiara Falcomatà, M J Lin, Gvantsa Pantsulaia, Alexander Tepper, Trung Nguyen et al. · 2026 · Cancer Cell
  21. Role of myeloid-derived suppressor cells in the formation of pre-metastatic niche
    Guoqi Ya, Weihong Ren, Rui Qin, Jiao He, Shuo Zhao · 2022 · Frontiers in Oncology
  22. An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of Radiotheranostics
    Viviana Benfante, Alessandro Stefano, Muhammad Usman Ali, Riccardo Laudicella, Walter Arancio, Antonino Cucchiara, Fabio Caruso, Francesco Paolo Cammarata, Claudia Coronnello, Giorgio Ivan Russo et al. · 2023 · Diagnostics
  23. Single-cell RNA sequencing in cancer research: discovering novel biomarkers and therapeutic targets for immune checkpoint blockade
    Boyu Sun, Ziyu Xun, Nan Zhang, Kai Liu, Xiangqi Chen, Haitao Zhao · 2023 · Cancer Cell International
  24. Blockade of TREM2 ameliorates pulmonary inflammation and fibrosis by modulating sphingolipid metabolism
    Gu, Xueqing, Kang, Hanyujie, Cao, Siyu, Tong, Zhaohui, Song, Nan · 2025 · Translational Research
  25. TAMs in Brain Metastasis: Molecular Signatures in Mouse and Man
    Michael Schulz, Lisa Sevenich · 2021 · Frontiers in Immunology
  26. Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts
    Eleonora Timperi, Emanuela Romano · 2023 · Frontiers in Immunology
  27. Embracing diversity: macrophage complexity in cancer
    Jan Hochstadt, Sarai Martínez Pacheco, María Casanova-Acebes · 2025 · Trends in cancer
  28. Polarization of Tumor Cells and Tumor‐Associated Macrophages: Molecular Mechanisms and Therapeutic Targets
    Guohao Wei, Bin Li, Mengyang Huang, Mengyao Lv, Zihui Liang, Chuandong Zhu, Lilin Ge, Jing Chen · 2025 · MedComm
  29. Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression
    Hinda Najem, Martina Ott, Cynthia Kassab, Arvind U.K. Rao, Ganesh Rao, Anantha Marisetty, Adam M. Sonabend, Craig Horbinski, Roel G.W. Verhaak, Anand Shankar et al. · 2022 · JCI Insight
  30. Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis
    A. Sigalov · 2022 · International Journal of Molecular Sciences
  31. TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas
    Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Wenjing Zhang, Yuzhou Chang, Dale B. Bosco, Tao Huang, Aastha Dheer, Shan Gao, Shengze Xu et al. · 2023 · Neuro-Oncology
  32. Nanomedicines for reversing immunosuppressive microenvironment of hepatocellular carcinoma
    Xier Pan, Shuting Ni, Kaili Hu · 2024 · Biomaterials
  33. Mechanisms of TREM2 mediated immunosuppression and regulation of cancer progression
    Xia Lei, Yani Gou, Jin Yong Hao, Xiao Jun Huang · 2024 · Frontiers in Oncology
  34. Targeting myeloid cells to improve cancer immune therapy
    Hui Chen, Zihan Xu, Judith A. Varner · 2025 · Frontiers in Immunology
  35. Understanding the complexity of tumor-associated macrophages: Druggable and therapeutic insights
    An-Qi Li, Fang Huang, Sulaiya Talaiti, Xiao Yi Yang, Huichang Bi, Jian‐Hong Fang · 2025 · Acta Pharmaceutica Sinica B
  36. Specialized functions and sexual dimorphism explain the functional diversity of the myeloid populations during glioma progression
    Natalia Ochocka, Paweł Segit, Kamil Wojnicki, Salwador Cyranowski, Julian Swatler, Karol Jacek, Wiesława Grajkowska, Bozena Kaminska · 2023 · Cell Reports
  37. Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs
    Clémence Henon, Julien Vibert, Thomas Eychenne, Nadège Gruel, Leo Colmet Daage, Carine Ngo, Marlène Garrido, Nicolas Dorvault, Maria Eugénia Marques Da Costa, Virginie Marty et al. · 2024 · Cell Reports Medicine
  38. Single-Cell Transcriptomes of Hereditary Kidney Cancers Underscore Genetically Defined Tumor Characteristics and Microenvironment
    Ryosuke Jikuya, Koichi Murakami, Akira Nishiyama, Ikuma Kato, Mitsuko Furuya, Jun Nakabayashi, Jordan A. Ramilowski, Haruka Hamanoue, Kazuhiro Maejima, Masashi Fujita et al. · 2022 · iScience
  39. Discovery of 2H-Indazole-3-carboxamide Derivatives as Novel Potent Prostanoid EP4 Receptor Antagonists for Colorectal Cancer Immunotherapy
    Zhiyuan Cheng, Yijie Wang, Yao Zhang, Chan Zhang, Mengru Wang, Wei Wang, Jiacheng He, Yang Wang, Hankun Zhang, Qiansen Zhang et al. · 2023 · Journal of Medicinal Chemistry
  40. The double-edged role and therapeutic potential of TREM2 in atherosclerosis
    Botao Zhu, Yuxuan Liu, Daoquan Peng · 2024 · Biomarker Research
  41. TREM2 promotes the formation of a tumor-supportive microenvironment in hepatocellular carcinoma
    Hanrui Guo, Meiling Wang, Caiya Ni, Chun Yang, Chunxue Fu, Xiaoman Zhang, Xueling Chen, Xiangwei Wu, Jun Wei Hou, Lianghai Wang · 2025 · Journal of Experimental & Clinical Cancer Research
  42. TREM2+ macrophages: a key role in disease development
    Xinxin Wang, Yunhan Wang, Lei Xiang Yang, Yi Zhang, Li Yang · 2025 · Frontiers in Immunology
  43. TREM2-mediated regulation of myeloid cells in the tumor microenvironment: new insights and therapeutic prospects
    Yueyu Huang, Wanxia Fang · 2025 · npj Precision Oncology
  44. Cyclophilin A is an endogenous ligand for the triggering receptor expressed on myeloid cells‐2 (TREM2)
    Kon-Young Ji, Su‐Man Kim, Su‐Min Yee, Min‐Jae Kim, Yu-Jin Ban, Eun‐Mi Kim, Eun Hee Lee, Ha‐Rim Choi, Hyosuk Yun, Chul Won Lee et al. · 2021 · The FASEB Journal
  45. Myeloid checkpoints for cancer immunotherapy
    Yixin Qian, Ting Yang, Huan Liang, Mi Deng · 2022 · Chinese Journal of Cancer Research
  46. Non-genetic Heterogeneity of Macrophages in Diseases—A Medical Perspective
    Grégoire Gessain, Camille Blériot, Florent Ginhoux · 2020 · Frontiers in Cell and Developmental Biology
  47. The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer—Challenges and opportunities
    Kohlhepp, Marlene Sophia, Liu, Hanyang, Tacke, Frank, Guillot, Adrien · 2023 · Frontiers in Molecular Biosciences
  48. HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling
    Hui Qiu, Zhiying Shao, Xin Wen, Debao Qu, Zhengyang Liu, Ziqin Chen, Xinyan Zhang, Xin Ding, Longzhen Zhang · 2024 · Journal of Translational Medicine
  49. Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy
    Sunita Keshari, Alexander S. Shavkunov, Qi Miao, Akata Saha, Tomoyuki Minowa, Martina Molgora, Charmelle D. Williams, Mehdi Chaib, Anna M. Highsmith, Josue Estiven Pineda et al. · 2024 · Cell Reports
  50. Enhanced Photothermal/Immunotherapy under NIR Irradiation Based on Hollow Mesoporous Responsive Nanomotor
    Wenjing Li, Yukun Wang, Han Xu · 2024 · Inorganic Chemistry
  51. The Role of Macrophages in Various Types of Tumors and the Possibility of Their Use as Targets for Antitumor Therapy
    Enar D. Jumaniyazova, А. V. Lokhonina, Dzhuliia Sh. Dzhalilova, Ekaterina Alexandrovna Miroshnichenko, Anna Mikhailovna Kosyreva, Timur Fatkhudinov · 2025 · Cancers
  52. The impact of the tumor microenvironment on macrophages
    Man Xiao, Xiaoduan Li · 2025 · Frontiers in Immunology
  53. Tumor-associated macrophages: untapped molecular targets to improve T cell-based immunotherapy
    Rui M. L. Coelho, Reno Debets, Dora Hammerl · 2025 · Molecular Cancer
  54. Immune dysfunction in Alzheimer disease
    Oleg Butovsky, Neta Rosenzweig, Kilian L. Kleemann, Mehdi Jorfi, Vijay Kumar Kuchroo, Rudolph E. Tanzi, Howard L. Weiner · 2025 · Nature reviews. Neuroscience
  55. Comparative Insight into Microglia/Macrophages-Associated Pathways in Glioblastoma and Alzheimer’s Disease
    Jian Shi, Shi‐Wei Huang · 2023 · International Journal of Molecular Sciences
  56. Gene-Expression Profiling to Decipher Breast Cancer Inter- and Intratumor Heterogeneity
    Alexander Swarbrick, Aranzazu Fernández-Martínez, Charles M. Perou · 2023 · Cold Spring Harbor Perspectives in Medicine
  57. Alveolar macrophages in lung cancer: opportunities and challenges
    Cheng-Yen Chang, Dominique Armstrong, David Brian Corry, Farrah Kheradmand · 2023 · Frontiers in Immunology
  58. FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury
    Hongxia Wang, Jialiang Ma, Xiaoling Li, Yanhui Peng, Manxia Wang · 2024 · European Journal of Pharmacology
  59. Dynamic immunoediting by macrophages in homologous recombination deficiency-stratified pancreatic ductal adenocarcinoma
    Wei-Feng Hong, Feng Zhang, Nan Wang, Jun-Ming Bi, Ding-Wen Zhang, Lusheng Wei, Zhentao Song, Gordon Brent Mills, Minmin Chen, Xuexin Li et al. · 2024 · Drug Resistance Updates
  60. Activation of NOD1 on tumor-associated macrophages augments CD8 + T cell–mediated antitumor immunity in hepatocellular carcinoma
    Feng Zhang, Qiuyu Jiang, Jialiang Cai, Fansheng Meng, Wenqing Tang, Zhiyong Liu, Xiahui Lin, Wenfeng Liu, Yi Zhou, Xizhong Shen et al. · 2024 · Science Advances
  61. TREM2-expressing macrophages in liver diseases
    Xiaochen Wang, Zhiyu Qiu, Zhenyu Zhong, Shuang Liang · 2025 · Trends in Endocrinology and Metabolism
  62. Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition
    Larissa S. Carnevalli, Molly A. Taylor, Matthew A. King, Anna M. L. Coenen-Stass, Adina M. Hughes, Sigourney Bell, Theresa A. Proia, Yanjun Wang, Antonio Ramos‐Montoya, Neha Wali et al. · 2021 · Molecular Cancer Therapeutics
  63. Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways
    Serena Filiberti, Mariapia Russo, Silvia Lonardi, Mattia Bugatti, William Vermi, Cathy Tournier, Emanuele Giurisato · 2022 · Biomedicines
  64. TREM2 has a significant, gender-specific, effect on human obesity
    Tzila Reich, Orit Adato, Naomi Schneid Kofman, Ariel Feiglin, Ron Unger · 2023 · Scientific Reports
  65. The Protective Role of TREM2 in the Heterogenous Population of Macrophages during Post-Myocardial Infarction Inflammation
    Sang Hyun Kim, Kwan Yong Lee, Kiyuk Chang · 2023 · International Journal of Molecular Sciences
  66. Applying causal discovery to single-cell analyses using CausalCell
    Yujian Wen, Jielong Huang, Hai Zhang, Shuhui Guo, Yehezqel Elyahu, Alon Monsonego, Yanqing Ding, Hao Zhu · 2023 · eLife
  67. Current understanding on TREM-2 molecular biology and physiopathological functions
    Shiv Bharadwaj, Yaroslava Groza, Joanna Maria Mierzwicka, Petr Malý · 2024 · International Immunopharmacology
  68. Immunomic longitudinal profiling of the NeoPembrOv trial identifies drivers of immunoresistance in high-grade ovarian carcinoma
    Olivia Le Saux, Maude Ardin, Justine Berthet, Sarah Ghamry-Barrin, Morgane Bourhis, Justine Cinier, Yasmine Lounici, Isabelle Treilleux, Pierre‐Alexandre Just, Guillaume Bataillon et al. · 2024 · Nature Communications
  69. Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas
    Pravesh Gupta, Minghao Dang, Shivangi Oberai, Simona Migliozzi, Rakesh Trivedi, Gayatri Kumar, Mekenzie Peshoff, Nancy Milam, Aml Ahmed, Krishna Bojja et al. · 2024 · Neuro-Oncology
  70. Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast
    Vidya C. Sinha, Amanda L. Rinkenbaugh, Mingchu Xu, Xinhui Zhou, Xiaomei Zhang, Sabrina L. Jeter-Jones, Jiansu Shao, Yuan Qi, John A. Zebala, Dean Y. Maeda et al. · 2021 · Nature Communications
  71. Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination
    Hou, Jinchao, Magliozzi, Roberta, Chen, Yun, Wu, Junjie, Wulf, John, Strout, Gregory, Fang, Xiangming, Colonna, Marco · 2025 · Proceedings of the National Academy of Sciences
  72. Immunotherapy in lung cancer brain metastases
    Eunice Paisana, Rita Cascão, Magda Alvoeiro, Francisco Félix, Guilherme Martins, Carla Guerreiro, Rafael Roque, Rafael Cruz, Teresa R. Pacheco, Ana Cristina Amado et al. · 2025 · npj Precision Oncology
  73. A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis
    Paul Hoover, Chirag Raparia, David Lieb, Yochay Tzur, Joyce B. Kang, Arnon Arazi, Rollin Leavitt, Rakesh Mishra, Sujal I. Shah, Daimon P. Simmons et al. · 2025 · The Journal of Experimental Medicine
  74. Mutational Analysis of PBRM1 and Significance of PBRM1 Mutation in Anti-PD-1 Immunotherapy of Clear Cell Renal Cell Carcinoma
    Abudureyimujiang Aili, Jie Wen, Lixiang Xue, Junjie Wang · 2021 · Frontiers in Oncology
  75. Heterogeneity of tumor-infiltrating myeloid cells in era of single-cell genomics
    Xiaojing Chu, Yu Zhang, Sijin Cheng · 2022 · Chinese Journal of Cancer Research
  76. Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer
    Mehdi Chaib, Jeremiah Ray Holt, Emilie L. Fisher, Laura M. Sipe, Margaret Sue Bohm, Sydney C. Joseph, Boston W. Simmons, Samson Eugin Simon, Johnathan R. Yarbro, Ubaid A. Tanveer et al. · 2023 · Science Advances
  77. TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
    Grégoire Gessain, Ahmed-Amine Anzali, Marvin Lerousseau, Kevin Mulder, Mathilde Bied, Anne Auperin, Daniel Stockholm, Nicolas Signolle, Farah Sassi, Maria Eugénia Marques Da Costa et al. · 2024 · Cancer Discovery
  78. Promising and challenging phytochemicals targeting LC3 mediated autophagy signaling in cancer therapy
    Peramaiyan Rajendran, Kaviyarasi Renu, Enas Mohamed Ali, Marwa Azmy M. Genena, Vishnupriya Veeraraghavan, Ramya Sekar, Ashok Kumar Sekar, Sujatha Tejavat, Parthasarathi Barik, Basem M. Abdallah · 2024 · Immunity Inflammation and Disease
  79. Identification and immunoprofiling of key prognostic genes in the tumor microenvironment of hepatocellular carcinoma
    Tian-bing Wang, Bang Chen, Tao Meng, Zhiqiang Liu, Wenyong Wu · 2021 · Bioengineered
  80. Macrophage heterogeneity and its interactions with stromal cells in tumour microenvironment
    Liren Cao, Xiaoyan Meng, Zhiyuan Zhang, Zhonglong Liu, Yue He · 2024 · Cell & Bioscience
  81. Current strategies for armoring chimeric antigen receptor T-cells to overcome barriers of the solid tumor microenvironment
    Dorothy Daiyi Yang, William Macmorland, James N. Arnold · 2025 · Frontiers in Immunology
  82. Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers
    Bruna Araújo David, Francesco Andreata, Camille Blériot, Florent Ginhoux, Paul Kubes, Matteo Iannacone · 2026 · Nature reviews. Immunology
  83. Synthesis and Evaluation of 68Ga-NOTA-COG1410 Targeting to TREM2 of TAMs as a Specific PET Probe for Digestive Tumor Diagnosis
    Dai Shi, Zhan Si, Zhan Xu, Yuan Cheng, Qingyu Lin, Zhequan Fu, Wenhui Fu, Tingting Yang, Hongcheng Shi, Dengfeng Cheng · 2022 · Analytical Chemistry
  84. The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke
    Wen-yu Ma, Shasha Wang, Qing-lin Wu, Xin‐Fu Zhou, Shifeng Chu, Nai‐Hong Chen · 2022 · International Immunopharmacology
  85. Tumor‐associated macrophages regulate the function of cytotoxic T lymphocyte through PD ‐1/ PD‐L1 pathway in multiple myeloma
    Jiangbo Zhang, Zhaoyun Liu, Panpan Cao, Hao Wang, Hui Liu, Luoming Hua, Hua Xue, Rong Fu · 2022 · Cancer Medicine
  86. TREM2 signalling as a multifaceted player in brain homoeostasis and a potential target for Alzheimer's disease treatment
    Gunel Ayyubova · 2023 · European Journal of Neuroscience
  87. Tumor-derived interleukin-1α and leukemia inhibitory factor promote extramedullary hematopoiesis
    Derek A. G. Barisas, Minseo Kim, Madhav Subramanian, Ashraf Ul Kabir, Karen Krchma, Jun Wu, Bernd H. Zinselmeyer, Colin L. Stewart, Kyunghee Choi · 2023 · PLoS Biology
  88. The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue
    Sprenkle, Neil T., Winn, Nathan C., Bunn, Kaitlyn E., Zhao, Yang, Park, Deborah J., Giese, Brenna G., Karijolich, John J., Ansel, K. Mark, Serezani, C. Henrique, Hasty, Alyssa H. et al. · 2023 · Cell Reports
  89. Subverted macrophages in the triple-negative breast cancer ecosystem
    Linxiao Shang, Yuting Zhong, Yan Yao, Cun Liu, Lu Wang, Wen‐Feng Zhang, Jingyang Liu, Xue Wang, Changgang Sun · 2023 · Biomedicine & Pharmacotherapy
  90. Single-cell RNA sequencing reveals myeloid and T cell co-stimulation mediated by IL-7 anti-cancer immunotherapy
    Hye Hyeon Eum, Dasom Jeong, Nayoung Kim, Areum Jo, Minsu Na, Huiram Kang, Yourae Hong, Jin‐Sun Kong, Gi Heon Jeong, Seung‐Ah Yoo et al. · 2024 · British Journal of Cancer
  91. Single-cell transcriptomics provide insight into metastasis-related subsets of breast cancer
    Shikun Zhu, Mi Zhang, Xuexue Liu, Qing Luo, Jiahong Zhou, Miao Song, Jia Feng, Jinbo Liu · 2023 · Breast Cancer Research
  92. Mild Hyperthermia Accelerates Bone Repair by Dynamically Regulating iNOS/Arg1 Balance in the Early Stage
    Jinhui Zhao, Yiping Luo, Lei Zhang, Yunfeng Chen, Yixing Chen, Xinhui Wu, Aihemaitijiang Aierken, Dilixiati Duolikun, Tianlong Wang, Zifei Zhou et al. · 2024 · Advanced Science
  93. Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
    Ziyi Wang, Yu Zhang, Xiangdong Li, Nan Xia, Sheng Han, Liyong Pu, Xuehao Wang · 2025 · Cancer Immunology Research
  94. Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells
    Gal Yagel, Dana Rimini, Michelle von Locquenghien, Roberto Avellino, Oren Barboy, Paulina Chalan, Gaya Granot, Ken Xie, Shir Shlomi-Loubaton, Fadi Sheban et al. · 2026 · Cancer Cell
  95. Overcoming Immune Resistance With Radiation Therapy in Prostate Cancer
    Arthur Mulvey, Emilien Muggeo-Bertin, Dominik Berthold, Fernanda Gabriela Herrera · 2022 · Frontiers in Immunology
  96. The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
    Umair Majid, Christian Holst Bergsland, Anita Sveen, Jarle Bruun, Ina Andrassy Eilertsen, Espen S. Bækkevold, Arild Nesbakken, Sheraz Yaqub, Frode Lars Jahnsen, Ragnhild A. Lothe · 2024 · Cellular Oncology
  97. Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer
    Alexis K. Elfstrum, Aditi S. Bapat, Kathryn L. Schwertfeger · 2024 · Cancer Medicine
  98. TREM2 in cardiovascular diseases: Mechanisms and therapeutic perspectives
    Wengen Zhu, Zhou Yue, Yufan Wang, Linjuan Guo, Chen Liu · 2025 · Ageing Research Reviews
  99. AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progression
    Qiaohua Wang, Yongjian Wu, Yili Long, Rongna Li, Yu Shi, Yanfen Zheng, Xiaohui Chen, Xiang Li, Yihong Zhou, Xi Huang et al. · 2025 · Nature Communications
  100. The integrated stress response promotes immune evasion through lipocalin 2
    Jozef P. Bossowski, Ray Pillai, John Kilian, Angela Wong Lau, Mari Nakamura, Ali Rashidfarrokhi, Yuan Hao, Ruxuan Li, Katherine Wu, Takamitsu Hattori et al. · 2026 · Nature