TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy
Molgora, Martina, Esaulova, Ekaterina, Vermi, William, Hou, Jinchao, Chen, Yun, Luo, Jingqin, Brioschi, Simone, Bugatti, Mattia, Omodei, Andrea Salvatore, Ricci, Biancamaria, Fronick, Catrina, Panda, Santosh K., Takeuchi, Yoshiko, Gubin, Matthew M., Faccio, Roberta, Cella, Marina, Gilfillan, Susan, Unanue, Emil R., Artyomov, Maxim N., Schreiber, Robert D., Colonna, Marco·2020·Cell
Cited by (657)
Items 201–300 of 657
- Clinical impact of anti-inflammatory microglia and macrophage phenotypes at glioblastoma marginsImran Noorani, Kastytis Šidlauskas, Sean Pellow, Reece Savage, Jeannette L Norman, David S. Chatelet, Mark Fabian, Paul Grundy, Jeng Ching, James A. R. Nicoll et al. · 2023 · Brain Communications
- Tumour-associated macrophages: versatile players in the tumour microenvironmentZoey Zeyuan Ji, Max Kam‐Kwan Chan, Alex Siu Wing Chan, Kam Tong Leung, Xiaohua Jiang, Ka‐Fai To, Yi Wu, Patrick Ming‐Kuen Tang · 2023 · Frontiers in Cell and Developmental Biology
- Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophagesYingzheng Xu, Hannah Hillman, Michael Chang, Fanta Barrow, Stoyan Ivanov, Xavier S. Revelo, Jesse W. Williams · 2025 · Communications Biology
- Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapyMichelle von Locquenghien, Pascale Zwicky, Ken Xie, Diego Adhemar Jaitin, Fadi Sheban, Adam Yalin, Florian Uhlitz, Chamutal Gur, Reut Sharet-Eshed, Eyal David et al. · 2025 · Cell
- MIF is a critical regulator of mononuclear phagocytic infiltration in hepatocellular carcinomaYunxi Liao, Chenyang Wu, Li Yang, Jinhua Wen, Dongyu Zhao · 2023 · iScience
- Single cell analyses reveal the PD-1 blockade response-related immune features in hepatocellular carcinomaYao Li, Fengwei Li, Lei Xu, Xiaodong Shi, Hui Xue, Jianwei Liu, Shilei Bai, Yeye Wu, Yang Zhao, Feng Xue et al. · 2024 · Theranostics
- Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid nicheHaensel, Daniel, Daniel, Bence, Gaddam, Sadhana, Pan, Cory, Fabo, Tania, Bjelajac, Jeremy, Jussila, Anna R., Gonzalez, Fernanda, Li, Nancy Yanzhe, Chen, Yun et al. · 2023 · Nature Communications
- Blocking CX3CR1+ Tumor-Associated Macrophages Enhances the Efficacy of Anti-PD1 Therapy in Hepatocellular CarcinomaXiaonan Xiang, Kai Wang, Hui Zhang, Haibo Mou, Zhixiong Shi, Yaoye Tao, Hongliang Song, Zhengxing Lian, Shuai Wang, Di Lu et al. · 2024 · Cancer Immunology Research
- Single‐cell transcriptome analysis deciphers the CD74‐mediated immune evasion and tumour growth in lung squamous cell carcinoma with chronic obstructive pulmonary diseaseDenian Wang, Sixiang Li, Zhi Yang, Chunyan Yu, Peng-Fei Wu, Ying Yang, Rui Zhang, Qingyan Li, Jian Yang, Hongchun Li et al. · 2024 · Clinical and Translational Medicine
- Unravelling monocyte functions: from the guardians of health to the regulators of diseaseAlexander Mildner, Ki-Wook Kim, Simon Yona · 2024 · Discovery Immunology
- Unraveling the role of M2 TAMs in ovarian cancer dynamics: a systematic reviewYa-Ping Wang, Caixia Ma, Xiabing Li, Fangfang Yang, Na Wang, Gaili Ji, Qing Liu, Hong Zhu, Shengnan Xu, Hongyu Li · 2025 · Journal of Translational Medicine
- Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18Sayuri Miyauchi, Kei‐ichiro Arimoto, Mengdan Liu, Yue Zhang, Dong‐Er Zhang · 2023 · Cell Reports
- sTREM2 is a plasma biomarker for human NASH and promotes hepatocyte lipid accumulationVishal M Kothari, Christopher E. Savard, Jingjing Tang, Sum P. Lee, Savitha Subramanian, Shari Wang, Laura J. den Hartigh, Karin Bornfeldt, George N. Ioannou · 2023 · Hepatology Communications
- The Yin Yang of Complement and CancerSeppo Meri, Elena Illica Magrini, Alberto Mantovani, Cecília Garlanda · 2023 · Cancer Immunology Research
- A novel polysaccharide isolated from Coriolus versicolor polarizes M2 macrophages into an M1 phenotype and reversesits immunosuppressive effect on tumor microenvironmentSixue Bi, Yongshuai Jing, Xuehui Cui, Yitong Gong, Junli Zhang, Xiaofei Feng, Zhen Shi, Qiusheng Zheng, Defang Li · 2024 · International Journal of Biological Macromolecules
- Molecular maps of synovial cells in inflammatory arthritis using an optimized synovial tissue dissociation protocolSam G. Edalat, Reto Gerber, Miranda Houtman, Janine Lückgen, Rui Lourenço Teixeira, Maria Del Pilar Palacios Cisneros, Tamara Pfanner, Tadeja Kuret, Nadja Ižanc, Raphael Micheroli et al. · 2024 · iScience
- Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancerMindy Kim Graham, Rulin Wang, Roshan V. Chikarmane, Bulouere Abel, Ajay M. Vaghasia, Anuj Gupta, Qizhi Zheng, Jessica L Hicks, Polina Sysa‐Shah, Xin Pan et al. · 2024 · Nature Communications
- Metabolism and macrophages in the tumor microenvironmentHannah Yang, Chan Kim, Weiping Zou · 2024 · Current Opinion in Immunology
- Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to interventionHancheng Wu, Jing Li, Ruilin Yao, Jing Liu, Lili Su, Wenjie You · 2025 · Theranostics
- Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growthJaime Mateus-Tique, Ashwitha Lakshmi, Bhavya Singh, Rhea Iyer, Alfonso R. Sánchez-Paulete, Chiara Falcomatà, M J Lin, Gvantsa Pantsulaia, Alexander Tepper, Trung Nguyen et al. · 2026 · Cancer Cell
- Role of myeloid-derived suppressor cells in the formation of pre-metastatic nicheGuoqi Ya, Weihong Ren, Rui Qin, Jiao He, Shuo Zhao · 2022 · Frontiers in Oncology
- An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of RadiotheranosticsViviana Benfante, Alessandro Stefano, Muhammad Usman Ali, Riccardo Laudicella, Walter Arancio, Antonino Cucchiara, Fabio Caruso, Francesco Paolo Cammarata, Claudia Coronnello, Giorgio Ivan Russo et al. · 2023 · Diagnostics
- Single-cell RNA sequencing in cancer research: discovering novel biomarkers and therapeutic targets for immune checkpoint blockadeBoyu Sun, Ziyu Xun, Nan Zhang, Kai Liu, Xiangqi Chen, Haitao Zhao · 2023 · Cancer Cell International
- Blockade of TREM2 ameliorates pulmonary inflammation and fibrosis by modulating sphingolipid metabolismGu, Xueqing, Kang, Hanyujie, Cao, Siyu, Tong, Zhaohui, Song, Nan · 2025 · Translational Research
- TAMs in Brain Metastasis: Molecular Signatures in Mouse and ManMichael Schulz, Lisa Sevenich · 2021 · Frontiers in Immunology
- Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblastsEleonora Timperi, Emanuela Romano · 2023 · Frontiers in Immunology
- Embracing diversity: macrophage complexity in cancerJan Hochstadt, Sarai Martínez Pacheco, María Casanova-Acebes · 2025 · Trends in cancer
- Polarization of Tumor Cells and Tumor‐Associated Macrophages: Molecular Mechanisms and Therapeutic TargetsGuohao Wei, Bin Li, Mengyang Huang, Mengyao Lv, Zihui Liang, Chuandong Zhu, Lilin Ge, Jing Chen · 2025 · MedComm
- Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expressionHinda Najem, Martina Ott, Cynthia Kassab, Arvind U.K. Rao, Ganesh Rao, Anantha Marisetty, Adam M. Sonabend, Craig Horbinski, Roel G.W. Verhaak, Anand Shankar et al. · 2022 · JCI Insight
- Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental ArthritisA. Sigalov · 2022 · International Journal of Molecular Sciences
- TREM2 mediates MHCII-associated CD4+ T-cell response against gliomasJiaying Zheng, Lingxiao Wang, Shunyi Zhao, Wenjing Zhang, Yuzhou Chang, Dale B. Bosco, Tao Huang, Aastha Dheer, Shan Gao, Shengze Xu et al. · 2023 · Neuro-Oncology
- Nanomedicines for reversing immunosuppressive microenvironment of hepatocellular carcinomaXier Pan, Shuting Ni, Kaili Hu · 2024 · Biomaterials
- Mechanisms of TREM2 mediated immunosuppression and regulation of cancer progressionXia Lei, Yani Gou, Jin Yong Hao, Xiao Jun Huang · 2024 · Frontiers in Oncology
- Targeting myeloid cells to improve cancer immune therapyHui Chen, Zihan Xu, Judith A. Varner · 2025 · Frontiers in Immunology
- Understanding the complexity of tumor-associated macrophages: Druggable and therapeutic insightsAn-Qi Li, Fang Huang, Sulaiya Talaiti, Xiao Yi Yang, Huichang Bi, Jian‐Hong Fang · 2025 · Acta Pharmaceutica Sinica B
- Specialized functions and sexual dimorphism explain the functional diversity of the myeloid populations during glioma progressionNatalia Ochocka, Paweł Segit, Kamil Wojnicki, Salwador Cyranowski, Julian Swatler, Karol Jacek, Wiesława Grajkowska, Bozena Kaminska · 2023 · Cell Reports
- Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTsClémence Henon, Julien Vibert, Thomas Eychenne, Nadège Gruel, Leo Colmet Daage, Carine Ngo, Marlène Garrido, Nicolas Dorvault, Maria Eugénia Marques Da Costa, Virginie Marty et al. · 2024 · Cell Reports Medicine
- Single-Cell Transcriptomes of Hereditary Kidney Cancers Underscore Genetically Defined Tumor Characteristics and MicroenvironmentRyosuke Jikuya, Koichi Murakami, Akira Nishiyama, Ikuma Kato, Mitsuko Furuya, Jun Nakabayashi, Jordan A. Ramilowski, Haruka Hamanoue, Kazuhiro Maejima, Masashi Fujita et al. · 2022 · iScience
- Discovery of 2H-Indazole-3-carboxamide Derivatives as Novel Potent Prostanoid EP4 Receptor Antagonists for Colorectal Cancer ImmunotherapyZhiyuan Cheng, Yijie Wang, Yao Zhang, Chan Zhang, Mengru Wang, Wei Wang, Jiacheng He, Yang Wang, Hankun Zhang, Qiansen Zhang et al. · 2023 · Journal of Medicinal Chemistry
- The double-edged role and therapeutic potential of TREM2 in atherosclerosisBotao Zhu, Yuxuan Liu, Daoquan Peng · 2024 · Biomarker Research
- TREM2 promotes the formation of a tumor-supportive microenvironment in hepatocellular carcinomaHanrui Guo, Meiling Wang, Caiya Ni, Chun Yang, Chunxue Fu, Xiaoman Zhang, Xueling Chen, Xiangwei Wu, Jun Wei Hou, Lianghai Wang · 2025 · Journal of Experimental & Clinical Cancer Research
- TREM2+ macrophages: a key role in disease developmentXinxin Wang, Yunhan Wang, Lei Xiang Yang, Yi Zhang, Li Yang · 2025 · Frontiers in Immunology
- TREM2-mediated regulation of myeloid cells in the tumor microenvironment: new insights and therapeutic prospectsYueyu Huang, Wanxia Fang · 2025 · npj Precision Oncology
- Cyclophilin A is an endogenous ligand for the triggering receptor expressed on myeloid cells‐2 (TREM2)Kon-Young Ji, Su‐Man Kim, Su‐Min Yee, Min‐Jae Kim, Yu-Jin Ban, Eun‐Mi Kim, Eun Hee Lee, Ha‐Rim Choi, Hyosuk Yun, Chul Won Lee et al. · 2021 · The FASEB Journal
- Myeloid checkpoints for cancer immunotherapyYixin Qian, Ting Yang, Huan Liang, Mi Deng · 2022 · Chinese Journal of Cancer Research
- Non-genetic Heterogeneity of Macrophages in Diseases—A Medical PerspectiveGrégoire Gessain, Camille Blériot, Florent Ginhoux · 2020 · Frontiers in Cell and Developmental Biology
- The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer—Challenges and opportunitiesKohlhepp, Marlene Sophia, Liu, Hanyang, Tacke, Frank, Guillot, Adrien · 2023 · Frontiers in Molecular Biosciences
- HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signalingHui Qiu, Zhiying Shao, Xin Wen, Debao Qu, Zhengyang Liu, Ziqin Chen, Xinyan Zhang, Xin Ding, Longzhen Zhang · 2024 · Journal of Translational Medicine
- Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapySunita Keshari, Alexander S. Shavkunov, Qi Miao, Akata Saha, Tomoyuki Minowa, Martina Molgora, Charmelle D. Williams, Mehdi Chaib, Anna M. Highsmith, Josue Estiven Pineda et al. · 2024 · Cell Reports
- Enhanced Photothermal/Immunotherapy under NIR Irradiation Based on Hollow Mesoporous Responsive NanomotorWenjing Li, Yukun Wang, Han Xu · 2024 · Inorganic Chemistry
- The Role of Macrophages in Various Types of Tumors and the Possibility of Their Use as Targets for Antitumor TherapyEnar D. Jumaniyazova, А. V. Lokhonina, Dzhuliia Sh. Dzhalilova, Ekaterina Alexandrovna Miroshnichenko, Anna Mikhailovna Kosyreva, Timur Fatkhudinov · 2025 · Cancers
- The impact of the tumor microenvironment on macrophagesMan Xiao, Xiaoduan Li · 2025 · Frontiers in Immunology
- Tumor-associated macrophages: untapped molecular targets to improve T cell-based immunotherapyRui M. L. Coelho, Reno Debets, Dora Hammerl · 2025 · Molecular Cancer
- Immune dysfunction in Alzheimer diseaseOleg Butovsky, Neta Rosenzweig, Kilian L. Kleemann, Mehdi Jorfi, Vijay Kumar Kuchroo, Rudolph E. Tanzi, Howard L. Weiner · 2025 · Nature reviews. Neuroscience
- Comparative Insight into Microglia/Macrophages-Associated Pathways in Glioblastoma and Alzheimer’s DiseaseJian Shi, Shi‐Wei Huang · 2023 · International Journal of Molecular Sciences
- Gene-Expression Profiling to Decipher Breast Cancer Inter- and Intratumor HeterogeneityAlexander Swarbrick, Aranzazu Fernández-Martínez, Charles M. Perou · 2023 · Cold Spring Harbor Perspectives in Medicine
- Alveolar macrophages in lung cancer: opportunities and challengesCheng-Yen Chang, Dominique Armstrong, David Brian Corry, Farrah Kheradmand · 2023 · Frontiers in Immunology
- FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injuryHongxia Wang, Jialiang Ma, Xiaoling Li, Yanhui Peng, Manxia Wang · 2024 · European Journal of Pharmacology
- Dynamic immunoediting by macrophages in homologous recombination deficiency-stratified pancreatic ductal adenocarcinomaWei-Feng Hong, Feng Zhang, Nan Wang, Jun-Ming Bi, Ding-Wen Zhang, Lusheng Wei, Zhentao Song, Gordon Brent Mills, Minmin Chen, Xuexin Li et al. · 2024 · Drug Resistance Updates
- Activation of NOD1 on tumor-associated macrophages augments CD8 + T cell–mediated antitumor immunity in hepatocellular carcinomaFeng Zhang, Qiuyu Jiang, Jialiang Cai, Fansheng Meng, Wenqing Tang, Zhiyong Liu, Xiahui Lin, Wenfeng Liu, Yi Zhou, Xizhong Shen et al. · 2024 · Science Advances
- TREM2-expressing macrophages in liver diseasesXiaochen Wang, Zhiyu Qiu, Zhenyu Zhong, Shuang Liang · 2025 · Trends in Endocrinology and Metabolism
- Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ InhibitionLarissa S. Carnevalli, Molly A. Taylor, Matthew A. King, Anna M. L. Coenen-Stass, Adina M. Hughes, Sigourney Bell, Theresa A. Proia, Yanjun Wang, Antonio Ramos‐Montoya, Neha Wali et al. · 2021 · Molecular Cancer Therapeutics
- Self-Renewal of Macrophages: Tumor-Released Factors and Signaling PathwaysSerena Filiberti, Mariapia Russo, Silvia Lonardi, Mattia Bugatti, William Vermi, Cathy Tournier, Emanuele Giurisato · 2022 · Biomedicines
- TREM2 has a significant, gender-specific, effect on human obesityTzila Reich, Orit Adato, Naomi Schneid Kofman, Ariel Feiglin, Ron Unger · 2023 · Scientific Reports
- The Protective Role of TREM2 in the Heterogenous Population of Macrophages during Post-Myocardial Infarction InflammationSang Hyun Kim, Kwan Yong Lee, Kiyuk Chang · 2023 · International Journal of Molecular Sciences
- Applying causal discovery to single-cell analyses using CausalCellYujian Wen, Jielong Huang, Hai Zhang, Shuhui Guo, Yehezqel Elyahu, Alon Monsonego, Yanqing Ding, Hao Zhu · 2023 · eLife
- Current understanding on TREM-2 molecular biology and physiopathological functionsShiv Bharadwaj, Yaroslava Groza, Joanna Maria Mierzwicka, Petr Malý · 2024 · International Immunopharmacology
- Immunomic longitudinal profiling of the NeoPembrOv trial identifies drivers of immunoresistance in high-grade ovarian carcinomaOlivia Le Saux, Maude Ardin, Justine Berthet, Sarah Ghamry-Barrin, Morgane Bourhis, Justine Cinier, Yasmine Lounici, Isabelle Treilleux, Pierre‐Alexandre Just, Guillaume Bataillon et al. · 2024 · Nature Communications
- Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomasPravesh Gupta, Minghao Dang, Shivangi Oberai, Simona Migliozzi, Rakesh Trivedi, Gayatri Kumar, Mekenzie Peshoff, Nancy Milam, Aml Ahmed, Krishna Bojja et al. · 2024 · Neuro-Oncology
- Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breastVidya C. Sinha, Amanda L. Rinkenbaugh, Mingchu Xu, Xinhui Zhou, Xiaomei Zhang, Sabrina L. Jeter-Jones, Jiansu Shao, Yuan Qi, John A. Zebala, Dean Y. Maeda et al. · 2021 · Nature Communications
- Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelinationHou, Jinchao, Magliozzi, Roberta, Chen, Yun, Wu, Junjie, Wulf, John, Strout, Gregory, Fang, Xiangming, Colonna, Marco · 2025 · Proceedings of the National Academy of Sciences
- Immunotherapy in lung cancer brain metastasesEunice Paisana, Rita Cascão, Magda Alvoeiro, Francisco Félix, Guilherme Martins, Carla Guerreiro, Rafael Roque, Rafael Cruz, Teresa R. Pacheco, Ana Cristina Amado et al. · 2025 · npj Precision Oncology
- A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritisPaul Hoover, Chirag Raparia, David Lieb, Yochay Tzur, Joyce B. Kang, Arnon Arazi, Rollin Leavitt, Rakesh Mishra, Sujal I. Shah, Daimon P. Simmons et al. · 2025 · The Journal of Experimental Medicine
- Mutational Analysis of PBRM1 and Significance of PBRM1 Mutation in Anti-PD-1 Immunotherapy of Clear Cell Renal Cell CarcinomaAbudureyimujiang Aili, Jie Wen, Lixiang Xue, Junjie Wang · 2021 · Frontiers in Oncology
- Heterogeneity of tumor-infiltrating myeloid cells in era of single-cell genomicsXiaojing Chu, Yu Zhang, Sijin Cheng · 2022 · Chinese Journal of Cancer Research
- Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancerMehdi Chaib, Jeremiah Ray Holt, Emilie L. Fisher, Laura M. Sipe, Margaret Sue Bohm, Sydney C. Joseph, Boston W. Simmons, Samson Eugin Simon, Johnathan R. Yarbro, Ubaid A. Tanveer et al. · 2023 · Science Advances
- TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell CarcinomaGrégoire Gessain, Ahmed-Amine Anzali, Marvin Lerousseau, Kevin Mulder, Mathilde Bied, Anne Auperin, Daniel Stockholm, Nicolas Signolle, Farah Sassi, Maria Eugénia Marques Da Costa et al. · 2024 · Cancer Discovery
- Promising and challenging phytochemicals targeting LC3 mediated autophagy signaling in cancer therapyPeramaiyan Rajendran, Kaviyarasi Renu, Enas Mohamed Ali, Marwa Azmy M. Genena, Vishnupriya Veeraraghavan, Ramya Sekar, Ashok Kumar Sekar, Sujatha Tejavat, Parthasarathi Barik, Basem M. Abdallah · 2024 · Immunity Inflammation and Disease
- Identification and immunoprofiling of key prognostic genes in the tumor microenvironment of hepatocellular carcinomaTian-bing Wang, Bang Chen, Tao Meng, Zhiqiang Liu, Wenyong Wu · 2021 · Bioengineered
- Macrophage heterogeneity and its interactions with stromal cells in tumour microenvironmentLiren Cao, Xiaoyan Meng, Zhiyuan Zhang, Zhonglong Liu, Yue He · 2024 · Cell & Bioscience
- Current strategies for armoring chimeric antigen receptor T-cells to overcome barriers of the solid tumor microenvironmentDorothy Daiyi Yang, William Macmorland, James N. Arnold · 2025 · Frontiers in Immunology
- Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepersBruna Araújo David, Francesco Andreata, Camille Blériot, Florent Ginhoux, Paul Kubes, Matteo Iannacone · 2026 · Nature reviews. Immunology
- Synthesis and Evaluation of 68Ga-NOTA-COG1410 Targeting to TREM2 of TAMs as a Specific PET Probe for Digestive Tumor DiagnosisDai Shi, Zhan Si, Zhan Xu, Yuan Cheng, Qingyu Lin, Zhequan Fu, Wenhui Fu, Tingting Yang, Hongcheng Shi, Dengfeng Cheng · 2022 · Analytical Chemistry
- The versatile role of TREM2 in regulating of microglia fate in the ischemic strokeWen-yu Ma, Shasha Wang, Qing-lin Wu, Xin‐Fu Zhou, Shifeng Chu, Nai‐Hong Chen · 2022 · International Immunopharmacology
- Tumor‐associated macrophages regulate the function of cytotoxic T lymphocyte through PD ‐1/ PD‐L1 pathway in multiple myelomaJiangbo Zhang, Zhaoyun Liu, Panpan Cao, Hao Wang, Hui Liu, Luoming Hua, Hua Xue, Rong Fu · 2022 · Cancer Medicine
- TREM2 signalling as a multifaceted player in brain homoeostasis and a potential target for Alzheimer's disease treatmentGunel Ayyubova · 2023 · European Journal of Neuroscience
- Tumor-derived interleukin-1α and leukemia inhibitory factor promote extramedullary hematopoiesisDerek A. G. Barisas, Minseo Kim, Madhav Subramanian, Ashraf Ul Kabir, Karen Krchma, Jun Wu, Bernd H. Zinselmeyer, Colin L. Stewart, Kyunghee Choi · 2023 · PLoS Biology
- The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissueSprenkle, Neil T., Winn, Nathan C., Bunn, Kaitlyn E., Zhao, Yang, Park, Deborah J., Giese, Brenna G., Karijolich, John J., Ansel, K. Mark, Serezani, C. Henrique, Hasty, Alyssa H. et al. · 2023 · Cell Reports
- Subverted macrophages in the triple-negative breast cancer ecosystemLinxiao Shang, Yuting Zhong, Yan Yao, Cun Liu, Lu Wang, Wen‐Feng Zhang, Jingyang Liu, Xue Wang, Changgang Sun · 2023 · Biomedicine & Pharmacotherapy
- Single-cell RNA sequencing reveals myeloid and T cell co-stimulation mediated by IL-7 anti-cancer immunotherapyHye Hyeon Eum, Dasom Jeong, Nayoung Kim, Areum Jo, Minsu Na, Huiram Kang, Yourae Hong, Jin‐Sun Kong, Gi Heon Jeong, Seung‐Ah Yoo et al. · 2024 · British Journal of Cancer
- Single-cell transcriptomics provide insight into metastasis-related subsets of breast cancerShikun Zhu, Mi Zhang, Xuexue Liu, Qing Luo, Jiahong Zhou, Miao Song, Jia Feng, Jinbo Liu · 2023 · Breast Cancer Research
- Mild Hyperthermia Accelerates Bone Repair by Dynamically Regulating iNOS/Arg1 Balance in the Early StageJinhui Zhao, Yiping Luo, Lei Zhang, Yunfeng Chen, Yixing Chen, Xinhui Wu, Aihemaitijiang Aierken, Dilixiati Duolikun, Tianlong Wang, Zifei Zhou et al. · 2024 · Advanced Science
- Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven HepatocarcinogenesisZiyi Wang, Yu Zhang, Xiangdong Li, Nan Xia, Sheng Han, Liyong Pu, Xuehao Wang · 2025 · Cancer Immunology Research
- Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cellsGal Yagel, Dana Rimini, Michelle von Locquenghien, Roberto Avellino, Oren Barboy, Paulina Chalan, Gaya Granot, Ken Xie, Shir Shlomi-Loubaton, Fadi Sheban et al. · 2026 · Cancer Cell
- Overcoming Immune Resistance With Radiation Therapy in Prostate CancerArthur Mulvey, Emilien Muggeo-Bertin, Dominik Berthold, Fernanda Gabriela Herrera · 2022 · Frontiers in Immunology
- The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltrationUmair Majid, Christian Holst Bergsland, Anita Sveen, Jarle Bruun, Ina Andrassy Eilertsen, Espen S. Bækkevold, Arild Nesbakken, Sheraz Yaqub, Frode Lars Jahnsen, Ragnhild A. Lothe · 2024 · Cellular Oncology
- Defining and targeting macrophage heterogeneity in the mammary gland and breast cancerAlexis K. Elfstrum, Aditi S. Bapat, Kathryn L. Schwertfeger · 2024 · Cancer Medicine
- TREM2 in cardiovascular diseases: Mechanisms and therapeutic perspectivesWengen Zhu, Zhou Yue, Yufan Wang, Linjuan Guo, Chen Liu · 2025 · Ageing Research Reviews
- AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progressionQiaohua Wang, Yongjian Wu, Yili Long, Rongna Li, Yu Shi, Yanfen Zheng, Xiaohui Chen, Xiang Li, Yihong Zhou, Xi Huang et al. · 2025 · Nature Communications
- The integrated stress response promotes immune evasion through lipocalin 2Jozef P. Bossowski, Ray Pillai, John Kilian, Angela Wong Lau, Mari Nakamura, Ali Rashidfarrokhi, Yuan Hao, Ruxuan Li, Katherine Wu, Takamitsu Hattori et al. · 2026 · Nature