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Cited by 895

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Open access
Sun, Yunfan, Wu, Liang, Zhong, Yu, Zhou, Kaiqian, Hou, Yong, Wang, Zifei, Zhang, Zefan, Xie, Jiarui, Wang, Chunqing, Chen, Dandan, Huang, Yaling, Wei, Xiaochan, Shi, Yinghong, Zhao, Zhikun, Li, Yuehua, Guo, Ziwei, Yu, Qichao, Xu, Liqin, Volpe, Giacomo, Qiu, Shuangjian, Zhou, Jian, Ward, Carl, Sun, Huichuan, Yin, Ye, Xu, Xun, Wang, Xiangdong, Esteban, Miguel A., Yang, Huanming, Wang, Jian, Dean, Michael, Zhang, Yaguang, Liu, Shiping, Yang, Xinrong, Fan, Jia·2021·Cell
DOI 10.1016/j.cell.2020.11.041
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Abstract

Hepatocellular carcinoma (HCC) has high relapse and low 5-year survival rates. Single-cell profiling in relapsed HCC may aid in the design of effective anticancer therapies, including immunotherapies. We profiled the transcriptomes of ∼17,000 cells from 18 primary or early-relapse HCC cases. Early-relapse tumors have reduced levels of regulatory T cells, increased dendritic cells (DCs), and increased infiltrated CD8+ T cells, compared with primary tumors, in two independent cohorts. Remarkably, CD8+ T cells in recurrent tumors overexpressed KLRB1 (CD161) and displayed an innate-like low cytotoxic state, with low clonal expansion, unlike the classical exhausted state observed in primary HCC. The enrichment of these cells was associated with a worse prognosis. Differential gene expression and interaction analyses revealed potential immune evasion mechanisms in recurrent tumor cells that dampen DC antigen presentation and recruit innate-like CD8+ T cells. Our comprehensive picture of the HCC ecosystem provides deeper insights into immune evasion mechanisms associated with tumor relapse.

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Research works printed but not linked: 1

  1. Zheng, 2017, Actual 10-Year Survivors After Resection of Hepatocellular Carcinoma, Ann. Surg. Oncol., 24, 1358, 10.1245/s10434-016-5713-2 · DOI

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Metadata

Authors
Sun, Y., Wu, L., Zhong, Y., Zhou, K., Hou, Y., Wang, Z., Zhang, Z., Xie, J., Wang, C., Chen, D., Huang, Y., Wei, X., Shi, Y., Zhao, Z., Li, Y., Guo, Z., Yu, Q., Xu, L., Volpe, G., Qiu, S., Zhou, J., Ward, C., Sun, H., Yin, Y., Xu, X., Wang, X., Esteban, M. A., Yang, H., Wang, J., Dean, M., Zhang, Y., Liu, S., Yang, X., & Fan, J.
Venue
Cell
Publisher
Elsevier BV
Published
2021-01
Volume
184
Issue
2
Pages
404-421.e16
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2020.11.041
OpenAlex
W3118017075
Cited by
895
References
90
FWCI
32.56
Type
journal article
Language
en
Open access
bronze
Licence
Funders
  • Shanghai Association for Science and Technology
  • Chinese Academy of Sciences
  • Science and Technology Planning Project of Guangdong Province
  • Natural Science Foundation of Guangdong Province
  • Science, Technology and Innovation Commission of Shenzhen Municipality
  • Shanghai Municipal Health and Family Planning Commission
  • National Natural Science Foundation of China

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CoChat. (2026). Citation check: Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma. https://app.cochat.ai/papers/10.1016/j.cell.2020.11.041
The paper
Sun, Y., Wu, L., Zhong, Y., Zhou, K., Hou, Y., Wang, Z., Zhang, Z., Xie, J., Wang, C., Chen, D., Huang, Y., Wei, X., Shi, Y., Zhao, Z., Li, Y., Guo, Z., Yu, Q., Xu, L., Volpe, G., . . . Fan, J. (2021). Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma. Cell. https://doi.org/10.1016/j.cell.2020.11.041

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.