Biomarkers for immunotherapy of hepatocellular carcinoma
Abstract
Immune-checkpoint inhibitors (ICIs) are now widely used for the treatment of patients with advanced-stage hepatocellular carcinoma (HCC). Two different ICI-containing regimens, atezolizumab plus bevacizumab and tremelimumab plus durvalumab, are now approved standard-of-care first-line therapies in this setting. However, and despite substantial improvements in survival outcomes relative to sorafenib, most patients with advanced-stage HCC do not derive durable benefit from these regimens. Advances in genome sequencing including the use of single-cell RNA sequencing (both of tumour material and blood samples), as well as immune cell identification strategies and other techniques such as radiomics and analysis of the microbiota, have created considerable potential for the identification of novel predictive biomarkers enabling the accurate selection of patients who are most likely to derive benefit from ICIs. In this Review, we summarize data on the immunology of HCC and the outcomes in patients receiving ICIs for the treatment of this disease. We then provide an overview of current biomarker use and developments in the past 5 years, including gene signatures, circulating tumour cells, high-dimensional flow cytometry, single-cell RNA sequencing as well as approaches involving the microbiome, radiomics and clinical markers. Novel concepts for further biomarker development in HCC are then discussed including biomarker-driven trials, spatial transcriptomics and integrated 'big data' analysis approaches. These concepts all have the potential to better identify patients who are most likely to benefit from ICIs and to promote the development of new treatment approaches.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Currently, there are no validated predictive biomarkers for patient response to immunotherapy in HCC.
“Currently, there are no validated predictive biomarkers for patient response to immunotherapy in HCC100.”
From Multi-omic analysis of hepatocellular carcinoma reveals aberrant cis-regulatory changes and dysregulated retrotransposons with prognostic potential (2025) · cites this paper as [100]
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21763 · Cited by 16,303 · see citing works
Sorafenib in advanced hepatocellular carcinoma
Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J.-F., de Oliveira, A. C., Santoro, A., Raoul, J.-L., Forner, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708857 · Cited by 13,097 · see citing works
Self-citationSlamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Fleming, T., Eiermann, W., Wolter, J., Pegram, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103153441101 · Cited by 11,500 · see citing works
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
Galle, P. R., Forner, A., Llovet, J. M., Mazzaferro, V., Piscaglia, F., Raoul, J.-L., Schirmacher, P., & Vilgrain, V. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.019 · Cited by 11,406 · see citing works
International Agency for Research on Cancer
National Cancer Institute (2020) · Definitions · doi:10.32388/pfg7jq · Cited by 9,493 · see citing works
Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma
Finn, R. S., Qin, S., Ikeda, M., Galle, P. R., Ducreux, M., Kim, T.-Y., Kudo, M., Breder, V., Merle, P., Kaseb, A. O., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1915745 · Cited by 7,470 · see citing works
Llovet, J. M., Kelley, R. K., Villanueva, A., Singal, A. G., Pikarsky, E., Roayaie, S., Lencioni, R., Koike, K., Zucman-Rossi, J., & Finn, R. S. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00240-3 · Cited by 7,055 · see citing works
Self-citationBiomarkers and surrogate endpoints: Preferred definitions and conceptual framework
Biomarkers Definitions Working Group (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113989 · Cited by 6,771 · see citing works
A New Era of Systemic Therapy for Hepatocellular Carcinoma with Regorafenib and Lenvatinib
Kudo, M. (2017) · Liver Cancer · doi:10.1159/000462153 · Cited by 5,974 · see citing works
Kudo, M., Finn, R. S., Qin, S., Han, K.-H., Ikeda, K., Piscaglia, F., Baron, A., Park, J.-W., Han, G., Jassem, J., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30207-1 · Cited by 5,497 · see citing works
Marrero, J. A., Kulik, L., Sirlin, C. B., Zhu, A. X., Finn, R. S., Abecassis, M. M., Roberts, L. R., & Heimbach, J. K. (2018) · Hepatology · doi:10.1002/hep.29913 · Cited by 4,549 · see citing works
Villanueva, A. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1713263 · Cited by 4,508 · see citing works
Self-citationBCLC strategy for prognosis prediction and treatment recommendation: the 2022 update
Reig, M., Forner, A., Rimola, J., Ferrer-Fàbrega, J., Burrel, M., Garcia-Criado, Á., Kelley, R. K., Galle, P. R., Mazzaferro, V., Salem, R., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.018 · Cited by 4,319 · cited 2× · see citing works
“Transarterial chemoembolization (TACE) has been globally adopted as the standard of care for patients with intermediate-stage (multinodular disease limited to the liver, and preserved liver function 17 ) HCC leading to a median OS >2.5 years 3,15,18–21 .”
BackgroundInfluentialEl-Khoueiry, A. B., Sangro, B., Yau, T., Crocenzi, T. S., Kudo, M., Hsu, C., Kim, T.-Y., Choo, S.-P., Trojan, J., Welling, T. H., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31046-2 · Cited by 4,280 · see citing works
A guide to cancer immunotherapy: from T cell basic science to clinical practice
Waldman, A. D., Fritz, J. M., & Lenardo, M. J. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0306-5 · Cited by 4,154 · see citing works
Bruix, J., Qin, S., Merle, P., Granito, A., Huang, Y., Bodoky, G., Pracht, M., Yokosuka, O., Rosmorduc, O., Breder, V. V., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)32453-9 · Cited by 3,657 · see citing works
Tumor mutational burden and response rate to PD-1 inhibition
Yarchoan, M., Hopkins, A., & Jaffee, E. M. (2017) · New England Journal of Medicine · doi:10.1056/nejmc1713444 · Cited by 3,230 · see citing works
Self-citationComprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Ally, A., Balasundaram, M., Carlsen, R., Chuah, E., Clarke, A., Dhalla, N., Holt, R. A., Jones, S. J. M., Lee, D., Ma, Y., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.046 · Cited by 2,490 · see citing works
Zhu, A. X., Finn, R. S., Edeline, J., Cattan, S., Ogasawara, S., Palmer, D., Verslype, C., Zagonel, V., Fartoux, L., Vogel, A., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30351-6 · Cited by 2,479 · see citing works
Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma
Abou‐Alfa, G. K., Meyer, T., Cheng, A., El-Khoueiry, A. B., Rimassa, L., Ryoo, B., Çiçin, İ., Merle, P., Chen, Y.-H., Park, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1717002 · Cited by 2,347 · see citing works
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Havel, J. J., Chowell, D., & Chan, T. A. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0116-x · Cited by 2,286 · see citing works
Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Escudier, B. J., Porta, C., Schmidinger, M., Ferran Algaba, B., Patard, J., Khoo, V. S., Eisen, T. G., & Horwich, A. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu259 · Cited by 2,253 · see citing works
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing
Zheng, C., Zheng, L., Yoo, J.-K., Guo, H., Zhang, Y., Guo, X., Kang, B., Hu, R., Huang, J. Y., Zhang, Q., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.035 · Cited by 2,152 · see citing works
Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
Sade-Feldman, M., Yizhak, K., Bjorgaard, S. L., Ray, J. P., de Boer, C. G., Jenkins, R. W., Lieb, D. J., Chen, J. H., Frederick, D. T., Barzily-Rokni, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.038 · Cited by 2,053 · see citing works
Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention
Huang, D. Q., El-Serag, H. B., & Loomba, R. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00381-6 · Cited by 1,855 · see citing works
Immunotherapies for hepatocellular carcinoma
Llovet, J. M., Castet, F., Heikenwalder, M., Maini, M. K., Mazzaferro, V., Pinato, D. J., Pikarsky, E., Zhu, A. X., & Finn, R. S. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00573-2 · Cited by 1,843 · see citing works
Surgery and portal hypertension.
Child, C. G., & Turcotte, J. (1964) · PubMed · Cited by 1,793 · see citing works
Finn, R. S., Ryoo, B.-Y., Merle, P., Kudo, M., Bouattour, M., Lim, H. Y., Breder, V., Edeline, J., Chao, Y., Ogasawara, S., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.19.01307 · Cited by 1,789 · see citing works
Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients
Davar, D., Dzutsev, A. K., McCulloch, J. A., Rodrigues, R. R., Chauvin, J.-M., Morrison, R. M., Deblasio, R. N., Menna, C., Ding, Q., Pagliano, O., et al. (2021) · Science · doi:10.1126/science.abf3363 · Cited by 1,781 · see citing works
Cheng, A.-L., Qin, S., Ikeda, M., Galle, P. R., Ducreux, M., Kim, T.-Y., Lim, H. Y., Kudo, M., Breder, V., Merle, P., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.030 · Cited by 1,743 · see citing works
Zhu, A. X., Kang, Y., Yen, C., Finn, R. S., Galle, P. R., Llovet, J. M., Assénat, E., Brandi, G., Pracht, M., Lim, H. Y., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30937-9 · Cited by 1,666 · see citing works
Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma
Zhang, Q., He, Y., Luo, N., Patel, S. J., Han, Y., Gao, R., Modak, M., Carotta, S., Haslinger, C., Kind, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.003 · Cited by 1,624 · see citing works
PD-1/PD-L1 pathway: current researches in cancer.
Han, Y., Liu, D., & Li, L. (2020) · PubMed Central · Cited by 1,602 · see citing works
Tremelimumab plus durvalumab in unresectable hepatocellular carcinoma
Abou-Alfa, G. K., Lau, G., Kudo, M., Chan, S. L., Kelley, R. K., Furuse, J., Sukeepaisarnjaroen, W., Kang, Y.-K., Van Dao, T., De Toni, E. N., et al. (2022) · NEJM Evidence · doi:10.1056/evidoa2100070 · Cited by 1,576 · see citing works
Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells
Ma, C., Han, M., Heinrich, B., Fu, Q., Zhang, Q., Sandhu, M., Agdashian, D., Terabe, M., Berzofsky, J. A., Fako, V., et al. (2018) · Science · doi:10.1126/science.aan5931 · Cited by 1,508 · see citing works
Self-citationPan-cancer single-cell landscape of tumor-infiltrating T cells
Zheng, L., Qin, S., Si, W., Wang, A., Xing, B., Gao, R., Ren, X., Wang, L., Wu, X., Zhang, J., et al. (2021) · Science · doi:10.1126/science.abe6474 · Cited by 1,402 · see citing works
The microbiome and human cancer
Sepich-Poore, G. D., Zitvogel, L., Straussman, R., Hasty, J., Wargo, J. A., & Knight, R. (2021) · Science · doi:10.1126/science.abc4552 · Cited by 1,332 · see citing works
Yau, T., Kang, Y.-K., Kim, T.-Y., El-Khoueiry, A. B., Santoro, A., Sangro, B., Melero, I., Kudo, M., Hou, M.-M., Matilla, A., et al. (2020) · JAMA Oncology · doi:10.1001/jamaoncol.2020.4564 · Cited by 1,273 · see citing works
McDermott, D. F., Huseni, M. A., Atkins, M. B., Motzer, R. J., Rini, B. I., Escudier, B., Fong, L., Joseph, R. W., Pal, S. K., Reeves, J. A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0053-3 · Cited by 1,260 · see citing works
Hoshida, Y., Nijman, S. M. B., Kobayashi, M., Chan, J. A., Brunet, J.-P., Chiang, D. Y., Villanueva, A., Newell, P., Ikeda, K., Hashimoto, M., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1089 · Cited by 1,238 · see citing works
Self-citationMass Cytometry: Single Cells, Many Features
Spitzer, M. H., & Nolan, G. P. (2016) · Cell · doi:10.1016/j.cell.2016.04.019 · Cited by 1,199 · see citing works
Finn, R. S., Ikeda, M., Zhu, A. X., Sung, M. W., Baron, A. D., Kudo, M., Okusaka, T., Kobayashi, M., Kumada, H., Kaneko, S., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.00808 · Cited by 1,167 · see citing works
Ren, Z., Xu, J., Bai, Y., Xu, A., Cang, S., Du, C., Li, Q., Lu, Y., Chen, Y., Guo, Y., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00252-7 · Cited by 1,124 · see citing works
Yau, T., Park, J.-W., Finn, R. S., Cheng, A.-L., Mathurin, P., Edeline, J., Kudo, M., Harding, J. J., Merle, P., Rosmorduc, O., et al. (2022) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00604-5 · Cited by 1,106 · see citing works
Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Vogel, A., Cervantes, A. M. R., Chau, I., Daniele, B., Llovet, J. M., Meyer, T., Nault, J., Neumann, U. P., Ricke, J., Sangro, B., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy308 · Cited by 1,047 · see citing works
Klein, E. A., Richards, D., Cohn, A. L., Tummala, M., Lapham, R. L., Cosgrove, D. O., Chung, G. G., Clement, J., Gao, J., Hunkapiller, N. M., et al. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2021.05.806 · Cited by 1,014 · see citing works
Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance
Marusyk, A., Janiszewska, M., & Polyak, K. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.03.007 · Cited by 1,009 · see citing works
Liquid Biopsy: From Discovery to Clinical Application
Alix‐Panabières, C., & Pantel, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1311 · Cited by 983 · see citing works
Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
Xue, R., Zhang, Q., Cao, Q., Kong, R., Xiao, X., Liu, H., Feng, M., Wang, F., Cheng, J., Zhao, L., et al. (2022) · Nature · doi:10.1038/s41586-022-05400-x · Cited by 956 · see citing works
Yau, T. (., Park, J. W. (.-W., Finn, R. S. (. S. )., Cheng, A. L. (.-L., Mathurin, P., Edeline, J., Kudo, M. (., Harding, J. J., Merle, P., Rosmorduc, O., et al. (2022) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · Cited by 934 · see citing works
Ruiz de Galarreta, M., Bresnahan, E., Molina-Sánchez, P., Lindblad, K. E., Maier, B., Sia, D., Puigvehi, M., Miguela, V., Casanova-Acebes, M., Dhainaut, M., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0074 · Cited by 912 · see citing works
Self-citationSingle-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma
Sun, Y., Wu, L. L., Zhong, Y., Zhou, K., Hou, Y., Wang, Z., Zhang, Z., Xie, J., Wang, C., Chen, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.041 · Cited by 893 · see citing works
Self-citationTumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer
Ma, L., Hernandez, M. O., Zhao, Y., Mehta, M., Tran, B. Q., Kelly, M. C., Rae, Z., Hernandez, J. M., Davis, J. L., Martin, S. P., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.08.007 · Cited by 844 · see citing works
Self-citationTremelimumab in combination with ablation in patients with advanced hepatocellular carcinoma
Duffy, A. G., Ulahannan, S. V., Makarova‐Rusher, O. V., Rahma, O. E., Wedemeyer, H. H., Pratt, D. W., Davis, J. L., Hughes, M. S., Heller, T., ElGindi, M., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.10.029 · Cited by 823 · see citing works
Self-citationGuidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition)
Zhou, J., Sun, H., Wang, Z., Cong, W., Wang, J., Zeng, M., Zhou, W., Bie, P., Liu, L., Wen, T., et al. (2020) · Liver Cancer · doi:10.1159/000509424 · Cited by 804 · see citing works
Self-citationHoechst, B., Ormandy, L. A., Ballmaier, M., Lehner, F., Krüger, C., Manns, M. P., Greten, T. F., & Korangy, F. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.020 · Cited by 793 · see citing works
Self-citationLiu, Y., Xun, Z., Ma, K., Liang, S., Li, X., Zhou, S., Sun, L., Liu, Y., Du, Y., Guo, X., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.01.011 · Cited by 749 · see citing works
High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy
Krieg, C., Nowicka, M., Guglietta, S., Schindler, S., Hartmann, F. J., Weber, L. M., Dummer, R., Robinson, M. D., Levesque, M. P., & Becher, B. (2018) · Nature Medicine · doi:10.1038/nm.4466 · Cited by 735 · see citing works
Lee, W. S., Yang, H., Chon, H. J., & Kim, C. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00500-y · Cited by 700 · see citing works
Kudo, M., Kawamura, Y., Hasegawa, K., Tateishi, R., Kariyama, K., Shiina, S., Toyoda, H., Imai, Y., Hiraoka, A., Ikeda, M., et al. (2021) · Liver Cancer · doi:10.1159/000514174 · Cited by 678 · see citing works
Fridman, W. H., Meylan, M., Petitprez, F., Sun, C., Italiano, A., & Sautès‐Fridman, C. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00619-z · Cited by 667 · see citing works
Deep learning in cancer pathology: a new generation of clinical biomarkers
Echle, A., Rindtorff, N. T., Brinker, T. J., Luedde, T., Pearson, A. T., & Kather, J. N. (2021) · British Journal of Cancer · doi:10.1038/s41416-020-01122-x · Cited by 667 · see citing works
Harnessing multimodal data integration to advance precision oncology
Boehm, K. M., Khosravi, P., Vanguri, R., Gao, J., & Shah, S. P. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00408-3 · Cited by 662 · see citing works
Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
Lo, Y. M. D., Han, D. S. C., Jiang, P., & Chiu, R. W. K. (2021) · Science · doi:10.1126/science.aaw3616 · Cited by 659 · see citing works
Zhu, A. X., Abbas, A. R., de Galarreta, M. R., Guan, Y., Lu, S., Koeppen, H., Zhang, W., Hsu, C.-H., He, A. R., Ryoo, B.-Y., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01868-2 · Cited by 652 · see citing works
Vanhersecke, L., Brunet, M., Guégan, J., Rey, C., Bougoüin, A., Cousin, S., Moulec, S. L., Besse, B., Loriot, Y., Larroquette, M., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00232-6 · Cited by 647 · see citing works
Harding, J. J., Nandakumar, S., Armenia, J., Khalil, D. N., Albano, M., Ly, M., Shia, J., Hechtman, J. F., Kundra, R., El Dika, I., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2293 · Cited by 602 · see citing works
Biology and significance of alpha-fetoprotein in hepatocellular carcinoma
Galle, P. R., Foerster, F., Kudo, M., Chan, S. L., Llovet, J. M., Qin, S., Schelman, W. R., Chintharlapalli, S., Abada, P. B., Sherman, M., et al. (2019) · Liver International · doi:10.1111/liv.14223 · Cited by 597 · see citing works
Xu, J., Shen, J., Gu, S., Zhang, Y., Wu, L., Wu, J., Shao, G., Zhang, Y., Xu, L., Yin, T., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-2571 · Cited by 562 · see citing works
Kelley, R. K., Rimassa, L., Cheng, A.-L., Kaseb, A., Qin, S., Zhu, A. X., Chan, S. L., Melkadze, T., Sukeepaisarnjaroen, W., Breder, V., et al. (2022) · The Lancet Oncology · doi:10.1016/s1470-2045(22)00326-6 · Cited by 535 · see citing works
ImmunoPET: Concept, Design, and Applications
Wei, W., Rosenkrans, Z. T., Liu, J., Huang, G., Luo, Q., & Cai, W. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00738 · Cited by 483 · see citing works
McCulloch, J. A., Davar, D., Rodrigues, R. R., Badger, J. H., Fang, J. R., Cole, A. M., Balaji, A. K., Vetizou, M., Prescott, S. M., Fernandes, M. R., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01698-2 · Cited by 472 · see citing works
Kelley, R. K., Sangro, B., Harris, W. P., Ikeda, M., Okusaka, T., Kang, Y., Qin, S., Tai, D. W.-M., Lim, H. Y., Yau, T. C. C., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.03555 · Cited by 450 · see citing works
Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma
Chaisaingmongkol, J., Budhu, A., Dang, H., Rabibhadana, S., Pupacdi, B., Kwon, S. M., Forgues, M., Pomyen, Y., Bhudhisawasdi, V., Lertprasertsuke, N., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.05.009 · Cited by 434 · see citing works
Self-citationQin, S., Bi, F., Gu, S., Bai, Y., Chen, Z., Wang, Z., Ying, J., Lu, Y., Meng, Z., Pan, H., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.21.00163 · Cited by 412 · see citing works
Sangro, B., Melero, I., Wadhawan, S., Finn, R. S., Abou-Alfa, G. K., Cheng, A.-L., Yau, T., Furuse, J., Park, J.-W., Boyd, Z., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.07.026 · Cited by 407 · see citing works
Vanguri, R. S., Luo, J., Aukerman, A. T., Egger, J. V., Fong, C. J., Horvat, N., Pagano, A., Araujo-Filho, J. D. A. B., Geneslaw, L., Rizvi, H., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00416-8 · Cited by 395 · see citing works
Systemic treatment of hepatocellular carcinoma: An EASL position paper
Bruix, J., Chan, S. L., Galle, P. R., Rimassa, L., & Sangro, B. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.07.004 · Cited by 382 · see citing works
Modulating the microbiome to improve therapeutic response in cancer
McQuade, J. L., Daniel, C. R., Helmink, B. A., & Wargo, J. A. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30952-5 · Cited by 376 · see citing works
Gut microbiome in HCC – Mechanisms, diagnosis and therapy
Schwabe, R. F., & Greten, T. F. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.08.016 · Cited by 370 · see citing works
Self-citationMa, L., Wang, L., Khatib, S. A., Chang, C.-W., Heinrich, S., Dominguez, D. A., Forgues, M., Candia, J., Hernandez, M. O., Kelly, M. C., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.06.028 · Cited by 370 · see citing works
Self-citationHo, W. J., Zhu, Q., Durham, J., Popovic, A., Xavier, S., Leatherman, J., Mohan, A., Mo, G., Zhang, S., Gross, N., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00234-4 · Cited by 360 · see citing works
Self-citationHo, D. W., Tsui, Y., Chan, L., Sze, K. M., Zhang, X., Cheu, J. W., Chiu, Y., Lee, J. M., Chan, A. C. Y., Cheung, E. T.-Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24010-1 · Cited by 324 · see citing works
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells
Ruf, B., Heinrich, B., & Greten, T. F. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00572-w · Cited by 318 · see citing works
Self-citationScheiner, B., Pomej, K., Kirstein, M. M., Hucke, F., Finkelmeier, F., Waidmann, O., Himmelsbach, V., Schulze, K., von Felden, J., Fründt, T., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.09.035 · Cited by 309 · see citing works
Kato, S., Kim, K. H., Lim, H. J., Boichard, A., Nikanjam, M., Weihe, E., Kuo, D. J., Eskander, R. N., Goodman, A. M., Galanina, N., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18613-3 · Cited by 295 · see citing works
Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma
Sangro, B., Chan, S. L., Meyer, T., Reig, M., El-Khoueiry, A. B., & Galle, P. R. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.10.021 · Cited by 294 · see citing works
Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy
Gohil, S. H., Iorgulescu, J. B., Braun, D. A., Keskin, D. B., & Livak, K. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00449-x · Cited by 282 · see citing works
Kaseb, A. O., Hasanov, E., Cao, H. S. T., Xiao, L., Vauthey, J.-N., Lee, S. S., Yavuz, B. G., Mohamed, Y. I., Qayyum, A., Jindal, S., et al. (2022) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00427-1 · Cited by 274 · see citing works
Qin, S., Li, Q., Gu, S., Chen, X., Lin, L.-Z., Wang, Z., Xu, A., Chen, X., Zhou, C., Ren, Z., et al. (2021) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(21)00109-6 · Cited by 255 · see citing works
Big data in basic and translational cancer research
Jiang, P., Sinha, S., Aldape, K., Hannenhalli, S., Sahinalp, C., & Ruppin, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-022-00502-0 · Cited by 254 · see citing works
Self-citationInflamed and non-inflamed classes of HCC: a revised immunogenomic classification
Montironi, C., Castet, F., Haber, P. K., Pinyol, R., Torres-Martin, M., Torrens, L., Mesropian, A., Wang, H., Puigvehi, M., Maeda, M., et al. (2023) · Gut · doi:10.1136/gutjnl-2021-325918 · Cited by 253 · see citing works
Self-citationChew, V., Lai, L., Pan, L., Lim, C. J., Li, J., Ong, R., Chua, C. J. H., Leong, J. Y., Lim, K. H., Toh, H. C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706559114 · Cited by 246 · see citing works
Paver, E. C., Cooper, W. A., Colebatch, A. J., Ferguson, P. M., Hill, S. K., Lum, T., Shin, J., O’Toole, S. A., Anderson, L. A., Scolyer, R. A., et al. (2020) · Pathology · doi:10.1016/j.pathol.2020.10.007 · Cited by 245 · see citing works
Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
Hung, M., Lee, J. S., Ma, C., Diggs, L. P., Heinrich, S., Chang, C.-W., Ma, L., Forgues, M., Budhu, A., Chaisaingmongkol, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21804-1 · Cited by 239 · see citing works
Self-citationMarron, T. U., Fiel, M. I., Hamon, P., Fiaschi, N., Kim, E., Ward, S. C., Zhao, Z., Kim, J., Kennedy, P., Gunasekaran, G., et al. (2022) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00385-x · Cited by 239 · see citing works
Budhu, A., Roessler, S. K., Zhao, X., Yu, Z., Forgues, M., Ji, J., Karoly, E. D., Qin, L., Ye, Q., Jia, H., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.054 · Cited by 238 · see citing works
Self-citationCohen, Y. C., Zada, M., Wang, S.-Y., Bornstein, C., David, E., Moshe, A., Li, B., Shlomi-Loubaton, S., Gatt, M. E., Gur, C., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01232-w · Cited by 235 · see citing works
MAIT Cells in Health and Disease
Provine, N. M., & Klenerman, P. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-080719-015428 · Cited by 228 · see citing works
Neutrophils as potential therapeutic targets in hepatocellular carcinoma
Geh, D., Leslie, J., Rumney, R., Reeves, H. L., Bird, T. G., & Mann, D. A. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00568-5 · Cited by 222 · see citing works
Qin, S., Chen, Z., Fang, W. J., Ren, Z., Xu, R., Ryoo, B., Meng, Z., Bai, Y., Chen, X., Liu, X., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.22.00620 · Cited by 203 · see citing works
Self-citationTumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin
Ruf, B., Bruhns, M., Babaei, S., Kedei, N., Ma, L., Revsine, M., Benmebarek, M.-R., Ma, C., Heinrich, B., Subramanyam, V., et al. (2023) · Cell · doi:10.1016/j.cell.2023.07.026 · Cited by 200 · see citing works
Self-citationKudo, M. (2020) · Cancers · doi:10.3390/cancers12051089 · Cited by 197 · see citing works
The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?
Hu, X., Chen, R., Wei, Q., & Xu, X. L. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.64537 · Cited by 197 · see citing works
Finn, R. S., Kudo, M., Merle, P., Meyer, T., Qin, S., Ikeda, M., Xu, R., Edeline, J., Ryoo, B.-Y., Ren, Z., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.08.031 · Cited by 187 · see citing works
T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma
Barsch, M., Salié, H., Schlaak, A. E., Zhang, Z., Hess, M., Mayer, L., Tauber, C., Otto-Mora, P., Ohtani, T., Nilsson, T., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.02.032 · Cited by 187 · see citing works
Liu, M., Zhou, J., Liu, X., Feng, Y., Yang, W., Wu, F., Cheung, O. K.-W., Sun, H., Zeng, X., Tang, W., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317257 · Cited by 175 · see citing works
Ang, C., Klempner, S. J., Ali, S. M., Madison, R. W., Ross, J. S., Severson, E. A., Fabrizio, D. A., Goodman, A. M., Kurzrock, R., Suh, J. H., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.26998 · Cited by 166 · see citing works
Singal, A. G., Hoshida, Y., Pinato, D. J., Marrero, J. A., Nault, J., Paradis, V., Tayob, N., Sherman, M., Lim, Y., Feng, Z., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.01.233 · Cited by 164 · see citing works
Self-citationMa, L., Heinrich, S., Wang, L., Keggenhoff, F. L., Khatib, S. A., Forgues, M., Kelly, M. C., Hewitt, S. M., Saif, A., Hernandez, J. M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35291-5 · Cited by 164 · see citing works
Self-citationDetecting Liver Cancer Using Cell-Free DNA Fragmentomes
Foda, Z. H., Annapragada, A. V., Boyapati, K., Bruhm, D. C., Vulpescu, N. A., Medina, J. E., Mathios, D., Cristiano, S., Niknafs, N., Luu, H. T., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0659 · Cited by 164 · see citing works
Feun, L. G., Li, Y., Wu, C., Wangpaichitr, M., Jones, P. D., Richman, S. P., Madrazo, B. L., Kwon, D., Garcia-Buitrago, M. T., Martin, P. B., et al. (2019) · Cancer · doi:10.1002/cncr.32339 · Cited by 160 · see citing works
Martín-Serrano, M. A., Kepecs, B., Torres‐Martín, M., Bramel, E. R., Haber, P. K., Merritt, E., Rialdi, A., Param, N. J., Maeda, M., Lindblad, K. E., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-326514 · Cited by 159 · see citing works
Self-citationChen, S., Feng, S., Wei, J., Liu, F., Li, B., Li, X., Hou, Y., Gu, D., Tang, M., Xiao, H., et al. (2019) · European Radiology · doi:10.1007/s00330-018-5986-x · Cited by 157 · see citing works
Agdashian, D., ElGindi, M., Xie, C., Sandhu, M., Pratt, D. W., Kleiner, D. E., Figg, W. D., Rytlewski, J. A., Sanders, C. M., Yusko, E. C., et al. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02299-8 · Cited by 150 · see citing works
Self-citationMRI radiomics features predict immuno-oncological characteristics of hepatocellular carcinoma
Hectors, S. J. C. G., Lewis, S. C., Besa, C., King, M. J., Said, D., Putra, J., Ward, S. C., Higashi, T., Thung, S. N., Shen, Y., et al. (2020) · European Radiology · doi:10.1007/s00330-020-06675-2 · Cited by 148 · see citing works
Molecular Markers of Response to Anti-PD1 Therapy in Advanced Hepatocellular Carcinoma
Haber, P. K., Castet, F., Torres-Martin, M., Andreu-Oller, C., Puigvehí, M., Miho, M., Radu, P., Dufour, J.-F., Verslype, C., Zimpel, C., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2022.09.005 · Cited by 145 · see citing works
Self-citationMurai, H., Kodama, T., Maesaka, K., Tange, S., Motooka, D., Suzuki, Y., Shigematsu, Y., Inamura, K., Mise, Y., Saiura, A., et al. (2022) · Hepatology · doi:10.1002/hep.32573 · Cited by 141 · see citing works
Liquid biopsy in the clinical management of hepatocellular carcinoma
von Felden, J., Garcia-Lezana, T., Schulze, K., Losic, B., & Villanueva, A. (2020) · Gut · doi:10.1136/gutjnl-2019-320282 · Cited by 141 · see citing works
Self-citationNguyen, P. H. D., Ma, S., Phua, C. Z. J., Kaya, N. A., Lai, H. L. H., Lim, C. J., Lim, J. Q., Wasser, M., Lai, L., Tam, W. L., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20171-7 · Cited by 140 · see citing works
Zhang, S., Yuan, L., Danilova, L., Mo, G., Zhu, Q., Deshpande, A., Bell, A. T. F., Elisseeff, J., Popel, A. S., Anders, R. A., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01218-y · Cited by 140 · see citing works
Self-citationHong, J. Y., Cho, H. J., Sa, J. K., Liu, X., Ha, S. Y., Lee, T., Kim, H., Kang, W., Sinn, D. H., Gwak, G., et al. (2022) · Genome Medicine · doi:10.1186/s13073-021-00995-8 · Cited by 136 · see citing works
Dharmapuri, S., Özbek, U., Lin, J., Sung, M. W., Schwartz, M., Branch, A. D., & Ang, C. (2020) · Cancer Medicine · doi:10.1002/cam4.3135 · Cited by 131 · see citing works
Tamborero, D., Dienstmann, R., Rachid, M. H., Boekel, J., López‐Fernández, A., Jonsson, M., Razzak, A., Braña, I., Petris, L. D., Yachnin, J., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00332-x · Cited by 131 · see citing works
von Felden, J., Craig, A. J., Garcia-Lezana, T., Labgaa, I., Haber, P. K., D'Avola, D., Asgharpour, A., Dieterich, D., Bonaccorso, A., Torres-Martín, M., et al. (2020) · Oncogene · doi:10.1038/s41388-020-01519-1 · Cited by 122 · see citing works
Self-citationChuah, S., Lee, J. J. X., Song, Y., Kim, H., Wasser, M., Kaya, N. A., Bang, K., Lee, Y. J., Jeon, S. H., Suthen, S., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.03.039 · Cited by 122 · see citing works
Zhu, A. X., Dayyani, F., Yen, C., Ren, Z., Bai, Y., Meng, Z., Pan, H., Dillon, P., Mhatre, S. K., Gaillard, V. E., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-3275 · Cited by 121 · see citing works
The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma
Heinrich, B., Gertz, E. M., Schäffer, A. A., Craig, A. J., Ruf, B., Subramanyam, V., McVey, J. C., Diggs, L. P., Heinrich, S., Rosato, U., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-325288 · Cited by 117 · see citing works
Self-citationTamminga, M., de Wit, S., Hiltermann, T. J. N., Timens, W., Schuuring, E. M. D., Terstappen, L. W. M. M., & Groen, H. J. M. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0649-2 · Cited by 116 · see citing works
Ng, H. H. M., Lee, R. Y., Goh, S., Tay, I. S. Y., Lim, X., Lee, B. T. K., Chew, V., Li, H., Tan, B., Lim, S., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000987 · Cited by 116 · see citing works
Diagnostic value of combining 11C-choline and 18F-FDG PET/CT in hepatocellular carcinoma
Castilla-Lièvre, M.-A., Franco, D., Gervais, P., Kühnast, B., Agostini, H., Marthey, L., Désarnaud, S., & Helal, B.-O. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3241-0 · Cited by 108 · see citing works
Qin, S., Chen, Z., Fang, W. J., Ren, Z., Xu, R., Ryoo, B., Meng, Z., Bai, Y., Chen, X., Liu, X., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.2022.40.4_suppl.383 · Cited by 108 · see citing works
Shao, Y., Liu, T., Hsu, C., Lu, L., Shen, Y., Lin, Z., Cheng, A., & Hsu, C. (2019) · Liver International · doi:10.1111/liv.14210 · Cited by 107 · see citing works
Winograd, P., Hou, S., Court, C. M., Lee, Y., Chen, P., Zhu, Y., Sadeghi, S., Finn, R. S., Teng, P., Wang, J. J., et al. (2020) · Hepatology Communications · doi:10.1002/hep4.1577 · Cited by 106 · see citing works
Lee, P.-C., Chao, Y., Chen, M.-H., Lan, K.-H., Lee, C.-J., Lee, I.-C., Chen, S.-C., Hou, M.-C., & Huang, Y.-H. (2020) · Cancers · doi:10.3390/cancers12010182 · Cited by 105 · see citing works
Peripheral Blood-Based Biomarkers for Immune Checkpoint Inhibitors
An, H. J., Chon, H. J., & Kim, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179414 · Cited by 105 · see citing works
Artificial intelligence and radiomics: fundamentals, applications, and challenges in immunotherapy
Dercle, L., McGale, J., Sun, S. H., Marabelle, A., Yeh, R., Deutsch, É., Mokrane, F., Farwell, M. D., Ammari, S., Schöder, H. M., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-005292 · Cited by 99 · see citing works
Qin, S., Chan, L. S., Gu, S., Bai, Y., Ren, Z., Lin, X., Chen, Z., Jia, W., Jin, Y., Guo, Y., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.08.032 · Cited by 97 · see citing works
Verset, G., Borbath, I., Karwal, M., Verslype, C., Vlierberghe, H. V., Kardosh, A., Zagonel, V., Stal, P. I., Sarker, D., Palmer, D. H., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-3807 · Cited by 92 · see citing works
A Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinoma
Liu, J., Tang, W., Budhu, A., Forgues, M., Hernandez, M. O., Candia, J., Kim, Y., Bowman, E. D., Ambs, S., Zhao, Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.038 · Cited by 86 · see citing works
Self-citationMyojin, Y., Kodama, T., Sakamori, R., Maesaka, K., Matsumae, T., Sawai, Y., Imai, Y., Ohkawa, K., Miyazaki, M., Tanaka, S., et al. (2022) · Cancers · doi:10.3390/cancers14040883 · Cited by 84 · see citing works
Reductions in AFP and PIVKA-II can predict the efficiency of anti-PD-1 immunotherapy in HCC patients
Sun, X., Mei, J., Lin, W., Yang, Z., Peng, W. J., Chen, J., Zhang, Y., Xu, L., & Chen, M. (2021) · BMC Cancer · doi:10.1186/s12885-021-08428-w · Cited by 83 · see citing works
Muhammed, A., Fulgenzi, C. A. M., Dharmapuri, S., Pinter, M., Balcar, L., Scheiner, B., Marron, T. U., Jun, T. W., Saeed, A., Hildebrand, H., et al. (2021) · Cancers · doi:10.3390/cancers14010186 · Cited by 83 · see citing works
Hatanaka, T., Kakizaki, S., Hiraoka, A., Tada, T., Hirooka, M., Kariyama, K., Tani, J., Atsukawa, M., Takaguchi, K., Itobayashi, E., et al. (2022) · Hepatology International · doi:10.1007/s12072-022-10358-z · Cited by 81 · see citing works
Yang, H., Kang, B., Ha, Y., Lee, S. H., Kim, I. H., Kim, H., Lee, W. S., Kim, G., Jung, S., Rha, S. Y., et al. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100672 · Cited by 81 · see citing works
Greten, T. F., Abou‐Alfa, G. K., Cheng, A., Duffy, A. G., El-Khoueiry, A. B., Finn, R. S., Galle, P. R., Goyal, L., He, A. R., Kaseb, A. O., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002794 · Cited by 81 · see citing works
Self-citationYuan, G., Song, Y., Li, Q., Hu, X., Zang, M., Dai, W., Cheng, X., Huang, W. M., Yu, W., Chen, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.613946 · Cited by 80 · see citing works
Canady, T. D., Li, N., Smith, L. D., Lu, Y., Kohli, M., Smith, A. M., & Cunningham, B. T. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904770116 · Cited by 77 · see citing works
Monge, C., Xie, C., Myojin, Y., Coffman, K., Hrones, D. M., Wang, S., Hernandez, J. M., Wood, B. J., Levy, E. B., Juburi, I., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-005640 · Cited by 76 · see citing works
Self-citationWu, L. Y., Fulgenzi, C. A. M., D’Alessio, A., Cheon, J., Nishida, N., Saeed, A., Wietharn, B., Cammarota, A., Pressiani, T., Personeni, N., et al. (2022) · Cancers · doi:10.3390/cancers14235834 · Cited by 75 · see citing works
Spahn, S., Roessler, D., Pompilia, R., Gabernet, G., Gladstone, B. P., Horger, M., Biskup, S., Feldhahn, M., Nahnsen, S., Hilke, F. J., et al. (2020) · Cancers · doi:10.3390/cancers12123830 · Cited by 75 · see citing works
Matsumae, T., Kodama, T., Myojin, Y., Maesaka, K., Sakamori, R., Takuwa, A., Oku, K., Motooka, D., Sawai, Y., Oshita, M., et al. (2022) · Cancers · doi:10.3390/cancers14143367 · Cited by 74 · see citing works
Biomarkers in Precision Cancer Immunotherapy: Promise and Challenges
McKean, W. B., Moser, J. C., Rimm, D. L., & Hu‐Lieskovan, S. (2020) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_280571 · Cited by 72 · see citing works
Yau, T. C. C., Zagonel, V., Santoro, A., Acosta-Rivera, M., Choo, S. P., Matilla, A., He, A. R., Gracián, A. C., El-Khoueiry, A. B., Sangro, B., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.22.00972 · Cited by 72 · see citing works
Fujiwara, N., Kobayashi, M., Fobar, A. J., Hoshida, A., Marquez, C. A., Koneru, B., Panda, G., Taguri, M., Qian, T., Raman, I., et al. (2021) · Med · doi:10.1016/j.medj.2021.03.017 · Cited by 70 · see citing works
Classification of prostate cancer using a protease activity nanosensor library
Dudani, J. S., Ibrahim, M., Kirkpatrick, J. D., Warren, A., & Bhatia, S. N. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805337115 · Cited by 69 · see citing works
Kaseb, A. O., Vence, L. M., Blando, J. M., Yadav, S. S., Ikoma, N., Pestana, R. C., Vauthey, J., Allison, J. P., & Sharma, P. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0605 · Cited by 66 · see citing works
Molecular profiling of hepatocellular carcinoma using circulating cell-free DNA
Kaseb, A., Sanchez, N. S., Sen, S., Kelley, R., Tan, B., Bocobo, A., Lim, K., Abdel-Wahab, R., Uemura, M., Pestana, R., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3341 · Cited by 66 · see citing works
The gut–liver axis: host microbiota interactions shape hepatocarcinogenesis
Silveira, M. A. D., Bilodeau, S., Greten, T. F., Wang, X. W., & Trinchieri, G. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.02.009 · Cited by 66 · see citing works
Self-citationQin, S., Kudo, M., Meyer, T., Finn, R., Vogel, P., Bai, Y., Guo, Y., Meng, Z., Zhang, T., Satoh, T., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.08.033 · Cited by 66 · see citing works
Pinato, D. J., Marron, T. U., Mishra-Kalyani, P. S., Gong, Y. U. T., Wei, G., Szafron, D., Sharon, E., Saeed, A., Jun, T. W., Dharmapuri, S., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.08.020 · Cited by 64 · see citing works
Bian, J., Lin, J., Long, J., Xu, Y., Yang, X., Lu, X., Sang, X., & Zhao, H. (2020) · PubMed Central · Cited by 63 · see citing works
Trajectory of immune evasion and cancer progression in hepatocellular carcinoma
Nguyen, P. H. D., Wasser, M., Tan, C. T., Lim, C. J., Lai, H. L. H., Seow, J. J. W., DasGupta, R., Phua, C. Z. J., Ma, S., Yang, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29122-w · Cited by 61 · see citing works
Emerging and Evolving Concepts in Cancer Immunotherapy Imaging
Dercle, L., Sun, S. H., Seban, R., Mekki, A., Sun, R., Tselikas, L., Hans, S., Bernard‐Tessier, A., Bouvier, F. M., Aide, N., et al. (2022) · Radiology · doi:10.1148/radiol.210518 · Cited by 61 · see citing works
Shi, A., Kasumova, G. G., Michaud, W. A., Cintolo-Gonzalez, J., Díaz‐Martínez, M., Ohmura, J. F., Mehta, A., Chien, I., Frederick, D. T., Cohen, S., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb3461 · Cited by 59 · see citing works
Using cell-free DNA for HCC surveillance and prognosis
Tran, N. H., Kisiel, J. B., & Roberts, L. R. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100304 · Cited by 59 · see citing works
VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment
Zhang, Y., Huang, H., Coleman, M., Žiemys, A., Gopal, P., Kazmi, S. M. A., & Brekken, R. A. (2021) · JCI Insight · doi:10.1172/jci.insight.150735 · Cited by 59 · see citing works
Kim, C., Yang, H., Kim, I. H., Kang, B., Kim, H., Kim, H., Lee, W. S., Jung, S., Lim, H. Y., Cheon, J., et al. (2022) · JAMA Oncology · doi:10.1001/jamaoncol.2022.4733 · Cited by 59 · see citing works
Yu, S., Wang, Y., Hou, J., Li, W.-Y., Wang, X., Xiang, L., Tan, D., Wang, W., Jiang, L., Claret, F. X., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231003 · Cited by 58 · see citing works
Self-citationWu, H., Zheng, X., Pan, T., Yang, X., Chen, X., Zhang, B., Peng, L., & Xie, C. (2022) · International Journal of Cancer · doi:10.1002/ijc.34118 · Cited by 57 · see citing works
Li, X.-S., Li, J., Li, H., & Jiang, T. (2020) · Bioscience Reports · doi:10.1042/bsr20200459 · Cited by 56 · see citing works
Mei, J., Sun, X., Lin, W., Li, S., Lu, L., Zou, J., Wei, W., & Guo, R. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s325600 · Cited by 51 · see citing works
Zhang, L., Chen, C., Chai, D., Li, C., Guan, Y., Liu, L., Kuang, T., Deng, W., & Wang, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.956533 · Cited by 46 · see citing works
Progress of MRI Radiomics in Hepatocellular Carcinoma
Gong, X.-Q., Tao, Y.-Y., Wu, Y., Liu, N., Yu, X., Wang, R., Zheng, J., Liu, N., Huang, X., Li, J., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.698373 · Cited by 46 · see citing works
Chow, P. K. H., Chen, M., Cheng, A., Kaseb, A. O., Kudo, M., Lee, H. C., Yopp, A. C., Zhou, J., Wang, L., Wen, X., et al. (2023) · Cancer Research · doi:10.1158/1538-7445.am2023-ct003 · Cited by 44 · see citing works
Huang, M., He, M., Guo, Y., Li, H., Shen, S., Xie, Y., Li, X., Xiao, H., Fang, L., Li, D., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-3840 · Cited by 42 · see citing works
Breeur, M., Ferrari, P., Dossus, L., Jenab, M., Johansson, M., Rinaldi, S., Travis, R. C., His, M., Key, T., Schmidt, J. A., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02553-4 · Cited by 41 · see citing works
Rizzo, A., Dall’Armellina, S., Pizzuto, D. A., Perotti, G., Zagaria, L., Lanni, V., Treglia, G., Racca, M., & Annunziata, S. (2022) · Cancers · doi:10.3390/cancers14164039 · Cited by 40 · see citing works
Molecular markers of response to anti-PD1 therapy in advanced hepatocellular carcinoma.
Haber, P. K., Torres‐Martín, M., Dufour, J., Verslype, C., Marquardt, J. U., Galle, P. R., Vogel, A., Meyer, T., Labgaa, I., Roberts, L. R., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.2021.39.15_suppl.4100 · Cited by 37 · see citing works
Self-citationHung, H., Lee, J., Wang, Y., Cheng, C., Wu, T., Lee, C., Wu, T.-J., Chou, H., Chan, K., & Lee, W. (2021) · Cancers · doi:10.3390/cancers13071607 · Cited by 36 · see citing works
Budhu, A., Pehrsson, E. C., He, A. R., Goyal, L., Kelley, R. K., Dang, H. T., Xie, C., Monge, C., Tandon, M., Ma, L., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101052 · Cited by 33 · see citing works
Self-citationGe, P., Li, S., Wang, W., Li, C., Fu, Y., Feng, Z., Li, L., Zhang, G., Gao, Z., Dang, X., et al. (2020) · Aging · doi:10.18632/aging.102971 · Cited by 33 · see citing works
Biomarkers for response to immunotherapy in hepatobiliary malignancies
Lin, Z., Qin, L., & Chen, J. (2022) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2022.08.002 · Cited by 31 · see citing works
Teng, W., Lin, C., Lin, P.-T., Hsieh, Y., Ho, M.-M., Hsieh, C.-H., Lin, C., & Lin, S. (2022) · Journal of Hepatology · doi:10.1016/s0168-8278(22)01098-4 · Cited by 30 · see citing works
Tao, Y.-Y., Shi, Y., Gong, X.-Q., Li, L., Li, Z.-M., Yang, L., & Zhang, X. M. (2023) · Cancers · doi:10.3390/cancers15020365 · Cited by 30 · see citing works
Zhao, B., Wang, W., Li, N., García‐Lezana, T., Che, C., Wang, X., Losic, B., Villanueva, A., & Cunningham, B. T. (2022) · Talanta · doi:10.1016/j.talanta.2022.123256 · Cited by 28 · see citing works
Self-citationWang, T., Denman, D., Bacot, S. M., & Feldman, G. M. (2022) · Biomedicines · doi:10.3390/biomedicines10051181 · Cited by 26 · see citing works
Pallozzi, M., Tommaso, N. D., Maccauro, V., Santopaolo, F., Gasbarrini, A., Ponziani, F. R., & Pompili, M. (2022) · Cancers · doi:10.3390/cancers14194631 · Cited by 26 · see citing works
Artificial Intelligence in the Diagnosis of Hepatocellular Carcinoma: A Systematic Review
Martinino, A., Aloulou, M., Chatterjee, S., Pereira, J. P. S., Singhal, S., Patel, T., Kirchgesner, T., Agnes, S., Annunziata, S., Treglia, G., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216368 · Cited by 25 · see citing works
Molecular Monitoring of Lymphomas
Schroers‐Martin, J. G., Alig, S., Garofalo, A., Tessoulin, B., Sugio, T., & Alizadeh, A. A. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-050520-044652 · Cited by 19 · see citing works
Pomyen, Y., Budhu, A., Chaisaingmongkol, J., Forgues, M., Dang, H. T., Ruchirawat, M., Mahidol, C., Wang, X. W., Pupacdi, B., Rabibhadana, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91560-1 · Cited by 19 · see citing works
Self-citationHung, Y., Shao, Y., Lee, J., Hsu, C., Hsu, C., Yang, M., & Chao, Y. (2021) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000477 · Cited by 18 · see citing works
Bell, M. M., Turkbey, E. B., & Escorcia, F. E. (2020) · The Cancer Journal · doi:10.1097/ppo.0000000000000435 · Cited by 17 · see citing works
Monge, C., Xie, C., Steinberg, S. M., & Greten, T. F. (2021) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s311496 · Cited by 17 · see citing works
Self-citationNeely, J., Yao, J. G., Kudo, M., Finn, R. S., Sangro, B., Melero, I., El-Khoueiry, A. B., Tschaika, M., Begic, D., Sama, A. R., et al. (2022) · Cancer Research · doi:10.1158/1538-7445.am2022-2145 · Cited by 16 · see citing works
Cao, Y., Chang, T., Schischlik, F., Wang, K., Sinha, S., Hannenhalli, S. S., Jiang, P., & Ruppin, E. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0092 · Cited by 15 · see citing works
Self-citationSidiropoulos, D. N., Stein-O’Brien, G., Danilova, L., Groß, N., Charmsaz, S., Xavier, S., Leatherman, J. M., Wang, H., Yarchoan, M. M., Jaffee, E. M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.160398 · Cited by 15 · see citing works
Self-citationThe Microbiome and Liver Cancer
Myojin, Y., & Greten, T. F. (2023) · The Cancer Journal · doi:10.1097/ppo.0000000000000646 · Cited by 14 · see citing works
Self-citationHeinrich, B., Ruf, B., Subramanyam, V., Myojin, Y., Lai, C. W., Craig, A. J., Fu, J., Xie, C., Kroemer, A., Greten, T. F., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.849958 · Cited by 12 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Antiangiogenic–immune-checkpoint inhibitor combinations: lessons from phase III clinical trials
Kuo, H., Khan, K. A., & Kerbel, R. S. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00886-y · Cited by 136 · see citing works
Immune microenvironment in hepatocellular carcinoma: from pathogenesis to immunotherapy
Seyhan, D., Allaire, M., Fu, Y., Conti, F., Wang, X. W., Gao, B., & Lafdil, F. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01308-4 · Cited by 131 · see citing works
Self-citationExtracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis
Tran, H. L., Zheng, W., Issadore, D., Im, H., Cho, Y., Zhang, Y., Liu, D., Liu, Y., Li, B., Liu, F., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c00706 · Cited by 106 · see citing works
Cancer stem cells and niches: challenges in immunotherapy resistance
Pan, Y., Yuan, C., Zeng, C., Sun, C., Xia, L., Wang, G., Chen, X., Zhang, B., Liu, J., & Ding, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02265-2 · Cited by 110 · see citing works
Le, J., Dian, Y., Zhao, D., Guo, Z., Luo, Z., Chen, X., Zeng, F., & Deng, G. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02426-3 · Cited by 109 · see citing works
Big data and artificial intelligence in cancer research
Wu, X., Li, W., & Tu, H. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.10.006 · Cited by 81 · see citing works
Salié, H., Wischer, L., D’Alessio, A., Godbole, I., Suo, Y., Otto-Mora, P., Beck, J., Neumann, O., Stenzinger, A., Schirmacher, P., et al. (2024) · Gut · doi:10.1136/gutjnl-2024-332837 · Cited by 78 · see citing works
Cappuyns, S., Piqué-Gili, M., Esteban-Fabró, R., Philips, G., Balaseviciute, U., Pinyol, R., Gris-Oliver, A., Vandecaveye, V., Abril-Fornaguera, J., Montironi, C., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.12.016 · Cited by 69 · see citing works
Self-citationCao, M., Deng, Y., Hao, Q., Yan, H., Wang, Q., Dong, C., Wu, J., He, Y., Huang, L., Xia, X., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02226-7 · Cited by 71 · see citing works
Intelligent Modular DNA Lysosome-Targeting Chimera Nanodevice for Precision Tumor Therapy
Cui, M.-R., Zhang, D., Zheng, X. P., Zhai, H., Xie, M., Fan, Q., Wang, L., Fan, C., & Chao, J. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c10010 · Cited by 65 · see citing works
Zhu, C., Zhang, C., Wang, S., Xun, Z., Zhang, D., Lan, Z., Zhang, L., Chao, J., Liang, Y., Pu, Z., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008686 · Cited by 60 · see citing works
Immunotherapy for hepatocellular carcinoma
Childs, A., Aidoo-Micah, G., Maini, M. K., & Meyer, T. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101130 · Cited by 58 · see citing works
Crosstalk between gut microbiotas and fatty acid metabolism in colorectal cancer
Zhang, H., Tian, Y., Xu, C., Chen, M., Xiang, Z., Gu, L., Xue, H., & Xu, Q. R. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02364-5 · Cited by 52 · see citing works
Development of Polymethine Dyes for NIR‐II Fluorescence Imaging and Therapy
Chen, X., Li, J., Roy, S., Ullah, Z., Gu, J., Huang, H., Yu, C., Wang, X., Wang, H., Zhang, Y., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304506 · Cited by 48 · see citing works
Self-citationLong, S., Li, M., Chen, J., Zhong, L., Abudulimu, A., Zhou, L., Liu, W., Pan, D., Dai, G., Fu, K., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009879 · Cited by 45 · see citing works
Role of the gut microbiota in tumorigenesis and treatment
Liu, Q., Yang, Y., Pan, M., Yang, F., Yu, Y., & Qian, Z. (2024) · Theranostics · doi:10.7150/thno.91700 · Cited by 43 · see citing works
Zhang, S., Deshpande, A. M., Verma, B. K., Wang, H., Mi, H., Yuan, L., Ho, W. J., Jaffee, E. M., Zhu, Q., Anders, R. A., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0943 · Cited by 42 · see citing works
Self-citationUnderstanding gut dysbiosis for hepatocellular carcinoma diagnosis and treatment
Yu, J., Chen, X., Yang, X., & Zhang, B. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.06.003 · Cited by 40 · see citing works
Immunotherapy in liver cancer: overcoming the tolerogenic liver microenvironment
Liu, Y., Yang, H., Li, T. X., & Zhang, N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1460282 · Cited by 39 · see citing works
Hepatocellular Carcinoma Immunotherapy: Predictors of Response, Issues, and Challenges
Rizzo, A., Brunetti, O., & Brandi, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011091 · Cited by 37 · see citing works
Recent progress of microneedles in transdermal immunotherapy: A review
Ai, X., Yang, J., Liu, Z., Guo, T., & Feng, N. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124481 · Cited by 34 · see citing works
Xie, P., Guo, L., Yu, Q., Zhao, Y., Yu, M., Wang, H., Wu, M., Xu, W., Xu, M., Zhu, X., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0954 · Cited by 34 · see citing works
Liu, Z., Wu, C.-Y., Wu, R., Wang, J.-C., Huang, C.-X., Wang, X., Zhang, Y., Zheng, L., Chen, Y., Lao, X., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.05.006 · Cited by 34 · see citing works
Self-citationLong, S., Li, M., Chen, J., Zhong, L., Dai, G., Pan, D., Liu, W., Yi, F., Ruan, Y., Zou, B., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-011126 · Cited by 33 · see citing works
Biomarkers predicting the efficacy of immune checkpoint inhibitors in hepatocellular carcinoma
Qin, R., Jin, T., & Xu, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1326097 · Cited by 29 · see citing works
Yu, X., Qian, J., Ding, L., Pan, C., Liu, X., Wu, Q., Wang, S., Liu, J., Shang, M., Su, R., et al. (2025) · Advanced Science · doi:10.1002/advs.202408788 · Cited by 28 · see citing works
Small-molecule-based targeted therapy in liver cancer
Ming, Y., Gong, Y., Fu, X., Ouyang, X., Peng, Y., & Pu, W. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.08.001 · Cited by 27 · see citing works
Rana, P. S., Ignatz-Hoover, J. J., Guo, C., Mosley, A. L., Malek, E., Federov, Y., Adams, D., & Driscoll, J. J. (2024) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-23-0931 · Cited by 28 · see citing works
Lin, Y., Ou, D., Su, Y., Hsu, C., Hsiao, C., Ko, B., Chen, S., Wang, J., Wang, J.-H., Wu, Y., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.08.035 · Cited by 32 · see citing works
Zou, C., Liu, X., Wang, W., He, L., Yin, A., Cao, Z., Zhu, M., Wu, Y., Liu, X., Ma, J., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03182-8 · Cited by 26 · see citing works
Circulating Gut Microbe-Derived Metabolites Are Associated with Hepatocellular Carcinoma
Banerjee, R., Wehrle, C. J., Wang, Z., Wilcox, J. D., Uppin, V., Varadharajan, V., Mrdjen, M., Hershberger, C. E., Reizes, O., Yu, J. S., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12091946 · Cited by 25 · see citing works
Gan, L., Lü, T., Lu, Y., Song, H., Zhang, J., Zhang, K., Lu, S., Wu, X., Nie, F., Di, S., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009111 · Cited by 25 · see citing works
Spatial single-cell omics: new insights into liver diseases
Suo, Y., Thimme, R., & Bengsch, B. (2025) · Gut · doi:10.1136/gutjnl-2024-332105 · Cited by 27 · see citing works
Myojin, Y., Babaei, S., Trehan, R., Hoffman, C., Kedei, N., Ruf, B., Benmebarek, M.-R., Bauer, K. C., Huang, P., Ma, C., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334026 · Cited by 24 · see citing works
Self-citationTREM2 promotes the formation of a tumor-supportive microenvironment in hepatocellular carcinoma
Guo, H., Wang, M., Ni, C., Yang, C., Fu, C., Zhang, X., Chen, X., Wu, X., Hou, J. W., & Wang, L. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03287-w · Cited by 27 · see citing works
Zhu, Z., Xia, X., Lu, Y., Li, D., He, X., Zhang, B., Xiong, G., Zhang, W., Liang, H., & Zhu, H. J. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103869 · Cited by 24 · see citing works
Interventional Oncology Meets Immuno-oncology: Combination Therapies for Hepatocellular Carcinoma
Bitar, R. D., Salem, R., Finn, R. S., Greten, T. F., Goldberg, S. N., & Chapiro, J. (2024) · Radiology · doi:10.1148/radiol.232875 · Cited by 25 · see citing works
Self-citationHan, J. W., Lee, S. K., Kwon, J. H., Nam, S. W., Yang, H., Bae, S. H., Kim, J. H., Nam, H., Kim, C. W., Lee, H. L., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3978 · Cited by 22 · see citing works
Han, H., Shi, Q., Zhang, Y., Ding, M., He, X.-Z., Liu, C., Zhao, D., Wang, Y., Du, Y.-P., Zhu, Y.-C., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03140-y · Cited by 20 · see citing works
Guo, Z., Li, Z., Guo, J., Gan, L., Mo, H., Zhang, J., Fu, Y., Wang, Y., Jin, M., Wu, Y., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07248-7 · Cited by 19 · see citing works
Qian, H., Huang, Y., Xu, L., Fu, H., & Lu, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-62457-6 · Cited by 18 · see citing works
Huang, Y., & Qian, H. (2024) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s493227 · Cited by 18 · see citing works
Hou, C., Lv, P., Yuan, H.-F., Zhao, L., Wang, Y., Zhang, H., Yang, G., & Zhang, X.-D. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01299-4 · Cited by 17 · see citing works
Xu, J., Wang, T., Li, J., Wang, Y., Zhu, Z., Xiao, F., Wang, J., Zhang, Z., Cai, W., Song, R., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00979-6 · Cited by 17 · see citing works
Liu, Z., Yang, L., Liu, C., Wang, Z., Xu, W., Lu, J., Wang, C., & Xu, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1371829 · Cited by 17 · see citing works
Radiomic features of primary retroperitoneal sarcomas: a prognostic study
Pasquali, S., Iadecola, S., Vanzulli, A., Infante, G., Bologna, M., Corino, V., Greco, G. F., Vigorito, R., Morosi, C., Beretta, A., et al. (2024) · European Journal of Cancer · doi:10.1016/j.ejca.2024.115120 · Cited by 17 · see citing works
Li, Y., Chen, Z., Wang, D., Du, W. T., Zhu, N., Shen, X., Mao, X., Su, Y., Qin, L., Chen, D., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02367-9 · Cited by 18 · see citing works
Role of UFMylation in tumorigenesis and cancer immunotherapy
Ding, L., Jiang, X. M., Li, T., & Wang, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1454823 · Cited by 16 · see citing works
Zhao, R., Zhang, C., Tang, C., Wu, X., Hu, S., Luo, Q., Jia, N., Fan, L., Wang, Y., Jiang, W., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118706 · Cited by 17 · see citing works
The Gut Microbiome Controls Liver Tumors via the Vagus NervePreprint
Bauer, K. C., Trehan, R., Ruf, B., Myojin, Y., Benmebarek, M.-R., Ma, C., Seifert, M., Nur, A., Qi, J., Huang, P., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.23.576951 · Cited by 18 · see citing works
Self-citationJin, Z.-C., Wei, J., Xiao, Y., Si, A., Chen, J.-J., Zhu, X., Li, J., Nie, F., Ding, R., Zhou, H., et al. (2025) · Hepatology · doi:10.1097/hep.0000000000001593 · Cited by 16 · see citing works
Self-citationCao, L., & Ouyang, H. W. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1374742 · Cited by 15 · see citing works
Gao, Y., Gong, Y., Lu, J., Yang, Y., Zhang, Y., Xiong, Y., & Shi, X. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116294 · Cited by 15 · see citing works
Li, Y., Li, X., Xiao, X., Cheng, J., Liu, C., Liu, C., Cai, P., Chen, W., Zhang, H., & Li, X. (2024) · European Radiology · doi:10.1007/s00330-024-11255-9 · Cited by 15 · see citing works
Nosaka, T., Murata, Y., Akazawa, Y., Tanaka, T., Takahashi, K., Naito, T., Matsuda, H., Ohtani, M., Imamura, Y., & Nakamoto, Y. (2024) · Cancers · doi:10.3390/cancers16091785 · Cited by 14 · see citing works
Complete Response to Immunotherapy in Patients With Hepatocellular Carcinoma
Lim, M., Espinoza, M., Huang, Y., Franses, J. W., Zhu, H., & Hsiehchen, D. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.61735 · Cited by 14 · see citing works
Zhang, Y., Ma, Y., Ma, E., Chen, X., Zhang, Y., Yin, B., & Zhao, J. (2025) · Cancer Drug Resistance · doi:10.20517/cdr.2024.165 · Cited by 14 · see citing works
Zheng, H., Cheng, J., Zhuang, Z., Li, D., Yang, J., Yuan, F., Fan, X., & Liu, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1412277 · Cited by 13 · see citing works
Weng, Y., Wang, L., Wang, Y., Xu, J., Fan, X., Luo, S., Hua, Q., Xu, J., Liu, G., Zhao, K.-B., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0589 · Cited by 13 · see citing works
He, B., Zhao, R., Zhang, B., Pan, H., Liu, J., Huang, L., Wei, Y., Yang, D., Liang, J., Wang, M., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186291 · Cited by 12 · see citing works
Quan, Z., Gao, Y., Sun, B., Guo, Y., Jin, Z., Hao, N., Jiang, D., Zheng, C., Li, X., & Chen, Q. (2025) · Biomarker Research · doi:10.1186/s40364-025-00820-z · Cited by 12 · see citing works
Gut microbiome, a novel precision medicine biomarker for hepatocellular carcinoma
Chen, P., Devkota, S., Shiao, S. L., Hendifar, A. E., & Yang, J. D. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1568962 · Cited by 12 · see citing works
Vianello, C., Monti, E., Leoni, I., Galvani, G., Giovannini, C., Piscaglia, F., Stefanelli, C., Gramantieri, L., & Fornari, F. (2024) · Cancers · doi:10.3390/cancers16040766 · Cited by 11 · see citing works
Dong, M., Li, C., Zhang, L., Zhou, J., Xiao, Y., Zhang, T., Jin, X., Fang, Z., Zhang, L., Han, Y., et al. (2024) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29428 · Cited by 11 · see citing works
Urquijo-Ponce, J. J., Mateu, C. A., Sánchez, M. L., Castelló-Miralles, I., & Moisés Diago, M. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i19.2512 · Cited by 11 · see citing works
Tang, Z., Wang, W., Gao, B., Liu, X., Liu, X., Zhuo, Y., Du, J., Ai, F., Yang, X., & Gu, H. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1456748 · Cited by 11 · see citing works
Qiao, Y., Xie, D., Li, Z., Cao, S., & Zhao, D. (2025) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2435598 · Cited by 11 · see citing works
Jiang, J., Feng, K., Zhang, L., & Ma, K. (2025) · Oncology and Translational Medicine · doi:10.1097/ot9.0000000000000086 · Cited by 10 · see citing works
Zhang, Y., Bao, X., Wang, Y., Li, L., Liu, L., & Wu, Q. (2025) · Biomarker Research · doi:10.1186/s40364-025-00836-5 · Cited by 9 · see citing works
Piao, M., Zhang, N., Li, J., Li, C., Xun, Z., Zhang, L., Wang, S., Sun, B., Li, S., Xu, Y., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114052 · Cited by 9 · see citing works
Li, T., Guo, S., Xu, C., Zhang, M., Lyu, C., Xu, H., Hou, Z., Zhang, M., Li, X., Ren, J., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010534 · Cited by 9 · see citing works
Advancements in immunotherapy for hepatocellular carcinoma
Ascari, S., Chen, R., Vivaldi, C., Stefanini, B., Sinno, A. D., Dalbeni, A., Federico, P., & Tovoli, F. (2025) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2025.2461631 · Cited by 8 · see citing works
Zheng, Z., Mei, J., Guan, R., Zhang, J., Xiong, X., Gan, J., Li, S., & Guo, R. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03713-6 · Cited by 8 · see citing works
Hatanaka, T., Kakizaki, S., Hiraoka, A., Tada, T., Hirooka, M., Kariyama, K., Tani, J., Atsukawa, M., Takaguchi, K., Itobayashi, E., et al. (2025) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16871 · Cited by 8 · see citing works
Wu, Z., Boen, J., Jindal, S., Basu, S., Bieniosek, M. F., He, S., LaPelusa, M. B., Mayer, A. T., Kaseb, A. O., Zou, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.11.656869 · Cited by 8 · see citing works
Zhao, H., Ren, R., Zhang, X., Zhan, M., Cui, J., Zhang, J., Liu, X., Wu, L., Chen, Y., Zhou, Y. J., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-1298 · Cited by 7 · see citing works
Liang, Z., Fang, X., Zhang, Z., Tao, M., Gong, W.-H., Jian, H., Tan, X., & Zeng, P. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111928 · Cited by 7 · see citing works
Biomaterials for biomarker imaging and detection
Wang, Y., Huang, X., Wu, G., Wu, W., Li, S., Su, C., Li, L., & Lv, Q. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.049 · Cited by 7 · see citing works
Acteoside as a rising star for clinical treatment: Current fundamental research and future outlooks
Zhang, F.-K., Jia, K., Wang, H., Liu, R., Xue, X., Huo, Z.-X., & Li, X. (2025) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2025.08.007 · Cited by 7 · see citing works
Scheiner, B., Lombardi, P., D’Alessio, A., Kim, G., Tafavvoghi, M., Petrenko, O., Goldin, R. D., Fulgenzi, C. A. M., Torkpour, A., Balcar, L., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010975 · Cited by 7 · see citing works
Kocheise, L., Kempski, J., Tang, Y., Balcar, L., Berger, V., Tomczak, M., Gorgulho, J., Masood, R., Giehren, F., Schmidt, C., et al. (2025) · Annals of Hepatology · doi:10.1016/j.aohep.2025.102138 · Cited by 7 · see citing works
From Theory to Practice: Which Biomarkers Are Ready for Predicting Response in Advanced HCC ?
Decraecker, M., Blanc, J., Amintas, S., & Manaud, G. (2026) · Liver International · doi:10.1111/liv.70684 · Cited by 7 · see citing works
Radio-immunomics in hepatocellular carcinoma: Unraveling the tumor immune microenvironment
Liu, Q., Zhu, W., Song, F., Lou, T., He, L., Zhou, W., & Feng, Z. (2024) · Meta-Radiology · doi:10.1016/j.metrad.2024.100098 · Cited by 7 · see citing works
Murata, Y., Nosaka, T., Akazawa, Y., Tanaka, T., Takahashi, K., Naito, T., Matsuda, H., Ohtani, M., & Nakamoto, Y. (2024) · Cancers · doi:10.3390/cancers16132410 · Cited by 7 · see citing works
Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment
Feng, P., Hu, X., Zhou, S., Liu, X., Zeng, L., & Liu, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1508034 · Cited by 7 · see citing works
Feng, Y., Fang, L., & Cao, G. (2025) · Hepatoma Research · doi:10.20517/2394-5079.2024.132 · Cited by 9 · see citing works
Zhou, M., Zhou, Z., Hu, L., Chen, S., Meng, F., Chen, J., & Shen, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06106-0 · Cited by 7 · see citing works
Li, Z., Ma, B., Shui, S., Tu, Z., Peng, W., Chen, Y., Zhou, J., Lan, F., Ying, B., & Wu, Y. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00700j · Cited by 6 · see citing works
Fang, H., Chen, X., Zhong, Y., Wu, S., Ke, Q., Huang, Q., Wang, L., & Zhang, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1446961 · Cited by 6 · see citing works
Liu, Z., Hu, Q., Wang, J., Zhu, X., Sun, J., Zhang, G., Fang, R., Wang, R., Zhang, B., Shi, H., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.161835 · Cited by 6 · see citing works
Xu, J., Wang, J., Li, J., Zhu, Z., Xiao, F., Cai, W., Song, R., Wang, T. F., & Li, H. (2025) · Journal of Medical Systems · doi:10.1007/s10916-025-02192-1 · Cited by 6 · see citing works
Tang, X., Wang, Q., Jin, R., & Hu, C. (2024) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s459250 · Cited by 6 · see citing works
Kim, J. H., Han, J. W., Cho, H. S., Jang, J. W., Tak, K. Y., & Sung, P. S. (2025) · Cancers · doi:10.3390/cancers17243967 · Cited by 5 · see citing works
Yamamoto, S., Kodama, T., Kuwano, A., Maesaka, K., Hashidate‐Yoshida, T., Shindou, H., Takeda, H., Shirai, K., Myojin, Y., Murai, K., et al. (2026) · Hepatology · doi:10.1097/hep.0000000000001677 · Cited by 5 · see citing works
Wang, Y., Li, F., Li, J., Huang, T., Huang, T., Zhang, N., Li, Y., Xun, Z., Zhu, Z., Tan, Q., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.06.003 · Cited by 5 · see citing works
Li, D., Fan, Y., He, B., Tang, Y., Deng, G., Guo, R., Deng, M., & Tang, D. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s523194 · Cited by 5 · see citing works
Battista, D. D., Yakymi, R., Scheibe, E., Sato, S., Gerstein, H., Markowitz, T. E., Lack, J., Mereu, R., Manieli, C., Zamboni, F., et al. (2024) · Cancers · doi:10.3390/cancers16071370 · Cited by 5 · see citing works
Nishida, N. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0739 · Cited by 5 · see citing works
Pan, X., Liao, B., Hu, Z., & Xiong, Y. (2026) · Biology · doi:10.3390/biology15010095 · Cited by 4 · see citing works
Chen, Y., Wang, K., Zhang, X., Tao, D., Shang, Y., Wang, P., Li, Q., & Liu, Y. (2024) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01061-8 · Cited by 4 · see citing works
- Authors
- Greten, T. F., Villanueva, A., Korangy, F., Ruf, B., Yarchoan, M., Ma, L., Ruppin, E., & Wang, X. W.
- Affiliations
- National Institutes of Health (US)
- Tisch Cancer Institute (US)
- National Cancer Institute (US)
- Johns Hopkins University (US)
- Corresponding author
- Greten, Tim F.
- ORCID
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2023-09-19
- Volume
- 20
- Issue
- 11
- Pages
- 780-798
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- OpenAlex
- W4386845699
- Cited by
- 227
- References
- 205
- Citations by year
- 2026: 66 · 2025: 88 · 2024: 71 · 2023: 2
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Keywords
- hepatocellular carcinoma, immune checkpoint inhibitors, predictive biomarkers, atezolizumab plus bevacizumab, single-cell RNA sequencing, circulating tumor cells, high-dimensional flow cytometry, tumor microbiome, radiomics, gene expression signatures, spatial transcriptomics, biomarker-driven trials, immunotherapy selection
- MeSH terms
- Sorafenib, Carcinoma, Hepatocellular, Humans, Immunotherapy, Liver Neoplasms, Biomarkers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review