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Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis
Open accessAbstract
Clonal hematopoiesis, a condition in which individual hematopoietic stem cell clones generate a disproportionate fraction of blood leukocytes, correlates with higher risk for cardiovascular disease. The mechanisms behind this association are incompletely understood. Here, we show that hematopoietic stem cell division rates are increased in mice and humans with atherosclerosis. Mathematical analysis demonstrates that increased stem cell proliferation expedites somatic evolution and expansion of clones with driver mutations. The experimentally determined division rate elevation in atherosclerosis patients is sufficient to produce a 3.5-fold increased risk of clonal hematopoiesis by age 70. We confirm the accuracy of our theoretical framework in mouse models of atherosclerosis and sleep fragmentation by showing that expansion of competitively transplanted Tet2-/- cells is accelerated under conditions of chronically elevated hematopoietic activity. Hence, increased hematopoietic stem cell proliferation is an important factor contributing to the association between cardiovascular disease and clonal hematopoiesis.
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“These cytokines display overlapping features, such as inducing cell cycle entry of HSCs and their differentiation, frequently toward the granulo-monocytic lineage 1,4-6,12-15 .”
From Type 1 interferon perturbates clonal competition by reshaping human blood development (2026) · cites this paper as [5]
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“The disease process itself has been suggested to reciprocally accelerate CH [41] (Figure 1).”
From Clonal hematopoiesis and inflammation – the perpetual cycle (2023) · cites this paper as [41]
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“The isolated effects of individual inflammatory cytokines, including type 1 interferons (IFNa/b) 1-3 , type 2 IFN (IFNg) 4-6 , TNFa 7,8 , and IL-1 9-11 , have been well-documented in mouse hematopoietic development.”
From Type 1 interferon perturbates clonal competition by reshaping human blood development (2026) · cites this paper as [5]
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“While clonal expansion during normal ageing has not yet been observed in mice, it has been reported in mouse models for disease61 and in physiologically aged macaques62.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [61]
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Metadata
- Authors
- Heyde, A., Rohde, D., McAlpine, C. S., Zhang, S., Hoyer, F. F., Gerold, J. M., Cheek, D., Iwamoto, Y., Schloss, M. J., Vandoorne, K., Iborra-Egea, O., Muñoz-Guijosa, C., Bayes-Genis, A., Reiter, J. G., Craig, M., Swirski, F. K., Nahrendorf, M., Nowak, M. A., & Naxerova, K.
- Affiliations
- Harvard University (US)
- Hospital Universitari Germans Trias i Pujol (ES)
- Stanford University (US)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Corresponding author
- Naxerova, Kamila
- ORCID
- Heyde, Alexander
- Rohde, David
- McAlpine, Cameron S.
- Zhang, Shuang
- Hoyer, Friedrich F.
- Gerold, Jeffrey M.
- Cheek, David
- Iwamoto, Yoshiko
- Schloss, Maximilian J.
- Vandoorne, Katrien
- Iborra-Egea, Oriol
- Muñoz-Guijosa, Christian
- Reiter, Johannes G.
- Craig, Morgan
- Swirski, Filip K.
- Nahrendorf, Matthias
- Nowak, Martin A.
- Naxerova, Kamila
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 184
- Issue
- 5
- Pages
- 1348-1361.e22
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC8109274
- OpenAlex
- W3130296909
- Cited by
- 267
- References
- 64
- Citations by year
- 2026: 33 · 2025: 48 · 2024: 45 · 2023: 47 · 2022: 61 · 2021: 33
- FWCI
- 31.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Science Foundation
- National Heart, Lung, and Blood Institute
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- clonal hematopoiesis, atherosclerosis, hematopoietic stem cell proliferation, somatic evolution, driver mutations, cardiovascular risk, TET2, sleep fragmentation, hematopoietic stem cell transplantation
- MeSH terms
- Clonal Hematopoiesis, Aging, Animals, Apolipoproteins E, Bone Marrow, Disease Models, Animal, Female, Hematopoietic Stem Cells, Humans, Mice, Inbred C57BL, Models, Biological, Sleep Deprivation, Cell Proliferation, Atherosclerosis, Mice, Clonal Evolution
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