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Reducing acetylated tau is neuroprotective in brain injury
Open accessAbstract
Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for Alzheimer's disease (AD). We report here that TBI induces tau acetylation (ac-tau) at sites acetylated also in human AD brain. This is mediated by S-nitrosylated-GAPDH, which simultaneously inactivates Sirtuin1 deacetylase and activates p300/CBP acetyltransferase, increasing neuronal ac-tau. Subsequent tau mislocalization causes neurodegeneration and neurobehavioral impairment, and ac-tau accumulates in the blood. Blocking GAPDH S-nitrosylation, inhibiting p300/CBP, or stimulating Sirtuin1 all protect mice from neurodegeneration, neurobehavioral impairment, and blood and brain accumulation of ac-tau after TBI. Ac-tau is thus a therapeutic target and potential blood biomarker of TBI that may represent pathologic convergence between TBI and AD. Increased ac-tau in human AD brain is further augmented in AD patients with history of TBI, and patients receiving the p300/CBP inhibitors salsalate or diflunisal exhibit decreased incidence of AD and clinically diagnosed TBI.
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“Beyond neurodegenerative and neurodevelopmental disorders, tau ablation has also been shown to improve outcomes in models of neurological injury and vascular stress, such TBI and high-salt diet-induced vascular dysfunction, with associated improvements in cognitive performance [72, 86, 87].”
From Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease (2026) · cites this paper as [72]
Experimental — accuracy not yet measuredIn the citing paper
“In addition, the acetylation of tau is an early pathological feature of neurodegeneration. Acetylated tau inhibits its degradation, promotes pathological aggregation and propagation, and contributes to tauopathy [46–51].”
From Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation (2023) · cites this paper as [51]
In the citing paper
“Inhibiting p300 with salsalate, a non-steroidal anti-inflammatory drug, could induce tau deacetylation, preserve tau axonal localization, and protect mice from neurodegeneration [51].”
From Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation (2023) · cites this paper as [51]
In the citing paper
“Abnormal acetylation of tau on lysine residues spans the microtubule-binding repeat region (MTBR), and this modification alone is sufficient to induce tau pathology and neurodegeneration [51].”
From Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation (2023) · cites this paper as [51]
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Metadata
- Authors
- Shin, M.-K., Vázquez-Rosa, E., Koh, Y., Dhar, M., Chaubey, K., Cintrón-Pérez, C. J., Barker, S., Miller, E., Franke, K., Noterman, M. F., Seth, D., Allen, R. S., Motz, C. T., Rao, S. R., Skelton, L. A., Pardue, M. T., Fliesler, S. J., Wang, C., Tracy, T. E., Gan, L., Liebl, D. J., Savarraj, J. P. J., Torres, G. L., Ahnstedt, H., McCullough, L. D., Kitagawa, R. S., Choi, H. A., Zhang, P., Hou, Y., Chiang, C.-W., Li, L., Ortiz, F., Kilgore, J. A., Williams, N. S., Whitehair, V. C., Gefen, T., Flanagan, M. E., Stamler, J. S., Jain, M. K., Kraus, A., Cheng, F., Reynolds, J. D., & Pieper, A. A.
- Affiliations
- University Hospitals of Cleveland (US)
- University of Iowa (US)
- Georgia Institute of Technology (US)
- Buffalo VA Medical Center (US)
- Gladstone Institutes (US)
- Buck Institute for Research on Aging (US)
- Weill Cornell Medicine (US)
- University of Miami (US)
- The University of Texas Health Science Center at Houston (US)
- The Ohio State University (US)
- Cleveland Clinic (US)
- The University of Texas Southwestern Medical Center (US)
- MetroHealth (US)
- Northwestern University (US)
- Case Western Reserve University (US)
- Cornell University (US)
- Corresponding author
- Pieper, Andrew A.
- ORCID
- Shin, Min-Kyoo
- Koh, Yeojung
- Dhar, Matasha
- Chaubey, Kalyani
- Cintrón-Pérez, Coral J.
- Barker, Sarah
- Miller, Emiko
- Franke, Kathryn
- Noterman, Maria F.
- Seth, Divya
- Allen, Rachael S.
- Motz, Cara T.
- Rao, Sriganesh Ramachandra
- Skelton, Lara A.
- Pardue, Machelle T.
- Fliesler, Steven J.
- Wang, Chao
- Tracy, Tara E.
- Gan, Li
- Liebl, Daniel J.
- Savarraj, Jude P.J.
- Ahnstedt, Hilda
- McCullough, Louise D.
- Choi, H. Alex
- Zhang, Pengyue
- Chiang, Chien-Wei
- Li, Lang
- Kilgore, Jessica A.
- Williams, Noelle S.
- Whitehair, Victoria C.
- Gefen, Tamar
- Flanagan, Margaret E.
- Stamler, Jonathan S.
- Jain, Mukesh K.
- Kraus, Allison
- Cheng, Feixiong
- Reynolds, James D.
- Pieper, Andrew A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 184
- Issue
- 10
- Pages
- 2715-2732.e23
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC8491234
- OpenAlex
- W3152963650
- Cited by
- 226
- References
- 64
- Citations by year
- 2026: 36 · 2025: 60 · 2024: 45 · 2023: 40 · 2022: 34 · 2021: 11
- FWCI
- 20.89
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- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX002439, IK2 RX002928)
- National Institutes of Health (5p30ag062428-02, UL1TR001412)
- National Institute on Aging (P30-AG062428, F32AG043301, R01AG066707, K01AG057862, R01AG062566, P30AG013854, K08AG065463)
- National Cancer Institute (P01CA217797, T32CA078586)
- National Institute of General Medical Sciences (T32GM007250)
- National Institute of Neurological Disorders and Stroke (R01NS098740)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- tau acetylation, traumatic brain injury, Alzheimer's disease, SIRT1, neurodegeneration, neurobehavioral impairment, blood biomarkers, salsalate, diflunisal, neuroprotection
- MeSH terms
- Neuroprotection, Brain Injuries, Traumatic, p300-CBP-Associated Factor, Acetylation, Alzheimer Disease, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Diflunisal, Female, Humans, Male, Mice, Inbred C57BL, Neurons, Salicylates, Biomarkers, tau Proteins, Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating), p300-CBP Transcription Factors, Mice, Sirtuin 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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