The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling
Open accessAbstract
Nucleotide-binding, leucine-rich repeat receptors (NLRs) are major immune receptors in plants and animals. Upon activation, the Arabidopsis NLR protein ZAR1 forms a pentameric resistosome in vitro and triggers immune responses and cell death in plants. In this study, we employed single-molecule imaging to show that the activated ZAR1 protein can form pentameric complexes in the plasma membrane. The ZAR1 resistosome displayed ion channel activity in Xenopus oocytes in a manner dependent on a conserved acidic residue Glu11 situated in the channel pore. Pre-assembled ZAR1 resistosome was readily incorporated into planar lipid-bilayers and displayed calcium-permeable cation-selective channel activity. Furthermore, we show that activation of ZAR1 in the plant cell led to Glu11-dependent Ca2+ influx, perturbation of subcellular structures, production of reactive oxygen species, and cell death. The results thus support that the ZAR1 resistosome acts as a calcium-permeable cation channel to trigger immunity and cell death.
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A wheat resistosome defines common principles of immune receptor channels
Förderer, A., Li, E., Lawson, A., Deng, Y.-N., Sun, Y., Logemann, E., Zhang, X., Wen, J., Han, Z., Chang, J., et al. (2022) · doi:10.1101/2022.03.23.485489 · Cited by 36
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Metadata
- Authors
- Bi, G., Su, M., Li, N., Liang, Y., Dang, S., Xu, J., Hu, M., Wang, J., Zou, M., Deng, Y., Li, Q., Huang, S., Li, J., Chai, J., He, K., Chen, Y.-H., & Zhou, J.-M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 184
- Issue
- 13
- Pages
- 3528-3541.e12
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3163855438
- Cited by
- 593
- References
- 69
- FWCI
- 51.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bi, G., Su, M., Li, N., Liang, Y., Dang, S., Xu, J., Hu, M., Wang, J., Zou, M., Deng, Y., Li, Q., Huang, S., Li, J., Chai, J., He, K., Chen, Y.-H., & Zhou, J.-M. (2021). The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling. Cell. https://doi.org/10.1016/j.cell.2021.05.003
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