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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity

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Targeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of Alzheimer’s disease

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Spatial Immunometabolism: Integrating Technologies to Decode Cellular Metabolism in Tissues

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Lupus Susceptibility Loci Predispose Mice to Clonal Lymphocytic Responses and Myeloid Expansion

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YTE-17 inhibits colonic carcinogenesis by resetting antitumor immune response via Wnt5a/JNK mediated metabolic signaling

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The kinase ITK controls a Ca 2+ -mediated switch that balances T H 17 and T reg cell differentiation

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Lysine demethylase 6 (KDM6): A promising therapeutic target in autoimmune disorders and cancer

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Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

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Decoding cardiac metabolic reprogramming through single-cell multi-omics: from mechanisms to therapeutic applications

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Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease

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Enhanced fatty acid oxidation by selective activation of PPARα alleviates autoimmunity through metabolic transformation in T-cells

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Polyamine: A metabolic compass for T helper cell fate direction

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DNA Methylation Signature in Monozygotic Twins Discordant for Psoriatic Disease

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T cell phenotype switching in autoimmune disorders: Clinical significance of targeting metabolism

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Alterations in Lymphocytic Metabolism—An Emerging Hallmark of MS Pathophysiology?

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Prognostic biomarker IL17A correlated with immune infiltrates in head and neck cancer

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Metabolic adaption of mucosal macrophages: Is metabolism a driver of persistence across tissues?

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Single-cell omics analysis with genome-scale metabolic modeling

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HSP90β shapes the fate of Th17 cells with the help of glycolysis‐controlled methylation modification

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Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment

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Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection

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Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling

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Vitamin A retinoic acid contributes to muscle stem cell and mitochondrial function loss in old age

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Multi-omics analysis of polyamine metabolism implicates NT5E/CD73 in the progression of pancreatic cancer

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Elucidating the mitochondrial function of murine lymphocyte subsets and the heterogeneity of the mitophagy pathway inherited from hematopoietic stem cells

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Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration

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Interactive, integrated analysis of single-cell transcriptomic and phylogenetic data with PhyloVision

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Recent Advances in Folates and Autoantibodies against Folate Receptors in Early Pregnancy and Miscarriage

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Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity

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Biases in machine-learning models of human single-cell data

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Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states

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A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells

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Lymphoma B cells remodel bone marrow stromal cells into extracellular matrix–producing cancer-associated fibroblasts

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T H 17 cells converted into exT H 17 cells sustain rheumatoid-like IL-17–independent inflammatory arthritis

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Computational approaches in rheumatic diseases – Deciphering complex spatio-temporal cell interactions

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Ze-Qi-Tang formula inhibits MDSCs glycolysis through the down-regulation of p21/Hif1α/Glut1 signal in psoriatic-like mice

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LL37/self-DNA complexes mediate monocyte reprogramming

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Machine learning identifies key cells and therapeutic targets during ferroptosis after spinal cord injury

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The indispensability of methyltransferase-like 3 in the immune system: from maintaining homeostasis to driving function

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BLOC1S1 Control of Vacuolar Organelle Fidelity Modulates Murine T H 2 Cell Immunity and Allergy Susceptibility

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Inferring metabolic objectives and trade-offs in single cells during embryogenesis

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The emerging roles of the urea cycle in tumor microenvironment and therapies

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Decoding immunometabolism with next-generation tools: lessons from dendritic cells and T cells

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IL-18 drives the Bhlhe40-mediated pathogenic Th17 cell response and exacerbates autoimmune disease progression

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Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells

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Therapeutic opportunities to modulate immune tolerance through the metabolism-chromatin axis

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scFASTCORMICS: A Contextualization Algorithm to Reconstruct Metabolic Multi-Cell Population Models from Single-Cell RNAseq Data

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Immunoinformatics: Pushing the boundaries of immunology research and medicine

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Targeting Nuclear Receptors for TH17-Mediated Inflammation: REV-ERBerations of Circadian Rhythm and Metabolism

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ScRNA-seq identified the metabolic reprogramming of human colonic immune cells in different locations and disease states

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Elevated enteric putrescine suppresses differentiation of intestinal germinal center B cells

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Application of Metabolomics across the Spectrum of Pulmonary and Critical Care Medicine

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New Insights and Implications of Cell–Cell Interactions in Developmental Biology

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Small extracellular vesicles secreted from TGF-β1-licensed mesenchymal stromal cells reduce inflammation-associated injury following corneal alkali burn

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Digital twins for in vivo metabolic flux estimations in patients with brain cancer

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Metabolic Landscape of Bronchoalveolar Lavage Fluid in Coronavirus Disease 2019 at Single Cell Resolution

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Autophagy-inducing nutritional interventions in experimental and clinical oncology

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Single-cell RNA-seq reveals the metabolic status of immune cells response to immunotherapy in triple-negative breast cancer

Liu, P.-W., Lin, J., Hou, R., Cai, Z., Gong, Y., He, P., & Yang, J. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.107926 · Cited by 7

Atlas of Cell Repertoire Within Neointimal Lesions Is Metabolically Altered in Hypertensive Rats

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Deciphering metabolic crosstalk in context: lessons from inflammatory diseases

Verheijen, F. W., Minh, T. T. N., Chang, J., Broere, F., Zaal, E. A., & Berkers, C. R. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13588 · Cited by 8

Inferring Metabolic States from Single Cell Transcriptomic Data via Geometric Deep Learning

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Predictive nomogram of the clinical outcomes of colorectal cancer based on methylated SEPT9 and intratumoral IL-10+ Tregs infiltration

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Cxcl9 modulates aging associated microvascular metabolic and angiogenic dysfunctions in subcutaneous adipose tissue

Fu, X., Zhao, Y., Cui, X., Huang, S., Lv, Y., Li, C., Gong, F., Yang, Z., Yang, X., & Xiao, R. (2025) · Angiogenesis · doi:10.1007/s10456-025-09970-y · Cited by 9

Enhanced flux potential analysis links changes in enzyme expression to metabolic flux

Li, X., Walhout, A. J. M., & Yilmaz, L. S. (2025) · Molecular Systems Biology · doi:10.1038/s44320-025-00090-9 · Cited by 7

Investigating intestinal epithelium metabolic dysfunction in celiac disease using personalized genome-scale models

McCreery, C. V., Alessi, D., Mollo, K., Fasano, A., & Zomorrodi, A. R. (2025) · BMC Medicine · doi:10.1186/s12916-025-03854-0 · Cited by 6

Oleic acid regulates CD4+ T cells differentiation by targeting ODC1-mediated STAT5A phosphorylation in Vogt-Koyanagi-Harada disease

Liao, W., Hu, R., Ji, Y., Zhong, Z., Huang, X., Cai, T., Zhou, C., Wang, Y., Ye, Z., & Yang, P. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156660 · Cited by 7

Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages

Ding, H., Xue, L., Zhu, S., Wang, Z., Gui, H., Zhang, G., Tang, N., Ren, H., & Chen, D. (2025) · Smart Medicine · doi:10.1002/smmd.70009 · Cited by 7

Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma

Liu, Q., Chen, H., Tang, D., Zhang, H., Chen, S., Meng, Y., Zheng, B., Liu, F., Zhou, J., & Zhang, W. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1562261 · Cited by 7

Mitochondrial One-Carbon Metabolism Drives CD34-Lineage Cells to Differentiate Into T Follicular Helper Cells to Form Tertiary Lymphoid Organs in Transplant Arteriosclerosis

Sun, X., Wu, J., He, T., Yao, M., Li, Q., Weng, C., Peng, L., Xiao, Q., Lu, Y., Yuan, H., et al. (2025) · Circulation · doi:10.1161/circulationaha.125.073691 · Cited by 7

Oral Administration of Ovalbumin Prevents Food Allergy via Improving Microbiota and Metabolic Disorders in a Dose-Dependent Manner

Zhang, S., Shi, Q., Wu, Y., Chen, X., Li, J., Chen, P., Wu, Y., Li, X., Zheng, S., Zhang, J., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c09864 · Cited by 7

HIVEP1 aggravates NASH by reprogramming polyamine metabolism in T H 17 cells

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STAT3 S727 phosphorylation drives pathogenic Th17 differentiation and neuroinflammation in autoimmune disease

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Diet, gut-brain axis, and metabolism-epigenome-immunity networks: A triad in neurological disease management

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Interrogation of T Cell–enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism

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Treponema pallidum recombinant protein Tp47 activates NOD-like receptor family protein 3 inflammasomes in macrophages via glycolysis

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Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle

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Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment

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The Polyamine Putrescine Is a Positive Regulator of Group 3 Innate Lymphocyte Activation

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Transcriptomes and metabolism define mouse and human MAIT cell heterogeneityPreprint

Chandra, S., Ascui, G., Riffelmacher, T., Chawla, A., Ramírez-Suástegui, C., Castelan, V. O. C., Seumois, G., Simon, H. A., Murray, M. P., Seo, G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.20.473182 · Cited by 7

Yeast9: A Consensus Yeast Metabolic Model Enables Quantitative Analysis of Cellular Metabolism By Incorporating Big DataPreprint

Zhang, C., Sánchez, B. J., Li, F., Eiden, C. W. Q., Scott, W. T., Liebal, U. W., Blank, L. M., Mengers, H. G., Anton, M., Rangel, A. E. T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.03.569754 · Cited by 7

S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolismPreprint

Huang, H., Yang, Y., Zhang, Q., Yang, Y., Xiong, Z., Mao, S., Song, T., Wang, Y., Liu, Z., Bu, H., et al. (2024) · eLife · doi:10.7554/elife.101731 · Cited by 7

Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase

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Multi-omics analysis reveals interactions between host and microbes in Bama miniature pigs during weaning

Ma, W., Li, Y., Hu, Y., Liu, X., Guo, Z., Zhong, B., Qiu, H., & Li, J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1482925 · Cited by 6

Vitamin A treatment restores vision failures arising from Leber’s hereditary optic neuropathy–linked mtDNA mutation

Ai, C., Li, H., Wang, C., Ji, Y., Wallace, D. C., Qian, J., Zhu, Y., & Guan, M. (2025) · JCI Insight · doi:10.1172/jci.insight.188962 · Cited by 7

Interplay between gut microbiota and intestinal lipid metabolism: mechanisms and implications

Hang, B., & Wang, Y. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2500102 · Cited by 7

Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosus

Ou, Q., Niu, L., Wang, D., Yao, G., Ren, Q., Li, Z., Mao, X., Teng, W., Chen, Z., Xiang, A. P., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02442-1 · Cited by 6

Beyond Bulk Metabolomics: Emerging Technologies for Defining Cell-Type Specific Metabolic Pathways in Health and Disease

Gong, Y., & Weinberg, S. E. (2025) · Biomolecules · doi:10.3390/biom15121687 · Cited by 6

Contextualizing TH17 cells in cancer

Pang, D., Bertocchi, A., Powrie, F. M., & Pohin, M. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-025-01250-6 · Cited by 7

The Th17/Treg axis: a key to understanding and treating autoimmune disorders

Xie, X., Liu, Y., & Li, H. (2026) · Open Life Sciences · doi:10.1515/biol-2025-1285 · Cited by 6

Metabolic reprogramming of Th17/Treg imbalance in autoimmune thyroid diseases

Zhou, M., Wu, W., Liu, Y., Wang, S. Q., & Peng, H. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02915-y · Cited by 6

MitoMAMMAL: a genome scale model of mammalian mitochondria predicts cardiac and BAT metabolism

Chapman, S. P., Brunet, T., Mourier, A., & Habermann, B. H. (2024) · Bioinformatics Advances · doi:10.1093/bioadv/vbae172 · Cited by 5

Microbiome–Immune Interaction in Pulmonary Arterial Hypertension: What Have We Missed?

Zhou, X., Tian, W., Gu, S., Rabinovitch, M., Nicolls, M. R., & Snyder, M. P. (2025) · Research · doi:10.34133/research.0669 · Cited by 6

Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20

Preiss, N. K., Kamal, Y., Wilkins, O. M., Li, C., Kolling, F., Trask, H. W., Usherwood, Y.-K., Cheng, C., Frost, H. R., & Usherwood, E. J. (2023) · Life Science Alliance · doi:10.26508/lsa.202201683 · Cited by 7

Metabolic insights into tumor pathogenesis: Unveiling pan‐cancer metabolism and the potential of untargeted metabolomics

Wang, T., & Gao, Y. (2023) · MedComm – Future Medicine · doi:10.1002/mef2.59 · Cited by 7

A multiomics approach reveals evidence for phenylbutyrate as a potential treatment for combined D,L-2- hydroxyglutaric aciduria

Phua, Y. L., D’Annibale, O., Karunanidhi, A., Mohsen, A.-W. A., Kirmse, B., Dobrowolski, S. F., & Vockley, J. (2024) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2024.108495 · Cited by 7

Compartmentalization of metabolism between cell types in multicellular organisms: A computational perspective

Li, X., Yilmaz, L. S., & Walhout, A. J. M. (2021) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2021.100407 · Cited by 6

WDR36 Regulates Trophectoderm Differentiation During Human Preimplantation Embryonic Development Through Glycolytic Metabolism

An, S., Hou, S., Xu, F., Yan, H., Zhang, W., Xiang, J., Chen, H., Zhang, H., Dong, L., Sun, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202412222 · Cited by 5

Spermidine restricts neonatal inflammation via metabolic shaping of polymorphonuclear myeloid-derived suppressor cells

Chen, J., Zhu, L., Cui, Z., Zhang, Y., Jia, R., Zhou, D., Hu, B., Zhong, W., Xu, J., Zhang, L., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci183559 · Cited by 5

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity

Wang, C., Wagner, A., Fessler, J., DeTomaso, D., Zaghouani, S., Zhou, Y., Pierce, K. A., Sobel, R. A., Clish, C. B., Yosef, N., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115799 · Cited by 5

Oleanolic acid alleviates ulcerative colitis by remodeling Th17 cells via targeting HSP90β-ODC1 pathway-mediated polyamine synthesis

Yuan, Y., Tian, Y., Zhao, Z., Yang, G., Wang, J., Zhu, F., Xue, G., Gao, F., Liu, Y., & Fan, H. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157441 · Cited by 6

In Silico Metabolic Modeling of Single Th17 Cells Reveals Regulators of Autoimmunity

Wagner, A. (2021) · eScholarship (California Digital Library)

Cell-specific metabolic models reveal novel metabolic regulators of Th17 pathogenicity: from single-cell RNA-Seq to actionable metabolic targets

Wagner, A., Wang, C., DeTomaso, D., Koul, A., Regev, A., Kuchroo, V. K., & Yosef, N. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.200.supp.163.21

In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity

Wagner, A., Wang, C., DeTomaso, D., Ávila-Pacheco, J., Zaghouani, S., Fessler, J., Akama‐Garren, E. H., Pierce, K. A., Ron‐Harel, N., Haigis, M. C., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.204.supp.150.22 · Cited by 4

Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine PathwayPreprint

Wang, C., Wagner, A., Fessler, J., Ávila-Pacheco, J., Karminski, J., Thakore, P. I., Zaghouani, S., Pierce, K. A., Bod, L., Schnell, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.23.911966 · Cited by 6

A Compass to Guide Insights into TH17 Cellular Metabolism and Autoimmunity

Wilson, A., Mosure, S., & Solt, L. A. (2021) · Immunometabolism · doi:10.20900/immunometab20220001 · Cited by 2