Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

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KEGG: new perspectives on genomes, pathways, diseases and drugs

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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Machine Learning Identifies Key Cells and Therapeutic Targets in Intervertebral Disc Degeneration: SASP-Driven Matrix Catabolism, Inflammation Amplification, and Metabolic Collapse

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Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

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Metabolic traits of T cells and the implications in autoimmune diseases

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Systematically exploring yeast metabolism through retrobiosynthesis and deep learning

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PLA2G12A-driven extracellular vesicle-lipid signaling amplifies pathogenic T cell responses in inflammatory diseases

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Metabolic Objectives and Trade-Offs: Inference and Applications

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Helicobacter pylori Chronic-Stage Inflammation Undergoes Fluctuations That Are Altered in tlpA Mutants

Johnson, K. S., Yang, C., Carter, J. E., Worthington, A. K., Robinson, E. K., Lopez-Magaña, R., Salgado, F., Arnold, I. C., & Ottemann, K. M. (2022) · Infection and Immunity · doi:10.1128/iai.00322-22 · Cited by 5

Coupling constrained-based flux sampling and clustering to tackle cancer metabolic heterogeneity

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Elucidating the cell metabolic heterogeneity during hematopoietic lineage differentiation based on Met-Flow

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Polyamines and hypusination are important for Clostridioides difficile toxin B (TcdB)-mediated activation of group 3 innate lymphocytes (ILC3s)

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Foxo1 drives the TGFβ1-dependent dichotomy of Th17 cell fates

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Genome and metabolome: chance and necessity

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Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in ratsPreprint

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Functional border-associated macrophages limit Alzheimer’s Disease progressionPreprint

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Interferon-β and interleukin-6 exert opposing effects on Foxp3 acetylation to control regulatory T cell induction

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Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

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Fructose intake driven glycolysis-ROS-EGFR axis specifically promotes the generation and pathogenicity of Th17 cells

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The transition from monocyte to tissue-resident macrophage requires DHPS

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Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine

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Comprehensive single-cell metabolic profiling identifies targets to sensitize triple-negative breast cancer to chemo-immunotherapy

Xu, Y., Liu, X.-Y., Zhang, H., Chen, L. J., Wang, H., Shao, Z.-M., Xiao, Y., & Jiang, Y.-Z. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102659 · Cited by 4

DGAT1 mediates sex-specific CD8+ T cell antitumour responses

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Fatty acid metabolism shapes immune responses in chronic lymphocytic leukemia

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Reference-guided computational framework identifies microenvironment metabolic subtypes and targets using pan-cancer single-cell datasets

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Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer

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Intratumoral T reg cell ablation elicits NK cell–mediated control of CD8 T cell–resistant tumors

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Photocatalytic Polyamine Depletion for the Treatment of Psoriasis

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Application of single cell methods in immunometabolism and immunotoxicology

Karmaus, P. W. F. (2024) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2024.100488 · Cited by 4

Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis

Brown, E., Nguyen, P. N. U., & Xavier, R. J. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.07.012 · Cited by 5

The immune mechanism of the mTOR/ACC1/CPT1A fatty acid oxidation signaling pathway in Hashimoto’s thyroiditis

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Differential Expression of ARG1 and MRC2 in Retinal Müller Glial Cells During Autoimmune Uveitis

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ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathwayPreprint

Anannya, O., Huang, W., & August, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.01.535229 · Cited by 4

Prevotella copri -related effects of a therapeutic food for malnutritionPreprint

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Plat safeguards maternally aged oocytes against programmed cell death through activating the Erk1/2 pathway

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Using gnotobiotic mice to decipher effects of gut microbiome repair in undernourished children on tuft and goblet cell function

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Altered phenotype and gene expression of regulatory T cells (Tregs) in children with Autism, and the relationship with comorbid gastrointestinal symptoms

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A mitochondrial-stress adipocyte–macrophage circuit sustaining metaflammation in human type 2 diabetic adipose tissue

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Immunometabolic mechanisms of osteosarcopenic obesity: chronic inflammation, trained immunity, and systemic immune dysregulation

Jiang, H., Zhang, Y., Luo, Z., Tang, X., 赫一佑, & Hao, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1808488 · Cited by 5

Metabolic control of pathogenesis in autoimmune diseases

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Itaconate: A Potential Therapeutic Strategy for Autoimmune Disease

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Dynamic metabolic regulation of histone modifications during the yeast metabolic cycle

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The relationship between different interleukins and T helper cells count in patients with immune thrombocytopenia

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Microbial reaction rate estimation using proteins and proteomes

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Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs Urea CyclePreprint

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Metabolism in hematology: Technological advances open new perspectives on disease biology and treatment

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Immune-responsive gene 1: The mitochondrial key to Th17 cell pathogenicity in CNS autoimmunity

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CXCR1 Depletion in Ly6C + cDC2 Alleviates Acute Lung Injury via Modulation of Th17/Treg Balance

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Mitochondrial Activity Regulates Human T Helper 17 Differentiation and Function

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Dysbiosis modulates CD8+ tissue-resident memory cells through a mechanism requiring polyamine metabolism during HIV infection

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Dysfunctional T cells due to the abnormal glucose metabolism in patients with primary immune thrombocytopenia

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HIF-1α in CD4+ T cells drives gout pathogenesis via metabolic reprogramming and Th17 differentiation

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Glycolysis maintains effector function of lung Th17 TRM cells in precision cut lung slices

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Long-term high-protein diet intake accelerates adipocyte senescence through macrophage CD38-mediated NAD+ depletion

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The Role of Metabolites in Cell–Cell Communication: A Review of Databases and Computational Tools

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Metabolic Checkpoints in IgA Nephropathy: From Pathogenesis to Precision Medicine

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Soluble fermentable dietary fiber attenuates age-related cognitive impairment via neuroimmune and antioxidant modulation: evidence from multilevel analyses in populations and aging mouse models

He, Y., Li, J., Cong, L., Li, H., Wu, J., Liang, S., Peng, Y., Zhou, Y., & Wu, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1718673 · Cited by 2

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Xu, W., Wu, R., Liu, Z., Yan, H., Zhang, H., Zheng, Y., & Cai, X. (2026) · Advanced Science · doi:10.1002/advs.202522093 · Cited by 2

ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: A human and experimental study

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Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200+ Egr2hi arthritogenic Th17 cells

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Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer’s pathogenesis

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Metabolic reprogramming of myeloid cells in cancer: from lactate–NAMPT axis to AI-guided therapeutics

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GDF15 suppresses liver inflammation independently of weight loss through neuroendocrine glucocorticoid signaling

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Th17/IL-17, Immunometabolism and Psoriatic Disease: A Pathological Trifecta

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COX5A as a potential biomarker for disease activity and organ damage in lupus

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Edwardsiella tarda induces airways inflammation and production of autoantibodies against lung tissues through regulation of the IL ‐33‐ ST2 axis

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A novel study on CXXC5: unraveling its regulatory mechanisms in hematopoietic stem cell biology through proteomics and gene editing

Liu, S., Gao, Y., Feng, X., Xu, Y., Hu, M., Fei, H., Zheng, H., Huang, J., Li, T., Zhao, C., et al. (2024) · Genes & Genomics · doi:10.1007/s13258-024-01540-8 · Cited by 2

A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells

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Recent developments and future perspectives in aging and macrophage immunometabolism

Pence, B. D. (2021) · AIMS molecular science · doi:10.3934/molsci.2021015 · Cited by 3

A Compass to Guide Insights into TH17 Cellular Metabolism and Autoimmunity

Wilson, A., Mosure, S., & Solt, L. A. (2021) · Immunometabolism · doi:10.20900/immunometab20220001 · Cited by 2

Spermidine Dampens Inflammation by Directly Inhibiting Th17 Cytokine Production through a PRDX1 Associated Antioxidant Pathway

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Immune Digital Twin Blueprint: A Comprehensive Mechanistic Model of the Human Immune SystemPreprint

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scFLUX: a web server for metabolic flux and variation prediction using transcriptomics dataPreprint

Zhang, Z., Chang, W., Alghamdi, N., Fei, M., Wan, C., Lu, A. Z., Zang, Y., Xu, Y., Wu, W., Cao, S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.18.496660 · Cited by 2

MEBOCOST: Metabolite-mediated Cell Communication Modeling by Single Cell TranscriptomePreprint

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PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunityPreprint

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Ketone body β-hydroxybutyrate restores neuronal Tau proteostasis via ketolysis-independent mechanismPreprint

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Multimodal profiling reveals Mycobacterium tuberculosis restricts lung mitochondrial immunometabolism to promote pathogenesisPreprint

Dkhar, H. K., Bajpai, P., Enriquez, A. B., Hopkins, L. B., Dawa, S., Sia, J. K., Paul, A., Madan-Lala, R., Keenum, M. C., Sharma, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.07.717012 · Cited by 2

Plasma polyamines during pregnancy and their relationships with maternal allergies and the immune response of the neonates

Gázquez, A., García‐Serna, A. M., Hernández‐Caselles, T., Martín‐Orozco, E., Cantero‐Cano, E., Prieto‐Sánchez, M. T., Molina‐Ruano, M. D., Castillo‐Lacalle, R., Vioqué, J., Morales, E., et al. (2024) · Pediatric Allergy and Immunology · doi:10.1111/pai.14167 · Cited by 1

Metabolites and metabolic pathway reactions links to sensitization of immunotherapy in pan-cancer

Yu, S., Gao, Y., Zhao, F., Zhou, J., & Zhang, J. (2025) · Molecular Therapy Oncology · doi:10.1016/j.omton.2025.200933 · Cited by 3

Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

Yang, H., Zhang, C., Kim, W., Shi, M., Kılıçlıoğlu, M., Bayram, C., Bolar, I., Tozlu, Ö. Ö., Baba, C., Yuksel, N., et al. (2024) · eLife · doi:10.7554/elife.98427.3 · Cited by 8

S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism

Huang, H., Yang, Y., Zhang, Q., Yang, Y., Xiong, Z., Mao, S., Song, T., Wang, Y., Liu, Z., Bu, H., et al. (2025) · eLife · doi:10.7554/elife.101731.3 · Cited by 1

IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells

Kania, A. K., Sanin, D. E., Gu, X., Gidley, M., Kokosinski, E., Smith, A. D., Pearce, E. L., & Pearce, E. J. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag028 · Cited by 1

Association between 1400 metabolites and IgA nephropathy: A Mendelian randomization analysis

Wang, C., Li, Y., Zhong, L., Sun, N., Luo, D., Xu, Y., & Qi, A. (2025) · Medicine · doi:10.1097/md.0000000000043353 · Cited by 1

Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction

Zhang, Y., Liu, Z., Sun, H., Wang, Z., Chen, Y., Hu, Z., Li, X., Xu, K., Chen, Y., Xu, Y., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1636699 · Cited by 1

Adenosine 2A receptor–dependent activation of AMPK represses T H 17 cell pathogenicity through epigenetic and metabolic reprogramming

Papadopoulou, G., Valakos, D., Polydouri, I., Moulara, A., Vatsellas, G., Angiari, S., Runtsch, M. C., Foretz, M., Viollet, B., Cassotta, A., et al. (2025) · Science Signaling · doi:10.1126/scisignal.adr3177 · Cited by 1

Use of regulatory cells for achieving functional tolerance of pig heart xenotransplants in humans: a literature review

Braileanu, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1648926 · Cited by 1

Metabolic heterogeneity in adipose resident immunocytes and its link to type 2 diabetes via response to catabolism defects

Huang, S., Chen, X., Yuan, Y., Yuan, Y., Shen, L., Wang, H., Tang, W., Bi, Y., & Wu, T. (2025) · Genomics · doi:10.1016/j.ygeno.2025.111152 · Cited by 1

Multi-omics and perturbation screens as discovery tools in immunometabolism

Chapman, N. M., & Chi, H. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003570 · Cited by 1

Metabolic adaptation in CD4+ T cells promotes immunosuppression in sepsis

Chapman, N. M., & Chi, H. (2026) · Nature Immunology · doi:10.1038/s41590-025-02403-4 · Cited by 1

Using animal models to decipher the role of polyamines in the pancreas and β Cell

Puente, A. A., Kinderlerer, L., Castillo, L., Mirmira, R. G., & Tersey, S. A. (2026) · Amino Acids · doi:10.1007/s00726-026-03504-6 · Cited by 1

Multiomics analysis of polyamine metabolism in colorectal cancer, highlighting the key role of extracellular putrescine in impairing CXCR6 + CD8 + T cell anti-tumor activity

Tan, Z., Zhang, Y., jia, C. P., Lian, H., & Wang, B. (2026) · PeerJ · doi:10.7717/peerj.20663 · Cited by 1

Distinct Malignant Cell States and Myeloid Glutamate Signaling Associated with Aggressive Pancreatic Neuroendocrine Tumors

Qiu, J. M., Cho, J. W., Nguyen, P. T., Lester, N. A., Su, J., Guo, J. A., Hoffman, H. I., Shiau, C., Caldwell, N. J., Muratani, S., et al. (2026) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-2565 · Cited by 1

The role of macrophage metabolic reprogramming in efferocytosis: A dual-edged sword in atherosclerosis and tumor progression

Chen, Q., Liu, C., Wang, Q., Zhang, X., Zheng, Y., Guo, M., & Wang, J. (2026) · Molecular Immunology · doi:10.1016/j.molimm.2026.04.006 · Cited by 1

Cold Stress Activates ACSL1 + Macrophages in a Fatty Acid‐Dependent Manner to Exacerbate Psoriasis

Shuai, C., Ge, Q., Zhang, L. K., Cao, H., Chen, H., Cheung, S., Wang, Y., Chen, L., Yuan, Y. Z., Li, X., et al. (2026) · Experimental Dermatology · doi:10.1111/exd.70280 · Cited by 1

Fueling bone loss: the immunometabolic reprogramming of the bone microenvironment in diabetic osteoporosis

Wang, Y., Han, J., Wang, Z., ZHANG, G., Niu, R., Wei, Y. L., Yi, K., & Quan, J. X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1850044 · Cited by 1

Gut microbiota and gut-derived metabolites in defining multiple sclerosis phenotypic continuum

Montini, F., Mangalam, A. K., Zeydan, B., Murray, J., & Kantarci, O. H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1858047 · Cited by 1

Analytical Methods and Application of Single-Cell and Single-Nucleus Transcriptomics in the Study of Ischemic Stroke

Mu, C., Ding, Y., Weiss, A., Rosenfeld, S., Li, F., & Geng, X. (2026) · Biomolecules · doi:10.3390/biom16071054 · Cited by 1

Spatial transcriptomics supports a role for SOX4-driven signaling throughout the disease course of biliary atresia

Ziogas, I. A., Conover, K. R., Dobrinskikh, E., Al‐Juboori, S. I., Gromer, K. D., Malladi, P., Wright, C. J., Sokol, R. J., Andrews, T. S., & Taylor, S. A. (2026) · Hepatology Communications · doi:10.1097/hc9.0000000000000992 · Cited by 2

Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases

Chen, Y., Shi, Y., & You, J. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02910-2 · Cited by 1

T cell-derived CCL5 drives macrophage immunometabolic remodeling in chronic prostatitis via the CCR5-ERK-PKM2/HIF-1α axis

Liu, X., Li, B., Dou, X., Ju, W., Liu, W., Zhang, F., Jin, C., Lu, Y., Wang, R., Chen, X., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104366 · Cited by 1

Polyamine Pathway Inhibitor DENSPM Suppresses Lipid Metabolism in Pheochromocytoma Cell Line

Ghayee, H. K., Costa, K. A., Xu, Y., Hatch, H. M., Rodriguez, M., Straight, S. C., Bustamante, M., Fang, Y., Smagulova, F. O., Bowden, J. A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810029 · Cited by 1

VI-VS: calibrated identification of feature dependencies in single-cell multiomics

Boyeau, P., Bates, S., Ergen, C., Jordan, M. I., & Yosef, N. (2024) · Genome biology · doi:10.1186/s13059-024-03419-z · Cited by 1

In Silico Metabolic Modeling of Single Th17 Cells Reveals Regulators of Autoimmunity

Wagner, A. (2021) · eScholarship (California Digital Library)

Cell-specific metabolic models reveal novel metabolic regulators of Th17 pathogenicity: from single-cell RNA-Seq to actionable metabolic targets

Wagner, A., Wang, C., DeTomaso, D., Koul, A., Regev, A., Kuchroo, V. K., & Yosef, N. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.200.supp.163.21

In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity

Wagner, A., Wang, C., DeTomaso, D., Ávila-Pacheco, J., Zaghouani, S., Fessler, J., Akama‐Garren, E. H., Pierce, K. A., Ron‐Harel, N., Haigis, M. C., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.204.supp.150.22 · Cited by 4

Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine PathwayPreprint

Wang, C., Wagner, A., Fessler, J., Ávila-Pacheco, J., Karminski, J., Thakore, P. I., Zaghouani, S., Pierce, K. A., Bod, L., Schnell, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.23.911966 · Cited by 6

A Compass to Guide Insights into TH17 Cellular Metabolism and Autoimmunity

Wilson, A., Mosure, S., & Solt, L. A. (2021) · Immunometabolism · doi:10.20900/immunometab20220001 · Cited by 2