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Cited by 42Viral Infections and VectorsViral Infections and Outbreaks ResearchVirology and Viral Diseases

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Primate hemorrhagic fever-causing arteriviruses are poised for spillover to humans

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Warren, Cody J., Yu, Shuiqing, Peters, Douglas K., Barbachano-Guerrero, Arturo, Yang, Qing, Burris, Bridget L., Worwa, Gabriella, Huang, I-Chueh, Wilkerson, Gregory K., Goldberg, Tony L., Kuhn, Jens H., Sawyer, Sara L.·2022·Cell
DOI 10.1016/j.cell.2022.09.022PMC PMC9588614
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Abstract

Simian arteriviruses are endemic in some African primates and can cause fatal hemorrhagic fevers when they cross into primate hosts of new species. We find that CD163 acts as an intracellular receptor for simian hemorrhagic fever virus (SHFV; a simian arterivirus), a rare mode of virus entry that is shared with other hemorrhagic fever-causing viruses (e.g., Ebola and Lassa viruses). Further, SHFV enters and replicates in human monocytes, indicating full functionality of all of the human cellular proteins required for viral replication. Thus, simian arteriviruses in nature may not require major adaptations to the human host. Given that at least three distinct simian arteriviruses have caused fatal infections in captive macaques after host-switching, and that humans are immunologically naive to this family of viruses, development of serology tests for human surveillance should be a priority.

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  • The high likelihood that newly identified pandemic-class agents will be publicly described, including novel versions devised by future LLMs, underscores the importance of verifying that screening is conducted against an up-to-date database.

    “The high likelihood that newly identified pandemic-class agents will be publicly described 4,5,26,27 , including novel versions devised by future LLMs, underscore the importance of verifying that screening is conducted against an up-to-date database.”

    From Human innovation and the creative agency of the world in the age of generative AI (2024) · cites this paper as [27]

    The Introduction (page unavailable) describes recent discoveries of diverse simian arteriviruses, and the Discussion (page unavailable) identifies them as a potential emerging threat. This published paper provides an example of a potentially dangerous agent being publicly described, but it does not establish a high likelihood that newly identified pandemic-class agents generally will be publicly described. The citation precedes the sentence’s separate points about future LLMs and screening databases. (LLM, conf=0.78)

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Metadata

Authors
Warren, C. J., Yu, S., Peters, D. K., Barbachano-Guerrero, A., Yang, Q., Burris, B. L., Worwa, G., Huang, I.-C., Wilkerson, G. K., Goldberg, T. L., Kuhn, J. H., & Sawyer, S. L.
Affiliations
  • University of Colorado Boulder (US)
  • The University of Texas MD Anderson Cancer Center (US)
  • National Institute of Allergy and Infectious Diseases (US)
  • University of Wisconsin–Madison (US)
  • National Institutes of Health (US)
Corresponding author
  • Kuhn, Jens H.
  • Sawyer, Sara L.
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
2022-10
Volume
185
Issue
21
Pages
3980-3991.e18
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2022.09.022
PMC
PMC9588614
OpenAlex
W4298150007
Cited by
42
References
5
Citations by year
2026: 6 · 2025: 9 · 2024: 11 · 2023: 14 · 2022: 2
FWCI
4.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Standards and Technology (70NANB15H226)
  • Burroughs Wellcome Fund (SCR_018302)
  • National Institutes of Health (DP1-DA-046108, F32-GM-125442, K99-AI151256-01A1, R01-AI-137011, R01AI151636, S10ODO21601)
  • U.S. Department of Health and Human Services
  • National Institute of Allergy and Infectious Diseases (HHSN272201800013C)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
simian hemorrhagic fever virus, CD163, intracellular receptors, host switching, spillover to humans, human monocytes, viral replication, Ebola virus, Lassa virus, serological surveillance, macaque
MeSH terms
Viral Zoonoses, Animals, Hemorrhagic Fevers, Viral, Humans, Macaca, Primates, Virus Replication, Arterivirus, Virus Internalization

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