The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
What is cancer metabolism?
Open accessAbstract
The uptake and metabolism of nutrients supports fundamental cellular process from bioenergetics to biomass production and cell fate regulation. Initial studies on metabolic networks in animal tissues revealed major differences in how tumors and normal tissue engaged central metabolic pathways. The discovery that oncogenes and tumor suppressors directly regulate cellular metabolic networks cemented the narrative that cancer metabolism is inherently different from metabolism in normal cells. Nevertheless, studies in cancer metabolism have revealed fundamental principles of mammalian cell metabolism, including the architecture and regulation of major metabolic networks and the intersection between metabolic pathways and cell fate control. As the field of cancer metabolism expands to include the stromal cells of tumors and even normal, differentiated tissue, it is increasingly clear that the principles of metabolism elucidated in cancer cells are relevant to a wide range of mammalian cells and that metabolic pathways can be rerouted to meet the demands of cells in particular lineages or states of development. The goal of this review is to provide an overview of how the field of cancer metabolism has provided a framework for revealing basic principles of cell metabolism and for dissecting the metabolic networks that allow cells to meet their specific demands. Understanding context-specific metabolic preferences and liabilities will enable continued development of approaches to specifically target cancer cells to help improve patient care.
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Cites
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Cited by
Metabolic remodeling in cancer and senescence and its therapeutic implications
Kim, Y., Jang, Y., Kim, M.-S., & Kang, C. (2024) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2024.02.008 · Cited by 36
Sun, J., Wang, J.-M., Zhang, Q., Lin, W.-Y., Tang, L., Lu, S.-Y., Li, B.-Q., Du, Z.-X., & Wang, H.-Q. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03561-x · Cited by 5
Metadata
- Authors
- Finley, L. W. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2023-04
- Volume
- 186
- Issue
- 8
- Pages
- 1670-1688
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4322626977
- Cited by
- 322
- References
- 163
- FWCI
- 31.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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