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Metabolic remodeling in cancer and senescence and its therapeutic implications

Kim, Yeonju, Jang, Yeji, Kim, Mi-Sung, Kang, Chanhee·2024·Trends in Endocrinology & Metabolism
DOI 10.1016/j.tem.2024.02.008
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Abstract

Cellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging. Recent advances in cancer metabolism represent a tremendous opportunity to treat cancer by targeting its altered metabolism. Interestingly, despite their stable growth arrest, senescent cells - a critical component of the aging process - undergo metabolic changes similar to cancer metabolism. A deeper understanding of the similarities and differences between these disparate pathological conditions will help identify which metabolic reprogramming is most relevant to the therapeutic liabilities of senescence. Here, we compare and contrast cancer and senescence metabolism and discuss how metabolic therapies can be established as a new modality of senotherapy for healthy aging.

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  • The future of senotherapy may lie in precision reprogramming through the synergistic modulation of immunity, protein degradation, and metabolism.

    “As discussed, the future of senotherapy may lie in precision reprogramming through the synergistic modulation of immunity, protein degradation, and metabolism141,142.”

    From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [141]

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Metadata

Authors
Kim, Y., Jang, Y., Kim, M.-S., & Kang, C.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2024-08
Volume
35
Issue
8
Pages
732-744
ISSN
1043-2760
DOI
10.1016/j.tem.2024.02.008
Cited by
36
References
34
Language
en
Licence
Funders
  • National Research Foundation of Korea (NRF-2020R1A5A1018081, RS-2023-00246366, RS-2023-00275353, NRF-2022R1A2C3011850)
  • Samsung Science & Technology Foundation (SSTF-BA2201 -09)

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