Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network

Redelman, Doug; Welniak, Lisbeth A.; Taub, Dennis; Murphy, William J.

doi:10.1016/j.cellimm.2007.12.003

Cited by 71Cytokine Signaling Pathways and InteractionsGrowth Hormone and Insulin-like Growth FactorsT-cell and B-cell Immunology

Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network

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Redelman, Doug, Welniak, Lisbeth A., Taub, Dennis, Murphy, William J.·2008·Cellular Immunology

DOI 10.1016/j.cellimm.2007.12.003PMC PMC4777337

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Abstract

Neuroendocrine hormones such as growth hormone (GH) and prolactin (PRL) have been demonstrated to accelerate the recovery of the immune response after chemotherapy and bone marrow transplantation and to enhance the restoration of immunity in individuals infected with HIV and in normal individuals with compromised immune systems associated with aging. As the mechanism of action of these hormones has been elucidated, it has become clear that they are integral members of the immunological cytokine/chemokine network and share regulatory mechanisms with a wide variety of cytokines and chemokines. The members of this cytokine network induce and can be regulated by members of the suppressor of cytokine signaling (SOCS) family of intracellular proteins. In order to take advantage of the potential beneficial effects of hormones such as GH or PRL, it is essential to take into consideration the overall cytokine network and the regulatory effects of SOCS proteins.

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Treatment with drugs that stimulate growth hormone secretion or treatment with growth hormone can have positive effects in restoring aspects of the aged immune system.
“Treatment with drugs that stimulate growth hormone secretion or treatment with growth hormone can have positive effects in restoring aspects of the aged immune system [117].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [117]
Growth hormone accelerates recovery of the immune system following transplantation of various cell types, and it replenished the severely affected T-cell compartment in patients with HIV.
“Growth hormone accelerates recovery of the immune system following transplantation of various cell types, and it replenished the severely affected T-cell compartment in patients with HIV [117].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [117]
Immune cells carry the growth hormone receptor, and growth hormone signaling involves JAK2-STAT-Ras-MAPK pathways that are shared by cytokine signaling pathways.
“Immune cells carry the growth hormone receptor, and growth hormone signaling involves JAK2-STAT-Ras-MAPK pathways that are shared by cytokine signaling pathways (summarized in [117]).”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [117]

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SOCS-3 Induces Myoblast Differentiation
Spangenburg, E. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410604200 · Cited by 51 · see citing works
Changes in body composition of human immunodeficiency virus-infected males receiving insulin-like growth factor I and growth hormone
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Functional Insulin-Like Growth Factor-1/Insulin-Like Growth Factor-1 Receptor-Mediated Circuit in Human and Murine Thymic Epithelial Cells
Coelho, V. D. M., Villa‐Verde, D. M. S., Farias-de-Oliveira, D. A., Brito, J. M., Dardenne, M., & Savino, W. (2002) · Neuroendocrinology · doi:10.1159/000048230 · Cited by 48 · see citing works
Loss of the CD56hiCD16− NK cell subset and NK cell interferon-γproduction during antiretroviral therapy for HIV-1: partial recovery by human growth hormone
Goodier, M. R., Imami, N., Moyle, G. J., Gazzard, B., & Gotch, F. (2003) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2003.02329.x · Cited by 48 · see citing works
Cellular localization of growth hormone receptors/binding proteins in immune tissues
Hull, K., Thiagarajah, A. S., & Harvey, S. (1996) · Cell and Tissue Research · doi:10.1007/s004410050676 · Cited by 41 · see citing works
Growth Hormone Receptors and Immunocompetent Cellsa
Dardenne, M., Coelho, V. D. M., Gagnerault, M., & Postel-Vinay, M. C. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09589.x · Cited by 34 · see citing works
The Inhibition of Apoptosis in EL4 Lymphoma Cells Overexpressing Growth Hormone
Arnold, R. E., & Weigent, D. A. (2004) · NeuroImmunoModulation · doi:10.1159/000076764 · Cited by 33 · see citing works
Growth Hormone Prevents Fas-Induced Apoptosis in Lymphocytes through Modulation of Bcl-2 and Caspase-3
Mitsunaka, H., Dobashi, H., Sato, M., Tanaka, T., Kitanaka, A., Yamaoka, G., Tokuda, M., Matoba, K., Hiraishi, T., & Ishida, T. (2001) · NeuroImmunoModulation · doi:10.1159/000054288 · Cited by 32 · see citing works
Use of Neuroendocrine Hormones to Promote Reconstitution after Bone Marrow Transplantation
Woody, M. A., Welniak, L. A., Richards, S. M., Taub, D. D., Tian, Z., Sun, R., Longo, D. L., & Murphy, W. J. (1999) · NeuroImmunoModulation · doi:10.1159/000026366 · Cited by 30 · see citing works
Self-citation
Growth hormone restores glucocorticoid‐induced T cell suppression
Dobashi, H., Sato, M., Tanaka, T., Tokuda, M., & Ishida, T. (2001) · The FASEB Journal · doi:10.1096/fj.00-0702fje · Cited by 29 · see citing works
Suppressor of Cytokine Signaling-2 Deficiency Induces Molecular and Metabolic Changes that Partially Overlap with Growth Hormone-Dependent Effects
Rico-Bautista, E., Greenhalgh, C. J., Tollet‐Egnell, P., Hilton, D. J., Alexander, W. S., Norstedt, G., & Flores‐Morales, A. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0040 · Cited by 29 · see citing works
Enhanced T-Cell Maturation, Differentiation and Function in HIV-1-Infected Individuals after Growth Hormone and Highly Active Antiretroviral Therapy
Pires, A., Pido-Lopez, J., Moyle, G. J., Gazzard, B., Gotch, F. M., & Imami, N. (2004) · Antiviral Therapy · doi:10.1177/135965350400900110 · Cited by 29 · see citing works
SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade
Pello, Ó. M., Moreno-Ortíz, M. D. C., Rodrı́guez-Frade, J. M., Martínez‐Muñoz, L., Lucas, D., Gómez, L., Lucas, P., Samper, E., Aracil, M., Martínez‐A, C., et al. (2006) · Blood · doi:10.1182/blood-2006-02-006353 · Cited by 28 · see citing works
The indirect participation of growth hormone in the thymocyte proliferation system.
Yamada, M., Hato, F., Kinoshita, Y., Tominaga, K., & Tsuji, Y. (1994) · PubMed · Cited by 28 · see citing works
Growth hormone protects human lymphocytes from irradiation‐induced cell death
Lempereur, L., Brambilla, D., Scoto, G. M., D'Alcamo, M., Goffin, V., Crosta, L., Palmucci, T., Rampello, L., Bernardini, R., & Cantarella, G. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705173 · Cited by 27 · see citing works
Immune Function in Transgenic Mice Overexpressing Growth Hormone (GH) Releasing Hormone, GH or GH Antagonist
Dialynas, E., Brown‐Borg, H. M., & Bartke, A. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-73.x · Cited by 27 · see citing works
Long‐Term Risk of Gastrointestinal Tumor Recurrence After Postoperative Treatment with Recombinant Human Growth Hormone
Tacke, J., Bolder, U., Herrmann, A., Berger, G., & Jauch, K. (2000) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607100024003140 · Cited by 22 · see citing works
CXCR4-mediated Suppressor of Cytokine Signaling Up-regulation Inactivates Growth Hormone Function
Garzón, R., Soriano, S. F., Rodrı́guez-Frade, J. M., Gómez, L., de Ana, A. M., Sánchez-Gómez, M., Martínez‐A, C., & Mellado, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408010200 · Cited by 21 · see citing works
SOCS-3 is Involved in the Downregulation of the Acute Insulin-Like Effects of Growth Hormone in Rat Adipocytes by Inhibition of Jak2/IRS-1 Signaling
Ridderstråle, M., Amstrup, J., Hilton, D. J., Billestrup, N., & Tornqvist, H. E. (2003) · Hormone and Metabolic Research · doi:10.1055/s-2003-39077 · Cited by 17 · see citing works
Growth hormone receptor and regulation of gene expression in fetal lymphoid cells
Chen, H.-T. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)00230-x · Cited by 17 · see citing works
Use of physiological doses of human growth hormone in haematological patients receiving intensive chemotherapy promotes haematopoietic recovery: a double-blind randomized, placebo-controlled study
Sirohi, B., Powles, R., Morgan, G. J., Treleaven, J., Kulkarni, S., Horton, C., Saso, R. M., Rolfe, D., Cook, G., Shaw, C., et al. (2006) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705545 · Cited by 17 · see citing works
The in vitro proliferation of thymus epithelial cells stimulated with growth hormone and insulin-like growth factor-I.
Tsuji, Y., Kinoshita, Y., Hato, F., Tominaga, K., & Yoshida, K. (1994) · PubMed · Cited by 17 · see citing works
Growth hormone and a partial mediator of its biological action, insulin-like growth factor I.
Pankov, Y. A. (1999) · PubMed · Cited by 15 · see citing works
[Regulation of cytokine and toll-like receptor signaling by SOCS family genes].
Takagi, H., Sanada, T., Minoda, Y., & Yoshimura, A. (2004) · PubMed · Cited by 14 · see citing works
GROWTH HORMONE RECEPTOR GENE EXPRESSION ON HUMAN LYMPHOCYTIC AND MONOCYTIC CELL LINES
Dérfalvi, B., Szalai, C., Mándi, Y., Király, A., & Falus, A. (1998) · Cell Biology International · doi:10.1006/cbir.1998.0324 · Cited by 11 · see citing works
Immune Function in Transgenic Mice Overexpressing Growth Hormone (GH) Releasing Hormone, GH or GH Antagonist
Dialynas, E., Brown‐Borg, H. M., & Bartke, A. (1999) · Experimental Biology and Medicine · doi:10.3181/00379727-221-44401 · Cited by 11 · see citing works
Growth hormone in inflammatory bowel disease.
Pascalis, B. D., Bianchi, A., Satta, M. A., Lupascu, A., Mentella, M. C., Leo, D., Fiore, F., Fedeli, P., Pontecorvi, A., Pola, P., et al. (2006) · PubMed · Cited by 9 · see citing works
Treatment IND for Advanced Pancreatic Cancer Authorized
Nightingale, S. L. (1995) · JAMA · doi:10.1001/jama.1995.03520370020010 · Cited by 6 · see citing works

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The immune system and developmental programming of brain and behavior
Bilbo, S. D., & Schwarz, J. M. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.08.006 · Cited by 579 · see citing works
The effects of ghrelin on inflammation and the immune system.
Baatar, D., Patel, K., & Taub, D. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.04.019 · Cited by 260 · see citing works
Self-citation
Peptide Hormone Regulation of Angiogenesis
Clapp, C., Thébault, S. C., Jeziorski, M. C., & de la Escalera, G. M. (2009) · Physiological Reviews · doi:10.1152/physrev.00024.2009 · Cited by 190 · see citing works
Thymus: the next (re)generation
Chaudhry, M. S., Velardi, E., Dudakov, J. A., & van den Brink, M. R. M. (2016) · Immunological Reviews · doi:10.1111/imr.12418 · Cited by 182 · see citing works
Perspectives on the endocrinology of poultry growth and metabolism
Scanes, C. G. (2009) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2009.04.013 · Cited by 152 · see citing works
Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies
Jarvis, J. P., Scheinfeldt, L. B., Soi, S., Lambert, C., Omberg, L., Ferwerda, B., Froment, A., Bodo, J.-M., Beggs, W., Hoffman, G., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002641 · Cited by 139 · see citing works
Infection, immunity and the neuroendocrine response
Borghetti, P., Saleri, R., Mocchegiani, E., Corradi, A., & Martelli, P. R. (2009) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2009.01.013 · Cited by 128 · see citing works
Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways
Taub, D. D., Murphy, W. J., & Longo, D. L. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.04.015 · Cited by 119 · see citing works
Self-citation
Neuroendocrine interactions in the immune system
Taub, D. D. (2008) · Cellular Immunology · doi:10.1016/j.cellimm.2008.05.006 · Cited by 113 · see citing works
Self-citation
Prolactin and Autoimmunity
Jara, L. J., Medina, G., Saavedra, M. Á., Lastra, O. L. V., & Navarro, C. (2009) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-009-8185-3 · Cited by 96 · see citing works
Chapter 7 Neuroendocrine–Immune Interactions in Teleost Fish
Kemenade, B. M. L. V.-V., Stolte, E. H., Metz, J. R., & Chadzińska, M. (2009) · Fish physiology · doi:10.1016/s1546-5098(09)28007-1 · Cited by 128 · see citing works
Neurotransmitters as Regulators of Tumor Angiogenesis and Immunity: The Role of Catecholamines
Sarkar, C., Chakroborty, D., & Basu, S. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9395-7 · Cited by 82 · see citing works
Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients
Wang, R., Ross, C. A., Cai, H., Cong, W., Daimon, C. M., Carlson, O. D., Egan, J. M., Siddiqui, S., Maudsley, S. R., & Martin, B. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00231 · Cited by 75 · see citing works
Neuroendocrine-immune interactions in teleost fish
Kemenade, B. M. L. V.-V., Stolte, E. H., Metz, J. R., & Chadzińska, M. (2009) · Cited by 74 · see citing works
Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease
Pérez, A. R., Silva-Barbosa, S. D., Berbert, L. R., Revelli, S. S., Beloscar, J., Savino, W., & Bottasso, O. A. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.03.010 · Cited by 68 · see citing works
Glass particles as an adjuvant: A model for adverse immunogenicity of therapeutic proteins
Fradkin, A. H., Carpenter, J. F., & Randolph, T. W. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22683 · Cited by 64 · see citing works
Prolactin in Inflammatory Response
Pereira-Suárez, A. L., López-Rincón, G., Neri, P. A. M., & Estrada‐Chávez, C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-12114-7_11 · Cited by 58 · see citing works
Preliminary Evidence of Increased Pain and Elevated Cytokines in Fibromyalgia Patients with Defective Growth Hormone Response to Exercise
Ross, R. L., Jones, K., Bennett, R., Ward, R. L., Druker, B., & Wood, L. (2010) · Open Immunology Journal · doi:10.2174/1874226201003010009 · Cited by 58 · see citing works
Potential Roles of Peripheral Dopamine in Tumor Immunity
Zhang, X., Liu, Q., Liao, Q., & Zhao, Y. (2017) · Journal of Cancer · doi:10.7150/jca.20850 · Cited by 56 · see citing works
Elevated prolactin levels in patients with rheumatoid arthritis: association with disease activity and structural damage.
Fojtíková, M., Studýnková, J. T., Filková, M., Lacinová, Z., Gatterová, J., Pavelká, K., Vencovský, J., & Šenolt, L. (2010) · PubMed · Cited by 55 · see citing works
Impact of Growth Hormone (GH) Deficiency and GH Replacement upon Thymus Function in Adult Patients
Morrhaye, G., Kermani, H., Legros, J., Baron, F., Beguin, Y. P., Moutschen, M. P., Cheynier, R., Martens, H., & Geenen, V. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005668 · Cited by 51 · see citing works
Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type 1 diabetes mellitus
Sickle, B. J. V., Simmons, J. H., Hall, R. T., Raines, M., Ness, K., & Spagnoli, A. (2009) · Cytokine · doi:10.1016/j.cyto.2009.08.011 · Cited by 48 · see citing works
Acute Thymic Involution and Mechanisms for Recovery
Ansari, A. R., & Liu, H. (2017) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-017-0462-x · Cited by 48 · see citing works
Changes in endocrine and immune responses of neonatal pigs exposed to a psychosocial stressor
Tuchscherer, M., Kanitz, E., Puppe, B., Tuchscherer, A., & Viergutz, T. (2009) · Research in Veterinary Science · doi:10.1016/j.rvsc.2009.04.010 · Cited by 49 · see citing works
Neurotransmitters: promising immune modulators in the tumor microenvironment
Xiao, L., Li, X., Fang, C., Yu, J., & Chen, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1118637 · Cited by 46 · see citing works
Identification of Ghrelin Receptor Blocker, D-[Lys3] GHRP-6 as a CXCR4 Receptor Antagonist
Patel, K. G., Dixit, V. D., Lee, J. H., Kim, J. W., Schaffer, E. M., Nguyen, D., & Taub, D. D. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.8.108 · Cited by 40 · see citing works
Self-citation
The effects of growth hormone on therapy resistance in cancer
Basu, R., & Kopchick, J. J. (2019) · Cancer Drug Resistance · doi:10.20517/cdr.2019.27 · Cited by 40 · see citing works
Hormonal Changes in Response to Extreme Environment Factors
Кубасов, Р. В. (2014) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn.v69i9-10.1138 · Cited by 36 · see citing works
Immunoregulation of autocrine prolactin: Suppressing the expression of costimulatory molecules and cytokines in T lymphocytes by prolactin receptor knockdown
Xu, D., Lin, L., Lin, X., Huang, Z., & Lei, Z. M. (2010) · Cellular Immunology · doi:10.1016/j.cellimm.2010.02.018 · Cited by 35 · see citing works
Detection of Growth Hormone Doping by Gene Expression Profiling of Peripheral Blood
Mitchell, C. J., Nelson, A. E., Cowley, M. J., Kaplan, W. H., Stone, G., Sutton, S. K., Lau, A., Lee, C. M. Y., & Ho, K. K. Y. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1038 · Cited by 33 · see citing works
Prolactin Is Not Required for the Development of Severe Chronic Experimental Autoimmune Encephalomyelitis
Costanza, M., Musio, S., Abou-Hamdan, M., Binart, N., & Pedotti, R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301128 · Cited by 33 · see citing works
Improvement of leucocyte functions in ovariectomised aged rats after treatment with growth hormone, melatonin, oestrogens or phyto-oestrogens
Baeza, I., Alvarado, C., Álvarez, P., Salazar, V., Castillo, C., Ariznavarreta, C., Fdez-Tresguerres, J., & la Fuente, M. D. (2009) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2009.02.002 · Cited by 33 · see citing works
The potential roles of dopamine in malignant glioma
Lan, Y., Wang, X., Xing, J., Lou, J., Ma, X., & Zhang, B. (2016) · Acta Neurologica Belgica · doi:10.1007/s13760-016-0730-2 · Cited by 28 · see citing works
Expression of the Growth Hormone/Insulin-Like Growth Factor Axis during Balb/c Thymus Ontogeny and Effects of Growth Hormone upon ex vivo T Cell Differentiation
Kermani, H., Goffinet, L., Mottet, M., Bodart, G., Morrhaye, G., Dardenne, O., Renard, C., Overbergh, L., Baron, F., Beguin, Y., et al. (2012) · Neuroimmunomodulation · doi:10.1159/000328844 · Cited by 27 · see citing works
Performance-enhancing sports supplements: Role in critical care
Weitzel, L., Sandoval, P., Mayles, W., & Wischmeyer, P. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b6f2e6 · Cited by 30 · see citing works
Combined treatment with GH, insulin, and indomethacin alleviates cancer cachexia in a mouse model
Chen, S., & Qiu, Z. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0341 · Cited by 22 · see citing works
Dual Characters of GH-IGF1 Signaling Pathways in Radiotherapy and Post-radiotherapy Repair of Cancers
Cheng, Y., Li, W., Gui, R., Wang, C., Song, J., Wang, Z., Wang, X., Shen, Y., Wang, Z., & Hao, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.671247 · Cited by 22 · see citing works
Repurposing prolactin as a promising immunomodulator for the treatment of COVID-19: Are common Antiemetics the wonder drug to fight coronavirus?
Sen, A. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110208 · Cited by 21 · see citing works
Effect of the p38 MAPK inhibitor SB-239063 on Lipopolysaccharide-induced psychomotor retardation and peripheral biomarker alterations in rats
Bison, S., Razzoli, M., Arban, R., Michielin, F., Bertani, S., & Carboni, L. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.04.020 · Cited by 18 · see citing works
Growth Hormone Releasing Hormone Reduces Circulating Markers of Immune Activation in Parallel with Effects on Hepatic Immune Pathways in Individuals with HIV-infection and Nonalcoholic Fatty Liver Disease
Stanley, T. L., Fourman, L. T., Wong, L. P., Sadreyev, R. I., Billingsley, J. M., Feldpausch, M. N., Zheng, I., Pan, C. S., Boutin, A., Lee, H., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab019 · Cited by 16 · see citing works
Detection of obestatin in seminal plasma and its relationship with ghrelin and semen parameters
Moretti, E., Collodel, G., Iacoponi, F., Geminiani, M., Pascarelli, N. A., Campagna, M. S., Franci, B., & Figura, N. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.03.027 · Cited by 14 · see citing works
Growth hormones therapy in immune response against Trypanosoma cruzi
Frare, E. O., Santello, F. H., Caetano, L. C., Caldeira, J. C., Toldo, M. P. A., & Júnior, J. C. D. P. (2009) · Research in Veterinary Science · doi:10.1016/j.rvsc.2009.10.001 · Cited by 13 · see citing works
Role of neuropeptides, hormones, and growth factors in regulating thymopoiesis in middle to old age
Patel, K. G., & Taub, D. D. (2009) · F1000 Biology Reports · doi:10.3410/b1-42 · Cited by 8 · see citing works
Self-citation
Influence of Helicobacter pylori Infection on Levels of Ghrelin and Obestatin in Human Semen
Moretti, E., Collodel, G., Campagna, M. S., Franci, M. B., Iacoponi, F., Mazzi, L., & Figura, N. (2012) · Journal of Andrology · doi:10.2164/jandrol.111.015446 · Cited by 8 · see citing works
Role of the Somatotropic Axis in Mammalian Aging
Brown‐Borg, H. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00002-6 · Cited by 7 · see citing works
Influence of feeding Tinospora cordifolia peripartum on lactation parameters in crossbred cows
Mallick, S., & Prakash, B. S. (2011) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2011.01228.x · Cited by 6 · see citing works
Regulation of intestinal morphology and GALT by pituitary hormones in the rat
Cárdenas‐Jaramillo, L. M., Quintanar‐Stephano, A., Luna, R. A. J., Rivera‐Aguilar, V., Oliver‐Aguillón, G., Campos‐Rodríguez, R., Kovács, K., & Berczi, I. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06648.x · Cited by 5 · see citing works
Impact of the Somatotrope Growth Hormone (GH)/Insulin-Like Growth Factor 1 (IGF-1) Axis Upon Thymus Function: Pharmacological Implications in Regeneration of Immune Functions
Goffinet, L., Mottet, M., Kermani, H., Renard-Charlet, C., Geenen, V. G., & Martens, H. (2011) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152211794519421 · Cited by 3 · see citing works
Macrophage Colony-Stimulating Factor Induces Prolactin Expression in Rat Pituitary Gland
Hoshino, S., Kurotani, R., Miyano, Y., Sakahara, S., Koike, K., Maruyama, M., Ishikawa, F., Sakatai, I., Abé, H., & Sakai, T. (2014) · ZOOLOGICAL SCIENCE · doi:10.2108/zs130226 · Cited by 3 · see citing works
Arginine Vasopressin: An Immunoregulatory Hormone
Quintanar‐Stephano, A., Organista‐Esparza, A., Chavira‐Ramírez, R., Campos‐Rodríguez, R., Berczi, I., & Kovács, K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801770-8.00005-7 · Cited by 3 · see citing works
New Aspects of Immunoregulation by Growth and Lactogenic Hormones
Berczi, I., Quintanar‐Stephano, A., Campos, R., & Kovács, K. (2014) · Advances in Neuroimmune Biology · doi:10.3233/nib-140086 · Cited by 2 · see citing works
Thymic gland aspects in childhood: morpho-functional reciprocal relationships betwen thymus, nervous and endocrine system, in particular, with the somatotrophic axis hormones
Миняйлова, Н. Н., Rovda, Y. I., Владимировна, В. А., Shabaldin, A. V., Зинчук, С. Ф., Валерьевна, Ш. О., Golomidov, A. V., Андреевна, Л. А., & Sokharev, V. V. (2023) · Medical Immunology (Russia) · doi:10.15789/1563-0625-tga-2500 · Cited by 2 · see citing works
Myasthenia Gravis Mimicking Third Cranial Nerve Palsy: A Case Report.
Khan, S. A., Shafiq, W., Siddiqi, A. I., Azmat, U., & Ahmad, W. (2021) · PubMed Central · doi:10.37029/jcas.v7i1.391 · Cited by 2 · see citing works
Strategies for Thymic Regeneration: Recent Advances Towards Clinical Therapy
Barsanti, M., Hun, M. L., Boyd, R. L., & Chidgey, A. P. (2016) · Springer eBooks · doi:10.1007/978-4-431-56027-2_3 · Cited by 2 · see citing works
Pathogenesis and Neuroendocrine Immunology
Straub, R. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-803321-0.00002-1 · Cited by 1 · see citing works
Tissue-Engineered Thymus
Kulkarni, G., & Jackson, J. D. (2021) · Reference series in biomedical engineering · doi:10.1007/978-3-030-44211-8_11 · Cited by 1 · see citing works
Introduction: Advances in Neuroimmune Biology: A Comprehensive way to Look at Biology
Berczi, I., & Katafuchi, T. (2011) · Advances in Neuroimmune Biology · doi:10.3233/nib-2011-001
Comunicación bidireccional entre el sistema inmune y neuroendocrino a través de la hormona de crecimiento, prolactina y hepcidina Bidirectional communication between neuroendocrine and immune systems through growth hormone, prolactin and hepcidin
Enríquez, C., & Paola Paez, R. (2013)
Гормональные изменения в ответ на экстремальные факторы внешней среды
Russian Federation (2014) · CyberLeninK (CyberLeninka)
Growth Hormone as Modulator of Adipose Inflammation
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Multifactorial Regulation of GLH Hormones
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Authors: Redelman, D., Welniak, L. A., Taub, D., & Murphy, W. J.
Affiliations: University of Nevada, Reno (US)
National Institutes of Health (US)
Corresponding author: Murphy, William J.
ORCID: Murphy, William J.
Venue: Cellular Immunology
Publisher: Elsevier BV
Published: 2008
Volume: 252
Issue: 1-2
Pages: 111-121
ISSN: 0008-8749 (ISSN-L)
DOI: 10.1016/j.cellimm.2007.12.003
PMC: PMC4777337
OpenAlex: W1974823036
Cited by: 71
References: 101
Citations by year: 2026: 1 · 2025: 1 · 2023: 2 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 7 · 2013: 2 · 2012: 8
FWCI: 0.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Cellular Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG022661)
National Center for Research Resources (P20RR016464)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: growth hormone, prolactin, neuroendocrine hormones, cytokine network, chemokines, suppressor of cytokine signaling, immune recovery, chemotherapy, bone marrow transplantation, HIV, immunosenescence
MeSH terms: Aging, Animals, Humans, Neurosecretory Systems, Prolactin, Growth Hormone, Signal Transduction, Cytokines

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Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network

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