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Cited by 984

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Estrogen receptors regulate innate immune cells and signaling pathways

Open access
Kovats, Susan·2015·Cellular Immunology
DOI 10.1016/j.cellimm.2015.01.018
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Abstract

Humans show strong sex differences in immunity to infection and autoimmunity, suggesting sex hormones modulate immune responses. Indeed, receptors for estrogens (ER) regulate cells and pathways in the innate and adaptive immune system, as well as immune cell development. ERs are ligand-dependent transcription factors that mediate long-range chromatin interactions and form complexes at gene regulatory elements, thus promoting epigenetic changes and transcription. ERs also participate in membrane-initiated steroid signaling to generate rapid responses. Estradiol and ER activity show profound dose- and context-dependent effects on innate immune signaling pathways and myeloid cell development. While estradiol most often promotes the production of type I interferon, innate pathways leading to pro-inflammatory cytokine production may be enhanced or dampened by ER activity. Regulation of innate immune cells and signaling by ERs may contribute to the reported sex differences in innate immune pathways. Here we review the recent literature and highlight several molecular mechanisms by which ERs regulate the development or functional responses of innate immune cells.

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Metadata

Authors
Kovats, S.
Venue
Cellular Immunology
Publisher
Elsevier BV
Published
2015-04
Volume
294
Issue
2
Pages
63-69
ISSN
0008-8749 (ISSN-L)
DOI
10.1016/j.cellimm.2015.01.018
OpenAlex
W2045688706
Cited by
984
References
3
FWCI
33.51
Type
journal article
Language
en
Open access
green

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