Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Cell transformation by the superoxide-generating oxidase Mox1

Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480

PDZ Domains and the Organization of Supramolecular Complexes

Sheng, M., & Sala, C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1 · Cited by 1,211

Reactive Oxygen Species as Intracellular Messengers During Cell Growth and Differentiation

Sauer, H., Wartenberg, M., & Hescheler, J. (2001) · Cellular Physiology and Biochemistry · doi:10.1159/000047804 · Cited by 1,118

Vascular NAD(P)H oxidases: specific features, expression, and regulation

Lassegue, B. P., & Clempus, R. E. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00758.2002 · Cited by 1,026

Identification of Renox, an NAD(P)H oxidase in kidney

Geiszt, M., Kopp, J. B., Várnai, P., & Leto, T. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130135897 · Cited by 840

Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5

Cheng, G., Cao, Z., Xu, X., Meir, E. G. V., & Lambeth, J. D. (2001) · Gene · doi:10.1016/s0378-1119(01)00449-8 · Cited by 820

The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

Vignais, P. V. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8520-9 · Cited by 799

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

Planat‐Benard, V., Bohl, B. P., & Bokoch, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13198 · Cited by 754

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

Frangioni, J. V., Beahm, P. H., Shifrin, V. I., Jost, C. A., & Neel, B. G. (1992) · Cell · doi:10.1016/0092-8674(92)90190-n · Cited by 596

Profibrotic epithelial TGF-β1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN

Veith, C., Hristova, M., Danyal, K., Habibovic, A., Dustin, C. M., McDonough, J. E., Vanaudenaerde, B. M., Kreuter, M., Schneider, M. A., Kahn, N. C., et al. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00444.2019 · Cited by 31

Reactive oxygen species cause endothelial dysfunction in chronic flow overload

Lu, X., Guo, X., Wassall, C. D., Kemple, M. D., Unthank, J. L., & Kassab, G. S. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00786.2009 · Cited by 27

Periaqueductal gray neuroplasticity following chronic morphine varies with age: Role of oxidative stress

Bajic, D., Berde, C. B., & Commons, K. G. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.028 · Cited by 29

Volume-sensitive NADPH oxidase activity and taurine efflux in NIH3T3 mouse fibroblasts

Friis, M., Vorum, K. G., & Lambert, I. H. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00571.2007 · Cited by 28

Quantitative interaction analysis permits molecular insights into functional NOX4 NADPH oxidase heterodimer assembly

O’Neill, S., Mathis, M., Kovačič, L., Zhang, S., Reinhardt, J., Scholz, D., Schopfer, U., Bouhelal, R., & Knaus, U. G. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001045 · Cited by 25

NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice

Herranz‐Itúrbide, M., López‐Luque, J., Gonzalez‐Sanchez, E., Caballero‐Díaz, D., Crosas‐Molist, E., Martín‐Mur, B., Gut, M. O., Esteve‐Codina, A., Jaquet, V., Jiang, J. X., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101841 · Cited by 27

Carnosic Acid Attenuates an Early Increase in ROS Levels during Adipocyte Differentiation by Suppressing Translation of Nox4 and Inducing Translation of Antioxidant Enzymes

Lee, D.-K., & Jang, H. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116096 · Cited by 27

Anti-Inflammatory Effect of Resveratrol Derivatives via the Downregulation of Oxidative-Stress-Dependent and c-Src Transactivation EGFR Pathways on Rat Mesangial Cells

Lee, I., Lin, H., Huang, T., Tseng, C., Cheng, H.-T., Huang, W., & Cheng, C. (2022) · Antioxidants · doi:10.3390/antiox11050835 · Cited by 27

Endothelial dysfunction due to the inhibition of the synthesis of nitric oxide: Proposal and characterization of an in vitro cellular model

da Silva, F. C., de Araújo, B. J., Cordeiro, C. S., Arruda, V. M., Faria, B. Q., Guerra, J. F. D. C., Araújo, T. G., & Fürstenau, C. R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.978378 · Cited by 27

Role of c-Src and reactive oxygen species in cardiovascular diseases

Hussain, M., Ikram, W., & Ikram, U. (2023) · Molecular Genetics and Genomics · doi:10.1007/s00438-023-01992-9 · Cited by 27

Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence

Demelash, A., Pfannenstiel, L. W., Liu, L., & Gastman, B. (2017) · Oncotarget · doi:10.18632/oncotarget.15962 · Cited by 27

Hearing vulnerability after noise exposure in a mouse model of reactive oxygen species overproduction

Morioka, S., Sakaguchi, H., Yamaguchi, T., Ninoyu, Y., Mohri, H., Nakamura, T., Hisa, Y., Ogita, K., Saito, N., & Ueyama, T. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14451 · Cited by 27

Lipophilic Extract and Tanshinone IIA Derived from Salvia miltiorrhiza Attenuate Uric Acid Nephropathy through Suppressing Oxidative Stress-Activated MAPK Pathways

Zhang, X., Zhou, M. L., An, L., Zhang, P., Li, P., & Chen, J. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500718 · Cited by 26

Vascular Functions of NADPH Oxidases

Brandes, R. P. (2010) · Hypertension · doi:10.1161/hypertensionaha.108.120295 · Cited by 26

The Ins and Outs of Small GTPase Rac1 in the Vasculature

Marinković, G., Heemskerk, N., van Buul, J. D., & de Waard, V. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.223610 · Cited by 25

Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities

Aboolian, A., Urner, S., Roden, M., Jha, J. C., & Jandeleit-Dahm, K. A. M. (2022) · Handbook of experimental pharmacology · doi:10.1007/164_2021_576 · Cited by 25

Prolonged fasting activates Nrf2 in postweaned elephant seals

Vázquez‐Medina, J. P., Soñanez‐Organis, J. G., Rodríguez, R., Viscarra, J. A., Nishiyama, A., Crocker, D. E., & Ortiz, R. M. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.081927 · Cited by 25

Functional Role of Nox4 in Autophagy

Forte, M., Palmerio, S., Yee, D., Frati, G., & Sciarretta, S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_16 · Cited by 25

Oxidative Stress and Cell Death in Cardiovascular Disease

Marı́n-Garcı́a, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-404599-6.00014-7 · Cited by 26

Knockout of p47 phox Uncovers a Critical Role of p40 phox in Reactive Oxygen Species Production in Microvascular Endothelial Cells

Fan, L. M., Teng, L., & Li, J.-M. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.191502 · Cited by 24

Low-Molecular-Weight Oxidants Involved in Disulfide Bond Formation

Ruddock, L. W. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4481 · Cited by 24

Upregulation of Heme Oxygenase 1 by Hemin Impairs Endothelium-Dependent Contractions in the Aorta of the Spontaneously Hypertensive Rat

Li, Z., Wang, Y., & Vanhoutte, P. M. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.173807 · Cited by 24

Differential resistance to platinum‐based drugs and 5‐fluorouracil in p22phox‐overexpressing oral squamous cell carcinoma: Implications of alternative treatment strategies

Hung, C., Chien, C., Chu, P., Wu, Y., Lin, C., Huang, C., Chan, L., Wang, Y., Yuan, S. F., Hour, T., et al. (2017) · Head & Neck · doi:10.1002/hed.24803 · Cited by 24

Thioredoxin attenuates oxidized low-density lipoprotein induced oxidative stress in human umbilical vein endothelial cells by reducing NADPH oxidase activity

Chen, B., Li, M., Shen, T., Gong, H., Qi, R., Zhao, Y., Sun, J., Bao, L., & Zhao, G. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.023 · Cited by 24

Oxidative activation of type III CD38 by NADPH oxidase–derived hydrogen peroxide in Ca 2+ signaling

Park, D., Nam, T., Kim, Y., Bae, Y. S., & Kim, U. (2018) · The FASEB Journal · doi:10.1096/fj.201800235r · Cited by 25

Hsp70 regulation on Nox4/p22phox and cytoskeletal integrity as an effect of losartan in vascular smooth muscle cells

Lorenzo, A. F. G., Bocanegra, V., Benardón, M. E., Cacciamani, V. E., & Vallés, P. G. (2013) · Cell Stress and Chaperones · doi:10.1007/s12192-013-0439-6 · Cited by 24

Critical Role of H2O2 Generated by NOX4 during Cellular Response under Glucose Deprivation

Owada, S., Shimoda, Y., Tsuchihara, K., & Esumi, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056628 · Cited by 24

Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production

Kakoki, M., Bahnson, E. M., Hagaman, J. R., Siletzky, R. M., Grant, R., Kayashima, Y., Li, F., Lee, E. Y., Sun, M., Taylor, J. M., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.127660 · Cited by 23

RNA interference targeting cytosolic NADP+-dependent isocitrate dehydrogenase exerts anti-obesity effect in vitro and in vivo

Nam, W. S., Park, K. M., & Park, J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.04.003 · Cited by 25

Sexual Dimorphism of NADPH Oxidase/H2O2 System in Rat Thyroid Cells; Effect of Exogenous 17β-Estradiol

Stępniak, J., Lewiñski, A., & Karbownik‐Lewińska, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124063 · Cited by 23

Ras and Nox: Linked signaling networks?

Wu, R. F., & Terada, L. S. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.037 · Cited by 24

Isolation and characterization of a putative liver progenitor population after treatment of fetal rat hepatocytes with TGF‐Beta

del Castillo, G., Alvarez, A. M., Carmona‐Cuenca, I., Fernández, M., Sánchez, A., & Fabregat, I. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21370 · Cited by 23

Molecular Roles of NADPH Oxidase-Mediated Oxidative Stress in Alzheimer’s Disease: Isoform-Specific Contributions

Kim, J., & Moon, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212299 · Cited by 26

NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores

Gola, L., Bierhansl, L., Csatári, J., Schroeter, C. B., Korn, L., Narayanan, V., Cerina, M., Abdolahi, S., Speicher, A., Hermann, A. M., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04758-z · Cited by 22

Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle

Dick, A. S., Ivanovska, J., Kantores, C., Belcastro, R., Tanswell, A. K., & Jankov, R. P. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.027 · Cited by 22

Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase

Gandara, A. C. P., Torres, A., Bahia, A. C., de Oliveira, P. L., & Schama, R. (2017) · BMC Evolutionary Biology · doi:10.1186/s12862-017-0940-0 · Cited by 22

Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes

Tang, X., Wang, J., Abboud, H. E., Chen, Y., Wang, J. J., & Zhang, S. X. (2022) · Diabetes · doi:10.2337/db22-0194 · Cited by 21

Group VIA Phospholipase A 2 Mediates Enhanced Macrophage Migration in Diabetes Mellitus by Increasing Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4

Tan, C., Day, R. T., Bao, S. S., TURK, J. W., & Zhao, Q. D. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302847 · Cited by 21

1α,25-Dihydroxyvitamin D3 prevents renal oxidative damage via the PARP1/SIRT1/NOX4 pathway in Zucker diabetic fatty rats

Wang, D., Li, Y., Wang, N., Luo, G., Wang, J., Luo, C., Yu, W., & Hao, L. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00270.2019 · Cited by 21

Fulvene-5 inhibition of Nadph oxidases attenuates activation of epithelial sodium channels in A6 distal nephron cells

Trac, D. Q., Liu, B., Pao, A. C., Thomas, S. V., Park, M., Downs, C. A., Ma, H., & Helms, M. N. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00098.2013 · Cited by 20

Nox 4 Regulation of Vascular Smooth Muscle Cell Differentiation Marker Gene Expression

Deliri, H., & McNamara, C. A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000254154.43871.50 · Cited by 21

TLR4 regulates pulmonary vascular homeostasis and remodeling via redox signaling

Chen, Y. (2015) · Frontiers in bioscience · doi:10.2741/4396 · Cited by 21

Peroxidasin-mediated crosslinking of collagen IV is independent of NADPH oxidases

Sirokmány, G., Kovács, H. A., Lázár, E., Kónya, K., Donkó, Á., Enyedi, B., Grasberger, H., & Geiszt, M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.03.009 · Cited by 21

Heat Shock Protein 70 and CHIP Promote Nox4 Ubiquitination and Degradation within the Losartan Antioxidative Effect in Proximal Tubule Cells

Lorenzo, A. F. G., Costantino, V. V., Appiolaza, M. L., Cacciamani, V. E., Benardón, M. E., Bocanegra, V., & Vallés, P. G. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430184 · Cited by 20

Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat

Hicks, S. D., Labinskyy, N., Piteo, B., Laurent, D., Mathew, J., Gupte, S. A., & Edwards, J. G. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00567.2012 · Cited by 20

Redox mechanisms in pathological angiogenesis in the retina: roles for NADPH oxidase

Chan, E. C., Liu, G., & Dusting, G. J. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666151029111127 · Cited by 20

GLX351322, a Novel NADPH Oxidase 4 Inhibitor, Attenuates TMJ Osteoarthritis by Inhibiting the ROS/MAPK/NF-κB Signaling Pathways

Zhen, J., Chen, X., Ma, H., Xie, X., Chen, X., Xu, W., & Zhang, S. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/1952348 · Cited by 19

p22phox confers resistance to cisplatin, by blocking its entry into the nucleus

Hung, C., Chien, C., Chiang, W., Lin, C., Hour, T., Chen, H., Wang, L., Ko, J., Chang, C., & Chen, J. Y. (2015) · Oncotarget · doi:10.18632/oncotarget.2893 · Cited by 19

Fluid shear stress upregulates placental growth factor in the vessel wall via NADPH oxidase 4

Rashdan, N. A., & Lloyd, P. G. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00408.2015 · Cited by 20

Gene Therapy for Cisplatin-Induced Ototoxicity

Sofia Waissbluth, A., Pitaro, J., & Daniel, S. J. (2012) · Otology & Neurotology · doi:10.1097/mao.0b013e318248ee66 · Cited by 19

Cells redox environment modulates BRCA1 expression and DNA homologous recombination repair

Wilson, A., & Yakovlev, V. A. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.015 · Cited by 19

NOX4-reactive oxygen species axis: critical regulators of bone health and metabolism

Dzubanova, M., Bond, J. M., Craige, S. M., & Tencerová, M. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1432668 · Cited by 18

Óxido nítrico y factores relacionados a oxidación e inflamación como posibles biomarcadores de insuficiencia cardíaca

Bonafede, R. J., & Manucha, W. A. (2018) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2017.12.004 · Cited by 25

Redox Properties, Bioactivity and Health Effects of Indicaxanthin, a Bioavailable Phytochemical from Opuntia ficus indica, L.: A Critical Review of Accumulated Evidence and Perspectives

Attanzio, A., Restivo, I., Tutone, M., Tesoriere, L., Allegra, M., & Livrea, M. A. (2022) · Antioxidants · doi:10.3390/antiox11122364 · Cited by 20

NADPH oxidase 4 deficiency attenuates experimental osteoarthritis in mice

Renaudin, F., Oudina, K., Gerbaix, M., Subilia, M. M., Paccaud, J., Jaquet, V., Krause, K., Ferrari, S., Laumonier, T., & Hannouche, D. (2023) · RMD Open · doi:10.1136/rmdopen-2022-002856 · Cited by 20

Astragaloside IV targets PRDX6, inhibits the activation of RAC subunit in NADPH oxidase 2 for oxidative damage

Cheng, C., Liu, K., Shen, F., Zhang, J., Xie, Y., Li, S., Hou, Y., & Bai, G. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154795 · Cited by 18

NADPH Oxidase 3: Beyond the Inner Ear

Herb, M. (2024) · Antioxidants · doi:10.3390/antiox13020219 · Cited by 19

Laminar shear stress enhances endothelial cell survival through a NADPH oxidase 2-dependent mechanism

Jeon, H., & Boo, Y. C. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.12.016 · Cited by 18

VAS2870 Inhibits Histamine-Induced Calcium Signaling and vWF Secretion in Human Umbilical Vein Endothelial Cells

Avdonin, P. V., Rybakova, E. Y., Авдонин, П. П., Авдонин, П. П., Авдонин, П. П., Tsitrina, A. A., & Goncharov, N. V. (2019) · Cells · doi:10.3390/cells8020196 · Cited by 18

Reactive Oxygen-Generating NADPH Oxidases in Plants

Fluhr, R. (2009) · Signaling and communication in plants · doi:10.1007/978-3-642-00390-5_1 · Cited by 20

Characterisation of Nox4 Inhibitors from Edible Plants

Kofler, P., Pircher, H., von Grafenstein, S., Diener, T., Höll, M., Liedl, K. R., Siems, K., & Jansen‐Dürr, P. (2013) · Planta Medica · doi:10.1055/s-0032-1328129 · Cited by 18

Cys-Oxidation of Protein Tyrosine Phosphatases: Its Role in Regulation of Signal Transduction and Its Involvement in Human Cancers

Meng, T., Lou, Y., Chen, Y., Hsu, S.-F., & Huang, Y.-F. (2006) · doi:10.29685/jcm.200602.0001 · Cited by 18

Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison

Meneses‐Valdés, R., Gallero, S., Henríquez‐Olguín, C., & Jensen, T. E. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.07.035 · Cited by 17

Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility, and Aging

Tranah, G. J., Barnes, H. N., Cawthon, P. M., Coen, P. M., Esser, K. A., Hepple, R. T., Huo, Z., Kramer, P. A., Toledo, F. G. S., Zhang, X., et al. (2024) · Aging Cell · doi:10.1111/acel.14114 · Cited by 16

Peroxisome proliferator‐activated receptor δ inhibits Porphyromonas gingivalis lipopolysaccharide‐induced activation of matrix metalloproteinase‐2 by downregulating NADPH oxidase 4 in human gingival fibroblasts

Yoo, T., Ham, S. A., Hwang, J. S., Lee, W. J., Paek, K. S., Oh, J., Kim, J., Do, J. T., Han, C., Kim, J., et al. (2015) · Molecular Oral Microbiology · doi:10.1111/omi.12137 · Cited by 17

Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML

Moloney, J. N., Jayavelu, A. K., Stanicka, J., Roche, S. L., O’Brien, R. L., Scholl, S., Böhmer, F.-D., & Cotter, T. G. (2017) · Oncotarget · doi:10.18632/oncotarget.22241 · Cited by 19

Egg White Hydrolysate: A new putative agent to prevent vascular dysfunction in rats following long-term exposure to aluminum

Martinez, C. S., Piagette, J. T., Escobar, A. G., Martín, Á., Palacios, R., Peçanha, F. M., Vassallo, D. V., Exley, C., Alonso, M. J., Salaíces, M., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110799 · Cited by 17

Bartter/Gitelman syndromes as a model to study systemic oxidative stress in humans

Maiolino, G., Azzolini, M., Rossi, G. P., Davis, P. A., & Calò, L. A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.02.037 · Cited by 17

Aluminum exposure for one hour decreases vascular reactivity in conductance and resistance arteries in rats

Schmidt, P. M., Escobar, A. G., Torres, J. G. D., Martinez, C. S., Rizzetti, D. A., Kunz, S. N., Vassallo, D. V., Alonso, M. J., Peçanha, F. M., & Wiggers, G. A. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.10.023 · Cited by 17

The Dual Role of NOX4 in Cardiovascular Diseases: Driver of Oxidative Stress and Mediator of Adaptive Remodeling

Labbé, P., Thorin, É., & Thorin‐Trescases, N. (2025) · Antioxidants · doi:10.3390/antiox14091137 · Cited by 16

NADPH oxidase 4 is correlated with gastric cancer progression and predicts a poor prognosis.

Du, S., Miao, J., Lu, X., Shi, L., Sun, J., Xu, E., Wang, X., Zhao, M., Chen, H., Wang, F., et al. (2019) · PubMed Central · Cited by 16

Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery

Zhang, S., Yin, Z., Qin, W., Ma, X., Zhang, Y., Liu, E., & Chu, Y. (2020) · Mediators of Inflammation · doi:10.1155/2020/2604967 · Cited by 16

Intrahepatic microcirculatory disorder, parenchymal hypoxia and NOX4 upregulation result in zonal differences in hepatocyte apoptosis following lipopolysaccharide- and D-galactosamine-induced acute liver failure in rats

Tanaka, M., TANAKA, K., MASAKI, Y., MIYAZAKI, M., Kato, M., Kotoh, K., Enjoji, M., Nakamuta, M., & Takayanagi, R. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1573 · Cited by 16

Targeting the redox-programmed cell death axis in breast cancer: from molecular mechanisms to therapeutic resistance

Wen, Y., Lin, Z., Jiang, Z., Li, Y., & Wu, T. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02743-y · Cited by 16

Smooth muscle cell-specific knockout of FBW7 exacerbates intracranial atherosclerotic stenosis

Shen, Y., Chen, X., Chi, C., Wang, H., Xue, J., Su, D., Wang, H., Li, M., Liu, B., & Dong, Q. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104584 · Cited by 15

Differential effects of NOX2 and NOX4 inhibition after rodent spinal cord injury

Khayrullina, G., Bermudez, S., Hopkins, D., Yauger, Y. J., & Byrnes, K. R. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281045 · Cited by 15

Role of Rac1 in regulation of NOX5-S function in Barrett's esophageal adenocarcinoma cells

Hong, J., Resnick, M. B., Behar, J., Wands, J. R., DeLellis, R. A., & Cao, W. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00027.2011 · Cited by 15

Potential Role of Protein Disulfide Isomerase in Metabolic Syndrome‐Derived Platelet Hyperactivity

Gaspar, R. S., Trostchansky, A., & Paes, A. M. D. A. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2423547 · Cited by 15

Lipoproteins and Cardiovascular Redox Signaling: Role in Atherosclerosis and Coronary Disease

Haghikia, A., & Landmesser, U. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7052 · Cited by 16

Blockade of TGF- β 1 Signalling Inhibits Cardiac NADPH Oxidase Overactivity in Hypertensive Rats

Miguel‐Carrasco, J. L., Baltanás, A., Cebrián, C., Moreno, M. U., López, B., Hermida, N., González, A., Dotor, J., Borrás‐Cuesta, F., Dı́ez, J., et al. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/726940 · Cited by 15

Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation

Mink, S. N., Kasian, K., Martinez, L. E. S., Jacobs, H. K., Bose, R., Cheng, Z.-Q., & Light, R. B. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01072.2007 · Cited by 15

Oxidative Stress and Nuclear Factor κB (NF-κB) Increase Peritoneal Filtration and Contribute to Ascites Formation in Nephrotic Syndrome

Udwan, K., Brideau, G., Fila, M., Edwards, A., Vogt, B., & Doucet, A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.724690 · Cited by 15

NOX4 alleviates breast cancer cell aggressiveness by co-ordinating mitochondrial turnover through PGC1α/Drp1 axis

Bhadane, D., Kamble, D., Deval, M., Das, S., & Sitasawad, S. L. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.111008 · Cited by 14

Ferroptosis in schizophrenia: Mechanisms and therapeutic potentials (Review)

Lv, S., & Luo, C. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13402 · Cited by 14

Glycosylation with O-linked β-N-acetylglucosamine induces vascular dysfunction via production of superoxide anion/reactive oxygen species

Souza-Silva, L., Alves-Lopes, R., Miguez, J. S., Justina, V. D., Neves, K. B., Mestriner, F., Tostes, R. C., Giachini, F. R. C., & Lima, V. V. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0225 · Cited by 15

Redox-Dependent Calpain Signaling in Airway and Pulmonary Vascular Remodeling in COPD

Kovács, L., & Su, Y. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_9 · Cited by 14

Rho GTPases: Non‐canonical regulation by cysteine oxidation

Hurst, M., McGarry, D. J., & Olson, M. F. (2021) · BioEssays · doi:10.1002/bies.202100152 · Cited by 15

Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart

Kawakami, R., Sunaga, H., Iso, T., Kaneko, R., Koitabashi, N., Obokata, M., Harada, T., Matsui, H., Yokoyama, T., & Kurabayashi, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-10993-4 · Cited by 14

Peptide screen identifies a new NADPH oxidase inhibitor: impact on cell migration and invasion

Mousslim, M., Pagano, A., Andreotti, N., Garrouste, F. L., Thuault, S., Peyrot, V., Parat, F., Luis, J., Culcasi, M., Laurent, S., et al. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.10.011 · Cited by 14

Photoreceptor oxidative stress in hyperoxia-induced proliferative retinopathy accelerates rd8 degeneration

Lajko, M., Cardona, H. J., Taylor, J. M., Farrow, K. N., & Fawzi, A. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180384 · Cited by 15

Simultaneous angiotensin receptor blockade and glucagon‐like peptide‐1 receptor activation ameliorate albuminuria in obese insulin‐resistant rats

Rodríguez, R., Escobedo, B., Lee, A. Y., Thorwald, M. A., Godoy-Lugo, J. A., Nakano, D., Nishiyama, A., Parkes, D. G., & Ortiz, R. M. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13206 · Cited by 14

Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor

Noce, B., Marchese, S., Massari, M., Lambona, C., Reis, J., Fiorentino, F., Raucci, A., Fioravanti, R., Castelôa, M., Mormino, A., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02644 · Cited by 15

Spatiotemporal H2O2 flashes coordinate actin cytoskeletal remodeling and regulate cell migration and wound healing

O’Mara, M., Zhang, S., & Knaus, U. G. (2025) · Nature Communications · doi:10.1038/s41467-025-62272-1 · Cited by 14

NOX4 has the potential to be a biomarker associated with colon cancer ferroptosis and immune infiltration based on bioinformatics analysis

Yang, X., Yu, Y., Wang, Z., Wu, P., Su, X., Wu, Z., Gan, J., & Zhang, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.968043 · Cited by 13

Antioxidant Defenses in the Lung

van der Vliet, A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-404577-4.00025-4 · Cited by 15

Downregulation of Wnt-Mediated ROS Generation Is Causally Implicated in Leprechaunism

Park, J. W., Kuehn, H. S., Kim, S. Y., Chung, K. M., Choi, H. J., Kim, M., Kim, J., Lee, S. Y., Bae, D. S., Jin, D., et al. (2009) · Molecules and Cells · doi:10.1007/s10059-010-0017-z · Cited by 13

The role of NADPH oxidase (NOX) enzymes in neurodegenerative disease

Ajayi, A., Yu, X., & Ström, A. (2012) · Frontiers in Biology · doi:10.1007/s11515-012-1250-y · Cited by 12

Postsynaptic p47phox regulates long-term depression in the hippocampus

Yi, J. H., Kim, D. H., Piers, T. M., Kim, S. C., Whitcomb, D. J., Regan, P. L., & Cho, K. (2018) · Cell Discovery · doi:10.1038/s41421-018-0046-x · Cited by 13

Exercise Training‐Enhanced, Endothelium‐Dependent Dilation Mediated by Altered Regulation of BK Ca Channels in Collateral‐Dependent Porcine Coronary Arterioles

Xie, W., Parker, J. L., & Heaps, C. L. (2012) · Microcirculation · doi:10.1111/micc.12016 · Cited by 13

GTPase-Rac enhances depolarization-induced superoxide production by the macula densa during tubuloglomerular feedback

Liu, R., & Juncos, L. A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00622.2009 · Cited by 13

Structural Insights into Nox4 and Nox2: Motifs Involved in Function and Cellular Localization

von Löhneysen, K., Noack, D., Wood, M. R., Friedman, J. S., & Knaus, U. G. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01393-09 · Cited by 127

NOX family: the ROS producer in plasma membrane

Li, L. (2005)

NADPH oxidase 4 function as a hydrogen peroxide sensor

Nisimoto, Y., Ogawa, H., Kadokawa, Y., & Qiao, S. (2018) · The Journal of Biochemistry · doi:10.1093/jb/mvy014 · Cited by 10

Molecular composition and regulation of the Nox family NAD(P)H oxidases

Sumimoto, H., Miyano, K., & Takeya, R. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.210 · Cited by 306

Point Mutations in the Proline-rich Region of p22 Are Dominant Inhibitors of Nox1- and Nox2-dependent Reactive Oxygen Generation

Kawahara, T., Ritsick, D., Cheng, G., & Lambeth, J. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501882200 · Cited by 231