The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer
Open accessAbstract
The serine/threonine protein kinase Akt is a major signal transducer of the phosphoinositide 3-kinase (PI 3-K) pathway in all cells and tissues and plays a pivotal role in the maintenance of cellular processes including cell growth, proliferation, survival and metabolism. The frequent aberrant activation of the PI 3-K/Akt pathway in human cancer has made it an attractive therapeutic target. Numerous studies have provided a comprehensive understanding of the specific functions of Akt signaling in cancer cells as well as the surrounding tumor microenvironment and this has informed and enabled the development of therapeutic drugs to target both PI 3-K and Akt. However, recent studies have provided evidence for distinct functions of the three mammalian Akt isoforms, particularly with respect to the regulation of cell motility and metastasis of breast cancer. Here we discus the mechanisms by which Akt signaling contributes to invasive migration and tumor metastasis, and highlight recent advances in our understanding of the contribution of the Akt pathway in the tumor-associated stroma.
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Cites
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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AKT/PKB signaling: navigating downstream
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Loss of PTEN facilitates HIF-1-mediated gene expression
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Cited by
PI3K signaling in cancer: beyond AKT
Lien, E. C., Dibble, C. C., & Toker, A. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.02.007 · Cited by 451
Self-citationDi Vizio, D., Morello, M., Dudley, A. C., Schow, P. W., Adam, R. M., Morley, S., Mulholland, D., Rotinen, M., Hager, M. H., Insabato, L., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.07.030 · Cited by 422
Distinct functions of AKT isoforms in breast cancer: a comprehensive review
Hinz, N., & Jücker, M. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0450-3 · Cited by 355
Clement, D. L., Mally, S., Stock, C., Lethan, M., Satir, P., Schwab, A., Pedersen, S. F., & Christensen, S. T. (2012) · Journal of Cell Science · doi:10.1242/jcs.116426 · Cited by 94
Endomembrane PtdIns(3,4,5)P3 activates the PI3K-Akt pathway
Jethwa, N., Chung, G. H. C., Lete, M. G., Alonso, A., Byrne, R. D., Calleja, V., & Larijani, B. (2015) · Journal of Cell Science · doi:10.1242/jcs.172775 · Cited by 68
Metadata
- Authors
- Chin, Y. R., & Toker, A.
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 21
- Issue
- 4
- Pages
- 470-476
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W2008282782
- Cited by
- 255
- References
- 8
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Chin, Y. R., & Toker, A. (2009). Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cellular Signalling. https://doi.org/10.1016/j.cellsig.2008.11.015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
