The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease
Open accessAbstract
Oncosomes are tumor-derived microvesicles that transmit signaling complexes between cell and tissue compartments. Herein, we show that amoeboid tumor cells export large (1- to 10-μm diameter) vesicles, derived from bulky cellular protrusions, that contain metalloproteinases, RNA, caveolin-1, and the GTPase ADP-ribosylation factor 6, and are biologically active toward tumor cells, endothelial cells, and fibroblasts. We describe methods by which large oncosomes can be selectively sorted by flow cytometry and analyzed independently of vesicles <1 μm. Structures resembling large oncosomes were identified in the circulation of different mouse models of prostate cancer, and their abundance correlated with tumor progression. Similar large vesicles were also identified in human tumor tissues, but they were not detected in the benign compartment. They were more abundant in metastases. Our results suggest that tumor microvesicles substantially larger than exosome-sized particles can be visualized and quantified in tissues and in the circulation, and isolated and characterized using clinically adaptable methods. These findings also suggest a mechanism by which migrating tumor cells condition the tumor microenvironment and distant sites, thereby potentiating advanced disease.
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Cites
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
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Gene expression correlates of clinical prostate cancer behavior
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Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
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Gene expression profiling identifies clinically relevant subtypes of prostate cancer
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Self-citationRac Activation and Inactivation Control Plasticity of Tumor Cell Movement
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Integrative molecular concept modeling of prostate cancer progression
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Self-citationARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles
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Cited by
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Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186
Doyle, L., & Wang, M. (2019) · Cells · doi:10.3390/cells8070727 · Cited by 3,236
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Self-citationExtracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003
Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance
Mashouri, L., Yousefi, H., Aref, A. R., Ahadi, A. M., Molaei, F., & Alahari, S. K. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0991-5 · Cited by 1,363
Metadata
- Authors
- Di Vizio, D., Morello, M., Dudley, A. C., Schow, P. W., Adam, R. M., Morley, S., Mulholland, D., Rotinen, M., Hager, M. H., Insabato, L., Moses, M. A., Demichelis, F., Lisanti, M. P., Wu, H., Klagsbrun, M., Bhowmick, N. A., Rubin, M. A., D'Souza-Schorey, C., & Freeman, M. R.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 181
- Issue
- 5
- Pages
- 1573-1584
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W1982669563
- Cited by
- 422
- References
- 47
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Di Vizio, D., Morello, M., Dudley, A. C., Schow, P. W., Adam, R. M., Morley, S., Mulholland, D., Rotinen, M., Hager, M. H., Insabato, L., Moses, M. A., Demichelis, F., Lisanti, M. P., Wu, H., Klagsbrun, M., Bhowmick, N. A., Rubin, M. A., D'Souza-Schorey, C., & Freeman, M. R. (2012). Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease. The American Journal of Pathology. https://doi.org/10.1016/j.ajpath.2012.07.030
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
