The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Transforming growth factor-β and the hallmarks of cancer
Open accessAbstract
Tumorigenesis is in many respects a process of dysregulated cellular evolution that drives malignant cells to acquire six phenotypic hallmarks of cancer, including their ability to proliferate and replicate autonomously, to resist cytostatic and apoptotic signals, and to induce tissue invasion, metastasis, and angiogenesis. Transforming growth factor-β (TGF-β) is a potent pleiotropic cytokine that functions as a formidable barrier to the development of cancer hallmarks in normal cells and tissues. Paradoxically, tumorigenesis counteracts the tumor suppressing activities of TGF-β, thus enabling TGF-β to stimulate cancer invasion and metastasis. Fundamental gaps exist in our knowledge of how malignant cells overcome the cytostatic actions of TGF-β, and of how TGF-β stimulates the acquisition of cancer hallmarks by developing and progressing human cancers. Here we review the molecular and cellular mechanisms that underlie the ability of TGF-β to mediate tumor suppression in normal cells, and conversely, to facilitate cancer progression and disease dissemination in malignant cells.
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TGF-β – an excellent servant but a bad master
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Metadata
- Authors
- Tian, M., Neil, J. R., & Schiemann, W. P.
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 23
- Issue
- 6
- Pages
- 951-962
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W2061958868
- Cited by
- 244
- References
- 18
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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